- Early life factors, gray matter brain volume and academic performance in overweight/obese children: The ActiveBrains projectPublication date: Available online 26 August 2019Source: NeuroImageAuthor(s): Patricio Solis-Urra, Irene Esteban-Cornejo, Cristina Cadenas-Sanchez, Maria Rodriguez-Ayllon, Jose Mora-Gonzalez, Jairo H. Migueles, Idoia Labayen, Juan Verdejo-Román, Arthur F. Kramer, Kirk I. Erickson, Charles H. Hillman, Andrés Catena, Francisco B. OrtegaAbstractEarly life factors may influence brain and academic outcomes later in life, especially duri
- The neurophysiology of schizophrenia: Current update and future directionsPublication date: Available online 26 August 2019Source: International Journal of PsychophysiologyAuthor(s): Derek J. Fisher, Dean F. Salisbury
- Partial Medial Meniscectomy Leads to Altered Walking Mechanics Two Years after Anterior Cruciate Ligament Reconstruction; Meniscal Repair Does NotPublication date: Available online 27 August 2019Source: Gait & PostureAuthor(s): Jacob J. Capin, Ashutosh Khandha, Thomas S. Buchanan, Lynn Snyder-MacklerAbstractBackgroundPartial meniscectomy dramatically increases the risk for post-traumatic, tibiofemoral osteoarthritis after anterior cruciate ligament reconstruction (ACLR). Concomitant medial meniscus surgery influences walking biomechanics (e.g., medial tibiofemoral joint loading) early
- The Influence of Sagittal Trunk Posture on the Magnitude and Rate of Patellofemoral Joint Stress during Stair Ascent in Asymptomatic FemalesPublication date: Available online 26 August 2019Source: Gait & PostureAuthor(s): Lee T. Atkins, Cevan Smithson, Daniel Grimes, Nancy Heuer
- Paralog dependency indirectly affects the robustness of human cells [NEW RESULTS]The protective redundancy of paralogous genes partly relies on the fact that they carry their functions independently. However, a significant fraction of paralogous proteins may form functionally dependent pairs, for instance through heteromerization. As a consequence, one could expect these heteromeric paralogs to be less protective against deleterious mutations. To test this hypothesis, we examined the robustness landscape of gene loss-of-funct
- Bacterial predator-prey coevolution accelerates genome evolution and selects on virulence-associated prey defences [NEW RESULTS]Generalist bacterial predators are likely to strongly shape many important ecological and evolutionary features of microbial communities, for example by altering the character and pace of molecular evolution, but investigations of such effects are scarce. Here we report how predator-prey interactions alter the evolution of fitness, genomes and phenotypic diversity in coevolving bacterial communities composed of Myxococcus xanthus as predator and
- Polygenic adaptation to an environmental shift: temporal dynamics of variation under Gaussian stabilizing selection and additive effects on a single trait [NEW RESULTS]Predictions about the effect of natural selection on patterns of linked neutral variation are largely based on models involving the rapid fixation of unconditionally beneficial mutations. However, when phenotypes adapt to a new optimum trait value, the strength of selection on individual mutations decreases as the population adapts. Here, I use explicit forward simulations of a single trait with additive-effect mutations adapting to an optimum sh
- Corrigendum to ‘LOW-ECHO SPHERE PHANTOMS AND METHODS FOR ASSESSING IMAGING PERFORMANCE OF MEDICAL ULTRASOUND SCANNERS’ [ULTRASOUND MED BIOL 40 (2014) 1697-1717]Publication date: Available online 26 August 2019Source: Ultrasound in Medicine & BiologyAuthor(s): Ernest L. Madsen, Chihwa Song, Gary R. Frank
- Use of 3D Printed Models to Create Molds for Shaping Implants for Surgical Repair of Orbital FracturesPublication date: Available online 27 August 2019Source: Academic RadiologyAuthor(s): William J. Weadock, Curtis J. Heisel, Alon Kahana, John KimRationale and ObjectivesSurgical repair of an isolated orbital fracture requires anatomically accurate implant shape and placement. We describe a three-dimensional (3D) printing technique to customize the shape of commercially available absorbable implants.Materials and MethodsWe reviewed our early expe
- Influence of Artifact Corrections on MRI Signal Intensity Ratios for Assessment of Gadolinium Brain RetentionPublication date: Available online 26 August 2019Source: Academic RadiologyAuthor(s): Marc Saake, Tobias Hepp, Alexandra Schmidle, Wolfgang Wuest, Rafael Heiss, Arnd Doerfler, Michael Uder, Tobias BäuerleRationale and ObjectivesDifferences in brain signal intensity ratios (SIRs) of deep brain nuclei in T1-weighted (T1w) magnetic resonance images were reported as an indicator of gadolinium brain retention. Variable methods of image reconstru
- Early prediction of acute xerostomia during radiation therapy for nasopharyngeal cancer based on delta radiomics from CT images.Related ArticlesEarly prediction of acute xerostomia during radiation therapy for nasopharyngeal cancer based on delta radiomics from CT images. Quant Imaging Med Surg. 2019 Jul;9(7):1288-1302 Authors: Liu Y, Shi H, Huang S, Chen X, Zhou H, Chang H, Xia Y, Wang G, Yang X Abstract Background: Acute xerostomia is the most common side effect of radiation therapy (RT) for head and neck (H&N) malignan
- [The application of computer-aided design combined with three-dimension printing in mandibular tumor surgery: a case report].Related Articles[The application of computer-aided design combined with three-dimension printing in mandibular tumor surgery: a case report]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 May 07;54(5):382-384 Authors: Li YJ, Li C, Wang W, Cai YC, Zhou YQ, Sun RH, Jiang J PMID: 31137101 [PubMed - indexed for MEDLINE]
- Novel Thoracoscopic Navigation System With Augmented Real-Time Image Guidance for Chest Wall Tumors.Related ArticlesNovel Thoracoscopic Navigation System With Augmented Real-Time Image Guidance for Chest Wall Tumors. Ann Thorac Surg. 2018 11;106(5):1468-1475 Authors: Lee CY, Chan H, Ujiie H, Fujino K, Kinoshita T, Irish JC, Yasufuku K Abstract BACKGROUND: We developed a thoracoscopic surgical navigation system with real-time augmented image guidance to assess the potential benefits for minimally
- Combination immunotherapy with TLR agonists and checkpoint inhibitors suppresses head and neck cancer.Related ArticlesCombination immunotherapy with TLR agonists and checkpoint inhibitors suppresses head and neck cancer. JCI Insight. 2017 09 21;2(18): Authors: Sato-Kaneko F, Yao S, Ahmadi A, Zhang SS, Hosoya T, Kaneda MM, Varner JA, Pu M, Messer KS, Guiducci C, Coffman RL, Kitaura K, Matsutani T, Suzuki R, Carson DA, Hayashi T, Cohen EE Abstract Checkpoint inhibitors have demonstrated efficacy in
- Oral Physiological Characteristics among Chinese Subjects in the Eastern Region of ChinaPublication date: Available online 26 August 2019Source: Archives of Oral BiologyAuthor(s): Huan Liu, Lanxi Qin, Yue Wu, Hilbert W. van der Glas, Jianshe Chen, Xinmiao WangAbstractObjectivesWith an increasing number of elderly in China, it becomes imperative to establish a comprehensive understanding of their physiological capabilities and investigate fundamental mechanisms underpinning the discrepancies between Chinese individuals and other eth
- Clinical Anatomy of the Ligaments of the Craniocervical Junction, R. Shane Tubbs, Joe Iwanaga, Marios Loukas, Rod J. Oskouian (Eds.). Cambridge Scholars Publishing (2019), 308, pages $85.42 ISBN 978-1-5275-2208-4Publication date: November 2019Source: World Neurosurgery, Volume 131Author(s): Ahmed Mohyeldin, Daniel M. Prevedello
- An Update on Endoscopic Mechanical and Powered Dacryocystorhinostomy in Acute Dacryocystitis and Lacrimal AbscessPublication date: Available online 26 August 2019Source: Annals of Anatomy - Anatomischer AnzeigerAuthor(s): Kelvin Kam-lung Chong, Haitham Abdulla Abdulghaffar Abdulla, Mohammad Javed AliAbstractPurposeTo provide a brief review of the literature on the utility and outcomes of endoscopic dacryocystorhinostomy (DCR) in patients with acute dacryocystitis (ADC) and lacrimal abscess.MethodsThe authors performed a PubMed search of all articles publis
- Differences in tumor initiation and progression of melanoma in the BrafCA;Tyr‐CreERT2;Ptenf/f model between male and female miceAbstract Cutaneous melanoma is an aggressive type of skin cancer with significant morbidity and mortality (Reed et al., 2012). To study the biology of this cancer, as well as test therapeutics, several transgenic mouse models were developed that mimic the human disease in terms of genetics, histology, and kinetics. A frequently utilized model is the Braf CA ;Tyr‐CreERT2;Pten f/f transgenic mouse, a spatiotemporal system using the Cre‐ERT2/L
- High-Intensity Interval Training improves cerebellar antioxidant capacity without affecting cognitive functions in ratsPublication date: Available online 26 August 2019Source: Behavioural Brain ResearchAuthor(s): Daniel Almeida Freitas, Etel Rocha-Vieira, Ricardo Augusto Leoni de Sousa, Bruno Alvarenga Soares, Artur Rocha-Gomes, Bruna Caroline Chaves Garcia, Ricardo Cardoso Cassilhas, Vanessa Amaral Mendonça, Ana Cristina Resende Camargos, José Antonio Michell De Gregorio, Ana Cristina Rodrigues Lacerda, Hércules Ribeiro LeiteAbstractHigh-in
- Pervasive and diverse collateral sensitivity profiles inform optimal strategies to limit antibiotic resistance [NEW RESULTS]Evolved resistance to one antibiotic may be associated with "collateral" sensitivity to other drugs. Here we provide an extensive quantitative characterization of collateral effects in Enterococcus faecalis , a gram-positive opportunistic pathogen. By combining parallel experimental evolution with high-throughput dose-response measurements, we measure phenotypic profiles of collateral sensitivity and resistance for a total of 900 mutant-drug comb
- Fitness-Dependent Recombination Can Be Evolutionarily Advantageous in Diploids: a Deterministic Mutation-Selection-Balance Model [NEW RESULTS]Recombination's omnipresence in nature is one of the most intriguing problems in evolutionary biology. The question of why recombination exhibits certain general features is no less interesting than that of why it exists at all. One such feature is recombination's fitness dependence (FD). The so far developed population-genetics models have focused on the evolution of FD recombination mainly in haploids, although the empirical evidence for this p
- How long do Red Queen dynamics survive under genetic drift? A comparative analysis of evolutionary and eco-evolutionary models [NEW RESULTS]Background: Red Queen dynamics are long term oscillations of genotype abundances driven by fluctuating selection in host-parasite systems. Much of our current understanding of these dynamics is based on theoretical concepts explored in mathematical models that are mostly (i) deterministic, inferring an infinite population size and (ii) evolutionary, thus ecological interactions that change population sizes are excluded. Here, we recall the differ
- Egg White Hydrolysate Retains the Nutritional Value of Proteins and Is Quickly Absorbed in RatsEgg white protein has a high net protein utilisation, with a score of 100 in the amino acid rating system. Although the enzymatic breakdown of egg white yields hydrolysates that are rapidly absorbed and various physiological activities can be expected from them, flavouring egg white to meet taste requirements as a food has been a difficult challenge. Herein, we developed a high-molecular-weight egg white hydrolysate and compared the absorption ra
- Healthcare-Associated Infections in the Neurocritical Care UnitAbstract Purpose of Review This article summarizes updated data and knowledge on healthcare-associated infections in the neurocritical care unit, with a focus on central nervous system infections and systemic infectious complications in patients with acute brain disease. It also reviews the concept of brain injury-induced immune modulation, an underlying mechanism to explain why
- Cancers, Vol. 11, Pages 1253: Acute Myeloid and Lymphoblastic Leukemia Cell Interactions with Endothelial Selectins: Critical Role of PSGL-1, CD44 and CD43Cancers, Vol. 11, Pages 1253: Acute Myeloid and Lymphoblastic Leukemia Cell Interactions with Endothelial Selectins: Critical Role of PSGL-1, CD44 and CD43 Cancers doi: 10.3390/cancers11091253 Authors: Caroline Spertini Bénédicte Baïsse Marta Bellone Milica Gikic Tatiana Smirnova Olivier Spertini Acute myeloid and lymphoblastic leukemia are poor prognosis hematologic malignancies, which disseminate from the bone marrow
- Guidance of EFSA on risk assessments for active substances of plant protection products that have stereoisomers as components or impurities and for transformation products of active substances that may have stereoisomersAbstract In response to the request of the European Commission to EFSA, this document provides guidance on the information necessary to perform the risk assessment of plant protection active substances that contain stereoisomers in their composition as active components or impurities. The guidance should also be used for active substances that without containing any stereogenic element may generate transformation products or metabolites that do
- De Ritis Ratio (Aspartate Transaminase/Alanine Transaminase) as a Significant Prognostic Factor in Patients Undergoing Radical Cystectomy with Bladder Urothelial Carcinoma: A Propensity Score-Matched StudyIntroduction. To investigate the correlation between preoperative De Ritis ratio (aspartate transaminase (AST)/alanine transaminase (ALT)) and postoperative outcome in patients with urothelial cell carcinoma (UC) treated with radical cystectomy. Materials and Methods. We analyzed the clinical and pathological data of 771 patients who underwent radical cystectomy for bladder UC. Patients were divided into two groups according to the optimal value
- Diagnostic Accuracy of circRNAs in Esophageal Cancer: A Meta-AnalysisPurpose. Early detection of esophageal cancer is beneficial to the survival and prognosis of patients. Circular RNAs (circRNAs) have been shown to be a potential biomarker for cancer, which can be used for the diagnosis of esophageal cancer. However, the roles of circRNAs in the diagnosis of esophageal cancer has been controversial. The present study, therefore, is aimed at determining the diagnostic accuracy of circRNAs in esophageal cancer. Met
- Radiofrequency ablation of turbinates after septoplasty has no effect on allergic rhinitis symptoms other than nasal obstructionBackground In this study we evaluated the effects of inferior turbinate radiofrequency ablation (RFA), performed after septoplasty, on patients with allergic rhinitis (AR) symptoms. Methods This was a prospective, randomized, controlled study involving 60 patients with both a deviated nasal septum (DNS) and AR. Those who underwent septoplasty/sham surgery constituted the Septo‐Sham group and those who underwent septoplasty/RFA formed the S
- Effects of endoscopic sinus surgery on objective and subjective measures of cognitive dysfunction in chronic rhinosinusitisBackground Chronic rhinosinusitis (CRS) is a common condition that has been associated with cognitive dysfunction. The purpose of this study was to evaluate the effect of endoscopic sinus surgery (ESS) on the subjective and objective measures of cognitive dysfunction and related quality‐of‐life measures in CRS. Methods Thirty‐five adults with CRS refractory to medical therapy were prospectively enrolled. Preoperatively and postoperatively
- What are new treatment concepts in systemic itch?Abstract Chronic pruritus is a relevant symptom burden in various systemic diseases. It is most commonly observed in patients with chronic kidney disease, hepatobiliary and hematological disorders as well as adverse drug reaction. Recent basic research has unraveled novel treatment targets which are currently in pre‐clinical phases, clinical trials or have already been licensed. While μ‐opioid receptor antagonists have been used since decades ma
- Headache Attributed to Autonomic Dysreflexia: Clinical Presentation, Pathophysiology, and TreatmentAbstract A patient presenting with marked elevation in blood pressure and concurrent headache often presents a diagnostic challenge for even the most seasoned clinician. When marked hypertension and headache occur in a patient with a history of upper spinal cord injury, the patient should be presumed to have autonomic dysreflexia until proven otherwise. Autonomic dysreflexia can at times trigger headaches, hypertension, and v
- The Clinical Use of IgG Food Sensitivity Testing with Migraine Headache Patients: a Literature ReviewAbstract Purpose of Review This literature review describes the relationship between IgG food sensitivities and their relation to migraine headaches. Recent Findings IgG food sensitivities have been linked to various symptoms and disorders. While food sensitivities and intolerances are recog
- Patients with Chronic Musculoskeletal Pain of 3–6-Month Duration Already Have Low Levels of Health-Related Quality of Life and Physical ActivityAbstract Purpose of Review: To determine the level of physical activity and health-related quality of life in patients with chronic musculoskeletal pain of 3–6-month duration who have not been diagnosed or treated before. Recent Findings: Low levels of quality of life and physical activity h
- Patient‐reported effect in patients receiving implant or tooth supported fixed prosthesisAbstract Objectives To compare the patient‐reported effect of treatment with implant supported fixed prosthesis (ISFP) and fixed dental prosthesis (FDP) in patients with a small number of tooth losses to replace. Methods From a population of 155 patients receiving either ISFP or FDP, 68 patients were matched in pairs based on gender, number of teeth replaced, zone of replacement, age, and number of remaining teeth. The patient‐reported
- Comparison of Voice Handicap Index in Patients with Esophageal and Tracheoesophageal Speech after Total LaryngectomyBackground: Successful speech rehabilitation has a great impact on the quality of life in totally laryngectomized patients. Objectives: The aim of this paper was to compare the self-assessed voice handicap of totally laryngectomized patients with two different methods of alaryngeal speech – esophageal (ES) and tracheoesophageal speech (TES). Method: The research comprised 83 totally laryngectomized, disease-free patients, split into two gr
- Subtle changes of gray matter volume in fibromyalgia reflect chronic musculoskeletal pain rather than disease‐specific effectsAbstract Fibromyalgia syndrome (FMS) is a chronic pain syndrome. Neuroimaging studies provided evidence of altered gray matter volume (GMV) in FMS but, similarly, in chronic pain of other origin as well. Therefore, the purpose of this study was to evaluate the disease specificity of GMV alterations in FMS by direct comparison. Structural MRI data of the brain were acquired in 25 females with FMS and two different control groups: 21 healthy subje
- MRI characteristics predict the efficacy of meloxicam treatment in patients with desmoid‐type fibromatosisAbstract Introduction This study aimed to determine the clinical significance of MRI characteristics as a possible predictor of responsiveness to meloxicam treatment in patients with desmoid‐type fibromatosis (DF). Additionally, it analysed the correlation between CTNNB1 mutation status and signal intensity of MRI. Methods Forty‐six patients consecutively treated with meloxicam composed this study. The low‐intensity area (LIA) on T2‐wei
- Risk factors for unplanned readmission in total laryngectomy patientsObjective To determine which patient or surgical factors affect the likelihood of unplanned readmission (within 30 days) after total laryngectomy (TL). Methods Retrospective chart review of all patients who underwent TL at a single institution from April 2007 through August 2016. Primary outcome was unplanned readmission to the hospital within 30 days of discharge. Univariable and multivariable logistic regression were performed to identif
- Static endoscopic swallow evaluation in childrenObjectives Static Endoscopic Evaluation of Swallowing (SEES) has been demonstrated to have a strong correlation with the Videofluoroscopic Swallow Study (VFSS) in adults. In children, Fiberoptic Endoscopic Evaluations of Swallow (FEES) are frequently performed to avoid repeated VFSS; however, a subset of the population does not tolerate FEES. The purpose of this study was to evaluate the utility of a modified SEES in children. Methods Char
- Validation of the Normalized Laryngeal Constriction Ratio in Normal and Disordered SwallowingPurpose The timing of laryngeal vestibule closure (LVC) is important for airway protection during swallowing. However, it is unknown whether the extent of LVC contributes to airway protection. The goal of this study is to validate the extent of LVC via a measure called laryngeal constriction ratio (LCR). Methods A retrospective analysis of videofluoroscopic swallows was conducted on 38 stroke participants and 40 healthy controls. The LCR w
- Duodenal nutrient exposure contributes to enhancing gastric accommodationThis study supports the role of duodenal feedback on the gastric accommodation reflex. Pyloric obstruction during intragastric infusion of a meal resulted in decreased gastric accommodation and dyspeptic symptoms in healthy subjects. Abstract Background The gastric accommodation reflex consists of a relaxation which creates a reservoir for the ingested food before emptying to the duodenum occurs. The mechanisms that control gastric accommod
- 24‐hour multi‐pH recording of the postprandial acid pocket and the nocturnal acid distribution at the esophagogastric junction in healthy volunteersWe demonstrated that the acid pocket is present in the postprandial period under both stationary and ambulatory conditions. Of interest, at night, a pool of acid can be demonstrated which is periodically shifted more distally. This pool of acid represents the reservoir from which nocturnal reflux originates. Abstract Background Postprandial stationary pH monitoring studies have identified the acid pocket. To what extent a similar pool of ac
- Accuracy of Pulmonary Nodule Volumetry at Different Exposure Parameters in Low-dose Computed Tomography: A Phantom StudyObjective To explore the exposure parameters with minimized radiation dose for accurate pulmonary nodule volumetry using low-dose computed tomography (LDCT). Methods An anthropomorphic chest phantom with 11 pulmonary nodules (6 solid nodules and 5 ground-glass opacities) was scanned using 256-slice multidetector computed tomography scanner at various tube voltage and current (combinations of 80, 100 and 120 kV with 10 to 30 mAs). Raw data
- Interstitial Lung Disease: Update on the Role of Computed Tomography in the Diagnosis of Idiopathic Pulmonary FibrosisIdiopathic pulmonary fibrosis is the commonest interstitial lung disease. Radiologists play an essential role in making an accurate diagnosis, and this is necessary given its prognostic implications and potential use of antifibrotic therapies. This review highlights the radiologic features and imaging classification of fibrosis with reference to recently updated international guidelines and emphasizing the importance of the multidisciplinary team
- Intraosseous Hibernoma: Five Cases and a Review of the LiteratureWe present 5 cases of intraosseous hibernoma, a rare benign tumor of brown fat. Our literature review reveals that the average age at presentation is 58.6 years, and 69.7% of patients are female. Lesions are most often located in the spine and pelvis. Computed tomography usually demonstrates sclerotic changes, although lesions can be lytic. Magnetic resonance imaging findings include heterogeneous T2 hyperintensity. Technetium 99m-methyl diphosph
- The Role of Positron Emission Tomography/Magnetic Resonance Imaging in Gynecological MalignanciesAccurate oncological staging for early detection is of utmost importance in patient care and increasing the overall patient survival outcome. Hybrid imaging in the form of positron emission tomography (PET)/computed tomography has been successfully implemented in oncological imaging and, where available, has been used consistently in patients with gynecologic malignancies. The implementation of PET/magnetic resonance imaging (MRI) enables high-qu
- Impact of Knowledge-Based Iterative Model Reconstruction on Image Quality and Hemodynamic Parameters in Dynamic Myocardial Computed Tomography Perfusion Using Low-Tube-Voltage Scan: A Feasibility StudyObjective Knowledge-based iterative model reconstruction (IMR) yields diagnostically acceptable image quality in low-dose static computed tomography (CT). We aimed to evaluate the feasibility of IMR in dynamic myocardial computed tomography perfusion (CTP). Methods We enrolled 24 patients who underwent stress dynamic CTP using a 256-slice CT. Images were reconstructed using filtered back projection (FBP), hybrid IR, and IMR. Image quality
- Whole-Body Computed Tomography Using Low-Dose Biphasic Injection Protocol With Adaptive Statistical Iterative Reconstruction V: Assessment of Dose Reduction and Image Quality in Trauma PatientsAim This study aimed to evaluate potential dose savings on a revised protocol for whole-body computed tomography and image quality after implementing Adaptive Statistical Iterative Reconstruction V (ASiR-V) algorism for trauma patients and compare it with routine protocol. Materials and Methods One hundred trauma patients were classified into 2 groups using 2 different scanning protocols. Group A (n = 50; age, 32.48 ± 8.09 years) underwen
- YY1 cooperates with TFEB to regulate autophagy and lysosomal biogenesis in melanomaAbstract Autophagy is a self‐proteolytic process that degrades intracellular material to maintain cellular homeostasis. Transcription factor EB (TFEB) is the master activator that regulates the transcription of genes involved in autophagy and lysosomal biogenesis. However, the cotranscriptional factors of TFEB are rarely identified. Here, we found that Yin Yang 1 (YY1) regulated autophagy and lysosome biogenesis in melanoma cells. YY1 cooperates
- Prevalence of near-death experiences in people with and without REM sleep intrusionBackground The origin and prevalence of near-death experiences are unknown. A recent study suggested a link with REM sleep intrusion but was criticized for its selection of control participants. We therefore assessed the association of REM intrusion and near-death experiences with different methods. Methods Using a crowd-sourcing platform, we recruited 1,034 lay peo
- Spotlight on the Association of Radioactive Iodine Treatment With Cancer Mortality in Patients With Hyperthyroidism is Keeping the Highest Risk From Antithyroid Drugs in the Blind SpotJuly 1, 2019, JAMA Internal Medicine released online an article authored by Kitahara et al entitled “Association of radioactive iodine treatment with cancer mortality in patients with hyperthyroidism.” The Altmetric Attention Score, a global indicator of interest from lay public and colleagues, skyrocketed to 223 by July 7, placing the article in the top 5% of all scored reports. The overall perception of death from cancer risk associated with 13
- Noncoplanar VMAT for Brain Metastases: A Plan Quality and Delivery Efficiency Comparison With Coplanar VMAT, IMRT, and CyberKnifeTechnology in Cancer Research &Treatment, Volume 18, Issue , January 2019. Purpose:To compare plan quality and delivery efficiency of noncoplanar volumetric modulated arc therapy with coplanar volumetric modulated arc therapy, intensity-modulated radiation therapy, and CyberKnife for multiple brain metastases.Methods:For 15 patients with multiple brain metastases, noncoplanar volumetric modulated arc therapy, coplanar volumetric modulated arc
- The Prognostic Landscape of Tumor-Infiltrating Immune Cells and Immune Checkpoints in GlioblastomaTechnology in Cancer Research &Treatment, Volume 18, Issue , January 2019. Tumor-infiltrating immune cells are part of a complex microenvironment and associated with improved clinical outcomes in a broad range of tumor types. However, a detailed map for the prognostic landscape of tumor-infiltrating immune cells and immune checkpoint modulators in glioblastoma is still lacking. Here, with the web-accessible resource, The Cancer Immunome Archi
- Age Differences in the Effects of Speaking Rate on Auditory, Visual, and Auditory-Visual Speech PerceptionObjectives: This study was designed to examine how speaking rate affects auditory-only, visual-only, and auditory-visual speech perception across the adult lifespan. In addition, the study examined the extent to which unimodal (auditory-only and visual-only) performance predicts auditory-visual performance across a range of speaking rates. The authors hypothesized significant Age × Rate interactions in all three modalities and that unimodal pe
- Utilization pattern and service settings of palliative care for patients with metastatic non–small‐cell lung cancerBackground Although the benefits of palliative care for patients with cancer has been well established, the current utilization pattern remains largely unknown. The authors investigated the temporal trends and service settings of palliative care among Medicare beneficiaries with newly diagnosed, metastatic non–small‐cell lung cancer (NSCLC). Methods In total, 69,414 patients with NSCLC were identified between January 1, 2001 and December 3
- Standardized activities for lay patient navigators in breast cancer care: Recommendations from a citywide implementation studyBackground There is a need for guidelines on patient navigation activities to promote both the quality of patient navigation and the standards of reimbursement for these services because a lack of reimbursement is a major barrier to the implementation, maintenance, and sustainability of these programs. Methods A broad community‐based participatory research process was used to identify the needs of patients for navigation. A panel of stakeh
- Physicians' perspectives on medication adherence and health promotion among cancer survivorsBackground Cancer survivors face an increased risk of cardiovascular events compared with the general population. Adopting a healthy lifestyle may reduce these risks, and guidelines encourage health‐promotion counseling for cancer survivors, but the extent of physician adherence is unclear. Methods This mixed‐method study surveyed 91 physicians, including 30 primary care physicians (PCPs), 30 oncologists, and 31 specialists (urologists, de
- The lay health worker–patient relationship in promoting pulmonary rehabilitation (PR) in COPD: What makes it work?Chronic Respiratory Disease, Volume 16, Issue , January-December 2019. Lay health workers (LHWs) can improve access to services and adherence to treatment, as well as promoting self-care and prevention. Their effect in promoting uptake and adherence in pulmonary rehabilitation (PR) for chronic obstructive pulmonary disease (COPD) has not been tested. PR is the most effective treatment for the symptoms and disability of COPD, but this effectivenes
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- Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,Topical Ectoine: A Promising Molecule in the Upper Airways Inflammation—A Systematic Review To date,...Topical Ectoine: A Promising Molecule in the Upper Airways Inflammation—A Systematic ReviewTo date, topical therapies guarantee a better delivery of high concentrations of pharmacologic agents to the mucosa of the upper airways (UA). Recently, topical administration of ectoine has just been recognized as adjuvant treatment in the Al
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
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00302841026182,
00306932607174,
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Anapafseos 5 Agios Nikolaos 72100 Crete Greece,
Medicine by Alexandros G. Sfakianakis
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