Τρίτη 27 Αυγούστου 2019

Rituximab-associated Hypogammaglobulinemia in pediatric patients with autoimmune diseases
Abstract Background Despite the increased use of rituximab in treating pediatric patients with autoimmune diseases in the last decade, there are limited data on rituximab safety in those subjects who have a developing immune system. The objective of this study is to determine the prevalence of hypogammaglobulinemia in children with autoimmune disease receiving rituximab within the first three years of treatment in the pediatric rheumatology...
Latest Results for Pediatric Rheumatology
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How Oracle Is Using Cloud Tech To Find Cancer Cures
American computing giant Oracle is working with a Egyptian non-profit organization to accelerate research efforts into cancer cures. (Source: Forbes.com Healthcare News)
MedWorm: Cancer & Oncology
9h
China Eases Rules on Cheap Drug Imports to Fight Chronic Diseases
The revised law would reduce penalties for buying generic pharmaceuticals from other countries without waiting for approval, though details are scant. (Source: NYT Health)
MedWorm: Cancer & Oncology
9h
Researchers to study media coverage of 'overdiagnosis' tests
Researchers from Australia plan to explore media coverage of the benefits and...Read more on AuntMinnie.comRelated Reading: AI may help reduce overdiagnosis of breast cancer Lung cancer overdiagnosis varies widely on CT screening Annals: Overdiagnosis must be better defined How serious is the risk of breast cancer overdiagnosis? ACR disputes NEJM paper on overdiagnosis (Source: AuntMinnie.com Headlines)MedWorm Message: Have you tried our new medical search engine? More powerful than before....
MedWorm: Cancer & Oncology
9h
Can Minimum Volume Thresholds Assure Complex Cancer Surgery Quality? Can Minimum Volume Thresholds Assure Complex Cancer Surgery Quality?
Setting volume thresholds does not guarantee that hospitals will adhere to those standards or that patients will have access to hospitals that do, a study of high-risk cancer surgery patients reveals.Reuters Health Information (Source: Medscape Medical News Headlines)
MedWorm: Cancer & Oncology
9h
Sniffing out cancer: Researchers say canine scent detection can be used as an effective cancer screening method
(Natural News) We’ve all heard stories of heroic dogs saving people’s lives, whether they alerted their sleeping owners to a fire in time for them to escape or they found people who were trapped in disaster areas. However, there’s a growing body of evidence that their life-saving abilities go a lot further than that: They... (Source: NaturalNews.com)
MedWorm: Cancer & Oncology
9h
Ambry Genetics ’ Data Reveal that Expanding Genetic Testing Guidelines...
Study finds that current guidelines exclude too many and test too narrowly, and reveals several new gene-cancer associations with potential to impact patient care.(PRWeb August 27, 2019)Read the full story at https://www.prweb.com/releases/ambry_genetics_data_reveal_that_expanding_genetic_testing_guidelines_could_identify_more_patients_with_increased_risks_of_cancer/prweb16517290.htm (Source: PRWeb: Medical Pharmaceuticals)MedWorm Message: Have you tried our new medical search engine? More powerful...
MedWorm: Cancer & Oncology
9h
After a'Living Memorial,' an Oncologist Spreads the Word After a'Living Memorial,' an Oncologist Spreads the Word
Tatiana Prowell, MD, has attended many memorial services. But none before the death of the patient — until this summer. Now, she asks: Why wait until a loved one dies to celebrate them?Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
MedWorm: Cancer & Oncology
12h
Finally, Cancer Patients Can Now Defer Payback on Student Loans Finally, Cancer Patients Can Now Defer Payback on Student Loans
After a long delay in implementing a bill, cancer patients can now defer payment on their student loans without interest accrual.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
MedWorm: Cancer & Oncology
12h
GSK Builds Oncology Pipeline as Drug Shown to Help Myeloma Patients GSK Builds Oncology Pipeline as Drug Shown to Help Myeloma Patients
GlaxoSmithKline said an experimental multiple myeloma treatment has shown a meaningful response in patients that have run out of three previous treatment options, in a boost for the British drugmaker's cancer drug business.Reuters Health Information (Source: Medscape Allergy Headlines)
MedWorm: Cancer & Oncology
12h
Justice Ruth Bader Ginsburg Treated for Pancreatic Cancer
Title: Justice Ruth Bader Ginsburg Treated for Pancreatic CancerCategory: Health NewsCreated: 8/23/2019 12:00:00 AMLast Editorial Review: 8/26/2019 12:00:00 AM (Source: MedicineNet Cancer General)
MedWorm: Cancer & Oncology
12h
Full Chemo Doses Early On for Breast Cancer
Full Chemo Doses Early On Maximize Breast Cancer Survival (Source: eMedicineHealth.com)
MedWorm: Cancer & Oncology
12h
aldesleukin (Proleukin)
Title: aldesleukin (Proleukin)Category: MedicationsCreated: 6/8/1999 12:00:00 AMLast Editorial Review: 8/23/2019 12:00:00 AM (Source: MedicineNet Cancer General)
MedWorm: Cancer & Oncology
12h
Management of Steroid-Refractory Immune-Related Adverse Events
 The increasing utilization of these immune checkpoint inhibitors has presented new of immune-related adverse events  that have proven to be extremely challenging to manage. (Source: CancerNetwork)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
MedWorm: Cancer & Oncology
12h
Gilteritinib Changes AML Landscape
The US Food and Drug Administration recently approved gilteritinib (Xospata), in addition to final trial data from the phase 3 ADMIRAL trial, making it the new standard of care for acute myeloid leukemia. (Source: CancerNetwork)
MedWorm: Cancer & Oncology
12h
Targeting the Sanctuary Site: Options when Breast Cancer Metastasizes to the Brain
Brain metatstasis is common in breast cancer and often has a poor prognosis, but there are several ways to manage brain metastasis in breast cancer including focal therapies as well as systemic options for specific populations, including emerging and novel therapies. (Source: CancerNetwork)
MedWorm: Cancer & Oncology
12h
There's a Troubling Rise in Colorectal Cancer Among Young Adults
Some experts blame our modern, sugary diet, while others think that gut microbiome changes and sedentary lifestyles may play a role. Altogether, the causes are far from clear. (Source: The Scientist)
MedWorm: Cancer & Oncology
15h
Mesothelioma Study Explores New Treatment When Chemotherapy Fails
A clinical trial is exploring whether a novel immunotherapy/antiangiogenic combination can serve as an effective second-line treatment for pleural mesothelioma. Early indications of the four-center, phase II clinical trial are positive. The combination involves nivolumab (Opdivo) , a well-known immunotherapy drug, and ramucirumab (Cyramza), a therapy drug that blocks the formation of blood vessels needed for new tumor growth. The Food and Drug Administration approved both drugs for the treatment...
MedWorm: Cancer & Oncology
22h
Upstate shines light on bladder cancer
Blue Light Cystoscopy helps doctors better detect and diagnose cancerous tumors in the bladder. (Source: SUNY Upstate Medical)
MedWorm: Cancer & Oncology
22h
My Special AFLAC Duck: A Gold Standard For CSR Programs
The " My Special Aflac Duck " in which the company provides pediatric cancer patients with a robotic " smart " duck to help them through painful treatments is reviewed. The initiative is a feel-good success story that follows principles of effective CSR initiatives. (Source: Forbes.com Healthcare News)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
MedWorm: Cancer & Oncology
23h
Cancer doctors don't focus on lifestyle risks
(Reuters Health) - Cancer specialists only rarely advise patients on lifestyle changes that could improve overall health and possibly also reduce the risk of recurrence, a new survey suggests. (Source: Reuters: Health)
MedWorm: Cancer & Oncology
23h
Screen At-risk Women for BRCA-related Cancer
The U.S. Preventive Services Task Force recently posted a final recommendation statement on risk assessment, genetic counseling and genetic testing for BRCA-related cancer in women. (Source: AAFP News)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
MedWorm: Cancer & Oncology
23h
FDA: Men Should Be Included in Breast Cancer Clinical Trials
MONDAY, Aug. 26, 2019 -- Men should be included in clinical trials of new breast cancer treatments, the U.S. Food and Drug Administration says. " Less than 1 percent of all breast cancer cases occur in men, but men are more likely to be diagnosed at... (Source: Drugs.com - Pharma News)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
MedWorm: Cancer & Oncology
23h
Stomach cancer: Eight risk factors to watch out for
STOMACH cancer symptoms can be vague and easy to mistake for other less serious conditions. Unfortunately, it tends to get diagnosed once it has advanced. Understanding the risk factors is essential to improving outcomes. (Source: Daily Express - Health)
MedWorm: Cancer & Oncology
23h
FDA urges that men be included in breast cancer trials
The U.S. Food and Drug Administration (FDA) on August 26 released a draft guidance...Read more on AuntMinnie.comRelated Reading: Men need breast cancer screening too SBI: Don't overlook men when it comes to breast cancer FDG-PET/CT helps stage men with breast cancer, too Male breast masses require careful investigation Mammography, US help diagnose male breast cancer (Source: AuntMinnie.com Headlines)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log...
MedWorm: Cancer & Oncology
23h
Childhood cancer survivors 10 times more likely to develop heart failure
Childhood cancer survivors have 10 times the risk of developing heart failure compared to children without cancer, a new study says. (Source: Health News - UPI.com)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
MedWorm: Cancer & Oncology
23h
Risk for Cardiovascular Disease Greater for Childhood Cancer Survivors
MONDAY, Aug. 26, 2019 -- Survivors of childhood cancer have an increased risk for all subtypes of cardiovascular disease (CVD), according to a research letter published online Aug. 26 in Circulation. Ashna Khanna, from the University of Toronto, and... (Source: Drugs.com - Pharma News)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
MedWorm: Cancer & Oncology
23h
A call to Technical Support
Relax, by Terry Freedman. I’m trying to, I’m trying! Hello. I’m calling because my printer has stopped working.Well, it doesn’t work any more.What I mean to say is, when I click on Print, my computer thinks it’s printed, but the printer just sits there.Yes, of course it’s plugged in.Yes, it’s switched on.I haven’t done anything. My computer and printer were moved from the second floor to the first floor, and now it doesn’t work.Yes,...
ICT in Education
17m
Protocol for a case-control diagnostic accuracy study to develop diagnostic criteria for psoriasis in children (DIPSOC study): a multicentre study recruiting in UK paediatric dermatology clinics
IntroductionDiagnosing psoriasis in children can be challenging. Early and accurate diagnosis is important to ensure patients receive psoriasis specific treatment and monitoring. It is recognised that the physical, psychological, quality of life, financial and comorbid burden of psoriasis are significant. The aim of this study is to develop clinical examination and history-based diagnostic criteria for psoriasis in children to help differentiate psoriasis from other scaly inflammatory rashes. The...
BMJ Open recent issues
18m
Multicentre prospective cohort study of nonoperative versus operative treatment for flail chest and multiple rib fractures after blunt thoracic trauma: study protocol
IntroductionA trend has evolved towards rib fixation for flail chest although evidence is limited. Little is known about rib fixation for multiple rib fractures without flail chest. The aim of this study is to compare rib fixation with nonoperative treatment for both patients with flail chest and patients with multiple rib fractures. Methods and analysisIn this study protocol for a multicentre prospective cohort study, all patients with three or more rib fractures admitted to one of the five participating...
BMJ Open recent issues
18m
Beyond exploratory: a tailored framework for designing and assessing qualitative health research
The objective of this commentary is to develop a framework for assessing the rigour of qualitative approaches that identifies and distinguishes between the diverse objectives of qualitative health research, guided by a narrative review of the published literature on qualitative guidelines and standards from peer-reviewed journals and national funding organisations that support health services research, patient-centered outcomes research and other applied health research fields. In this framework,...
BMJ Open recent issues
18m
Evaluation of reliability of self-collected vaginal swabs over physician-collected samples for diagnosis of bacterial vaginosis, candidiasis and trichomoniasis, in a resource-limited setting: a cross-sectional study in India
ObjectivesSelf-collected vaginal swabs can facilitate diagnosis of vaginal discharge (VD) in resource-limited settings, provided reliability of the method is established. The aim of this study was to evaluate the concordance between self-collected and physician-collected vaginal swabs for aetiological diagnosis of VD and to determine the prevalence of bacterial vaginosis (BV), vulvovaginal candidiasis (VVC) and trichomonas vaginitis (TV). MethodsA total of 550 females (median age: 32 years; range:...
BMJ Open recent issues
18m
Multicentre, randomised waitlist control trial investigating a parent-assisted social skills group programme for adolescents with brain injuries: protocol for the friends project
IntroductionAdolescents with brain injury frequently have difficulties with social competence, which persist into adulthood affecting their participation in daily life. To date, there has been limited research into the efficacy of social competence interventions in this population. Research from the Program for the Education and Enrichment of Relational Skills (PEERS) has demonstrated significant improvements in social competence skills, maintained at 1-year to 5-year follow-up, for adolescents with...
BMJ Open recent issues
18m
Patients with heart failure with and without a history of stroke in the Netherlands: a secondary analysis of psychosocial, behavioural and clinical outcomes up to three years from the COACH trial
ObjectiveTo identify differences in psychosocial, behavioural and clinical outcomes between patients with heart failure (HF) with and without stroke. Design and participantsA secondary analysis of 1023 patients with heart failure enrolled in the Coordinating study evaluating Outcomes of Advising and Counselling in Heart failure. SettingSeventeen hospitals located across the Netherlands. Outcomes measuresDepressive symptoms (Centre for Epidemiological Studies Depression Scale), quality of life...
BMJ Open recent issues
18m
The factors influencing the effective early career and rapid transition to a nursing specialty in differing contexts of practice: a modified Delphi consensus study
ObjectivesThis study aimed to test and further develop the ‘Early Career and Rapid Transition to a Nursing Specialty’ (TRANSPEC) model to a nursing specialty developed from a systematic review. Semi-structured interviews of specialist clinically based nurses and a consensus Delphi study with an expert panel were used to expand and achieve consensus, agreement, reliability and stability of the model. DesignA modified Delphi, two rounds (64 and 52 Likert items) of reiterative online questionnaires...
BMJ Open recent issues
18m
Clinical characteristics of patients under 40 years old with early-onset hyperuricaemia: a retrospective monocentric study in China
ObjectiveTo investigate the clinical characteristics of patients with early-onset hyperuricaemia (HUC). MethodsA retrospective study using data from the Second Affiliated Hospital of Soochow University was conducted. 623 patients with HUC were divided into early-onset group and late-onset group. Another 201 healthy subjects ≤40 years old were regarded as control group. The data of physical measurements and biochemistry test were collected. Clinical data of early-onset group were compared with late-onset...
BMJ Open recent issues
18m
Relative influence of intellectual disabilities and autism on mental and general health in Scotland: a cross-sectional study of a whole country of 5.3 million children and adults
ObjectivesTo determine the relative extent that autism and intellectual disabilities are independently associated with poor mental and general health, in children and adults. DesignCross-sectional study. For Scotland’s population, logistic regressions investigated odds of intellectual disabilities and autism predicting mental health conditions, and poor general health, adjusted for age and gender. Participants1 548 819 children/youth aged 0-24 years, and 3 746 584 adults aged more than 25 years,...
BMJ Open recent issues
18m
Receiving the home care service offered by certified care workers prior to a patients death and the probability of a home death: observational research using an instrumental variable method from Japan
ObjectivesTo assess the association between receiving the certified care workers’ home care service, which is provided by non-medical professionals prior to a patients’ death and the probability of a home death. DesignObservational research using the full-time translated number of certified care workers providing home care service per member of the population aged 65 or above, during the year prior to patient’s death per municipality as an instrumental variable. SettingThe certified care workers’...
BMJ Open recent issues
18m
Influence of obesity on in-hospital and postoperative outcomes of hepatic resection for malignancy: a 10-year retrospective analysis from the US National Inpatient Sample
ObjectivesThe influence of obesity on the outcomes of curative liver resection for malignancies remains controversial. We aimed to compare the in-hospital outcomes of liver resection for malignancy between obese and non-obese patients. DesignThis was a population-based, retrospective, observational study using data from the Nationwide Inpatient Sample (NIS), the largest all-payer US inpatient care database. SettingHospitalisations of adults ≥18 years old with diagnoses of primary hepatobiliary...
BMJ Open recent issues
18m

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