Journal of International Medical Research, Volume 48, Issue 5, May 2020. ObjectiveTo evaluate the effect of sitagliptin on skeletal muscle expression of peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), irisin, and phosphoadenylated adenylate activated protein kinase (p-AMPK) in a rat model of type 2 diabetes mellitus (T2DM).MethodsA high-fat diet/streptozotocin T2DM rat model was established. Rats were divided into T2DM, low-dose sitagliptin (ST1), high-dose sitagliptin (ST2),...
Mon May 04, 2020 15:23
Journal of International Medical Research, Volume 48, Issue 5, May 2020. ObjectivesTo investigate the antidepressant effects of electroacupuncture (EA) on chronic unpredictable mild stress (CUMS) in rats, as well as the effects of EA on hippocampal neurons, synaptic morphology, and 5-hydroxytryptamine (HT) receptor expression.MethodsForty adult male Wistar rats were randomly divided into normal control, CUMS, EA, and paroxetine groups. CUMS modeling was performed for 21 days, followed by 14 days...
Mon May 04, 2020 13:16
Journal of International Medical Research, Volume 48, Issue 5, May 2020.
Mon May 04, 2020 12:32
Journal of International Medical Research, Volume 48, Issue 5, May 2020. A 60-year-old male patient presented with a serum α-fetoprotein (AFP) level of 2940.5 ng/mL accompanied by a significant increase in serum globulin. Hepatitis B virus (HBV) DNA was 2.85 × 103 (normal value <1.0 × 103). B-mode ultrasound and magnetic resonance imaging showed characteristic manifestations and he was clinically diagnosed with hepatocellular carcinoma in January 2015. He received radiofrequency ablation and tenofovir...
Mon May 04, 2020 12:28
Journal of International Medical Research, Volume 48, Issue 5, May 2020. Timely recognition of the characteristic electrocardiographic pattern of de Winter syndrome is important for providing immediate reperfusion therapy for acute anterior myocardial infarction. In this case, an electrocardiogram showed 1- to 3-mm upsloping ST-segment depression at the J point in leads V1 to V6, with loss of R wave progression in leads V1 to V4. Urgent angiography showed occlusion of the proximal left anterior descending...
Mon May 04, 2020 12:19
Journal of International Medical Research, Volume 48, Issue 5, May 2020. ObjectiveTo investigate the value of ultrasound in the dynamic assessment of lung injury after acute paraquat poisoning.MethodsA prospective observational study was performed on patients with paraquat poisoning from admission to day 28 or discharge. Ultrasound assessment of the lungs was performtyed every 48 hours. The correlation of the lung ultrasound score (LUS) with other indicators was analyzed.ResultsTwenty-six patients...
Mon May 04, 2020 12:15
Journal of International Medical Research, Volume 48, Issue 5, May 2020. BackgroundMesenchymal stem cells (MSCs) may be used to treat steroid-refractory graft versus host disease (GVHD). However, the effects of MSCs in haploidentical peripheral blood stem cell transplantation (haplo-PBSCT) have not been confirmed in randomized studies.MethodsWe conducted a randomized clinical study to investigate the effects of pre-infusion (1 × 106 cells/kg) MSCs on hematopoietic recovery, Epstein–Barr and cytomegalovirus...
Mon May 04, 2020 12:11
Journal of International Medical Research, Volume 48, Issue 5, May 2020. Diffuse large B-cell lymphoma (DLBCL) is the most common adult non-Hodgkin lymphoma (NHL) and is highly invasive, with a poor prognosis. The main clinical treatment for DLBCL involves chemotherapy or a combination of chemotherapy and targeted drugs. CD56 expression is considered as an indicator of poor prognosis in patients with acute myeloid leukemia and anaplastic large cell lymphoma; however, its role in DLBCL remains unclear....
Mon May 04, 2020 12:07
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