This article explores the known and the emerging areas of clinical research on patients with BRCAwt ovarian cancer. Expert opinion: Discovery of molecular changes tied to annotated disease information, along with an expanding array of pathway targets and targeted therapeutic agents, creates optimism and opportunity for women with ovarian cancer. Using precision oncology approaches, clinical researchers are, and will be, poised to select more effective treatments for ovarian cancer patients. ...
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In this study we examined the effect of sample collection and sample processing procedures on NMR measured serum lipoproteins and small-molecule metabolites in serum and urine, using a cohort of men diagnosed with either prostate cancer or benign prostatic hyperplasia. We determined day-to-day reliability of metabolites by systematic sample collection at two different days, in both fasting and non-fasting conditions. Study participants received prostate massage the first day to assess the differences...
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Authors: Wang H, Song Y, Chai Y, Yuan R Abstract In this work, we found that polyethyleneimine (PEI), a widely applied organic high-molecular polymer, could act as a new co-reactant to obviously improve the electrochemiluminescence (ECL) of S2O82--O2 system. And owing to its abundant amine groups in the polymeric structure, PEI was further used to covalently crosslink with massive L-cysteine (L-Cys), an effective co-reactant of S2O82--O2 ECL system, to obtain a new co-reactive high-molecular...
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Authors: Qin W, Zhang Z, Qin R, Han J, Zhao R, Gu Y, Pan Y, Gu J, Ren S Abstract Accurate, simple and economical methods for quantifying N-glycans are continuously required for discovering disease biomarkers and quality control of biopharmaceuticals. Quantitative N-glycomics based on MS using exogenous isotopic labeling internal standards is promising as it is simple and accurate. However, it is largely hampered by the lack of available glycan internal standard libraries with good coverage...
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This study indicates that the urinary hydroxylmethylation modifications of hm5dC, hm5rC, and hm5rCm may serve as potential indicator of cancers. PMID: 31446947 [PubMed - in process] (Source: Analytica Chimica Acta)
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(Source: Cancer Management and Research)
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(Source: OncoTargets and Therapy)
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(Source: OncoTargets and Therapy)
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(Source: OncoTargets and Therapy)
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(Source: OncoTargets and Therapy)
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(Source: OncoTargets and Therapy)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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(Source: OncoTargets and Therapy)
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(Source: OncoTargets and Therapy)
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(Source: OncoTargets and Therapy)
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Conclusion: Our comparative study of conventional MRI and [18F]FET PET revealed that the latter is a valuable tool for predicting the treatment responses of patients with glioblastomas to follow-up temozolomide maintenance treatment while considering its cost-effectiveness. Thus, [18F]FET PET scans enable clinical outcomes to be predicted accurately and at a low cost. Moreover, given the robustness of the data in the sensitivity analyses, the level of certainty of this outcome is acceptable. (Source:...
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AbstractT cell receptor (TCR) gene-engineered T cells have shown promise in the treatment of melanoma and synovial cell sarcoma, but their application to epithelial cancers has been limited. The identification of novel therapeutic TCRs for the targeting of these tumors is important for the development of new treatments. Here, we describe the preclinical characterization of a TCR directed against Kita-Kyushu Lung Cancer Antigen-1 (KK-LC-1, encoded byCT83), a cancer germline antigen with frequent expression...
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Authors: Miguel Muñoz Marisa Rosso Rafael Coveñas Hepatoblastoma (HB) is the most common malignant liver tumor that occurs during childhood. The prognosis of children with HB is favorable when a complete surgical resection of the tumor is possible, but for high-risk patients, the prognosis is much worse. New anti-HB strategies must be urgently developed. The undecapeptide substance P (SP) after binding to the neurokinin-1 receptor (NK-1R), regulates cancer cell proliferation, exerts...
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HIV infection increases the risk of cancer. HIV-associated lymphocytopenia and immune dysregulation permit immune evasion of oncogenic viruses and premalignant lesions. Various types of immunotherapy, including monoclonal antibodies, interferon, cytokines, immunomodulatory drugs (IMiDs), allogeneic hematopoietic stem cell transplant, and most importantly ART have shown efficacy in HIV-related cancer. Emerging data suggest that checkpoint inhibitors targeting the PD-1/PD-L1 pathway can be safe and...
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Dendritic cell (DC)-based vaccines pulsed with high hydrostatic pressure (HHP)-inactivated tumor cells have been demonstrated to be a promising immunotherapy for solid tumors. We focused on sole injection of tumor cells that were inactivated by HHP and their combination with local radiotherapy (RTx) for in vivo induction of anti-tumor immune responses. HHP-treatment of tumor cells resulted in predominantly necrotic cells with degraded DNA. We confirmed that treatments at 200 MPa or higher completely...
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(Source: Frontiers in Oncology)
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In conclusion, we uncovered an unexpected novel role of TRAIL-R4 in PDAC cells. In contrast to its known pro-tumoral, anti-apoptotic function, TRAIL-R4 augments the anti-tumoral cytotoxic activity of γδ T cells. (Source: Frontiers in Immunology)
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Authors: Carlo Buonerba Simona Iaccarino Pasquale Dolce Martina Pagliuca Michela Izzo Luca Scafuri Ferdinando Costabile Vittorio Riccio Dario Ribera Brigitta Mucci Simone Carrano Fernanda Picozzi Davide Bosso Luigi Formisano Roberto Bianco Sabino De Placido Giuseppe Di Lorenzo Some commonly available patient or disease characteristics may be associated with progression-free survival (PFS) and overall survival (OS) in EGFR-mutant non-small cell...
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The increasing utilization of these immune checkpoint inhibitors has presented new of immune-related adverse events that have proven to be extremely challenging to manage. (Source: CancerNetwork)
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The US Food and Drug Administration recently approved gilteritinib (Xospata), in addition to final trial data from the phase 3 ADMIRAL trial, making it the new standard of care for acute myeloid leukemia. (Source: CancerNetwork)
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Brain metatstasis is common in breast cancer and often has a poor prognosis, but there are several ways to manage brain metastasis in breast cancer including focal therapies as well as systemic options for specific populations, including emerging and novel therapies. (Source: CancerNetwork)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Some experts blame our modern, sugary diet, while others think that gut microbiome changes and sedentary lifestyles may play a role. Altogether, the causes are far from clear. (Source: The Scientist)
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A clinical trial is exploring whether a novel immunotherapy/antiangiogenic combination can serve as an effective second-line treatment for pleural mesothelioma. Early indications of the four-center, phase II clinical trial are positive. The combination involves nivolumab (Opdivo) , a well-known immunotherapy drug, and ramucirumab (Cyramza), a therapy drug that blocks the formation of blood vessels needed for new tumor growth. The Food and Drug Administration approved both drugs for the treatment...
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Blue Light Cystoscopy helps doctors better detect and diagnose cancerous tumors in the bladder. (Source: SUNY Upstate Medical)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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The " My Special Aflac Duck " in which the company provides pediatric cancer patients with a robotic " smart " duck to help them through painful treatments is reviewed. The initiative is a feel-good success story that follows principles of effective CSR initiatives. (Source: Forbes.com Healthcare News)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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(Reuters Health) - Cancer specialists only rarely advise patients on lifestyle changes that could improve overall health and possibly also reduce the risk of recurrence, a new survey suggests. (Source: Reuters: Health)
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The U.S. Preventive Services Task Force recently posted a final recommendation statement on risk assessment, genetic counseling and genetic testing for BRCA-related cancer in women. (Source: AAFP News)
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MONDAY, Aug. 26, 2019 -- Men should be included in clinical trials of new breast cancer treatments, the U.S. Food and Drug Administration says. " Less than 1 percent of all breast cancer cases occur in men, but men are more likely to be diagnosed at... (Source: Drugs.com - Pharma News)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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STOMACH cancer symptoms can be vague and easy to mistake for other less serious conditions. Unfortunately, it tends to get diagnosed once it has advanced. Understanding the risk factors is essential to improving outcomes. (Source: Daily Express - Health)
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The U.S. Food and Drug Administration (FDA) on August 26 released a draft guidance...Read more on AuntMinnie.comRelated Reading: Men need breast cancer screening too SBI: Don't overlook men when it comes to breast cancer FDG-PET/CT helps stage men with breast cancer, too Male breast masses require careful investigation Mammography, US help diagnose male breast cancer (Source: AuntMinnie.com Headlines)
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Childhood cancer survivors have 10 times the risk of developing heart failure compared to children without cancer, a new study says. (Source: Health News - UPI.com)
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MONDAY, Aug. 26, 2019 -- Survivors of childhood cancer have an increased risk for all subtypes of cardiovascular disease (CVD), according to a research letter published online Aug. 26 in Circulation. Ashna Khanna, from the University of Toronto, and... (Source: Drugs.com - Pharma News)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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MONDAY, Aug. 26, 2019 -- The treatments that childhood cancer patients receive often save their lives, but they also make survivors prone to heart troubles, a new study finds. For the study, researchers examined heart disease rates in nearly 7,300... (Source: Drugs.com - Daily MedNews)
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Acupressure is a form of complementary or alternative medicine. Read about research on the efficacy of acupressure for headache, and learn some simple acupressure techniques to try at home. (Source: Health News from Medical News Today)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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