We describe the synthesis and characterization of [Cu(POP)( 1 )][PF6], [Cu(POP)( 2 )][PF6], [Cu(xantphos)( 1 )][PF6], and [Cu(xantphos)( 2 )][PF6] in which ligands 1 and 2 are 2-(pyridin-2-yl)quinoline and 2-(6-methylpyridin-2-yl)quinoline, respectively. With 2,2'-bipyridine (bpy) as a benchmark, we assess the impact of the extended π-system on structural and solid-state photophysical properties. The single crystal structures of [Cu(POP)( 2 )][PF6], [Cu(xantphos)( 1 )][PF6], and [Cu(xantphos)( 2...
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The syntheses of 4,40 -bis(4-dimethylaminophenyl)-6,60 -dimethyl-2,20 -bipyridine (1 ), 4,40 -bis(4-dimethylaminophenylethynyl)-6,60 -dimethyl-2,20 -bipyridine (2 ), 4,40 -bis(4- diphenylaminophenyl)-6,60 -dimethyl-2,20 -bipyridine (3 ), and 4,40 -bis(4-diphenylaminophenylethynyl)- 6,60 -dimethyl-2,20 -bipyridine (4 ) are reported along with the preparations and characterisations of their homoleptic copper(I) complexes [CuL2 ][PF6 ] (L = 1 -4 ). The solution absorption spectra of the complexes exhibit...
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Secondary bacterial infections are part of the problem, and we need to ramp up research on new drugs to fight them -- Read more on ScientificAmerican.com
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As fear of mortality rises, so does tribalism and support for authoritarian leaders, according to terror-management theory. -- Read more on ScientificAmerican.com
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Scientists at the Kavli Institute for Theoretical Physics engage in a series of conversations -- Read more on ScientificAmerican.com
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ObjectiveTo determine the impact to date of the ongoing Crohn’s & Colitis UK inflammatory bowel disease (IBD) clinical nurse specialists (CNS) campaign.MethodsA survey-based design was used. 2 questionnaires were sent to the UK IBD nursing community and promoted via nursing and clinical networks. Respondents were asked to provide data at both an individual and trust level about their nursing services.Results394 IBD CNS posts were identified across the UK, with a 32% increase in posts since the...
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AbstractThe outbreak of coronavirus disease 2019 (COVID-19) has spread rapidly in China. Until now, no definite effective treatment has been identified. We reported on 3 patients with severe COVID-19 who received high-dose intravenous immunoglobulin (IVIg) with satisfactory recovery. Based on these observations, randomized studies of high-dose IVIg should be considered in deteriorating patients infected with COVID-19.
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AbstractBackgroundState-mandated school entry immunization requirements in the United States play an important role in achieving high vaccine coverage, but variations in vaccine exemption policies result in a patchwork of vaccine coverage across the country.MethodsIn this study, we evaluate epidemiological effects and spatial variations in nonmedical exemption (NME) rates in the context of vaccine policies. We first analyze the correlation between NME rates and vaccine coverage for 3 significant...
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Abstract Next generation sequencing technologies have made it possible to investigate the role of rare variants (RVs) in disease etiology. Because RVs associated with disease susceptibility tend to be enriched in families with affected individuals, study designs based on affected sib pairs (ASP) can be more powerful than case–control studies. We construct tests of RV‐set association in ASPs for single genomic regions as well as for multiple regions. Single‐region tests can efficiently detect a...
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Publication date: Available online 1 April 2020Source: Journal of Controlled ReleaseAuthor(s): Tuying Yong, Dongdong Wang, Xin Li, Yuchen Yan, Jun Hu, Lu Gan, Xiangliang Yang
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Publication date: Available online 1 April 2020Source: Journal of Controlled ReleaseAuthor(s): Qing Yao, Xue Jiang, Yuan-Yuan Zhai, Lan-Zi Luo, He-Lin Xu, Jian Xiao, Longfa Kou, Ying-Zheng Zhao
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Publication date: Available online 1 April 2020Source: Journal of Controlled ReleaseAuthor(s): Hyounkoo Han, Doyeon Kim, Yongho Jang, Minkyu Seo, Kwangmeyung Kim, Jong Bum Lee, Hyuncheol Kim
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Publication date: Available online 1 April 2020Source: Journal of Controlled ReleaseAuthor(s): Victoria Fasiku, Calvin A. Omolo, Thirumala Govender
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Publication date: Available online 1 April 2020Source: Journal of Controlled ReleaseAuthor(s): Maohua Chen, Jie He, Songzhi Xie, Tao Wang, Pan Ran, Zhanlin Zhang, Xiaohong Li
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Publication date: Available online 31 March 2020Source: Journal of Controlled ReleaseAuthor(s): Jean-Michel Rabanel, Philippe Delbreil, Xavier Banquy, Davide Brambilla, Charles Ramassamy
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Publication date: Available online 31 March 2020Source: Journal of Controlled ReleaseAuthor(s): Essi Taipaleenmäki, Gustav Christensen, Edit Brodszkij, Sidsel A. Mouritzen, Noga Gal, Sidsel Madsen, Mette Skou Hedemann, Tine Ahrendt Knudsen, Henrik Max Jensen, Sofie Laage Christiansen, Flemming Vang Sparsø, Brigitte Städler
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Publication date: Available online 31 March 2020Source: Journal of Controlled ReleaseAuthor(s): Adam A. Walters, Julie Tzu-Wen Wang, Khuloud T. Al-Jamal
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Publication date: Available online 31 March 2020Source: Journal of Controlled ReleaseAuthor(s): Saurav Bhattacharya, Avijit Ghosh, Santanu Maiti, Manisha Ahir, Gouranga H. Debnath, Payal Gupta, Mousumi Bhattacharjee, Swatilekha Ghosh, Sreya Chattopadhyay, Prasun Mukherjee, Arghya Adhikary
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Publication date: Available online 31 March 2020Source: Journal of Controlled ReleaseAuthor(s): Jasmim Leal, Xiujuan Peng, Xinquan Liu, Dhivya Arasappan, Dennis C. Wylie, Sarah H. Schwartz, Jason J. Fullmer, Bennie C. McWilliams, Hugh D.C. Smyth, Debadyuti Ghosh
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Publication date: Available online 31 March 2020Source: Journal of Controlled ReleaseAuthor(s): Menglu Qin, Jing Jin, Qimanguli Saiding, Yi Xiang, Yong Wang, Flávia Sousa, Bruno Sarmento, Wenguo Cui, Xinliang Chen
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Publication date: Available online 31 March 2020Source: Journal of Controlled ReleaseAuthor(s): Xin Xu, Kunpeng Liu, Binbin Jiao, Kejun Luo, Jian Ren, Guan Zhang, Qingsong Yu, Zhihua Gan
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Abstract Increasing evidence suggests that DNA methylation has key roles in the replication of retroviruses, including lentiviruses, and pathogenesis of diseases. However, the precise characteristics of CpG islands are not known for many retroviruses. In this study, we compared the distribution of CpG islands among strains of equine infectious anemia virus (EIAV), a lentivirus in the family Retroviridae and a model for HIV research. We identified CpG islands in 32 full-length EIAV...
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Publication date: 31 March 2020Source: Cell Reports, Volume 30, Issue 13Author(s): Naiara Santana-Codina, Amrita Singh Chandhoke, Qijia Yu, Beata Małachowska, Miljan Kuljanin, Ajami Gikandi, Marcin Stańczak, Sebastian Gableske, Mark P. Jedrychowski, David A. Scott, Andrew J. Aguirre, Wojciech Fendler, Nathanael S. Gray, Joseph D. Mancias
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Publication date: 31 March 2020Source: Cell Reports, Volume 30, Issue 13Author(s): Tugba Keskin, Arnaud Bakaric, Patricia Waszyk, Gaylor Boulay, Matteo Torsello, Sandrine Cornaz-Buros, Nadja Chevalier, Thibaud Geiser, Patricia Martin, Angela Volorio, Sowmya Iyer, Anupriya Kulkarni, Igor Letovanec, Stéphane Cherix, Gregory M. Cote, Edwin Choy, Antonia Digklia, Michael Montemurro, Ivan Chebib, Petur G. Nielsen
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Publication date: 31 March 2020Source: Cell Reports, Volume 30, Issue 13Author(s): Aurélie Morin, Judith Goncalves, Sophie Moog, Luis-Jaime Castro-Vega, Sylvie Job, Alexandre Buffet, Marie-Joséphine Fontenille, Justine Woszczyk, Anne-Paule Gimenez-Roqueplo, Eric Letouzé, Judith Favier
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Publication date: 31 March 2020Source: Cell Reports, Volume 30, Issue 13Author(s): Lucy Rutten, Morgan S.A. Gilman, Sven Blokland, Jarek Juraszek, Jason S. McLellan, Johannes P.M. Langedijk
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Publication date: 31 March 2020Source: Cell Reports, Volume 30, Issue 13Author(s): Yuyang Tang, Beverly O. Woodward, Lorena Pastor, Alvin M. George, Oksana Petrechko, Franklin J. Nouvet, David W. Haas, Guochun Jiang, James E.K. Hildreth
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Publication date: 31 March 2020Source: Cell Reports, Volume 30, Issue 13Author(s): Yawen Li, Yufei Hu, Jiawei Wang, Xin Liu, Wei Zhang, Linfeng Sun
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Non-conventional Axonal Organelles Control TRPM8 Ion Channel Trafficking and Peripheral Cold Sensing
Publication date: 31 March 2020Source: Cell Reports, Volume 30, Issue 13Author(s): Víctor Hugo Cornejo, Carolina González, Matías Campos, Leslie Vargas-Saturno, María de los Ángeles Juricic, Stéphanie Miserey-Lenkei, María Pertusa, Rodolfo Madrid, Andrés Couve
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