Cells, Vol. 8, Pages 990: Intraarticular Ligament Degeneration Is Interrelated with Cartilage and Bone Destruction in Osteoarthritis Cells doi: 10.3390/cells8090990 Authors: Gundula Schulze-Tanzil Osteoarthritis (OA) induces inflammation and degeneration of all joint components including cartilage, joint capsule, bone and bone marrow, and ligaments. Particularly intraarticular ligaments, which connect the articulating bones such as the anterior cruciate ligament (ACL) and meniscotibial...
14h
Cells, Vol. 8, Pages 988: Non-Coding RNA Regulates the Myogenesis of Skeletal Muscle Satellite Cells, Injury Repair and Diseases Cells doi: 10.3390/cells8090988 Authors: Zhao Chen Lian Li Li Wang Deng Yu Lian : Skeletal muscle myogenesis and injury-induced muscle regeneration contribute to muscle formation and maintenance. As myogenic stem cells, skeletal muscle satellite cells have the ability to proliferate, differentiate and self-renew, and are involved...
15h
Cells, Vol. 8, Pages 989: CTCs 2020: Great Expectations or Unreasonable Dreams Cells doi: 10.3390/cells8090989 Authors: Elisabetta Rossi Francesco Fabbri Circulating tumor cells (CTCs) are cellular elements that can be scattered into the bloodstream from primary cancer, metastasis, and even from a disseminated tumor cell (DTC) reservoir. CTCs are “seeds”, able to give rise to new metastatic lesions. Since metastases are the cause of about 90% of cancer-related...
15h
Cells, Vol. 8, Pages 980: Osteopontin-Enhanced Autophagy Attenuates Early Brain Injury via FAK–ERK Pathway and Improves Long-Term Outcome after Subarachnoid Hemorrhage in Rats Cells doi: 10.3390/cells8090980 Authors: Chengmei Sun Budbazar Enkhjargal Cesar Reis Tongyu Zhang Qiquan Zhu Keren Zhou Zhiyi Xie Lingyun Wu Jiping Tang Xiaodan Jiang John H. Zhang Osteopontin (OPN) enhances autophagy, reduces apoptosis, and attenuates early brain injury (EBI) after...
17h
Cells, Vol. 8, Pages 987: Neuroinflammatory Reactions in the Brain of 1,2-DCE-Intoxicated Mice during Brain Edema Cells doi: 10.3390/cells8090987 Authors: Xiaoxia Jin Tong Wang Yingjun Liao Jingjing Guo Gaoyang Wang Fenghong Zhao Yaping Jin We previously reported that expression of matrix metalloproteinase-9 (MMP-9) mRNA and protein was upregulated during 1,2-dichloroethane (1,2-DCE) induced brain edema in mice. We also found that the p38 mitogen-activated protein kinase...
17h
Cells, Vol. 8, Pages 986: RNA Sequencing of H3N2 Influenza Virus-Infected Human Nasal Epithelial Cells from Multiple Subjects Reveals Molecular Pathways Associated with Tissue Injury and Complications Cells doi: 10.3390/cells8090986 Authors: Kai Sen Tan Anand Kumar Andiappan Bernett Lee Yan Yan Jing Liu See Aik Tang Josephine Lum Ting Ting He Yew Kwang Ong Mark Thong Hui Fang Lim Hyung Won Choi Olaf Rotzschke Vincent T Chow De Yun Wang The human...
17h
Cells, Vol. 8, Pages 985: Osteopontin is An Important Regulative Component of the Fetal Bone Marrow Hematopoietic Stem Cell Niche Cells doi: 10.3390/cells8090985 Authors: Huimin Cao Benjamin Cao Chad K. Heazlewood Melanie Domingues Xuan Sun Emmanuel Debele Narelle E. McGregor Natalie A. Sims Shen Y. Heazlewood Susan K. Nilsson Osteopontin (OPN) is an important component in both bone and blood regulation, functioning as a bridge between the two. Previously,...
19h
Cells, Vol. 8, Pages 983: Pravastatin and Gemfibrozil Modulate Differently Hepatic and Colonic Mitochondrial Respiration in Tissue Homogenates from Healthy Rats Cells doi: 10.3390/cells8090983 Authors: Anna Herminghaus Eric Laser Jan Schulz Richard Truse Christian Vollmer Inge Bauer Olaf Picker Statins and fibrates are widely used for the management of hypertriglyceridemia but they also have limitations, mostly due to pharmacokinetic interactions or side effects. It...
21h
Cells, Vol. 8, Pages 984: The Rebirth of Matrix Metalloproteinase Inhibitors: Moving Beyond the Dogma Cells doi: 10.3390/cells8090984 Authors: Gregg B. Fields The pursuit of matrix metalloproteinase (MMP) inhibitors began in earnest over three decades ago. Initial clinical trials were disappointing, resulting in a negative view of MMPs as therapeutic targets. As a better understanding of MMP biology and inhibitor pharmacokinetic properties emerged, it became clear that initial MMP inhibitor...
21h
Cells, Vol. 8, Pages 981: Regulation of IKs Potassium Current by Isoproterenol in Adult Cardiomyocytes Requires Type 9 Adenylyl Cyclase Cells doi: 10.3390/cells8090981 Authors: Yong Li Thomas Hof Tanya A. Baldwin Lei Chen Robert S. Kass Carmen W. Dessauer The subunits KCNQ1 and KCNE1 generate the slowly activating, delayed rectifier potassium current, IKs, that responds to sympathetic stimulation and is critical for human cardiac repolarization. The A-kinase anchoring...
23h
Cells, Vol. 8, Pages 982: E. coli Enterotoxin LtB Enhances Vaccine-Induced Anti-H. pylori Protection by Promoting Leukocyte Migration into Gastric Mucus via Inflammatory Lesions Cells doi: 10.3390/cells8090982 Authors: Xiaoyan Peng Rongguang Zhang Chen Wang Feiyan Yu Mingyang Yu Shuaiyin Chen Qingtang Fan Yuanlin Xi Guangcai Duan Current studies indicate that the anti-H. pylori protective efficacy of oral vaccines to a large extent depends on using mucosal adjuvants...
23h
Abstract Calcium contents of demineralised human cortical bone determined by titrimetric assay and atomic absorption spectrophotometry technique were verified by comparing to neutron activation analysis which has high recovery of more than 90%. Conversion factors determined from the comparison is necessary to correct the calcium content for each technique. Femurs from cadaveric donors were cut into cortical rings and demineralised in 0.5 M hydrochloric acid for varying immersion...
1h
Abstract Hepatocellular carcinoma up-regulated EZH2-associated long non-coding RNA (HEIH) is a newly discovered lncRNA and has been suggested to be dysregulated in human cancers. However, the role of HEIH in triple-negative breast cancer (TNBC) was still unknown. Thus, the aim of our study was to investigate the clinical significance and biological function of HEIH in TNBC. In our study, we found that HEIH was overexpressed in TNBC tissues and cell lines compared with adjacent...
17h
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