P53-R273H mutation enhances colorectal cancer stemness through regulating specific lncRNAsTP53 is one of the most frequently mutated genes among all cancer types, and TP53 mutants occur more than 60% in colorectal cancer (CRC). Among all mutants, there are three hot spots, including p53-R175H, p53-...- Metformin targets a YAP1-TEAD4 complex via AMPKα to regulate CCNE1/2 in bladder cancer cellsMetformin has been reported to function as the anti-tumor inhibiting the growth of different types of cancers, including bladder cancer. But there are few reports on the roles of Yap1, the key molecule of Hipp...
- Cripto-1 expression in patients with clear cell renal cell carcinoma is associated with poor disease outcomeCripto-1 (CR-1) has been reported to be involved in the development of several human cancers. The potential role of CR-1 in clear cell renal cell carcinoma (ccRCC) is still not clear.
- Cardamonin inhibits breast cancer growth by repressing HIF-1α-dependent metabolic reprogrammingCardamonin, a chalcone isolated from Alpiniae katsumadai, has anti-inflammatory and anti-tumor activities. However, the molecular mechanism by which cardamonin inhibits breast cancer progression largely remains t...
- Cancers, Vol. 11, Pages 1258: Neurokinin-1 Receptor Antagonists against HepatoblastomaCancers, Vol. 11, Pages 1258: Neurokinin-1 Receptor Antagonists against Hepatoblastoma Cancers doi: 10.3390/cancers11091258 Authors: Miguel Muñoz Marisa Rosso Rafael Coveñas Hepatoblastoma (HB) is the most common malignant liver tumor that occurs during childhood. The prognosis of children with HB is favorable when a complete surgical resection of the tumor is possible, but for high-risk patients, the prognosis is much worse. N
- Cancers, Vol. 11, Pages 1259: Predictors of Outcomes in Patients with EGFR-Mutated Non-Small Cell Lung Cancer Receiving EGFR Tyrosine Kinase Inhibitors: A Systematic Review and Meta-AnalysisCancers, Vol. 11, Pages 1259: Predictors of Outcomes in Patients with EGFR-Mutated Non-Small Cell Lung Cancer Receiving EGFR Tyrosine Kinase Inhibitors: A Systematic Review and Meta-Analysis Cancers doi: 10.3390/cancers11091259 Authors: Carlo Buonerba Simona Iaccarino Pasquale Dolce Martina Pagliuca Michela Izzo Luca Scafuri Ferdinando Costabile Vittorio Riccio Dario Ribera Brigitta Mucci Simone Carrano Fer
- Macroevolutionary bursts and constraints generate a rainbow in a clade of tropical birds [NEW RESULTS]Background: Bird plumage exhibits a diversity of colors that serve functional roles ranging from signaling to camouflage and thermoregulation. However, birds must maintain a balance between evolving colorful signals to attract mates, minimizing conspicuousness to predators, and optimizing adaptation to climate conditions. Examining plumage color macroevolution provides a framework for understanding this dynamic interplay over phylogenetic scales.
- Artificial Intelligence Methods for Surgical Site Infection: Impacts on Detection, Monitoring, and Decision MakingSurgical Infections, Ahead of Print.
- Magnetic Resonance Imaging Pilot Study of Intravenous Glyburide in Traumatic Brain InjuryJournal of Neurotrauma, Ahead of Print.
- Endoscopic stenting of malignant, benign and iatrogenic colorectal disorders: a primer for radiologistsAbstract In recent years, endoscopic placement of intraluminal stents is increasingly used to manage a widening range of colorectal disorders. Self-expanding metal stents represent an established alternative to surgery for the palliation of unresectable carcinomas and currently allow a “bridge-to-surgery” strategy to relieve large bowel obstruction and optimise the patients’ clinical conditions before elective oncologic resec
- Trends in scientific research in Insights into Imaging : a bibliometric reviewAbstract Objectives To analyse the coverage and main bibliometric indicators of Insights into Imaging in Scopus and the Emerging Sources Citation Index (ESCI) from the Web of Science Core Collection database. Methods The evolution of journal production in the Scopus database was analysed acc
- Local translation of yeast ERG4 mRNA at the endoplasmic reticulum requires the brefeldin A resistance protein Bfr1 [Article]Brefeldin A resistance factor 1 (Bfr1p) is a non-essential RNA-binding protein and multi-copy suppressor of brefeldin A sensitivity in Saccharomyces cerevisiae. Deletion of BFR1 leads to multiple defects, including altered cell shape and size, change in ploidy, induction of P-bodies and chromosomal mis-segregation. Bfr1p has been shown to associate with polysomes, binds to several hundred mRNAs, and can target some of them to P-bodies. Although t
- Interplay between substrate recognition, 5 end tRNA processing and methylation activity of human mitochondrial RNase P [Article]Human mitochondrial ribonuclease P (mtRNase P) is an essential three protein complex that catalyzes the 5’ end maturation of mitochondrial precursor tRNAs (pre-tRNAs). MRPP3 (Mitochondrial RNase P Protein 3), a protein-only RNase P (PRORP), is the nuclease component of the mtRNase P complex and requires a two-protein S-adenosyl methionine (SAM)-dependent methyltransferase MRPP1/2 sub-complex to function. Dysfunction of mtRNase P is linked to seve
- A Deep Learning Approach for Detecting Copy Number Variation in Next-Generation Sequencing DataCopy number variants (CNV) are associated with phenotypic variation in several species. However, properly detecting changes in copy numbers of sequences remains a difficult problem, especially in lower quality or lower coverage next-generation sequencing data. Here, inspired by recent applications of machine learning in genomics, we describe a method to detect duplications and deletions in short-read sequencing data. In low coverage data, machine
- Treehouse: a user-friendly application to obtain subtrees from large phylogeniesPhylogenetic trees that contain hundreds to thousands of taxa are now routinely generated. Retrieving the relationships among a subset of taxa in these large phylogenies can be a challenging or time-consuming ...
- Acceptability of mandatory tuberculosis notification among private practitioners in Yogyakarta, IndonesiaIndonesia ranks second globally in the number of cases not reported to the National Tuberculosis Control Program, accounting for 11% of the total cases lost worldwide. In 2016, the Ministry of Health has issue...
- Exploration of shared genetic susceptibility loci between type 1 diabetes and rheumatoid arthritis in the Pakistani populationType 1 diabetes (T1D) and rheumatoid arthritis (RA) are autoimmune diseases. It is known that certain genetic loci and factors that increase the overall autoimmunity risk can be shared among different autoimmu...
- Proportion of neonatal sepsis and determinant factors among neonates admitted in University of Gondar comprehensive specialized hospital neonatal Intensive care unit Northwest Ethiopia 2017Neonatal sepsis is one of the most common causes of neonatal hospitalization in developing countries. It is also a major cause of mortality in the world affecting both developed and developing countries. Diagn...
- Interleukin-15 Enhances Anti-GD2 Antibody-Mediated Cytotoxicity in an Orthotopic PDX Model of NeuroblastomaPurpose: Immunotherapy with interleukin (IL)-2, granulocyte-macrophage colony-stimulating factor (GM-CSF), and an anti-disialoganglioside (GD2) antibody significantly increases event-free survival in children with high-risk neuroblastoma. However, therapy failure in one-third of these patients and IL-2-related toxicities pose a major challenge. We compared the immunoadjuvant effects of IL-15 with those of IL-2 for enhancing antibody-dependent cel
- Analysis of Tumor Genomic Pathway Alterations Using Broad-Panel Next Generation Sequencing in Surgically Resected Lung AdenocarcinomaPurpose: The majority of broad-panel tumor genomic profiling has used a gene-centric approach, although much of that data is unused in clinical decision-making. We hypothesized that a pathway-centric approach using next-generation sequencing, combined with conventional clinicopathologic features, may better predict disease-free survival (DFS) in early-stage lung adenocarcinoma. Experimental Design: Utilizing our prospectively maintained database
- A phase 1 study of the anti-CC chemokine receptor 4 antibody, mogamulizumab, in combination with nivolumab in patients with advanced or metastatic solid tumorsPurpose: Regulatory T-cells (Tregs) expressing CC chemokine receptor 4 (CCR4) can suppress antitumor immune responses and are associated with poor prognoses in several cancers. We assessed the safety and efficacy of combined mogamulizumab (anti-CCR4 antibody) and nivolumab (anti-programmed death-1 [PD-1] antibody) in immunotherapy-naive patients with advanced/metastatic solid tumors. Experimental Design: This study (NCT02476123) comprised dose-e
- Sorafenib population pharmacokinetics and skin toxicities in children and adolescents with refractory/relapsed leukemia or solid tumor malignanciesPurpose: To determine the pharmacokinetics and skin toxicity profile of sorafenib in children with refractory/relapsed malignancies. Experimental Design: Sorafenib was administered concurrently or sequentially with clofarabine and cytarabine (Clo/AraC) to leukemia patients or with bevacizumab and cyclophosphamide (Bev/Cyclo) to patients with solid tumor malignancies. The population pharmacokinetics (PPK) of sorafenib and its metabolites and skin
- Localized Treatment with Oncolytic Adenovirus Delta-24-RGDOX Induces Systemic Immunity against Disseminated Subcutaneous and Intracranial MelanomasPurpose: Intratumoral injection of oncolytic adenovirus Delta-24-RGDOX induces efficacious anti-glioma immunity in syngeneic glioma mouse models. We hypothesized that localized treatment with the virus is effective against disseminated melanomas. Experimental Design: We tested the therapeutic effect of injecting Delta-24-RGDOX into primary subcutaneous (s.c.) B16-Red-FLuc tumors in s.c./s.c. and s.c./intracranial (i.c.) melanoma models in C57BL/6
- An Interesting Unknown Combined Pathology in a Patient with Acute Balance ProblemA 54-year-old woman with acute-onset nausea and vomiting presented to outpatient clinic. She had headache for 3 weeks. She had difficulty during tandem gait and was falling to the right. Otherwise, her neurological examination was normal. She had normal hearing. VNG analysis revealed spontaneous nystagmus beating to the left with optical fixation. However, she had horizontal and slightly down-beating gaze-evoked nystagmus at primary gaze position
- "Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"[jour]; +54 new citations54 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"[jour] These pubmed results were generated on 2019/08/27PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publ
- Statins as Potential Therapeutics for Lung Cancer: Molecular Mechanisms and Clinical OutcomesLung cancer is the most common cancer worldwide. It also has the highest malignancy-associated mortality rate. Treatment options are limited by cancer and tumor heterogeneity, resistance to treatment options, and an advanced stage at time of diagnosis, all of which are common. Statins are a class of lipid-lowering medications that have been studied for their antitumor effects in various types of cancers. Multiple mechanisms have been proposed to
- The Impact of Serum Glucose in the Treatment of Locoregionally Advanced Pancreatic CancerIntroduction: Studies have consistently identified an increased risk of pancreatic cancer in diabetics, yet the role hyperglycemia may play in predicting prognosis is less clear. This work aims to evaluate the impact of glycemic state and antidiabetics on outcomes after systemic and local treatment for locoregionally advanced pancreatic cancer. Materials and Methods: This retrospective study consisted of 303 patients with newly diagnosed
- Long-Term Vitamin K Antagonists and Cancer Risk: A Systematic Review and Meta-AnalysisObjectives: Vitamin K antagonists (VKAs) remain one of the most commonly used anticoagulation therapies. The potential anticancer effect of long-term use of VKAs has been a matter of debate with conflicting results. Our goal was to perform a systematic review and meta-analysis examining the association between long-term VKAs use and cancer risk. Methods: Systematic searches of multiple major databases were performed from inception until
- An Albumin-Bilirubin (ALBI) Grade–based Prognostic Model For Patients With Hepatocellular Carcinoma Within Milan CriteriaObjective: The Milan criteria are recommended as the major reference for liver transplantation in patients with small hepatocellular carcinoma (HCC). However, alternative anticancer treatments are often utilized due to severe donor organ shortage. This study aimed to develop and validate an albumin-bilirubin (ALBI) grade–based prognostic model to stratify survival in patients within Milan criteria undergoing nontransplant therapy. Pat
- Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,Atmosphere, Vol. 10, Pages 502: Tropical Atlantic Variability: Observations and Modeling Atmosphere,...Atmosphere, Vol. 10, Pages 502: Tropical Atlantic Variability: Observations and ModelingAtmosphere, Vol. 10, Pages 502: Tropical Atlantic Variability: Observations and Modeling Atmosphere doi: 10.3390/atmos10090502 Authors: William Cabos Alba de la Vara Shunya Koseki We review the state-of-the-art knowledge of Tropical Atlantic Variability (TAV
- Clinical Utility of a Blood-based Protein Assay on Diagnostic Colonoscopy Referrals for Elevated-risk Colorectal Cancer Patients in Primary CareBackground: Colonoscopies are effective in finding early stage colorectal cancer (CRC), which when found in a timely manner, dramatically improve survival rates. A significant number of at-risk patients are still not screened. We investigated the utility of a blood-based protein assay to assess for CRC in patients with elevated risk on the quality of preventive care delivered by board-certified primary care physicians (PCPs) in the United Sta
- The Impact of Radiotherapy Facility Volume on the Survival and Guideline Concordance of Patients With Muscle-invasive Bladder Cancer Receiving Bladder-preservation TherapyObjectives: Higher facility surgical volume predicts for improved outcomes in patients with muscle-invasive bladder cancer (MIBC) who undergo radical cystectomy. We investigated the association between facility radiotherapy (RT) case volume and overall survival (OS) for patients with MIBC who received bladder-preserving RT, and the relationship with adherence to National Comprehensive Cancer Network (NCCN) guidelines for bladder preservation.
- Prechemotherapy Hemoglobin Levels as a Predictive Factor of Ovarian Cancer Survival: A Systematic Review and Meta-AnalysisObjectives: The impact of anemia on cancer survival has been previously mentioned in various oncological fields. To date, however, it remains unknown whether prechemotherapy hemoglobin (Hgb) levels are predictive of ovarian cancer survival (OC). The purpose of the present systematic review is to accumulate evidence in this field. Materials and Methods: We used the Medline, Scopus, Clinicaltrials.gov, EMBASE, Cochrane Central Register of
- Association Between Smoking and Survival Benefit of Immunotherapy in Advanced Malignancies: A Systematic Review and Meta-AnalysisObjectives: Smoking is associated with an increased tumor mutational burden. As tumor mutational burden has been shown to correlate with response to immunotherapy (IO), we hypothesized that a history of smoking may be associated with better response to IO. Methods: We utilized a systematic review with stratified meta-analysis of randomized clinical trials of IO versus standard of care in patients with advanced solid organ malignancies.
- e3 Diagnostics-Bertec Parnership to Provide Improved Solutions for Balance Disorderse3 Diagnostics has partnered with Bertec, which designs and manufactures clinical balance assessment and rehabilitation solutions, including balance plates, computerized dynamic posturography equipment, and vestibular ocular reflex assessment devices. Bertec's Balance Advantage systems features a full line of clinical systems for both assessment and treatment of balance problems. In addition to helping clinical teams serve the needs of patients w
- [ASAP] A Single Fluorescent Chemosensor for Simultaneous Discriminative Detection of Gaseous Phosgene and a Nerve Agent MimicAnalytical ChemistryDOI: 10.1021/acs.analchem.9b03230
- The Relation of Readiness for Return to Work and Return to Work Among Iranian Cancer SurvivorsAbstract Return to work after completion of cancer treatments has many benefits for patients, families, and society. Readiness for return to work (RRTW) seems to be an effective factor for return to work in cancer survivors. Therefore, the present study was to investigate return to work and its relation to RRTW among Iranian survivors of cancer. This descriptive-correlational study examined a total of 227 survived cancer patien
- e3 Diagnostics-Bertec Parnership to Provide Improved Solutions for Balance Disorderse3 Diagnostics has partnered with Bertec, which designs and manufactures clinical balance assessment and rehabilitation solutions, including balance plates, computerized dynamic posturography equipment, and vestibular ocular reflex assessment devices. Bertec's Balance Advantage systems features a full line of clinical systems for both assessment and treatment of balance problems. In addition to helping clinical teams serve the needs of patients w
- Seizure Risk following Open and Expanded Endoscopic Endonasal Approaches for Intradural Skull Base TumorsJ Neurol Surg BDOI: 10.1055/s-0039-1694968 Objectives The incidence of seizures following a craniotomy for tumor removal varies between 15 and 20%. There has been increased use of endoscopic endonasal approaches (EEAs) for a variety of intracranial lesions due to its more direct approach to these pathologies. However, the incidence of postoperative seizures in this population is not well described. Methods T
- Dynamic turnover of centromeres drives karyotype evolution in Drosophila [NEW RESULTS]Centromeres are the basic unit for chromosome inheritance, but their evolutionary dynamics is poorly understood. We generate high-quality reference genomes for multiple Drosophila obscura group species to reconstruct karyotype evolution. All chromosomes in this lineage were ancestrally telocentric and the creation of metacentric chromosomes in some species was driven by de novo seeding of new centromeres at ancestrally gene-rich regions, independ
- Osteonecrosis of the jaw in patients with inflammatory bowel disease treated with tumour necrosis factor alpha inhibitorsPrevious reports have suggested a possible association between tumour necrosis factor alpha (TNF-α) inhibitors, used in the treatment of immune-mediated inflammatory diseases, and medication-related osteonecrosis of the jaw (MRONJ). However, a comprehensive assessment of the frequency and severity of MRONJ caused by these agents is lacking. The aim of this cohort study was to investigate the occurrence of MRONJ in a population of patients with in
- Healthy habits ward off dementia — for select seniorsNature, Published online: 27 August 2019; doi:10.1038/d41586-019-02555-yFor a fortunate group, exercise and the right diet could protect against cognitive symptoms that develop with age.
- Surgical-orthodontic approach for facial rejuvenation based on a reverse faceliftOrthodontic treatment combined with a maxillomandibular advancement (MMA) can be an effective option for patients who need not only corrected occlusion but also facial rejuvenation. In this case series, two pa...
- [ASAP] Generation of a Molecular Network from Electron Ionization Mass Spectrometry Data by Combining MZmine2 and MetGem SoftwareAnalytical ChemistryDOI: 10.1021/acs.analchem.9b02802
- [ASAP] Lipid Coverage in Nanospray Desorption Electrospray Ionization Mass Spectrometry Imaging of Mouse Lung TissuesAnalytical ChemistryDOI: 10.1021/acs.analchem.9b02045
- Tension pneumoperitoneum caused by rupture of intraabdominal soft tissue emphysema in a child supported with high-frequency oscillatory ventilation: a case reportWe reported a case with tension pneumoperitoneum while being on high-frequency oscillatory ventilation.
- A Direct and Simple Method to Assess Drosophila melanogaster's Viability from Embryo to AdultThis protocol is designed to assess the viability of Drosophila at every developmental stage, from embryo to adult. The method can be used to determine and compare the viability of different genotypes or growth conditions.
- Single Cell Durotaxis Assay for Assessing Mechanical Control of Cellular Movement and Related Signaling EventsMechanical forces are important for controlling cell migration. This protocol demonstrates the use of elastic hydrogels that can be deformed using a glass micropipette and a micromanipulator to stimulate cells with a local stiffness gradient to elicit changes in cell structure and migration.
- A short comment on statistical versus mathematical modellingNature Communications, Published online: 27 August 2019; doi:10.1038/s41467-019-11865-8While the crisis of statistics has made it to the headlines, that of mathematical modelling hasn’t. Something can be learned comparing the two, and looking at other instances of production of numbers.Sociology of quantification and post-normal science can help.
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
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00302841026182,
00306932607174,
alsfakia@gmail.com,
Anapafseos 5 Agios Nikolaos 72100 Crete Greece,
Medicine by Alexandros G. Sfakianakis
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