Related ArticlesPatient Education and Engagement Through Multimedia: Prospective Pilot Study on Health Literacy in Patients with Cerebral Aneurysms. World Neurosurg. 2020 Mar 28;: Authors: Agarwal N, Funahashi R, Taylor T, Jorge A, Feroze R, Zhou J, Hansberry DR, Gross B, Jankowitz B, Friedlander RM Abstract INTRODUCTION: Improving the comprehension and communication of patient education materials may augment patient participation in shared clinical...
Fri Apr 03, 2020 14:31
Zusammenfassung Immunologische Parameter werden seit vielen Jahren beim triple-negativen Mammakarzinom als prognostische Marker in translationalen Forschungsprojekten beschrieben. In den letzten Jahren haben sich aus diesen Forschungskonzepten neue Therapiekonzepte entwickelt, die ganz aktuell in klinischen Studien validiert werden konnten. Somit bestehen jetzt auch für das Mammakarzinom die Möglichkeit einer Immuncheckpoint-Inhibitor-Therapie in Kombination mit einer Chemotherapie.
Fri Apr 03, 2020 03:00
Related ArticlesIsolated sudden onset anosmia in COVID-19 infection. A novel syndrome? Rhinology. 2020 Apr 02;: Authors: Gane SB, Kelly C, Hopkins C Abstract BACKGROUND: The amelioration of the current COVID pandemic relies on swift and efficient case finding as well as stringent social distancing measures. Current advice suggests that fever or new onset dry cough are the commonest presenting complaints. METHODOLOGY: We present a case report...
Fri Apr 03, 2020 14:23
Related ArticlesQuantification of airflow in the sinuses following functional endoscopic sinus surgery. Rhinology. 2020 Apr 02;: Authors: Siu J, Dong J, Inthavong K, Shang Y, Douglas RG Abstract BACKGROUND: Despite functional endoscopic sinus surgery (FESS) being the standard of care in medically recalcitrant chronic rhinosinusitis (CRS), its effect on sinus ventilation has not been fully characterized. Airflow simulations can help improve our understanding...
Fri Apr 03, 2020 14:23
Publication date: Available online 3 April 2020Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): J.W. Nolte, M. Alders, L.H.E. Karssemakers, A.G. Becking, R.C.M. Hennekam
Fri Apr 03, 2020 14:15
Publication date: Available online 3 April 2020Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): P. Onclin, H.J.A. Meijer, B. van Minnen, A. Vissink, G.M. Raghoebar
Fri Apr 03, 2020 14:15
Related ArticlesA novel targeted GPC3/CD3 bispecific antibody for the treatment hepatocellular carcinoma. Cancer Biol Ther. 2020 Apr 02;:1-7 Authors: Yu L, Yang X, Huang N, Lang QL, He QL, Jian-Hua W, Liang-Peng G Abstract Hepatocellular carcinoma (HCC) is the most frequent primary liver cancer but has shown limited success to date in the treatment of advanced stage. Recruitment of T cells for cancer treatment is a rapidly growing strategy in immunotherapy...
Fri Apr 03, 2020 14:15
Related ArticlesSignificant response to apatinib monotherapy in heavily pretreated advanced HER2-positive breast cancer: a case report and literature review. Cancer Biol Ther. 2020 Apr 01;:1-7 Authors: Danni L, Lingyun Z, Jian W, Hongfei Y, Lu X, Peng Y, Xiujuan Q, Yunpeng L, Yuee T Abstract Although HER2-targeted therapy has been shown to prolong the survival of patients with HER2-positive breast cancer, most patients eventually progress due to drug...
Fri Apr 03, 2020 14:15
Abstract Artificial intelligence (AI) is revolutionizing healthcare and transforming the clinical practice of physicians across the world. Radiology has a strong affinity for machine learning and is at the forefront of the paradigm shift, as machines compete with humans for cognitive abilities. AI is a computer science simulation of the human mind that utilizes algorithms based on collective human knowledge and the best available evidence to process various forms of inputs and...
Fri Apr 03, 2020 03:00
I met him on March 3, 2020, a 70-year-old man with a 6-month history of classic stable angina. He had left-arm achiness whenever he walked uphill, reliably triggered by the same level of exertion and always relieved with rest. A stress test showed a large, reversible inferolateral defect, prompting…
Thu Apr 02, 2020 03:00
Related ArticlesAnemia management in dialysis patients: a PIVOT and a new path? Curr Opin Nephrol Hypertens. 2020 May;29(3):351-355 Authors: Nair S, Trivedi M Abstract PURPOSE OF REVIEW: We will examine the current and future options in management of anemia in dialysis patients focusing on recent trials in iron supplementation and alternatives to erythropoietin-stimulating agents (ESAs). RECENT FINDINGS: We review the literature on Erythropoietin...
Fri Apr 03, 2020 14:12
Related ArticlesHypoxia inhibits TNF-α-induced TSLP expression in keratinocytes. PLoS One. 2019;14(11):e0224705 Authors: Tashiro N, Segawa R, Tobita R, Asakawa S, Mizuno N, Hiratsuka M, Hirasawa N Abstract The expression of thymic stromal lymphopoietin (TSLP), a cytokine which greatly contributes to the induction of type I allergy, is upregulated in chronic inflammation such as atopic dermatitis and psoriasis. As hypoxia in the epidermis is important...
Fri Apr 03, 2020 14:12
Related ArticlesA Placebo-Controlled, Randomized Trial of Enarodustat in Patients with Chronic Kidney Disease Followed by Long-Term Trial. Am J Nephrol. 2019;49(2):165-174 Authors: Akizawa T, Nangaku M, Yamaguchi T, Arai M, Koretomo R, Matsui A, Hirakata H Abstract BACKGROUND: Enarodustat (JTZ-951) is an oral hypoxia-inducible factor prolyl hydroxylase inhibitor that mimics adaptive responses to hypoxic conditions and may provide a new therapeutic...
Fri Apr 03, 2020 14:12
88 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Anticancer Res"[jour] These pubmed results were generated on 2020/04/03PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Fri Apr 03, 2020 14:12
Related ArticlesShould the PBL tutor be present? A cross-sectional study of group effectiveness in synchronous and asynchronous settings. BMC Med Educ. 2020 Mar 31;20(1):103 Authors: Edelbring S, Alehagen S, Mörelius E, Johansson A, Rytterström P Abstract BACKGROUND: The tutorial group and its dynamics are a cornerstone of problem-based learning (PBL). The tutor's support varies according to the setting, and it is pertinent to explore group effectiveness...
Fri Apr 03, 2020 14:11
Related ArticlesMedical assessment in the age of digitalisation. BMC Med Educ. 2020 Mar 31;20(1):101 Authors: Egarter S, Mutschler A, Tekian A, Norcini J, Brass K Abstract BACKGROUND: Digital assessment is becoming more and more popular within medical education. To analyse the dimensions of this digital trend, we investigated how exam questions (items) are created and designed for use in digital medical assessments in Germany. Thus, we want to explore...
Fri Apr 03, 2020 14:11
Related ArticlesExamining validity and reliability of objective structured clinical examination for evaluation of clinical skills of midwifery undergraduate students: a descriptive study. BMC Med Educ. 2020 Mar 31;20(1):96 Authors: Kolivand M, Esfandyari M, Heydarpour S Abstract BACKGROUND: Clinical evaluation is one of the main pillars of medical education. The Objective Structured Clinical Examination is one of the commonly adopted practical tools...
Fri Apr 03, 2020 14:11
Related ArticlesA pragmatic randomised controlled trial of SAFMEDS to produce fluency in interpretation of electrocardiograms. BMC Med Educ. 2020 Mar 31;20(1):102 Authors: Rabbitt L, Byrne D, O'Connor P, Gorecka M, Jacobsen A, Lydon S Abstract BACKGROUND: SAFMEDS (Say-All-Fast-Minute-Every-Day-Shuffled) is a flashcard-type behavioural instructional methodology, involving one-minute learning trials that function both as practice and assessment, used to...
Fri Apr 03, 2020 14:11
Related ArticlesSelf-regulated learning: the effect on medical student learning outcomes in a flipped classroom environment. BMC Med Educ. 2020 Mar 31;20(1):100 Authors: Zheng B, Zhang Y Abstract BACKGROUND: The flipped-classroom model is increasingly being adopted in competency-based medical education. However, it poses a major challenge to students who have not mastered self-regulated learning strategies. This study explores which self-regulated learning...
Fri Apr 03, 2020 14:11
Related ArticlesThe influence of gender on clinical examination skills of medical students in Jordan: a cross-sectional study. BMC Med Educ. 2020 Mar 31;20(1):98 Authors: Sabet F, Zoghoul S, Alahmad M, Al Qudah H Abstract BACKGROUND: A graduating medical doctor is expected to be competent in physical examinations across all systems. The exploration of how gender affects the development of clinical skills has not been explored in an Arab context, despite...
Fri Apr 03, 2020 14:11
Related ArticlesA qualitative study of health professions curricula and management of lateral ankle ligament sprain demonstrates inconsistency. BMC Med Educ. 2020 Mar 31;20(1):99 Authors: Green T, Willson G, Fallon K Abstract BACKGROUND: Health educators aim to graduate students who are safe, effective and practice evidence-based medicine (EBM). Clinical Practice Guidelines (CPGs) are tools for translating evidence into clinical practice for health professionals...
Fri Apr 03, 2020 14:11
Related ArticlesLebanese students' motivation in medical school: does it change throughout the years? A cross-sectional study. BMC Med Educ. 2020 Mar 31;20(1):94 Authors: Sarkis AS, Hallit S, Hajj A, Kechichian A, Karam Sarkis D, Sarkis A, Nasser Ayoub E Abstract BACKGROUND: Students entering medical school are driven by different types of motivation: autonomous motivation, controlled motivation, or amotivation. Motivation types can influence students'...
Fri Apr 03, 2020 14:11
Related ArticlesTraining in obstetric and neonatal emergencies in Mexico: effect on knowledge and self-efficacy by gender, age, shift, and profession. BMC Med Educ. 2020 Mar 31;20(1):97 Authors: Fritz J, Montoya A, Lamadrid-Figueroa H, Flores-Pimentel D, Walker D, Treviño-Siller S, González-Hernández D, Magaña-Valladares L Abstract BACKGROUND: Continuing education is essential for healthcare workers. Education interventions can help to maintain and improve...
Fri Apr 03, 2020 14:11
Related ArticlesEvaluation of the "license, master, doctorate" reform in medical school of University of Lomé (Togo): strengths and weaknesses. BMC Med Educ. 2020 Mar 31;20(1):95 Authors: Teclessou JN, Kpelao E, Saka B Abstract INTRODUCTION: The License, Master and Doctorate (LMD) reform that structured high studies in three cycles, has been instituted since the Bologna declaration in 1999. To be conformed to international standards, the LMD system has...
Fri Apr 03, 2020 14:11
Publication date: March 2020Source: Revue des Maladies Respiratoires, Volume 37, Issue 3Author(s):
Fri Apr 03, 2020 14:11
Related ArticlesReview of Narcolepsy and Other Common Sleep Disorders in Children. Adv Pediatr. 2019 08;66:147-159 Authors: Nallu S, Guerrero GY, Lewis-Croswell J, Wittine LM PMID: 31230690 [PubMed - indexed for MEDLINE]
Fri Apr 03, 2020 14:10
Related ArticlesGreater Muscle Stiffness during Contraction at Menstruation as Measured by Shear-Wave Elastography. Tohoku J Exp Med. 2020 04;250(4):207-213 Authors: Ham S, Kim S, Choi H, Lee Y, Lee H Abstract It is important to measure mechanical properties of muscle, since muscle stiffness is an important component of stabilizing or controlling joint stability. The levels of sex hormones especially estrogen vary over the phase of the menstrual cycle...
Fri Apr 03, 2020 17:08
Related ArticlesEffectiveness of Profiling Serum IL-18 and Neopterin in Diagnosis of Adult-Onset Still's Disease Complicated by Pulmonary Tuberculosis: A Case Report. Tohoku J Exp Med. 2020 04;250(4):201-206 Authors: Kamada M, Kenzaka T Abstract Adult-onset Still's Disease (AOSD) is a systemic inflammatory disorder characterized by high fever, skin rashes, and joint pains, and is extremely rare in patients over 80 years of age. An 88-year-old woman was...
Fri Apr 03, 2020 17:08
Nature Communications, Published online: 03 April 2020; doi:10.1038/s41467-020-15317-6Non-human primate models are important for the development of high quality vision restoration therapies for blindness. Here, the authors demonstrate restoration of light responses in foveal retinal ganglion cells of the living macaque following optogenetic gene therapy.
Fri Apr 03, 2020 03:00
Nature Communications, Published online: 03 April 2020; doi:10.1038/s41467-020-15491-7Developing cyanobacteria as CO2-neutral cell factories relies on the knowledge of the regulation mechanisms for growth and metabolism. Here, the authors develop an inducible CRISPRi gene repression library in Synechocystis sp. PCC 6803 and screens genes potentially affecting growth and L-lactate tolerance and production.
Fri Apr 03, 2020 03:00
Nature Communications, Published online: 03 April 2020; doi:10.1038/s41467-020-15371-0Macrophages can differentiate to perform homeostatic tissue-specific functions. Here the authors show that RXR signalling is critical for large peritoneal macrophage (LPM) expansion during neonatal life and LPM lipid metabolism and survival during adult homeostasis, and that ovarian cancer growth relies on RXR-dependent LPMs.
Fri Apr 03, 2020 03:00
Nature Communications, Published online: 03 April 2020; doi:10.1038/s41467-020-15451-1Quasi-2D halide perovskites are good candidates for efficient and stable solar cells but they suffer from high open-circuit voltage (Voc) deficit. Here He et al. show that homogeneous energy landscape of the charge transport levels is important to suppressing the recombination and increasing Voc.
Fri Apr 03, 2020 03:00
Nature Communications, Published online: 03 April 2020; doi:10.1038/s41467-020-15428-0Identifying kinases responsible for specific phosphorylation events remains challenging. Here, the authors leverage kinase inhibitor profiles for the identification of kinase-substrate site pairs in cell extracts, developing a method that can identify the enzymes responsible for unassigned phosphorylation events.
Fri Apr 03, 2020 03:00
Nature Communications, Published online: 03 April 2020; doi:10.1038/s41467-020-15515-2Earth’s drylands are expected to expand due to climate change, but how this will affect vegetation remains unclear. Here the authors use models to show that despite expansion, primary productivity in drylands is likely to increase through the 21st Century.
Fri Apr 03, 2020 03:00
Nature Communications, Published online: 03 April 2020; doi:10.1038/s41467-020-15241-9XPD is part of the TFIIH complex which plays major roles in transcription initiation and nucleotide excision repair (NER). Here the authors present a high-resolution crystal structure of the XPD-MAT1 interface and dissect the role of this interface in transcription and NER.
Fri Apr 03, 2020 03:00
Nature Communications, Published online: 03 April 2020; doi:10.1038/s41467-020-15463-xPulmonary arterial hypertension (PAH) is a heterogeneous disease, causing severe breathing problems and cardiac morbidity. Here, the authors study chromatin marks in pulmonary arterial endothelial cells from PAH patients and controls and find changes in transcription factor and enhancer activity that suggest an aberrant response to signalling in PAH.
Fri Apr 03, 2020 03:00
Fri Apr 03, 2020 03:00
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