GlaxoSmithKline said an experimental multiple myeloma treatment has shown a meaningful response in patients that have run out of three previous treatment options, in a boost for the British drugmaker's cancer drug business.Reuters Health Information (Source: Medscape Allergy Headlines)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Title: desloratadine (Clarinex, Clarinex Reditabs)Category: MedicationsCreated: 5/26/2002 12:00:00 AMLast Editorial Review: 8/22/2019 12:00:00 AM (Source: MedicineNet Allergies General)
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Study from The Journal of Allergy and Clinical Immunology: In Practice, an official journal of the AAAAI, reveals visits increased 3.2-fold among children from 2008 to 2016 and 1.9-fold among adults.(PRWeb August 26, 2019)Read the full story at https://www.prweb.com/releases/emergency_department_visits_for_anaphylaxis_have_increased_since_2008/prweb16517311.htm (Source: PRWeb: Medical Pharmaceuticals)
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PreGel America, Inc. of Concord, North Carolina is voluntarily recalling a single lot of Lemon 50, a powdered flavoring. The product is being recalled due to the possible presence of undeclared milk in the product. (Source: FDA Food Safety)
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JuJu Bakes, LLC, DBA The Cookie Dough Cafe of Bloomington, IL is recalling 15 cases of 1.6 ounce Chocolate Chip Chilled Gourmet Edible Cookie Dough Bars, because they may contain peanuts. (Source: FDA Food Safety)
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“Decorated Red Apple Cookies” are being voluntarily recalled by Southern Pacific Whole Foods Market stores because they may contain undeclared egg (Source: FDA Food Safety)
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Ruleau Brothers Inc. of Stephenson, MI, is recalling its 8 ounce containers of "Door County Whitefish Smoked Whitefish Pate" because they may contain undeclared allergens of Egg, Soy, and Anchovies. People who have allergies to Eggs, Soy, and Anchovies run the risk of serious or life-threatening all (Source: FDA Food Safety)
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GRAND BK CORP. of Maspeth, New York is recalling its 14 ounce packages of "CALIFORNIA ALOHA MIX" because they may contain undeclared tree nuts (Almonds, Walnuts and Cashews). People who have allergies or severe sensitivity to tree nuts (Almonds, Walnuts and Cashews) run the risk of serious or life-threatening allergic reaction if they consume these products. (Source: FDA Food Safety)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory...
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Great One Trading Inc. is recalling the above because it may contain undeclared egg. People who have an allergy or severe sensitivity to egg run the risk of serious or life-threatening allergic reaction if they consume these products. (Source: FDA Food Safety)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Nestl é USA has initiated a recall of Hot Pockets® Four Cheese Pizza Snack Bites due to misbranding and undeclared allergens. The product was donated to a charitable organization in Missouri and was not sold in retail. The product contain the known allergens egg, milk, soy, and wheat, which are not decl ared. People who have an allergy or severe sensitivity to eggs, milk, soy or wheat run the risk of serious or life-threatening allergic reaction if they consume this product. (Source: FDA Food Alergies)
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First Source of Tonawanda, NY, is voluntarily recalling various packaged goods, as well as Products sold in grocery store bulk bins. All these products contain undeclared Milk. People who have an allergy or sensitivity to Milk run the risk of serious or life-threatening allergic reaction if they consume this product. (Source: FDA Food Alergies)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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California Popsicle, Inc. dba Polly Ann Ice Cream of South San Francisco, CA is recalling ice bars, because it may contain undeclared milk. People who have an allergy or severe sensitivity to milk run the risk of serious or life-threatening allergic reaction if they consume these products. (Source: FDA Food Alergies)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate...
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Daisy ’s Bakery Inc. of Clifton, New Jersey is recalling 4 ounce packages of Gourmet Concha, because it may contain undeclared milk. People who have an allergy or severe sensitivity to milk run the risk of serious or life-threatening allergic reaction if they consume these products. (Source: FDA Food Alergies)
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CAMBRIDGE, Massachusetts (January 15, 2018) – Nine Whole Foods Market stores in Connecticut, Massachusetts, and Rhode Island are voluntarily recalling cheesecake bars because the product potentially contained a tree nut allergen (almond flour) that was not listed on the product label. People who have an allergy or severe sensitivity to almo nds run the risk of serious or life-threatening allergic reactions if they consume these products (Source: FDA Food Alergies)
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Kroger stores in Michigan are recalling select bulk dark chocolate products following the GKI Foods LLC recall of dark chocolate products due to an undeclared milk allergen. People who have an allergy or severe sensitivity to milk run the risk of a serious or life-threatening allergic reaction if they consume this product. (Source: FDA Food Alergies)
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Slade Gorton, Boston, MA is recalling the following products because they may contain undeclared milk. People who have an allergy or severe sensitivity to milk run the risk of serious or life-threatening allergic reaction if they consume these products. (Source: FDA Food Alergies)
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New American Food Products, LLC of Methuen, MA is voluntarily recalling various packaged goods because they contain undeclared milk. People who have an allergy or severe sensitivity to milk run the risk of serious or life-threatening allergic reaction if they consume this product. (Source: FDA Food Alergies)
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The assorted muffin four pack may include a banana nut muffin containing walnuts, an allergen not listed on the label. People who have an allergy or sensitivity to nuts should not consume this product. (Source: FDA Food Alergies)
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Five Whole Foods Market stores in Northern California are voluntarily recalling frosted Pumpkin Drop cookies because the products contained tree nut allergens (walnuts) that were not listed on the product label. People who have an allergy or severe sensitivity to walnuts run the risk of serious or life-threatening allergic reactions if they consume these products. (Source: FDA Food Alergies)
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January 8, 2018 - Gilster-Mary Lee, 520 Old St. Mary ’s Road, of Perryville, Missouri, is voluntarily recalling one lot of Essential Everyday® Coat& Bake Original Chicken coating, UPC 41303-01572 at the consumer level because it may contain undeclared milk. People who have an allergy or severe sensitivity to milk run the risk of serious or life-threatening allergic reaction if they consume these products. (Source: FDA Food Alergies)
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Colorado Nut Company of Denver, CO is recalling Cashew Cranberry Cherry Jubilee, Oat Bran Nutty Crunch, Honey Nutty Granola, Peanut Delight, and Frontier Trail Mix, because they may contain undeclared Milk. People who have an allergy or severe sensitivity to Milk run the risk of serious or life-threatening allergic reaction if they consume these products. (Source: FDA Food Alergies)
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HEALTH MART CHILDRENS ALLERGY RELIEF (Loratadine) Tablet, Chewable [Strategic Sourcing Services LLC]
Updated Date: Thu, 22 Aug 2019 00:00:00 EDT (Source: DailyMed Drug Label Updates)
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Updated Date: Thu, 22 Aug 2019 00:00:00 EDT (Source: DailyMed Drug Label Updates)
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Updated Date: Thu, 22 Aug 2019 00:00:00 EDT (Source: DailyMed Drug Label Updates)
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Updated Date: Thu, 22 Aug 2019 00:00:00 EDT (Source: DailyMed Drug Label Updates)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Condition: HIV-1-infection Intervention: Other: This is an observational study only. Sponsors: Massachusetts General Hospital; Africa Health Research Institute; Mbarara University of Science and Technology; National Institute of Allergy and Infectious Diseases (NIAID); Wellcome Trust; ViiV Healthcare; Harvard Medical School; University of KwaZulu; E mory University Recruiting (Source: ClinicalTrials.gov)
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Conditions: HIV/AIDS; Adherence, Medication Intervention: Device: Digital Pill Sponsors: University of Colorado, Denver; National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)
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Conditions: Immune Thrombocytopenic Purpura; Splenectomy; Status Intervention: Procedure: Immunolabeling Sponsor: University Hospital, Bordeaux Completed (Source: ClinicalTrials.gov)
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Condition: Hen Egg Allergy Interventions: Biological: AR201 Powder; Biological: Placebo powder Sponsor: Aimmune Therapeutics, Inc. Recruiting (Source: ClinicalTrials.gov)
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In this study, we focused on Lactobacillus helveticus SBT2171 (LH2171), which reportedly modifies some unique immune responses and ameliorated symptoms of patients allergic to mites and house dust in the previous studies. We examined the effect of LH2171 on cytokine production by antigen-stimulated murine naïve splenocytes in vitro and demonstrated that it inhibited IL-4 and IL-13 production while enhancing IFN-γ and IL-10 production. Then, we examined the anti-allergic effect of LH2171 in vivo using...
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Publication date: Available online 26 August 2019Source: Food ChemistryAuthor(s): Maxime Gavage, Kaatje van Vlierberghe, Christof Van Poucke, Marc De Loose, Kris Gevaert, Marc Dieu, Patsy Renard, Thierry Arnould, Nathalie GillardAbstractTo protect allergic patients and guarantee correct food labeling, robust, specific and sensitive detection methods are urgently needed. Mass spectrometry (MS)-based methods could overcome the limitations of current detection techniques. The first step in the development...
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Publication date: October 2019Source: Fish & Shellfish Immunology, Volume 93Author(s): Phattarunda Jaree, Taro Kawai, Chu-Fang Lo, Anchalee Tassanakajon, Kunlaya SomboonwiwatAbstractThe viral responsive protein 15 from the black tiger shrimp Penaeus monodon (PmVRP15) is a highly responsive gene upon white spot syndrome virus (WSSV) challenge. It is identified from hemocyte and important for WSSV trafficking and assembly. However, the knowledge of PmVRP15 gene regulation is limited. In the present...
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Publication date: October 2019Source: Fish & Shellfish Immunology, Volume 93Author(s): Hongsen Xu, Jing Xing, Xiaoqian Tang, Xiuzhen Sheng, Wenbin ZhanAbstractIn our previous study, a DNA plasmid encoding the VAA gene of Vibrio anguillarum was constructed and demonstrated to confer moderated protection against V. anguillarum challenge. Here, a bicistronic DNA vaccine (pVAA-IRES-IL2), co-expressing the VAA gene of V. anguillarum and Interleukin-2 (IL2) gene of flounder, was constructed to increase...
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Publication date: October 2019Source: Fish & Shellfish Immunology, Volume 93Author(s): Jun Bo, Ying Yang, Ronghui Zheng, Chao Fang, Yulu Jiang, Jie Liu, Mengyun Chen, Fukun Hong, Christyn Bailey, Helmut Segner, Kejian WangAbstractPathogenic disease is a major factor affecting the aquaculture of the rockfish Sebastiscus marmoratus, an important commercial species inhabiting the nearshore waters of the Western Pacific Ocean. Antimicrobial peptides (AMPs), as critical components of innate immunity,...
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Some viral infections culminate in very different outcomes in different individuals. They can be rapidly cleared in some, cause persistent infection in others, and cause mortality from immunopathology in yet others. The conventional view is that the different outcomes arise as a consequence of the complex interactions between a large... (Source: Proceedings of the National Academy of Sciences)
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Viperin is an interferon (IFN)-inducible multifunctional protein. Recent evidence from high-throughput analyses indicates that most IFN-inducible proteins, including viperin, are intrinsically expressed in specific tissues; however, the respective intrinsic functions are unknown. Here we show that the intrinsic expression of viperin regulates adipose tissue thermogenesis, which is known to counter... (Source: Proceedings of the National Academy of Sciences)
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Increasing evidence demonstrates that IL-17A promotes tumorigenesis, metastasis, and viral infection. Natural killer (NK) cells are critical for defending against tumors and infections. However, the roles and mechanisms of IL-17A in regulating NK cell activity remain elusive. Herein, our study demonstrated that IL-17A constrained NK cell antitumor and antiviral activity... (Source: Proceedings of the National Academy of Sciences)MedWorm Message: If you are looking to buy something in the January...
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Dynamic small ubiquitin-like modifier (SUMO) linkages to diverse cellular protein groups are critical to orchestrate resolution of stresses such as genome damage, hypoxia, or proteotoxicity. Defense against pathogen insult (often reliant upon host recognition of “non-self” nucleic acids) is also modulated by SUMO, but the underlying mechanisms are incompletely understood.... (Source: Proceedings of the National Academy of Sciences)
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In PNAS Eom et al. (1) report that viperin (virus-inhibitory protein, endoplasmic reticulum-associated, interferon-inducible), which is best known as a nuclear factor κB-induced protein in macrophages involved in the innate immune response, has a heretofore unknown role in the adipocyte. In this paper, the authors investigate the possibility that viperin,... (Source: Proceedings of the National Academy of Sciences)
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ConclusionsIn this first-in-human clinical study, cervical ILIT was demonstrated safe and induced allergen tolerance after 3 injections. (Source: American Journal of Otolaryngology)
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(Source: Journal of Neuroimmunology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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In the last decades, immunologists have started to consider intracellular metabolism in relationship with dynamics and functions of immune cells, especially when it became clear that microenvironmental alterations were associated with immune dysfunctions. Regulatory T cells (Tregs) are equipped with a variety of immunological and metabolic sensors, and encompass circulating as well as tissue-resident cells, being therefore particularly susceptible to microenvironmental cues. Moreover, Tregs undergo...
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In this study, we show that high fat diet (HFD)-induced obese mice developed an exacerbated EAE as indicated by higher clinical scores and more severe pathological changes in spinal cord than the control mice fed with normal diet (ND), following immunization with myelin oligodendrocyte glycoprotein (MOG) 35–55 peptide. The exacerbation of EAE in HFD mice was associated with enhanced microglial activation and increased expansion of Th1 and Th17 cells. The HFD mice also showed aggravated disease in...
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Uncontrolled inflammation is a leading cause of many clinically relevant diseases. Current therapeutic strategies focus mainly on immunosuppression rather than on mechanisms of inflammatory resolution. Glucocorticoids (GCs) are still the most widely used anti-inflammatory drugs. GCs affect most immune cells but there is growing evidence for cell type specific mechanisms. Different subtypes of monocytes and macrophages play a pivotal role both in generation as well as resolution of inflammation. Activation...
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Cancer immunotherapy involves in blocking the interactions between PD-1/PD-L1 immune checkpoint with antibodies and has shown unprecedented positive outcomes in clinics. Particularly, the PD-L1 antibody therapy has shown the efficiency in blocking membrane PD-L1 and efficacy in treating some advanced solid cancers. However, this therapy has limited effects on many solid tumors, suspecting to be revelent to PD-L1 located in other cellular compartments, where they play additional roles and are associated...
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The pyrogenic property being the first activity described, members of the interleukin-1 superfamily (IL-1α, IL-1β, IL-18, and the newest members: IL-33, IL-36, IL-37, and IL-38) are now known to be involved in several inflammatory diseases such as obesity, atherosclerosis, cancer, viral and parasite infections, and auto-inflammatory syndromes as well as liver diseases. Inflammation processes are keystones of chronic liver diseases, of which the etiology may be viral or toxic, as in alcoholic or non-alcoholic...
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Background: HIV-1 and M. tuberculosis co-infected patients are commonly at risk of immune reconstitution inflammatory syndrome (IRIS) when initiating antiretroviral treatment (ART). Evidence indicates that innate immunity plays a role in TB-IRIS. Here, we evaluated the phenotype of γδ T cells and invariant NKT cells in tuberculosis-associated IRIS. Methods: Forty-eight HIV+/TB+ patients (21 IRIS) and three control groups: HIV-/TB- (HD, n=11), HIV+/TB- (n=26), and HIV-/TB+ (n=22) were studied. Samples...
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Systemic lupus erythematosus (SLE) is a serious autoimmune disease with variety of organ manifestations. The most dreadful one, affecting the majority of SLE patients, is kidney manifestation – lupus nephritis (LN). Dendritic cells (DC) are believed to be one of the culprits of immune dysregulation in LN. Flow cytometry analysis was applied to identify the frequency and activity of peripheral blood DCs subpopulations: myeloid and plasmacytoid, in LN patients. Magnetically isolated mDCs and pDCs were...
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In conclusion, our results indicate a role for UNG, MSH2, MSH6 and PMS2 in the generation of SHM in humans comparable to their function in mice. However, we observed differences in strand targeting between humans and mice, emphasizing the importance of studying molecular mechanisms in the human setting. The here developed method combining NGS and ARGalaxy analysis of BCR mutation data forms the basis for efficient SHM analyses of other immune deficiencies. (Source: Frontiers in Immunology)
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Neutrophils are best known for their critical role in host defense, for which they utilize multiple innate immune mechanisms, including microbe-associated pattern recognition, phagocytosis, production of reactive oxygen species, and the release of potent proteases, mediators, antimicrobials, and neutrophil extracellular traps. Beyond their well-established contribution to innate immunity, neutrophils were more recently reported to interact with various other cells, including cells from the adaptive...
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ConclusionsTreatment with aMASCT plus apatinib was safe and effective for the management of advanced solid tumors. (Source: Cancer Immunology, Immunotherapy)
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Kawasaki disease (KD) is the leading cause of acquired heart disease among children, and the etiology is unknown. Noval Rivas et al. demonstrate that a murine model of KD vasculitis is dependent on intestinal barrier dysfunction leading to secretory IgA leakage and IgA-C3 immune complex deposition in cardiovascular lesions. (Source: Immunity)
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Impaired immune responses and increased susceptibility to infection characterize acute inflammatory conditions such as pancreatitis and alcoholic hepatitis and are major causes of morbidity and mortality. However, the mechanisms that drive this apparent immune paresis remain poorly understood. Monocytes mediate host responses to damage and pathogens in health and disease, and three subsets of monocytes have been defined based on CD14 and CD16 expression. We sought to determine the changes in monocyte...
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Dysregulation of the ubiquitin-editing enzyme A20 contributes to the development of several human inflammatory diseases. Liu et al. demonstrate that suppression of A20 enzymatic activity in alveolar macrophages promotes lung fibrosis by reducing transcriptional factor C/EBPβ degradation and enhancing targeted gene expression, which directs the profibrotic phenotype of macrophages. (Source: Immunity)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with...
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Recent data revealed the importance of immune reconstitution (IR) for the evaluation of possible biomarkers in NIH-defined cGVHD and its clinical aspects. In this large pediatric study (n=146) we have analyzed whether cellular and humoral parameters of IR in the long-term follow-up (FU) with a special emphasis on B-cell reconstitution correlate with NIH-defined cGVHD criteria. HYPOTHESIS: We were especially interested, whether meaningful cGVHD biomarkers could be defined in a large pediatric cohort....
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Metabolic insufficiency is a major barrier for antitumor immunity. Rivadeneira et al. demonstrate that engineering an oncolytic virus to express a metabolic modulator, in this case the adipokine leptin, improves T cell metabolic function in the tumor microenvironment, allowing a superior antitumor response compared to a control oncolytic. (Source: Immunity)
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Macrophages are immune sentinels essential for pathogen recognition and immune defense. Nucleic acid-sensing toll-like receptors like TLR7 activate tailored proinflammatory and interferon responses in macrophages. Here we found that TLR7 activation constrained itself and other TLRs from inducing interferon response genes in macrophages through MAPK kinase 1/2 (MEK1/2)-dependent IRF1 inhibition. Downstream of the MEK1/2-ERK pathway, TLR7-activated macrophages induced interleukin-10 (IL-10), a signal...
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Type I IFNs, but not type III IFNs (IFN λ), promote inflammation at the site of infection. Forero et al. find that differential expression of proinflammatory genes results from selective induction of the transcription factor IRF1 by type I IFNs. Type III IFNs induce a tissue repair program, suggesting a division of labor that spans proi nflammatory and tissue repair functions to promote protective immunity. (Source: Immunity)
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B6.Nba2 mice spontaneously develop a lupus-like disease characterized by elevated levels of serum anti nuclear autoantibody (ANA) immune complexes and constitutive type I interferon (IFNα) production. During disease progression, both plasmacytoid dendritic cells (pDCs) and antibody secreting plasma cells accumulate in spleens of B6.Nba2 mice. Indoleamine 2,3-dioxygenase (IDO) has been suggested to play a role in several autoimmune diseases including in the MRL/lpr model of mouse lupus-like disease;...
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Bullous Pemphigoid (BP) is a skin autoimmune blistering disease characterized by immune-mediated degradation of the dermo-epidermal junction and release of a large number of inflammatory cytokines. Interleukin-1β (IL-1β) is a pleiotropic pro-inflammatory cytokine associated with inflammasome activation and known to be pivotal in several auto-immune and auto-inflammatory diseases. We sought to clarify the presence of inflammasome-dependent IL-1β and to investigate its role in BP. Skin biopsy specimens...
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Interleukin-2-inducible T cell kinase (ITK) is critical for T cell signaling and cytotoxicity, and control of Epstein-Barr virus (EBV). We identified a patient with a novel homozygous missense mutation (D540N) in a highly conserved residue in the kinase domain of ITK who presented with EBV-positive lymphomatoid granulomatosis. She was treated with interferon and chemotherapy and her disease went into remission; however, she has persistent elevation of EBV DNA in the blood, low CD4 T cells, low NK...
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Human CD52 is a small glycopeptide (12 amino acid residues) with one N-linked glycosylation site at Asn3 and several possible O-glycosylation serine/threonine sites. Soluble CD52 is released from the surface of activated T cells and initiates immunosuppression by first sequestering pro-inflammatory HMGB1 followed by binding to the inhibitory sialic acid-binding immunoglobulin-like lectin-10 (Siglec-10) receptor on activated T cells. Our analysis of native CD52 purified from human spleen confirmed...
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Laboratory courses in immunology require a different skill set for their development than lecture courses. They vary widely in their form based on factors like institutional budget and class size, and also in the prioritization of learning goals centered around reinforcing lecture concepts and/or building fundamental skills in the field of immunology. Lab activities can come from a variety of sources including: published research protocols, commercial kits, computer-based tools or simulations, and...
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The ART program in low- and middle-income countries (LMIC) like India, has a public health approach with the standardized regimen for all people living with HIV (PLHIV). Based on the evidence from high-income countries (HIC), the risk of an enhanced and accentuated onset of premature-aging or age-related diseases has been observed in PLHIV. However, very limited data is available on residual inflammation and immune activation in the populations who are on first-generation anti-HIV drugs like zidovudine...
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This is the first case of NBAS disease detected by NBS for primary immunodeficiency. NBS with KRECs is revealing unknown potentialities detecting conditions that benefit from early recognition like NBAS deficiency. Immune phenotyping should be mandatory in patients with NBAS deficiency since they can exhibit severe immunodeficiency with hypogammaglobulinemia as the most frequent finding. Fever during infections is a known trigger of acute liver failure in this syndrome, so immune dysfunction, should...
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Dengue is one of the most important diseases transmitted by mosquitoes. Dengvaxia®, a vaccine registered in several countries, cannot be administered in non-immune individuals and children younger than nine years old, due to safety reasons. There are two vaccine candidates coursing efficacy trials, but their registration date is completely unknown at this moment. So, the development of new vaccines or vaccine strategies continues being a priority for the WHO. This work reviews some heterologous prime-boost...
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ConclusionESS is associated with improvement in subjective and some aspects of objective cognition. (Source: International Forum of Allergy and Rhinology)
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ConclusionFor patients with both DNS and AR, both types of surgery afford postoperative symptomatic improvement. Both types of surgery yielded improvement in both nasal obstruction and symptoms other than nasal obstruction. However, performing RFA after septoplasty did not afford further short ‐term symptomatic improvements. Thus, septoplasty without RFA may be optimal for patients with both DNS and AR. (Source: International Forum of Allergy and Rhinology)
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Authors: Mao R, Liu H, Yi B, Purohit S, Kuczma M, Kraj P, She JX Abstract Regulatory T cells (TR) show great promise for treating autoimmune diseases, allergies and preventing transplant rejection; however, their clinical application has been hampered by the lack of efficient ex vivo or in vivo expansion strategies. Here we report screening data on 130,000 low molecular weight (LMW) compounds for their TR promoting potential using a self-developed high-throughput cell-based assay. One of...
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In conclusion, serum neopterin levels may be used as a promising indicator of disease activity in s-JIA and MAS and for evaluating it. It may also be a useful marker to diagnose the transition to MAS from active-phase s-JIA. PMID: 31449879 [PubMed - as supplied by publisher] (Source: Clinical Immunology)
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Conclusions Adverse events were common among cardiology patients. Adverse drug events were the most frequent AEs, and non-ADEs were more critical than ADEs. Such data should be recognized among practicing physicians to improve the patients' outcomes. (Source: Journal of Patient Safety)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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This issue of Pediatric Clinics of North America clearly illustrates why medical schools in the twenty-first century are actively seeking new ways to teach medicine. As noted by Dr Secord in her preface, there have been remarkable changes in our understanding of many of the basic premises of allergy and immunology, with significant advances in treatment accompanying this new understanding. This proliferation of new knowledge is certainly not limited to immunology and allergy; rather, it is being...
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PEDIATRIC CLINICS OF NORTH AMERICA (Source: Pediatric Clinics of North America)
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CONCLUSION: This work demonstrates an association of the main polymorphisms in the HLA-DRB1 gene to AIH with or without cholangitis in a Brazilian sample.RESUMO CONTEXTO: Hepatite autoimune (HAI) é uma doença hepática inflamatória crônica, rara, associada à perda da tolerância imunológica aos auto-antígenos. A susceptibilidade à HAI é parcialmente determinada pela presença de genes relacionados ao antígeno leucocitário humano (HLA), principalmente variantes alélicas do DRB1. OBJETIVO: O objetivo...
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Title: Health Tip: Cleaning Out EarwaxCategory: Health NewsCreated: 8/23/2019 12:00:00 AMLast Editorial Review: 8/23/2019 12:00:00 AM (Source: MedicineNet Hearing General)
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BACKGROUND: Cochlear implantation (CI) procedure carries the potential risk for vestibular system insult or stimulation with resultant dysfunction due to its proximity to the cochlea. The vestibular system plays an essential role in crucial tasks such as p... (Source: SafetyLit)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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This special interest group focuses on the intersection of sociocultural factors with audiology and speech-language pathology services. 1. What would you say to encourage other colleagues to join SIG 14? SIG 14 has an amazing community of professionals, and I enjoy the discussions and information shared. I appreciate being able to tap them on the shoulder when I have a complicated case. Having access to Perspectives is also a great perk of SIG 14, with articles focused on culturally and linguistically...
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CONCLUSION: The TVP muscle is substantially reduced in volume, length, and thickness in children with 22q11DS. These findings serve as preliminary support for the association of patient hearing and otologic severity and TVP dysmorphology. PMID: 31446782 [PubMed - as supplied by publisher] (Source: The Cleft Palate-Craniofacial Journal)
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The accumulation of lingering senescent cells is a cause of aging, via the inflammatory and other signals secreted by these cells. This is now widely accepted in the research community, and the first senolytic drugs that can selectively clear some of the burden of senescent cells already exist. Unfortunately it is not yet widely appreciated that these first low cost rejuvenation therapies do in fact exist, and are easily obtained and used. Hundreds of millions of people suffer from inflammatory conditions...
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Recently, a study conducted by Motol University Hospital in Prague discovered a chemical that breaks up cancerous tumors inside patient’s bladders, allowing the tumor fragments to pass in their urine without any discomfort or causing damage to other tissue cells. A study of 20 bladder cancer patients has shown proof of this after only a few doses of the chemical. What’s even more exciting, is that this chemical, Alpah1H, is naturally found in human breast milk! Although a pharmaceutical company...
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You're reading Internet of Things for health sector – the present and the future, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. IoT devices had overwhelm the world conventional snags that were taking it to the paranoid ambiance, because of IoT world had turned into digital valley, from mobile charger to the plan IOT devices playing their pivot role to build the intended world as well as...
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