Related ArticlesResource-Stratified Guideline-Based Cancer Care Should Be a Priority: Historical Context and Examples of Success. Am Soc Clin Oncol Educ Book. 2020 Mar;40:1-10 Authors: Hunter N, Dempsey N, Tbaishat F, Jahanzeb M, Al-Sukhun S, Gralow JR Abstract Low- and middle-income countries (LMICs) are shouldering most of the burden of the rapidly increasing cancer incidence and mortality worldwide, and this situation is projected to worsen in coming...
Wed Apr 01, 2020 13:12
Related ArticlesThe Evolution of Antibody-Drug Conjugates: A Positive Inflexion Point. Am Soc Clin Oncol Educ Book. 2020 Mar;40:1-8 Authors: Tolcher AW Abstract In 2019, an important inflection point occurred when the U.S. Food and Drug Administration approved three new antibody-drug conjugates (ADCs) for the treatment of malignancies, including urothelial cancer (enfortumab vedotin-ejfv), diffuse large B-cell lymphoma (polatuzumab vedotin-piiq), and...
Wed Apr 01, 2020 13:12
Related ArticlesThe Evolution of Clinical Trials in Metastatic Breast Cancer: Design Features and Endpoints That Matter. Am Soc Clin Oncol Educ Book. 2020 Mar;40:1-11 Authors: Seidman AD, Maues J, Tomlin T, Bhatnagar V, Beaver JA Abstract The evolution of thought in assessing benefit in clinical trials of systemic therapy for metastatic breast cancer (MBC) is well documented, with most agents garnering regulatory approval based either on an advantage...
Wed Apr 01, 2020 13:12
Related ArticlesThe Use of Health-Related Technology to Reduce the Gap Between Developed and Undeveloped Regions Around the Globe. Am Soc Clin Oncol Educ Book. 2020 Mar;40:1-10 Authors: Ngwa W, Olver I, Schmeler KM Abstract Cancer is the second leading cause of death worldwide, with approximately 70% of the 9.6 million deaths per year occurring in low- and middle-income countries (LMICs), where there is critical shortage of human and material resources...
Wed Apr 01, 2020 13:12
Related ArticlesClinical Controversies in the Management of Smoldering Multiple Myeloma. Am Soc Clin Oncol Educ Book. 2020 Mar;40:1-6 Authors: Lomas OC, Ghobrial IM Abstract Forty years ago this year, smoldering multiple myeloma was defined as a clinical entity that identifies a group of patients with a substantial burden of disease but with a relatively indolent natural history compared with symptomatic disease. Since then, there has been a revolution...
Wed Apr 01, 2020 13:12
Publication date: Available online 31 March 2020Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): A. Alyahya, A. Bin Ahmed, Y. Nusair, R. Ababtain, A. Alhussain, A. Alshafei
Wed Apr 01, 2020 13:11
Publication date: Available online 31 March 2020Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): R. Kelly, N. Cereceda-Monteoliva, C. Frezzini, T.W.M. Walker, A.R.M. Cobb, P. Ayliffe
Wed Apr 01, 2020 13:11
Related ArticlesNitroreductase-mediated release of inhibitors of Lysine-Specific Demethylase 1 (LSD1) from prodrugs in transfected acute myeloid leukaemia cells. Chembiochem. 2020 Mar 30;: Authors: Jung M, Herrlinger EM, Hau M, Redhaber DM, Greve G, Willmann D, Steimle S, Müller M, Lübbert M, Miething CC, Schüle R Abstract Lysine-specific demethylase 1 (LSD1) has evolved as a promising therapeutic target for cancer treatment, especially in acute myeloid...
Wed Apr 01, 2020 13:08
Related ArticlesInterdependence of Physical and Psychological Morbidity Among Patients with Cancer and Family Caregivers: Review of the Literature. Psychooncology. 2020 Mar 29;: Authors: Streck BP, Wardell DW, LoBiondo-Wood G, Beauchamp JES Abstract OBJECTIVE: Caregivers for patients with cancer have an integral role in maintaining patients' health. Although patients and caregivers experience the impact of cancer individually, studies suggest their health...
Wed Apr 01, 2020 13:08
Related ArticlesThe Evolving Complexity of Treating Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor-2 (HER2)-Negative Breast Cancer: Special Considerations in Older Breast Cancer Patients-Part II: Metastatic Disease. Drugs Aging. 2020 Mar 30;: Authors: Hill A, Gutierrez E, Liu J, Sammons S, Kimmick G, Sedrak MS Abstract Breast cancer is a disease of aging, and the incidence of breast cancer is projected to increase dramatically as the...
Wed Apr 01, 2020 13:08
Related ArticlesUSP32 promotes tumorigenesis and chemoresistance in gastric carcinoma via upregulation of SMAD2. Int J Biol Sci. 2020;16(9):1648-1657 Authors: Dou N, Hu Q, Li L, Wu Q, Li Y, Gao Y Abstract USP32, a member of the ubiquitin-specific proteases family, has been implicated in the development of breast cancer and small lung cancer. However, its biological functions and clinical significance in gastric cancer (GC) remain unclear. In the present...
Wed Apr 01, 2020 13:08
Related ArticlesThe Many Facets of CD38 in Lymphoma: From Tumor-Microenvironment Cell Interactions to Acquired Resistance to Immunotherapy. Cells. 2020 Mar 26;9(4): Authors: Calabretta E, Carlo-Stella C Abstract The CD38 antigen is expressed in several hematological malignancies, and the anti-CD38 monoclonal antibodies Daratumumab and Isatuximab have an established role in the therapy of multiple myeloma. However, data on the therapeutic utility of CD38...
Wed Apr 01, 2020 13:08
Related ArticlesFOXO1 overexpression is correlated with poor prognosis in epithelial ovarian cancer. Cancer Biomark. 2020 Mar 27;: Authors: Liu L, Yi J, Yuan J, Yao T, Lin Z, Ning Y, Zeng Z Abstract OBJECTIVE: To investigate FOXO1 expression in epithelial ovarian cancer (EOC), and to explore its correlation with clinicopathological parameters and prognosis of EOC. METHODS: Two hundred and sixteen cases of paraffin-embedded EOC and 41 paratumor...
Wed Apr 01, 2020 13:08
Related ArticlesResults of the ACCEL trial: Dosimetry in accelerated partial breast irradiation. Radiother Oncol. 2020 Mar 27;147:50-55 Authors: Quirk S, Grendarova P, Craighead P, Phan T, Lesiuk M, Pinilla J, Liu HW, Wilson J, Bignell K, Austin T, Olivotto IA, Roumeliotis M Abstract PURPOSE: To report the achieved dosimetry in the ACCEL trial and compare the results to reported dosimetry from the major accelerated partial breast irradiation (APBI) phase...
Wed Apr 01, 2020 13:08
Related ArticlesTROPiCS-02: A Phase III study investigating sacituzumab govitecan in the treatment of HR+/HER2- metastatic breast cancer. Future Oncol. 2020 Mar 30;: Authors: Rugo HS, Bardia A, Tolaney SM, Arteaga C, Cortes J, Sohn J, Marmé F, Hong Q, Delaney RJ, Hafeez A, André F, Schmid P Abstract Patients with HR+/HER2- metastatic breast cancer (MBC) whose cancers have progressed despite conventional therapies represent an unmet clinical need. Trop-2,...
Wed Apr 01, 2020 13:08
Related ArticlesDirect-acting antivirals and interferon-based therapy on hepatocellular carcinoma risk in chronic hepatitis-C patients. Future Oncol. 2020 Mar 30;: Authors: Ma L, Liu J, Wang W, Yang F, Li P, Cai S, Zhou X, Chen X, Zhuang X, Zhang H, Cao G Abstract Aim: It was controversial whether direct-acting antiviral (DAA) is better than interferon-based therapy (IBT) in preventing HCV-related hepatocellular carcinoma (HCC). Therefore, we accomplished...
Wed Apr 01, 2020 13:08
Related ArticlesPhase II trial evaluating the efficacy and safety of the anti-CD20 monoclonal antibody obinutuzumab in patients with marginal zone lymphoma. Future Oncol. 2020 Mar 30;: Authors: Grunenberg A, Kaiser LM, Woelfle S, Schmelzle B, Viardot A, Möller P, Barth TF, Muche R, Dreyhaupt J, Buske C Abstract Marginal zone lymphoma (MZL) belongs to the group of indolent B-cell non-Hodgkin's lymphomas, which is characterized by an indolent course. In...
Wed Apr 01, 2020 13:08
Related ArticlesNovel markers of human ovarian granulosa cell differentiation toward osteoblast lineage: A microarray approach. Mol Med Rep. 2019 Nov;20(5):4403-4414 Authors: Brązert M, Kranc W, Celichowski P, Ożegowska K, Budna-Tukan J, Jeseta M, Pawelczyk L, Bruska M, Zabel M, Nowicki M, Kempisty B Abstract Under physiological conditions, human ovarian granulosa cells (GCs), are responsible for a number of processes associated with folliculogenesis...
Wed Apr 01, 2020 13:04
Related ArticlesA full-spectrum-absorption from nickel sulphide nanoparticles for efficient NIR-II window photothermal therapy. Nanoscale. 2019 Nov 14;11(42):20161-20170 Authors: Lei Z, Zhang W, Li B, Guan G, Huang X, Peng X, Zou R, Hu J Abstract Near-infrared (NIR) light has been widely applied in the field of photothermal therapy (PTT). Recent advances in the light wavelength for efficient cancer PTT have gradually shifted from the first NIR (NIR-I)...
Wed Apr 01, 2020 13:04
Related ArticlesPersonalizing post-treatment cancer care: a cross-sectional survey of the needs and preferences of well survivors of breast cancer. Curr Oncol. 2019 04;26(2):e138-e146 Authors: Kwan JYY, Croke J, Panzarella T, Ubhi K, Fyles A, Koch A, Dinniwell R, Levin W, McCready D, Chung C, Liu F, Bender JL Abstract Background: Improved treatments resulting in a rising number of survivors of breast cancer (bca) calls for optimization of current specialist-based...
Wed Apr 01, 2020 13:04
Related ArticlesComprehensive 4D robustness evaluation for pencil beam scanned proton plans. Radiother Oncol. 2019 07;136:185-189 Authors: Ribeiro CO, Meijers A, Korevaar EW, Muijs CT, Both S, Langendijk JA, Knopf A Abstract Due to anticipated clinical benefits, moving targets are potential future indications for pencil beam scanned proton therapy (PBS-PT). However, currently they are not widely treated at PBS-PT facilities due to dosimetric uncertainties...
Wed Apr 01, 2020 13:04
Related ArticlesDefining the immunogram of breast cancer: a focus on clinical trials. Expert Opin Biol Ther. 2019 05;19(5):383-385 Authors: Tarantino P, Curigliano G Abstract In phase III ImPassion130 trial, the addition of immunotherapy to chemotherapy improved overall survival in metastatic triple-negative breast cancer patients. This benefit was significant only in patients harboring PD-L1-positive tumors, suggesting that stratification according...
Wed Apr 01, 2020 13:04
Related ArticlesEx-vivo Mechanical Testing of Novel Laryngeal Clamps Used for Laryngeal Advancement Constructs. Front Vet Sci. 2020;7:139 Authors: Grzeskowiak RM, Schumacher J, Mulon PY, Steiner RC, Cassone L, Anderson DE Abstract Rostral laryngeal advancement, also known as laryngeal tie-forward, is used to treat horses for intermittent dorsal displacement of the soft palate and has a morbidity rate of about 6%. We hypothesized that a novel laryngeal...
Wed Apr 01, 2020 13:03
Related ArticlesEvaluation of Phytosomal Curcumin as an Anti-inflammatory Agent for Chronic Glial Activation in the GFAP-IL6 Mouse Model. Front Neurosci. 2020;14:170 Authors: Ullah F, Liang H, Niedermayer G, Münch G, Gyengesi E Abstract Chronic glial activation is characterized by an increased number of activated microglia and astroglia; these secrete free radicals and cytotoxic cytokines, subsequently causing neuronal damage. This study investigated...
Wed Apr 01, 2020 13:02
Related ArticlesShape Information Improves the Cross-Cohort Performance of Deep Learning-Based Segmentation of the Hippocampus. Front Neurosci. 2020;14:15 Authors: Brusini I, Lindberg O, Muehlboeck JS, Smedby Ö, Westman E, Wang C Abstract Performing an accurate segmentation of the hippocampus from brain magnetic resonance images is a crucial task in neuroimaging research, since its structural integrity is strongly related to several neurodegenerative...
Wed Apr 01, 2020 13:02
Abstract Parental care involves elaborate behavioural interactions between parents and their offspring, with offspring stimulating their parents via begging to provision resources. Thus, begging has direct fitness benefits as it enhances offspring growth and survival. It is nevertheless subject to a complex evolutionary trajectory, because begging may serve as a means for the offspring to manipulate parents in the context of evolutionary conflicts of interest. Furthermore, it has been hypothesized...
Wed Apr 01, 2020 12:52
Abstract Objectives To evaluate the oral condition of alcohol and tobacco dependents and identify salivary protein candidates for biomarkers of oral disorders. Subjects and methods Thirty‐three male volunteers were evaluated for alcohol abuse rehabilitation; nine were selected for proteomic analysis. Intraoral examination was performed, and non‐stimulated saliva was collected. Salivary proteins were extracted and processed for analysis. A list of proteins identified in saliva was...
Wed Apr 01, 2020 12:08
New England Journal of Medicine, Ahead of Print.
Tue Mar 31, 2020 12:00
New England Journal of Medicine, Ahead of Print.
Tue Mar 31, 2020 07:00
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