Abstract Objective To assess whether biological aging as measured by leukocyte telomere length (LTL) is associated with clinical disability and brain volume loss in multiple sclerosis (MS). Methods Adults with MS/CIS in the UCSF‐EPIC cohort study were included. LTL was measured on DNA samples by quantitative PCR and expressed as telomere to somatic DNA ratio (T/S). Expanded Disability Status Scale (EDSS) and 3D T1‐weighted brain MRI were performed at baseline and follow‐up. Associations...
Wed Sep 04, 2019 21:04
Functional dynamics of thalamic local field potentials correlate with modulation of neuropathic pain
Abstract Understanding the functional dynamics of neural oscillations in the sensory thalamus is essential for elucidating the perception and modulation of neuropathic pain. Local field potentials were recorded from the sensory thalamus of twelve neuropathic pain patients. Single and combinational neural states were defined by the activity state of a single or paired oscillations. Relationships between the duration or occurrence rate of neural state and pre‐operative pain level or pain relief induced...
Wed Sep 04, 2019 11:34
Abstract Virtual reality (VR) is a promising tool for expanding the possibilities of psychological experimentation and implementing immersive training applications. Despite a recent surge in interest, there remains an inadequate understanding of how VR impacts basic cognitive processes. Due to the artificial presentation of egocentric distance cues in virtual environments, a number of cues to depth in the optic array are impaired or placed in conflict with each other. Moreover,...
Wed Sep 04, 2019 03:00
Abstract Musical improvisation is a sophisticated cognitive process that combines creativity, goal‐directed action, sensory monitoring, and social interaction. With a renewed interest in quantifying creative processes facilitated by recent advances in neuroimaging technology, musical improvisation has emerged as an ideal paradigm to study creativity. However, many studies isolate the top‐down processes related to creativity from those related to production and auditory perception, leaving the question...
Tue Sep 03, 2019 19:57
Publication date: November 2019Source: World Neurosurgery, Volume 131Author(s): Rajesh Chhabra, Apinderpreet Singh, Pravin Salunke, Ramandeep VirkBackgroundVascular complications during transsphenoidal surgery can be devastating. Direct vascular injury during surgery can lead to various complications including pseudoaneurysm formation. Postoperative hematoma and direct vascular handling due to arachnoid tear can induce vasospasm. The vasospasm might present with varying clinical symptomatology and...
Wed Sep 04, 2019 14:35
Publication date: Available online 3 September 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Santanu Bora, Amandeep Kumar, Shashwat Mishra, Guru D. Satyarthee, Pankaj K. Singh, Dattaraj Sawarkar, Satish Verma, Sachin Borkar, Rajeev Sharma, Sarat P. Chandra, Shashank S. KaleAbstractObjectiveFungal infections of central nervous system (CNS) commonly affect immunocompromised patients, however, recently such cases have been reported even amongst immunocompetent patients.Patients & methodsIn...
Wed Sep 04, 2019 13:45
Publication date: Available online 3 September 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Xin-jie Ning, Qun Gao, Chuan Chen, Cong Ling, Jia-ji Liang, Zhang-yu Li, Hui WangAbstractObjectiveTo observe the effects of superficial temporal artery-middle cerebral artery bypass (STA-MCA bypass) on hemodynamics and clinical outcomes in the patients with atherosclerotic stenosis in the intracranial segment of internal carotid artery and (or) middle cerebral artery.Patients and MethodsThe data...
Wed Sep 04, 2019 13:45
Publication date: Available online 3 September 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Jia Wang, Yilin Yang, Xi Liu, Yunyou DuanAbstractWe analyzed the relationship between quantitative CEUS parameters and microvessel density (MVD) of different pathologic grades of cerebral gliomas. ICEUS was performed in 49 patients with cerebral gliomas. The enhancement characteristics of cerebral gliomas were observed before and after tumor resection. The number of microvessels was counted by...
Wed Sep 04, 2019 13:45
Publication date: Available online 3 September 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Ali Rashidi, Jens Neumann, Daniela Adolf, I. Erol Sandalcioglu, Michael LuchtmannAbstractObjectiveAfter a decompressive craniectomy (DC), a cranioplasty (CP) is often performed in order to improve neurosurgical outcome and cerebral blood circulation. But even though the performance of a CP subsequent to a DC has become routine medical practice, patients can in fact develop many complications from...
Wed Sep 04, 2019 13:45
Publication date: Available online 3 September 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Rahul Rahangdale, Thomas Scott, Timothy Leichliter, Susan Baser, James Valeriano
Wed Sep 04, 2019 13:45
Wed Sep 04, 2019 03:00
Abstract Purpose of Review Walking impairments are highly prevalent in persons with multiple sclerosis (PwMS) and are associated with reduced quality of life. Walking is traditionally quantified with various measures, including patient self-reports, clinical rating scales, performance measures, and advanced lab-based movement analysis techniques. Yet, the majority of these measures do not fully characterize walking (i.e., gait quality)...
Wed Sep 04, 2019 03:00
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