Antibiotics, Vol. 9, Pages 155: Monoclonal Antibodies as an Antibacterial Approach Against Bacterial Pathogens Antibiotics doi: 10.3390/antibiotics9040155 Authors: Zurawski McLendon In the beginning of the 21st century, the frequency of antimicrobial resistance (AMR) has reached an apex, where even 4th and 5th generation antibiotics are becoming useless in clinical settings. In turn, patients are suffering from once-curable infections, with increases in morbidity and mortality....
Wed Apr 01, 2020 03:00
Antibiotics, Vol. 9, Pages 154: The Costs, Benefits and Human Behaviours for Antimicrobial Use in Small Commercial Broiler Chicken Systems in Indonesia Antibiotics doi: 10.3390/antibiotics9040154 Authors: Coyne Patrick Arief Benigno Kalpravidh McGrane Schoonman Sukarno Rushton There are growing concerns over the threat to human health from the unregulated use of antimicrobials in livestock. Broiler production is of great economic and social importance...
Wed Apr 01, 2020 03:00
Antibiotics, Vol. 9, Pages 153: Carbapenem-Resistant but Cephalosporin-Susceptible Pseudomonas aeruginosa in Urinary Tract Infections: Opportunity for Colistin Sparing Antibiotics doi: 10.3390/antibiotics9040153 Authors: Márió Gajdács This paper briefly reports the occurrence and epidemiology of carbapenem-resistant but cephalosporin-susceptible (Car-R/Ceph-S) Pseudomonas aeruginosa isolates from urinary tract infections (UTIs) in a tertiary-care hospital in the Southern Region of Hungary,...
Wed Apr 01, 2020 03:00
Antioxidants, Vol. 9, Pages 295: Sesamol Alleviates Airway Hyperresponsiveness and Oxidative Stress in Asthmatic Mice Antioxidants doi: 10.3390/antiox9040295 Authors: Liou Chen Yu Yeh Shen Huang Sesamol, isolated from sesame seeds (Sesamum indicum), was previously shown to have antioxidative, anti-inflammatory, and anti-tumor effects. Sesamol also inhibited lipopolysaccharide (LPS)-induced pulmonary inflammatory response in rats. However, it remains unclear how sesamol...
Wed Apr 01, 2020 03:00
Antioxidants, Vol. 9, Pages 294: Sirt3 Exerts Its Tumor-Suppressive Role by Increasing p53 and Attenuating Response to Estrogen in MCF-7 Cells Antioxidants doi: 10.3390/antiox9040294 Authors: Marija Pinterić Iva I. Podgorski Marijana Popović Hadžija Vedrana Filić Mladen Paradžik Bastien Lucien Jean Proust Ana Dekanić Ivan Ciganek Denis Pleše Dora Marčinko Tihomir Balog Sandra Sobočanec Estrogen (E2) is a major risk factor for the initiation and progression...
Wed Apr 01, 2020 03:00
Antioxidants, Vol. 9, Pages 293: Potential Antioxidant and Enzyme Inhibitory Effects of Nanoliposomal Formulation Prepared from Salvia aramiensis Rech. f. Extract Antioxidants doi: 10.3390/antiox9040293 Authors: Karatoprak Yücel Göger Sobarzo-Sánchez Akkol Salvia aramiensis Rech. f. is a species that grows only in Hatay, Turkey and is used as a traditional stomachic tea. Neither the chemical composition nor the potential bioactivity of the plant has been investigated...
Wed Apr 01, 2020 03:00
Arts, Vol. 9, Pages 46: Between Yerushalayim DeLita and Jerusalem—The Memorial Inscription from the Bimah of the Great Synagogue of Vilna Arts doi: 10.3390/arts9020046 Authors: Seligman During excavations of the bimah (the platform for reading the Torah) of the 17th-century Great Synagogue of Vilna (Vilnius, Lithuania), an important memorial inscription was exposed. This paper describes the new finds associated with the baroque-rococo architecture of the bimah and focuses on the inscription...
Wed Apr 01, 2020 03:00
Behavioral Sciences, Vol. 10, Pages 70: Alexithymia as a Predictor of Arousal and Affect Dysregulations when Batterers with Attention Deficit Hyperactivity Disorder Cope with Acute Stress Behavioral Sciences doi: 10.3390/bs10040070 Authors: Ángel Romero-Martínez Marisol Lila Luis Moya-Albiol Empirical research has stated that Attention Deficit Hyperactivity Disorder (ADHD) might underlie intimate partner violence against women (IPVAW) perpetration. Even though there is a clear...
Wed Apr 01, 2020 03:00
Beverages, Vol. 6, Pages 21: Functional Beverages in Selected Countries of Asia Pacific Region: A Review Beverages doi: 10.3390/beverages6020021 Authors: Lei Cong Phil Bremer Miranda Mirosa Functional beverages have gained increasing market share over the last decade. As the Asia Pacific region is one of the largest and most important markets for functional foods, it is critical when developing and promoting new products that food manufacturers/marketers have a good understanding...
Wed Apr 01, 2020 03:00
Biology, Vol. 9, Pages 68: Estrogen Signaling Induces Mitochondrial Dysfunction-Associated Autophagy and Senescence in Breast Cancer Cells Biology doi: 10.3390/biology9040068 Authors: Bajbouj Shafarin Taneera Hamad Previous work has shown that although estrogen (E2) disrupts cellular iron metabolism and induces oxidative stress in breast and ovarian cancer cells, it fails to induce apoptosis. However, E2 treatment was reported to enhance the apoptotic effects of doxorubicin...
Wed Apr 01, 2020 03:00
Biomolecules, Vol. 10, Pages 535: Combining Virtual Screening Protocol and In Vitro Evaluation towards the Discovery of BACE1 Inhibitors Biomolecules doi: 10.3390/biom10040535 Authors: Judite R. M. Coimbra Salete J. Baptista Teresa C. P. Dinis Maria M. C. Silva Paula I. Moreira Armanda E. Santos Jorge A. R. Salvador The treatment options for a patient diagnosed with Alzheimer’s disease (AD) are currently limited. The cerebral accumulation of amyloid-β...
Wed Apr 01, 2020 03:00
Biomolecules, Vol. 10, Pages 534: Oxidized LDL Modify the Human Adipocyte Phenotype to an Insulin Resistant, Proinflamatory and Proapoptotic Profile Biomolecules doi: 10.3390/biom10040534 Authors: Concepción Santiago-Fernández Flores Martin-Reyes Mónica Tome Luis Ocaña-Wilhelmi Jose Rivas-Becerra Franz Tatzber Edith Pursch Francisco J. Tinahones Eduardo García-Fuentes Lourdes Garrido-Sánchez Little information exists in humans on the regulation that oxidized...
Wed Apr 01, 2020 03:00
Biomolecules, Vol. 10, Pages 533: Regulation of the Single Polar Flagellar Biogenesis Biomolecules doi: 10.3390/biom10040533 Authors: Seiji Kojima Hiroyuki Terashima Michio Homma Some bacterial species, such as the marine bacterium Vibrio alginolyticus, have a single polar flagellum that allows it to swim in liquid environments. Two regulators, FlhF and FlhG, function antagonistically to generate only one flagellum at the cell pole. FlhF, a signal recognition particle (SRP)-type...
Wed Apr 01, 2020 03:00
Biomolecules, Vol. 10, Pages 532: Structural Dynamics of the Lipid Antigen-Binding Site of CD1d Protein Biomolecules doi: 10.3390/biom10040532 Authors: Bruno Cuevas-Zuviría Marina Mínguez-Toral Araceli Díaz-Perales María Garrido-Arandia Luis F. Pacios CD1 molecules present lipid antigens to T-cells in early stages of immune responses. Whereas CD1‒lipid‒T-cell receptors interactions are reasonably understood, molecular details on initial trafficking and loading of lipids onto...
Wed Apr 01, 2020 03:00
Brain Sciences, Vol. 10, Pages 206: Probiotics Alleviate the Progressive Deterioration of Motor Functions in a Mouse Model of Parkinson's Disease Brain Sciences doi: 10.3390/brainsci10040206 Authors: Tsung-Hsun Hsieh Chi-Wei Kuo Kai-Hsuan Hsieh Meng-Jyh Shieh Chih-Wei Peng Yen-Chien Chen Ying-Ling Chang Ying-Zu Huang Chih-Chung Chen Pi-Kai Chang Kai-Yun Chen Hsin-Yung Chen Parkinson’s disease (PD) is one of the common long-term degenerative...
Wed Apr 01, 2020 03:00
Brain Sciences, Vol. 10, Pages 207: Handle the Autism Spectrum Condition During Coronavirus (COVID-19) Stay At Home period: Ten Tips for Helping Parents and Caregivers of Young Children Brain Sciences doi: 10.3390/brainsci10040207 Authors: Antonio Narzisi COVID-19 has become pandemic [...]
Wed Apr 01, 2020 03:00
Brain Sciences, Vol. 10, Pages 205: Comparative Study of Novel Noninvasive Cerebral Autoregulation Volumetric Reactivity Indices Reflected by Ultrasonic Speed and Attenuation as Dynamic Measurements in the Human Brain Brain Sciences doi: 10.3390/brainsci10040205 Authors: Basant K. Bajpai Rolandas Zakelis Mantas Deimantavicius Daiva Imbrasiene This is a comparative study of two novel noninvasive cerebrovascular autoregulation (CA) monitoring methods based on intracranial blood...
Wed Apr 01, 2020 03:00
Brain Sciences, Vol. 10, Pages 204: Learning a Path from Real Navigation: The Advantage of Initial View, Cardinal North and Visuo-Spatial Ability Brain Sciences doi: 10.3390/brainsci10040204 Authors: Veronica Muffato Chiara Meneghetti Background: Spatial cognition research strives to maximize conditions favoring environment representation. This study examined how initial (egocentric) navigation headings interact with allocentric references in terms of world-based information (such...
Wed Apr 01, 2020 03:00
Cancers, Vol. 12, Pages 857: Tunneling Nanotubes and Tumor Microtubes in Cancer Cancers doi: 10.3390/cancers12040857 Authors: Cora Roehlecke Mirko H. H. Schmidt Intercellular communication among cancer cells and their microenvironment is crucial to disease progression. The mechanisms by which communication occurs between distant cells in a tumor matrix remain poorly understood. In the last two decades, experimental evidence from different groups proved the existence of thin membranous...
Wed Apr 01, 2020 03:00
Cancers, Vol. 12, Pages 855: Green Chemistry Synthesis of Silver Nanoparticles and Their Potential Anticancer Effects Cancers doi: 10.3390/cancers12040855 Authors: Zubair Ahmed Ratan Mohammad Faisal Haidere Md. Nurunnabi Sadi Md. Shahriar A.J. Saleh Ahammad Youn Young Shim Martin J.T. Reaney Jae Youl Cho Nanobiotechnology has grown rapidly and become an integral part of modern disease diagnosis and treatment. Biosynthesized silver nanoparticles (AgNPs) are a class...
Wed Apr 01, 2020 03:00
Cancers, Vol. 12, Pages 854: Progress towards Patient-Specific, Spatially-Continuous Radiobiological Dose Prescription and Planning in Prostate Cancer IMRT: An Overview Cancers doi: 10.3390/cancers12040854 Authors: Emily Jungmin Her Annette Haworth Pejman Rowshanfarzad Martin A. Ebert Advances in imaging have enabled the identification of prostate cancer foci with an initial application to focal dose escalation, with subvolumes created with image intensity thresholds. Through...
Wed Apr 01, 2020 03:00
Cancers, Vol. 12, Pages 856: CD44s Induces miR-629-3p Expression in Association with Cisplatin Resistance in Head and Neck Cancer Cells Cancers doi: 10.3390/cancers12040856 Authors: Junichiro Chikuda Kurataka Otsuka Iwao Shimomura Kagenori Ito Hiroaki Miyazaki Ryou-u Takahashi Masahiro Nagasaki Yoshiki Mukudai Takahiro Ochiya Toshikazu Shimane Tatsuo Shirota Yusuke Yamamoto Cisplatin (cis-diamminedichloroplatinum II [CDDP] ) is a well-known chemotherapeutic...
Wed Apr 01, 2020 03:00
Cancers, Vol. 12, Pages 852: Cell Intrinsic and Systemic Metabolism in Tumor Immunity and Immunotherapy Cancers doi: 10.3390/cancers12040852 Authors: Michael F. Coleman Alyssa J. Cozzo Alexander J. Pfeil Suhas K. Etigunta Stephen D. Hursting Immune checkpoint inhibitor (ICI) therapy has shown extraordinary promise at treating cancers otherwise resistant to treatment. However, for ICI therapy to be effective, it must overcome the metabolic limitations of the tumor microenvironment....
Wed Apr 01, 2020 03:00
Cancers, Vol. 12, Pages 853: The Core-Clock Gene NR1D1 Impacts Cell Motility in Vitro and Invasiveness in A Zebrafish Xenograft Colon Cancer Model Cancers doi: 10.3390/cancers12040853 Authors: Alireza Basti Rita Fior Müge Yalҫin Vanda Póvoa Rosario Astaburuaga Yin Li Julian Naderi Miguel Godinho Ferreira Angela Relógio Malfunctions of circadian clock trigger abnormal cellular processes and influence tumorigenesis. Using an in vitro and in vivo xenograft model,...
Wed Apr 01, 2020 03:00
Cancers, Vol. 12, Pages 850: L-Glucose: Another Path to Cancer Cells Cancers doi: 10.3390/cancers12040850 Authors: Koki Ono Shota Takigawa Katsuya Yamada Cancerous tumors comprise cells showing metabolic heterogeneity. Among numerous efforts to understand this property, little attention has been paid to the possibility that cancer cells take up and utilize otherwise unusable substrates as fuel. Here we discuss this issue by focusing on L-glucose, the mirror image isomer of naturally...
Wed Apr 01, 2020 03:00
Cancers, Vol. 12, Pages 851: Attenuation of the Hypoxia Inducible Factor Pathway after Oncolytic Adenovirus Infection Coincides with Decreased Vessel Perfusion Cancers doi: 10.3390/cancers12040851 Authors: Iris Yousaf Jakob Kaeppler Sally Frost Len W. Seymour Egon J. Jacobus The interplay between oncolytic virus infection and tumour hypoxia is particularly unexplored in vivo, although hypoxia is present in virtually all solid carcinomas. In this study, oncolytic adenovirus...
Wed Apr 01, 2020 03:00
Cancers, Vol. 12, Pages 849: Observational Multicenter Study on the Prognostic Relevance of Coagulation Activation in Risk Assessment and Stratification in Locally Advanced Breast Cancer. Outline of the ARIAS Trial Cancers doi: 10.3390/cancers12040849 Authors: Laura Pizzuti Eriseld Krasniqi Chiara Mandoj Daniele Marinelli Domenico Sergi Elisabetta Capomolla Giancarlo Paoletti Claudio Botti Ramy Kayal Francesca Romana Ferranti Isabella Sperduti Letizia Perracchio...
Wed Apr 01, 2020 03:00
Cells, Vol. 9, Pages 856: Macrophage-Derived Extracellular Vesicle Promotes Hair Growth Cells doi: 10.3390/cells9040856 Authors: Ramya Lakshmi Rajendran Prakash Gangadaran Chang Hoon Seo Mi Hee Kwack Ji Min Oh Ho Won Lee Arunnehru Gopal Young Kwan Sung Shin Young Jeong Sang-Woo Lee Jaetae Lee Byeong-Cheol Ahn Hair loss is a common medical problem affecting both males and females. Dermal papilla (DP) cells are the ultimate reservoir of cells with the potential...
Wed Apr 01, 2020 03:00
Cells, Vol. 9, Pages 852: Highly Sensitive and Multiplexed In-Situ Protein Profiling with Cleavable Fluorescent Streptavidin Cells doi: 10.3390/cells9040852 Authors: Renjie Liao Thai Pham Diego Mastroeni Paul D. Coleman Joshua Labaer Jia Guo The ability to perform highly sensitive and multiplexed in-situ protein analysis is crucial to advance our understanding of normal physiology and disease pathogenesis. To achieve this goal, we here develop an approach using cleavable...
Wed Apr 01, 2020 03:00
Cells, Vol. 9, Pages 855: Platelet-Leukocyte Interplay in Cancer Development and Progression Cells doi: 10.3390/cells9040855 Authors: Dagmar Stoiber Alice Assinger Beyond their crucial role in hemostasis, platelets are increasingly recognized as regulators of inflammation. Via modulation of the immune system by direct and indirect interactions with leukocytes, platelets regulate several aspects of tumor-associated pathology. They influence inflammatory processes in cancer at various...
Wed Apr 01, 2020 03:00
Cells, Vol. 9, Pages 853: Gut Microbiota, Its Role in Induction of Alzheimer’s Disease Pathology, and Possible Therapeutic Interventions: Special Focus on Anthocyanins Cells doi: 10.3390/cells9040853 Authors: Muhammad Sohail Khan Muhammad Ikram Jun Sung Park Tae Ju Park Myeong Ok Kim The human gut is a safe environment for several microbes that are symbiotic and important for the wellbeing of human health. However, studies on gut microbiota in different animals have suggested...
Wed Apr 01, 2020 03:00
Cells, Vol. 9, Pages 854: SIV Infection and the HIV Proteins Tat and Nef Induce Senescence in Adipose Tissue and Human Adipose Stem Cells, Resulting in Adipocyte Dysfunction Cells doi: 10.3390/cells9040854 Authors: Jennifer Gorwood Tina Ejlalmanesh Christine Bourgeois Matthieu Mantecon Cindy Rose Michael Atlan Delphine Desjardins Roger Le Le Grand Bruno Fève Olivier Lambotte Jacqueline Capeau Véronique Béréziat Claire Lagathu Background: Aging is...
Wed Apr 01, 2020 03:00
Cells, Vol. 9, Pages 851: Targeting and Crossing the Blood-Brain Barrier with Extracellular Vesicles
Cells, Vol. 9, Pages 851: Targeting and Crossing the Blood-Brain Barrier with Extracellular Vesicles Cells doi: 10.3390/cells9040851 Authors: Julien Saint-Pol Fabien Gosselet Sophie Duban-Deweer Gwënaël Pottiez Yannis Karamanos The blood–brain barrier (BBB) is one of the most complex and selective barriers in the human organism. Its role is to protect the brain and preserve the homeostasis of the central nervous system (CNS). The central elements of this physical and physiological...
Wed Apr 01, 2020 03:00
Cells, Vol. 9, Pages 850: TRPCs: Influential Mediators in Skeletal Muscle Cells doi: 10.3390/cells9040850 Authors: Jun Hee Choi Seung Yeon Jeong Mi Ri Oh Paul D. Allen Eun Hui Lee Ca2+ itself or Ca2+-dependent signaling pathways play fundamental roles in various cellular processes from cell growth to death. The most representative example can be found in skeletal muscle cells where a well-timed and adequate supply of Ca2+ is required for coordinated Ca2+-dependent skeletal...
Wed Apr 01, 2020 03:00
Children, Vol. 7, Pages 26: Characterization of Pediatric Seizures in the Commonwealth of the Northern Mariana Islands Children doi: 10.3390/children7040026 Authors: Yogesh Taylor Chang Saipan is a United States (US) territory Western Pacific island where little recent data exists regarding epidemiology, clinical presentation, and standard of care for pediatric seizures. This paper characterizes these features in Saipan’s pediatric population with comparisons to mainland...
Wed Apr 01, 2020 03:00
Climate, Vol. 8, Pages 51: Potential Risks of Plant Invasions in Protected Areas of Sri Lanka under Climate Change with Special Reference to Threatened Vertebrates Climate doi: 10.3390/cli8040051 Authors: Champika S. Kariyawasam Lalit Kumar Sujith S. Ratnayake There is substantial global concern over the potential impacts of plant invasions on native biodiversity in protected areas (PAs). Protected areas in tropical island countries that host rich biodiversity face an imminent...
Wed Apr 01, 2020 03:00
Dentistry Journal, Vol. 8, Pages 30: Clinical Evaluation of the Nasopalatine Canal in Implant-Prosthetic Treatment: A Pilot Study Dentistry Journal doi: 10.3390/dj8020030 Authors: Enrique Fernández Bodereau Viviana Yolanda Flores Pablo Naldini Daniel Torassa Patricia Tortolini Implant-prosthetic rehabilitation of missing teeth in the anterior maxilla is often challenging due to ongoing bone resorption and remodeling events and may require regeneration procedures involving...
Wed Apr 01, 2020 03:00
Dentistry Journal, Vol. 8, Pages 31: Dental Caries Preventive Considerations: Awareness of Undergraduate Dental Students Dentistry Journal doi: 10.3390/dj8020031 Authors: Hani Nassar The aim of this study was to assess awareness and knowledge of undergraduate dental students of common caries-related preventive considerations and to highlight these factors in a concise manner to act as a guide for dental practitioners. A sample of 118 undergraduate students at a local government dental...
Wed Apr 01, 2020 03:00
Diagnostics, Vol. 10, Pages 198: Blockchain and Artificial Intelligence Technology for Novel Coronavirus Disease-19 Self-Testing Diagnostics doi: 10.3390/diagnostics10040198 Authors: Mashamba-Thompson Crayton The novel coronavirus disease 19 (COVID-19) is rapidly spreading with a rising death toll and transmission rate reported in high income countries rather than in low income countries. The overburdened healthcare systems and poor disease surveillance systems in resource-limited...
Wed Apr 01, 2020 03:00
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