Synchronous bilateral pheochromocytomas and bilobar medullary thyroid carcinoma revealed by 18F-FDOPA PET/CT in a MEN-2A asymptomatic patient
Marianela Rotania12
Gérard Chabrier3
Alessio Imperiale145
Email author
1.Biophysics and Nuclear Medicine, Hautepierre HospitalUniversity Hospitals of StrasbourgStrasbourgFrance
2.Molecular and Nuclear MedicineInstituto OultonCordobaArgentina
3.Endocrinology and Internal Medicine Department, Hautepierre HospitalUniversity Hospitals of StrasbourgStrasbourgFrance
4.Faculty of Medicine, FMTSUniversity of StrasbourgStrasbourgFrance
5.Molecular Imaging—DRHIM, IPHC, UMR 7178, CNRS/UnistraStrasbourgFrance
Endocrine imaging
First Online: 02 September 2019
Type-2A multiple endocrine neoplasia (MEN-2A) syndrome is a rare autosomal dominant inheritance disease characterized by the presence of pheochromocytoma (PHEO), medullary thyroid carcinoma (MTC), and parathyroid adenoma or hyperplasia. In patients with MEN-2A, PHEO is frequently asymptomatic and bilateral, and MTC is multifocal, usually representing the first manifestation of the disease.
Herein, we present the scholar clinical case of a 38-years-old woman with MEN-2A syndrome addressed for clinical examination and primary biochemical investigation following the diagnosis of a mutation in codon 634 of gene RET exon 11. Patient showed increased plasma normetanephrine (14.7 nmol/l, normal <10.9), noradrenaline (680 ng/l, normal <400), adrenaline (257 ng/l, normal <90), dopamine (64 ng/l, normal <50), chromogranin-A (114 ug/L, normal <100), and calcitonin values (241 ng/L, normal <10). At clinical examination, small non-toxic goiter (afterwards confirmed by cervical ultrasonography) was...
| Synchronous bilateral pheochromocytomas and bilobar medullary thyroid carcinoma revealed by 18 F-FDOPA PET/CT in a MEN-2A asymptomatic patient |
Gérard Chabrier3
Alessio Imperiale145
Email author
1.Biophysics and Nuclear Medicine, Hautepierre HospitalUniversity Hospitals of StrasbourgStrasbourgFrance
2.Molecular and Nuclear MedicineInstituto OultonCordobaArgentina
3.Endocrinology and Internal Medicine Department, Hautepierre HospitalUniversity Hospitals of StrasbourgStrasbourgFrance
4.Faculty of Medicine, FMTSUniversity of StrasbourgStrasbourgFrance
5.Molecular Imaging—DRHIM, IPHC, UMR 7178, CNRS/UnistraStrasbourgFrance
Endocrine imaging
First Online: 02 September 2019
Type-2A multiple endocrine neoplasia (MEN-2A) syndrome is a rare autosomal dominant inheritance disease characterized by the presence of pheochromocytoma (PHEO), medullary thyroid carcinoma (MTC), and parathyroid adenoma or hyperplasia. In patients with MEN-2A, PHEO is frequently asymptomatic and bilateral, and MTC is multifocal, usually representing the first manifestation of the disease.
Herein, we present the scholar clinical case of a 38-years-old woman with MEN-2A syndrome addressed for clinical examination and primary biochemical investigation following the diagnosis of a mutation in codon 634 of gene RET exon 11. Patient showed increased plasma normetanephrine (14.7 nmol/l, normal <10.9), noradrenaline (680 ng/l, normal <400), adrenaline (257 ng/l, normal <90), dopamine (64 ng/l, normal <50), chromogranin-A (114 ug/L, normal <100), and calcitonin values (241 ng/L, normal <10). At clinical examination, small non-toxic goiter (afterwards confirmed by cervical ultrasonography) was...
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου