Given the ubiquity of laparoscopic cholecystectomy in the modern era, the incidence of incidentally diagnosed gallbladder cancers (GBCs) is rising. This unique clinical scenario poses specific challenges regarding the role of staging, re-resection, and adjuvant treatment for patients with this disease. This review will address these controversies with the latest published data.
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Gallbladder cancer is the most common biliary tract malignancy. Margin-clearing surgery is a cornerstone of gallbladder cancer management, but several aspects of surgical management are controversial. This review will discuss the current state of surgical management for gallbladder cancer as well as aspects of gallbladder surgery that remain debated, including operative extent, lymphadenectomy extent, and management of incidentally discovered gallbladder cancer.
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Gallbladder cancer is a highly aggressive disease with variable prevalence across the globe. Particularly the Indo-Gangetic belt in Northern India has an incidence as high as 21/100,000. Majority of cases are detected either incidentally on pathological evaluation of cholecystectomy specimens or present with advanced disease. Radical surgery remains the mainstay of cure but only a small subset of patients is operable at presentation, and even with curative surgery recurrence rates remain high. Much...
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Gallbladder cancer, one of the family of biliary tract cancers, has a poor prognosis. Adjuvant therapy comprising radiotherapy, chemotherapy plus radiation therapy and systemic chemotherapy may all play a role in improving survival. Most extant data on adjuvant therapy are retrospective studies or meta-analyses based on these studies. Recently, a phase III study demonstrated that capecitabine is a standard treatment option for biliary tract cancers, including gallbladder cancer. Ongoing studies investigating...
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Biliary tract cancer (BTC) is comprised of intrahepatic cholangiocarcinoma (ICC), extrahepatic cholangiocarcinoma (EHC) and gallbladder cancer (GBC). These tumors arise in the biliary epithelium, share histological characteristics and are associated with grim prognosis even when diagnosed at early stages. Moreover, its relatively low incidence in developed countries has precluded the development of clinical trials addressing specific differences among BTC subgroups in terms of their biology, treatment...
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Abstract Background In the context of global health, the work of nurses is of key importance, given their role as diplomats in global health and as fundamental forces in the construction of global partnerships. This study seeks to identify the understanding and perceptions of Brazilian nursing faculty members regarding literacy of human rights related to health in nursing undergraduate programs. ...
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Abstract Background Female genital mutilation/cutting (FGM/C) is a traditional harmful practice that has been prevalent in Egypt for many years. The medicalization of FGM/C has been increasing significantly in Egypt making it the country with the highest rate of medicalization. In this qualitative study, we explored the drivers and motives behind why healthcare professionals perform FGM/C and why mothers rely on them to perform the...
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Objective: To assess final adult height (FAH) in children with short stature treated with gonadotropin-releasing hormone analogue (GnRHa). Methods: All patients with idiopathic short stature (ISS) with normally timed puberty and a Tanner stage between 2 and 3, who achieved their FAH between 2005 and 2015, were included in this clinical historical cohort study. Height gain, FAH, and mid-parental height of 28 children with ISS who received GnRHa treatment for 1.8 ± 1.0 years to delay their puberty...
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Colesteatoma residual iatrogênico fratura do muro
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RESUMEN: Objetivo: de este estudio fue determinar la efectividad de dos biomateriales, el plasma rico en fibrina (PRF) y la membrana de colágeno en la regeneración ósea guiada. Materiales y método: Fueron utilizados 30 cobayos adultos machos entre 900 a 1100 g. divididos en tres grupos de 10 cobayos cada uno (Grupo A: Control, grupo B: Membrana de colágeno y grupo C: Plasma rico en fibrina). A cada grupo se le creó un defecto óseo mandibular unilateral de 2mm. Al grupo A no se colocó un biomaterial,...
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ABSTRACT: Objective: The objective of this study was to conduct a bibliometric analysis of periodontal research done in Brazil. Methodology: This study was developed by examining papers published at the 2017 Annual Meeting of the Brazilian Society of Dental Research (SBPqO). Summaries related to the field of Periodontics have been evaluated. An Excel spreadsheet with details of institutions, funding agencies, states, regions, subjects, and types of research methods was collected. Descriptive...
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RESUMEN: Objetivo: Evaluar el grado de concordancia entre las prevalencias de trastornos articulares inflamatorios (TAI) de las Articulaciones Temporomandibulares (ATM), obtenidas con los Criterios Diagnósticos de Investigación para Trastornos Temporomandibulares (RDC/TMD) y los Criterios Diagnósticos para Trastornos Temporomandibulares (DC/TMD). Materiales y métodos: 59 pacientes adultos chilenos fueron examinados según el Eje I de los RDC/TMD y el Eje I de los DC/TMD para determinar la prevalencia...
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RESUMEN: Objetivo: El objetivo de este estudio fue comparar el paralelismo entre el Plano de Frankfort (PF) trazado en tejidos blandos y la horizontal verdadera cuando el paciente se ubica en Posición Natural de Cabeza (PNC). Materiales y métodos: La muestra contó con 97 voluntarios. A cada uno de los participantes se le tomó una fotografía facial de perfil para luego analizar mediante el software Photoshop® la angulación del PF trazado en tejidos blandos. Se utilizó t-test para determinar si...
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RESUMEN: Objetivo: comparar la radiopacidad de distintos cementos de resina y corroborar si cumplen con los requisitos de normativas ISO. Material y método: Se prepararon muestras de 1 mm de grosor de los cementos de resina: RelyX U200 (3M ESPE), Calibra (Dentsply Sirona), Calibra Universal (Dentsply Sirona) y Bifix SE (VOCO). Las muestras fueron radiografiadas junto a una cuña de aluminio escalonada. Las imágenes fueron analizadas para determinar el valor en escala de grises y su respectivo valor...
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RESUMEN: Objetivo: el objetivo de este estudio epidemiológico, fue determinar la prevalencia y severidad de caries dental, expresados en el índice de dientes definitivos con caries, obturados y perdidos (COPD), índice de dientes primarios con caries, extraídos y obturados (ceod) e Índice Significante de Caries (ISC) además establecer la necesidad de tratamiento restaurador y recursos humanos necesarios para ello, en una población escolar de 6 a 12 años de la Provincia de Santiago, Región Metropolitana....
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RESUMEN: Las perforaciones radiculares son uno de los accidentes que pueden ocurrir dentro del tratamiento endodóntico rehabilitador de un diente y comprometen el pronóstico de éste. El objetivo de este reporte es describir el tratamiento y seguimiento de un diente con pronóstico desfavorable, con falsa vía y perforación en el 1/3 medio radicular. El manejo de la perforación se realizó con BiodentineTM y la rehabilitación con prótesis fija unitaria con poste de fibra individualizado. A los controles...
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RESUMEN: La Pansinusitis aguda odontogénica es un cuadro infeccioso infrecuente que afecta a todos los senos paranasales, en el cual se hace necesario un diagnóstico precoz para obtener una menor morbilidad. Un correcto diagnóstico requiere una evaluación dental exhaustiva, apoyándose con imágenes apropiadas. El presente caso clínico reporta paciente femenino de 17 años, sin enfermedades crónicas de base, diagnosticada con pansinusitis aguda odontogénica a través de examen de tomografía axial computarizada....
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RESUMEN: El reborde fibroso móvil mandibular -producto de reabsorción alveolar extrema, trauma oclusal o inestabilidad protésica - se deforma bajo presión, alterando la retención, soporte y estabilidad protésica. La impresión debe registrarlo en forma pasiva, evitando comprimirlo y desplazarlo, transfiriendo la presión hidráulica del material de impresión a la zona de soporte útil del reborde. Se presenta una alternativa simplificada de impresión para reborde móvil mandibular. Se discuten sus ventajas...
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RESUMEN: Este caso clínico de boca dividida tiene como objetivo comparar los resultados clínicos obtenidos a 6 meses mediante el uso de técnica VISTA, en combinación con injerto de tejido conectivo (ITC) versus Mucograft® en el tratamiento de recesiones gingivales III de Miller, con fenotipo gingival fino. El resultado muestra que ambos injertos logran mejorar el fenotipo gingival y un mayor porcentaje de cobertura radicular, sin embargo, el ITC provee mayor volumen gingival. No obstante, el Mucograft®...
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RESUMEN: El Tumor Odontogénico Epitelial Calcificante (TOEC), también denominado Tumor de Pindborg, se define como una neoplasia benigna, caracterizada por la proliferación epitelial; presenta secreción de una proteína tipo amiloide con tendencia a la calcificación. Representa menos del 1% de los tumores odontogénicos. Reportamos un caso en paciente de 75 años con un TOEC en la región maxilar izquierda en relación a una pieza dentaria incluida. El caso no mostró sintomatología específica, sólo una...
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RESUMEN: Objetivo: El propósito del reporte de caso fue evaluar la cobertura radicular (CR) en el sector anterior luego de haber realizado la técnica de túnel modificada utilizando Matriz Dérmica Acelular (MDA). Consideraciones clínicas: La literatura ha descrito el uso de la técnica de túnel desde hace varias décadas y en los últimos años se ha perfeccionado con desplazamiento del tejido gingival hacia coronal simultáneo con el uso de MDA con el fin de lograr mejores resultados. Aunque en situaciones...
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ABSTRACT: The maxillary midline diastema is a common esthetic problem in patients. Assess and diagnose may be challenging due to the many factors that influences the alteration of tooth eruption process and tooth shape. Due to the various advantages and the reversibility of treatments, composite resins are today a suitable aesthetic and functional option, even so, its management and technique require a trained and experienced clinician in order to obtain an optimal outcome. The following report,...
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RESUMEN: El tratamiento de trastornos óseos genéticos a nivel dentomaxilofacial suele ser muy complejo e invasivo. La displasia cleidocraneal es una condición que se caracteriza por generar a nivel oral hiperdoncia, y en consecuencia, apiñamiento dentario, retardo en la erupción y retención de dientes temporales, entre otros. En este caso el paciente presentaba dentición mixta primera fase a los 13 años de edad, fue tratado en conjunto con un equipo multidisciplinario donde se ha logrado un tratamiento...
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RESUMEN: Las revisiones sistemáticas corresponden al máximo nivel de evidencia y son la principal herramienta para resolver incertidumbres clínicas(1). Sin embargo, dado sus características, presentan desventajas para su aplicación rápida y sencilla(2). Dado lo anterior es que se han creado nuevos formatos dentro de los que se incluyen los resúmenes estructurados de revisiones sistemáticas, dentro de los que se incluyen los Friendly Summary Of The Body Of Evidence (FRISBEE) (4). El proceso de elaboración...
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Abstract Diabetes is a chronic disease associated with triglyceride metabolism disorder, being an etiological factor in fatty liver disease, hypertension, and cardiovascular diseases. Diet-based therapy including energy balance and herbal supplements is a suitable approach to ameliorate progression of the disease. Leaves of Lippia triphylla (lemon verbena) from the family Verbenaceae are a foodstuff used as a tea drink or cooking seasoning, with confirmed safety during long-term...
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Abstract Two new sarpagine-type indole alkaloids (1 and 2), together with five known alkaloids; 12-methoxy-4-methylvoachalotine (3), 16-demethoxycarbonylvoacamine (4), isositsirikine (5), affinisine (6), affinine (7), were isolated from the bark of Tabernaemontana macrocarpa Jack. The structures of these alkaloids were determined based on spectroscopic data, chemical correlation, and comparison with the literature. 16-Demethoxycarbonylvoacamine (4) showed antiplasmodial activities...
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Abstract From the methanolic extract of the leaves of Lansium domesticum, three new onoceranoid-type triterpenoids, lansium acids X–XII and a new cycloartane-type triterpene, lansium acid XIII, were isolated. The chemical structures of the isolated new compounds were elucidated on the basis of chemical/physicochemical evidence. For new onoceranoid-type triterpenoids, the absolute configurations were established by comparison of experimental and predicted electronic circular dichroism...
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Abstract Computer hardware development coupled with the development of quantum chemistry, new computational models and algorithms, and user-friendly interfaces have lowered the barriers to the use of computation in the discovery and structure elucidation of natural products. Consequently, the use of computational chemistry software as a tool to discover and determine the structure of natural products has become more common in recent years. In this review, we provide several examples...
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Abstract Diarylheptanoid, 1-(4-hydroxyphenyl)-7-phenyl(6E)-6-hepten-3-one (HPPH), has been reported to enhance myoblast differentiation via estrogen receptor (ER). However, the underlying signaling pathway promising this action remains unknown. The present study thus aimed to investigate the signaling pathway of HPPH that enhances myoblast differentiation. Confluence C2C12 myoblasts were induced to differentiate in the absence or presence of HPPH (10 nM). Differentiation markers...
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Abstract Wnt signaling has been implicated in numerous aspects of development, cell biology, and physiology. When aberrantly activated, Wnt signaling can also lead to the formation of tumors. Thus, Wnt signaling is an attractive target for cancer therapy. Based on our screening program targeting Wnt signaling activity using a cell-based luciferase screening system assessing TCF/β-catenin transcriptional activity, we isolated a series of terpenoids and heterocyclic aromatic compounds...
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Title: Health Tip: Cleaning Out EarwaxCategory: Health NewsCreated: 8/23/2019 12:00:00 AMLast Editorial Review: 8/23/2019 12:00:00 AM (Source: MedicineNet Hearing General)
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The aim of this study was to evaluate the effects of the aqueous extract of Baillonella toxisperma stem bark on dexamethasone-induced insulin resistance in rats. A quantitative phytochemical study was done on the aqueous extract of Baillonella toxisperma for the total phenol, flavonoid, and flavonol determination. Insulin resistance was induced by intraperitoneal injection of dexamethasone (1 mg/kg) for 8 days, one hour before oral administration of different treatments (extract at doses of 60, 120,...
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A comprehensive resource describing innovative technologies and digital health tools that can revolutionize the delivery of health care in low- to middle-income countries, particularly in remote rural impoverished communities Revolutionizing Tropical Medicine offers an up-to-date guide for healthcare and other professionals working in low-resource countries where access to health care facilities for diagnosis and treatment is challenging. Rather thanRead More...
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