Abstract Nivolumab, a fully human IgG4 immune checkpoint modulator, binds to the programmed cell death 1 (PD‐1) receptor on T cells and blocks their inhibition. Thus, it increases the anticancer host immune response by allowing T cells to attack tumor cells. Although anti‐PD‐1 immunotherapy is typically well accepted, deregulation of immune tolerance caused by nivolumab may determine immune‐related adverse events, among which skin toxicities represent the most common. We report a case of severe...
Abstract In this study, the application of a recently introduced device based on electromagnetic energy transfer by microwaves for fat reduction, permitted to study specifically the modifications of thick fibrous collagen interlobular septa in the subcutaneous adipose tissue, related to the formation of large clusters of adipocytes. The use of Picrosirius Red staining associated with circularly polarized microscopy gave evidence of appreciable modifications of the fibrous connective tissue forming...
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Related ArticlesImplementation of auricular malformation screenings in the newborn population. Int J Pediatr Otorhinolaryngol. 2020 Mar 12;133:109999 Authors: Liu YC, Kini S, Barton G, Pham T, Marcet-Gonzalez J, Novak B Abstract BACKGROUND AND OBJECTIVE: Research has shown that it is important to initiate ear molding early for children with auricular malformations in order to achieve the best results. Currently our institute relies on the traditional...
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