Publication date: Available online 17 September 2019Source: Academic RadiologyAuthor(s): Amer M. Mohiuddin, Richard B. Gunderman
Wed Sep 18, 2019 15:47
Abstract Purpose Pancreatic adenocarcinoma (PAC) represents one of the most fatal types of cancer with an exceptionally poor prognosis, underscoring the need for improved diagnostic and treatment approaches. An over-expression of somatostatin receptors (SST) as well as of the chemokine receptor CXCR4 has been shown for many tumour entities. Respective expression data for PAC, however, are scarce and contradictory. ...
Wed Sep 18, 2019 15:51
Abstract Background Our previous study identified a Wilms tumor-suppressing peptide (WTSP) that was upregulated in healthy children, but downregulated in children with Wilms tumor (WT). This study aimed to investigate the effect of WTSP on WT growth in vivo and in vitro. Methods WTSP was synthesized by solid-phase synthesis of FOMC-protected...
Wed Sep 18, 2019 15:51
Abstract Purpose To determine the frequency of co-occurring genes in non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutation and the predictive effect of co-mutations on the efficacy of EGFR tyrosine kinase inhibitors (EGFR-TKIs). Methods 54 patients with advanced NSCLC were tested for 422 clinically...
Wed Sep 18, 2019 15:51
Abstract Purpose Metastatic lymph node (LN) burden is one of the most important prognosticators in human solid cancers, but has rarely been examined in laryngeal and hypopharyngeal cancers (LHC). We evaluated the nodal factors predictive of recurrence and survival in patients with LHC. Methods This study included 141 consecutive patients who...
Wed Sep 18, 2019 15:51
Abstract Background The neutrophil to lymphocyte ratio (NLR) is known to be prognostic for patients with advanced cancers treated with immune checkpoint inhibitors (ICI), but has generally been evaluated as a single threshold value at baseline. We evaluated NLR at baseline and within first month during treatment in patients who received ICI for advanced cancer to evaluate the prognostic value of baseline and of changes from baseline...
Wed Sep 18, 2019 15:51
Abstract Purpose Previously, the combination of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) and bevacizumab (BEV) was investigated. A subgroup analysis of the IMpower150 trial, which investigated the combination of atezolizumab, carboplatin, paclitaxel, and bevacizumab (ABCP), demonstrated the benefit of ABCP in patients harboring EGFR mutations. This study aims to assess the prognostic significance of...
Wed Sep 18, 2019 15:51
Publication date: Available online 17 September 2019Source: Acta HistochemicaAuthor(s): Mirca Marini, Lidia Ibba-Manneschi, Irene Rosa, Eleonora Sgambati, Mirko ManettiAbstractTelocytes (TCs), also known as CD34+ stromal/interstitial cells, have recently been identified within the connective tissue of a variety of organs including the normal human testis. Testicular TCs appear to constitute a widespread reticular network distributed either in the peritubular or in the intertubular stromal spaces...
Wed Sep 18, 2019 15:53
Abstract Background Dental caries is the most common chronic disease in the US and disproportionately affects racial/ethnic minorities. Caries is heritable, and though genetic heterogeneity exists between ancestries for a substantial portion of loci associated with complex disease, a genome-wide association study (GWAS) of caries specifically in African Americans has not been performed previously. ...
Wed Sep 18, 2019 03:00
Abstract Background Implant prostheses require sufficient interocclusal space. In cases of limited interocclusal space, reducing or extracting over-erupted opposing teeth, orthodontic intrusion, or surgical reconstruction of the edentulous space are commonly used to restore the interocclusal space. However, there are disadvantages to these approaches. Case presentation...
Wed Sep 18, 2019 03:00
Open maternal communication is positively associated with female friendship. Female friendship and open paternal communication is negatively associated with depressive symptoms, which increase with age. Abstract Attachment theory holds that parental relationships have lifelong effects on offspring social lives. The tend‐and‐befriend hypothesis posits that female friendships among humans evolved as part of a primate‐wide coping mechanism to mediate stress by relying on social support. Here we...
Tue Sep 17, 2019 22:00
Abstract Gut microbial communities communicate bidirectionally with the brain through endocrine, immune, and neural signaling, influencing the physiology and behavior of hosts. The emerging field of microbial endocrinology offers innovative perspectives and methods to analyze host‐microbe relationships with relevance to primate ecology, evolution, and conservation. Herein we briefly summarize key findings from microbial endocrinology and explore how applications of a similar framework could inform...
Wed Sep 18, 2019 13:31
Publication date: Available online 17 September 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): Shixing Ma, Xiaole Li, Aobo Zhang, Shaopeng Liu, Haoming Zhao, Huaqiang ZhaoAbstractThe purpose of this study was to assess the influence of two suture methods on the postoperative complications of extraction of mandibular third molars (M3M). We searched the MEDLINE (PubMed), Cochrane Library, and Web of Science databases until 18 May 2018 for randomised controlled trials (RCT)...
Wed Sep 18, 2019 16:30
Abstract Objective To investigate a cohort of adult single-sided deafness (SSD) patients who received a cochlear implant and to determine the impact of underlying causes of etiology and duration of deafness on outcome Study design Retrospective data analysis Setting Tertiary...
Wed Sep 18, 2019 03:00
Abstract Purpose To compare the surgical outcomes of endoscopic transcanal tympanoplasty (ETT) and conventional microscopic tympanoplasty (CMT) in repairing anterior tympanic membrane perforations (ATMPs). Methods We retrospectively analyzed the graft success rate, hearing outcomes, operative time, hospitalization period and complications in patients who...
Wed Sep 18, 2019 03:00
Abstract Purpose An automated, objective, fast and simple classification system for the grading of facial palsy (FP) is lacking. Methods An observational single center study was performed. 4572 photographs of 233 patients with unilateral peripheral FP were subjectively rated and automatically analyzed applying a machine learning approach including Supervised...
Wed Sep 18, 2019 03:00
Wed Sep 18, 2019 03:00
Publication date: Available online 17 September 2019Source: Cancer/RadiothérapieAuthor(s): C. Verry, E. Porcel, C. Chargari, C. Rodriguez-Lafrasse, J. BalossoRésuméLa nanomédecine a connu un développement important depuis les années 2000 et ce n’est que très récemment que deux nanoparticules métalliques ont fait leur apparition dans des essais cliniques chez l’homme. Le mécanisme d’action de ces agents radiosensibilisants repose sur la présence d’atomes avec un numéro atomique (Z) élevé permettant...
Wed Sep 18, 2019 17:24
Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01491H, PaperTatsuro Nakao, Kazuma Mawatari, Yutaka Kazoe, Emi Mori, Hisashi Shimizu, Takehiko KitamoriA rapid and sensitive enzyme-linked immunosorbent assay (ELISA) is required for on-site clinical diagnosis. Previously, a microfluidic ELISA in which antibody-immobilized beads are packed in a microchannel for a high...The content of this RSS Feed (c) The Royal Society of Chemistry
Wed Sep 18, 2019 02:00
Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01519A, PaperFida'a Alshawawreh, Fabio Lisi, Nicholas Ariotti, Padmavathy Bakthavathsalam, Tania Benedetti, Richard Tilley, John Justin GoodingHerein, a glucose meter-based immunosensing platform is developed that allows the quantification of procalcitonin (PCT) in whole blood samples. PCT is a biomarker for sepsis and its early detection would...The content of this RSS Feed (c) The Royal Society of Chemistry
Wed Sep 18, 2019 02:00
Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01275C, Critical ReviewBingbing Gao, Xin Li, Ya-Qiong Yang, Jianlin Chu, Bingfang HePaper has unique advantages over other materials, including low cost, flexibility, porosity, and self-driven liquid pumping, thus making it widely used in various fields in biology, chemistry, physics and materials...The content of this RSS Feed (c) The Royal Society of Chemistry
Wed Sep 18, 2019 02:00
Analyst, 2019, Advance ArticleDOI: 10.1039/C9AN01176E, PaperAbdullah S. Mondol, Samir F. El-Mashtoly, Tatjana Frick, Klaus Gerwert, Jürgen Popp, Iwan W. SchieLabel-free screening for cancer cells exposed to monoclonal antibody-based drugs using HCS-RS.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
Wed Sep 18, 2019 02:00
Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01481K, PaperVeikko Uahengo, Johannes Naimhwaka, Daniel Likius, Ateeq Rahman, Mohamed I Elzagheid, Lydia Rhyman, Ponnadurai Ramasami, Ping CaiA naphthyl derivative colorimetric sensor (L) bearing hydrazone receptors was synthesized via a one-step reaction process, and its recognition properties towards biologically important anions in acetonitrile-water mixture were investigated by...The content of this RSS Feed (c) The Royal Society of Chemistry
Wed Sep 18, 2019 02:00
Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01507H, PaperAndrew Mills, Yusufu DilidaerA colourimetric vacuum air pressure indicator is described, based on the very low level of CO2 in air. The indicator uses the pH indicator dye, ortho-cresolphthalein, OCP, which is violet...The content of this RSS Feed (c) The Royal Society of Chemistry
Wed Sep 18, 2019 02:00
Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN00751B, PaperArthur Viode, Stephane Epelbaum, Imen Benyounes, Marc Verny, Bruno Dubois, Christophe Junot, francois Fenaille, Foudil Lamari, Francois BecherTau and α-synuclein are central in several neurodegenerative diseases, including Alzheimer Disease (AD), Dementia with Lewy bodies (DLB) and Parkinson disease (PD). New analytical methods for precise quantification of cerebrospinal...The content of this RSS Feed (c) The Royal Society of Chemistry
Wed Sep 18, 2019 02:00
The Journal of Antibiotics, Published online: 18 September 2019; doi:10.1038/s41429-019-0234-4Antiviral effect of sinefungin on in vitro growth of feline herpesvirus type 1
Wed Sep 18, 2019 03:00
Abstract Agenesis of the internal carotid artery (ICA) is a rare congenital vascular disorder of the cerebral circulation. CT scan of the skull base disclosing complete absence of the bony carotid canal helps to differentiate an agenesis from aplasia or hypoplasia. Although most of the patients remain asymptomatic (thanks to the sufficient collateral circulation provided by the circle of Willis) cerebral infarcts, transient ischemic attacks or intracranial aneurysms have been rarely...
Wed Sep 18, 2019 03:00
Wed Sep 18, 2019 03:00
Replication-competent oncolytic viruses (OVs) have been proven to be a potent anticancer weapon for clinical therapy. The preexisting neutralizing antibody in patients is a big challenge for oncolytic efficacy...
Wed Sep 18, 2019 03:00
ATPase associated with a variety of cellular activities (AAA ATPase) family members are closely linked to tumor formation and progression. However, their roles in hepatocellular carcinoma (HCC) largely remain ...
Wed Sep 18, 2019 03:00
The post עברית, תחת שמי התכלת של א"י appeared first on האקדמיה ללשון העברית.
Wed Sep 18, 2019 17:43
בעברית שבפינו אנחנו רגילים להביע כלליות וסתמיות על ידי תוספת 'שהוא', למשל 'בכל מצב שהוא', 'איזה עניין שהוא'. הרכיב 'שהוא' משמש הרבה בצירופים שבראשם מילת שאלה – מהם שנכתבים במילה אחת: מישהו, איזשהו, מתי שהוא, איך שהוא, איפה שהוא, לאן שהוא. מילת שאלה מטבעה מכוונת למסומן שאינו ידוע, ולכן היא מתאימה לעמוד ביסוד כינוי סתמי, לא מסוים, לא ידוע. כך גם כינוי הגוף 'הוא'. תחילתו של מבנה זה בלשון חז"ל בצירוף משהו (גם בכתיבים מה שהוא, משהוא). אלא שמשמעו בספרות חז"ל שונה מן המוכר היום. 'משהו' פירושו 'מעט', 'קצת'....
Wed Sep 18, 2019 17:48
New study on guppies shows that animals evolve in response the the environment they create in the absence of predators, rather than in response to the risk of being eaten.
Wed Sep 18, 2019 14:57
The ancestor of some of the largest flying birds ever has been found in Waipara, New Zealand.
Wed Sep 18, 2019 02:36
Intermittent claudication is a symptom of atherosclerosis of the lower limbs (peripheral arterial disease (PAD)) and is characterized by pain and cramps of lower limb muscles during exercise. Claudication leads to a reduction in physical activity of patients. PAD is a systemic disease. Atherosclerotic lesions located in the arteries of the lower limbs not only pose the risk of the ischemic limb loss, but above all, they are an important prognostic factor. Patients with claudication are at significant...
Wed Sep 18, 2019 18:05
Undifferentiated and dedifferentiated endometrial carcinomas (UDEC) are aggressive uterine tumors which may show loss of expression of SMARCA4 (BRG1) or SMARCB1 (INI-1). The recently described SMARCA4-deficient undifferentiated uterine sarcoma (SDUS) has a morphology which overlaps with UDEC. In this study, we compared clinical, morphologic, immunohistochemical, and molecular characteristics to identify features which differentiate SDUS from UDEC. Cases of SDUS (n=12) were compared with cases of...
Tue Sep 17, 2019 03:00
Neoadjuvant chemoradiotherapy (CRT) is the standard of care for locally advanced rectal cancer. Morphologic changes such as fibrosis, inflammatory infiltrates, and the formation of extracellular mucin pools can be identified in the resection specimen after neoadjuvant CRT. The association of mucin pool formation with clinicopathologic variables and outcomes is unclear. The aim of this study was to meta-analyze all available evidence with regard to mucin pool formation and clinicopathologic outcomes...
Tue Sep 17, 2019 03:00
The entity “pericytoma with t(7;12)” was described as a rare, distinct perivascular myoid neoplasm provisionally classified within the family of myopericytic tumors that demonstrates t(7;12)(p22;q13) translocation with resultant ACTB-GLI1 fusion and biologically was felt to behave in an indolent fashion. However, a recent study showed that tumors with this and similar translocations may have variable morphology and immunohistochemical phenotype with inconsistent myopericytic characteristics and a...
Tue Sep 17, 2019 03:00
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