• Priming mobilization of hair follicle stem cells triggers permanent loss of regeneration after alkylating chemotherapy

  Nature Communications, Published online: 27 August 2019; doi:10.1038/s41467-019-11665-0Hair follicles (HFs) are sensitive to chemotherapy but recover from quiescent HF stem cells, although sometimes chemotherapy results in permanent loss. Here, Kim et al. establish a model of permanent chemotherapy-induced alopecia to uncover the underlying mechanisms depleting human HF stem cells.

  Nature Communications - current - nature.com science feeds

  Mon Aug 26, 2019 17:00
• Dispersion relation of the collective excitations in a resonantly driven polariton fluid

  Nature Communications, Published online: 27 August 2019; doi:10.1038/s41467-019-11886-3Owing to its driven-dissipative nature, and its solid-state environment, a resonantly driven polariton condensate can be accompanied by an incoherent reservoir of excitons. Stepanov et al. demonstrate that this situation strongly modifies the spectrum of collective excitations, which determines many quantum hydrodynamic features in a polariton fluid.

  Nature Communications - current - nature.com science feeds

  Mon Aug 26, 2019 17:00
• ZIKV infection induces robust Th1-like Tfh cell and long-term protective antibody responses in immunocompetent mice

  Nature Communications, Published online: 27 August 2019; doi:10.1038/s41467-019-11754-0Here, the authors show that Zika virus (ZIKV) infection induces Th1-like Tfh cells that depend on T-bet for their development and are essential for class switching of ZIKV-specific IgG2c antibodies and maintenance of long-term neutralizing antibody responses.

  Nature Communications - current - nature.com science feeds

  Mon Aug 26, 2019 17:00
• Micro-/nano-voids guided two-stage film cracking on bioinspired assemblies for high-performance electronics

  Nature Communications, Published online: 27 August 2019; doi:10.1038/s41467-019-11803-8Metal film-based electronics usually fail via uncontrolled cracking at small strains. Here, the authors design a micro-/nano-structured surface with bundled flexible nanowires onto which a metal film can stretch more than a regular flat surface, retard penetrating cracks and remain sensitive.

  Nature Communications - current - nature.com science feeds

  Mon Aug 26, 2019 17:00
• A stable zirconium based metal-organic framework for specific recognition of representative polychlorinated dibenzo-<i>p</i>-dioxin molecules

  Nature Communications, Published online: 27 August 2019; doi:10.1038/s41467-019-11912-4The sensing of polychlorinated dibenzo-p-dioxins (PCDDs) is important for the environment and public health but challenging to achieve. Here the authors report a stable zirconium-based metal-organic framework for the selective sensing of two representative PCCDs based on the fluorescence quenching method.

  Nature Communications - current - nature.com science feeds

  Mon Aug 26, 2019 17:00
• Highly active ruthenium metathesis catalysts enabling ring-opening metathesis polymerization of cyclopentadiene at low temperatures

  Nature Communications, Published online: 27 August 2019; doi:10.1038/s41467-019-11806-5Due to the low ring strain and facile dimerization, ring-opening metathesis polymerization of cyclopentadiene, readily obtainable from petroleum feedstock, has not been realized. Here the authors show an ultrarapidly initiating trifluoromethanesulfonamide-based ruthenium catalyst enables it at low temperatures.

  Nature Communications - current - nature.com science feeds

  Mon Aug 26, 2019 17:00
• Structure of a bound peptide phosphonate reveals the mechanism of nocardicin bifunctional thioesterase epimerase-hydrolase half-reactions

  Nature Communications, Published online: 27 August 2019; doi:10.1038/s41467-019-11740-6NocTE is a nonribosomal peptide synthetase thioesterase that completes the biosynthesis of pro-nocardicin G, the precursor for nocardicin β-lactam antibiotics. Here the authors provide mechanistic insights into NocTE by determining its crystal structures in the ligand-free form and covalently linked to a fluorophosphonate substrate mimic.

  Nature Communications - current - nature.com science feeds

  Mon Aug 26, 2019 17:00
• A Semi-Quantitative Drug Affinity Responsive Target Stability (DARTS) assay for studying Rapamycin/mTOR interaction

  In this study, we enhanced the data analysis capabilities of the DARTS experiment by monitoring the changes in protein stability and estimating the affinity of protein-ligand interactions. The interactions can be plotted into two curves: a proteolytic curve and a dose-dependence curve. We have used mTOR-rapamycin interaction as an exemplary case.

  JoVE: Journal of Visualized Experiments

  Tue Aug 27, 2019 11:40
• Quantitative Fluorescence In Situ Hybridization (FISH) and Immunofluorescence (IF) of Specific Gene Products in KSHV-Infected Cells

  We describe a protocol utilizing fluorescence in situ hybridization (FISH) to visualize multiple herpesviral RNAs within lytically infected human cells, either in suspension or adherent. This protocol includes quantification of fluorescence producing a nucleocytoplasmic ratio and can be extended for simultaneous visualization of host and viral proteins with immunofluorescence (IF).

  JoVE: Journal of Visualized Experiments

  Tue Aug 27, 2019 11:40
• A short comment on statistical versus mathematical modelling

  Nature Communications - current - nature.com science feeds

  Mon Aug 26, 2019 17:00
• Priming mobilization of hair follicle stem cells triggers permanent loss of regeneration after alkylating chemotherapy

  Nature Communications - current - nature.com science feeds

  Mon Aug 26, 2019 17:00
• Dispersion relation of the collective excitations in a resonantly driven polariton fluid

  Nature Communications - current - nature.com science feeds

  Mon Aug 26, 2019 17:00
• ZIKV infection induces robust Th1-like Tfh cell and long-term protective antibody responses in immunocompetent mice

  Nature Communications - current - nature.com science feeds

  Mon Aug 26, 2019 17:00
• Micro-/nano-voids guided two-stage film cracking on bioinspired assemblies for high-performance electronics

  Nature Communications - current - nature.com science feeds

  Mon Aug 26, 2019 17:00
• A stable zirconium based metal-organic framework for specific recognition of representative polychlorinated dibenzo-<i>p</i>-dioxin molecules

  Nature Communications - current - nature.com science feeds

  Mon Aug 26, 2019 17:00
• Highly active ruthenium metathesis catalysts enabling ring-opening metathesis polymerization of cyclopentadiene at low temperatures

  Nature Communications - current - nature.com science feeds

  Mon Aug 26, 2019 17:00
• Structure of a bound peptide phosphonate reveals the mechanism of nocardicin bifunctional thioesterase epimerase-hydrolase half-reactions

  Nature Communications - current - nature.com science feeds

  Mon Aug 26, 2019 17:00
• Gold Nanostars Help Design New Nanomedicines

  Researchers from Northwestern University have developed a novel way to track how nanoparticles interact with cancer cells and whether they reach their tagets. The team’s work shows that if a nanoparticle targets cancer cells, it undergoes more rotational and translational movement compared to nanoparticles that cannot target cancer cells effectively. This exciting development can be used to screen different nanoparticle formulation

  Medgadget

  Tue Aug 27, 2019 11:18
• Atypical Presentation of Giant Mandibular Aneurysmal Bone Cyst with Cemento-Ossifying Fibroma Mimicking Sarcoma

  Aneurysmal bone cysts (ABCs) are an uncommon osteolytic intraosseous bone lesions. ABCs commonly involve metaphysis of long bones and are rarely diagnosed in craniofacial bones. The World Health Organization (WHO) designates ABCs as benign, but locally destructive, rapidly growing masses. ABC can be clinically misdiagnosed as a malignant tumor. In this article, we present a case of a 12-year-old female patient who presented to a maxillofascial ou

  Case Reports in Otolaryngology

  Tue Aug 27, 2019 07:15
• Daily briefing: Press pause on facial-recognition technology

  Nature, Published online: 27 August 2019; doi:10.1038/d41586-019-02567-8Facial-recognition urgently needs better safeguards, says Microsoft researcher. Plus: how Brazil’s fires are caused by deforestation, and the gripping history of a psychiatric success story.

  Nature - Issue - nature.com science feeds

  Mon Aug 26, 2019 17:00
• Memo to Italy’s president: your researchers need you

  Nature, Published online: 27 August 2019; doi:10.1038/d41586-019-02560-1The collapse of Italy’s coalition government has left researchers vulnerable. The president should use his moral authority with party leaders to make sure that promises of increased funding are kept.

  Nature - Issue - nature.com science feeds

  Mon Aug 26, 2019 17:00
• Standard Operating Procedure for Lyssavirus Surveillance of the Bat Population in Taiwan

  This protocol introduces a standard laboratory operating procedure for diagnostic testing of lyssavirus antigens in bats in Taiwan.

  JoVE: Journal of Visualized Experiments

  Tue Aug 27, 2019 10:39
• Use of In Vivo Single-fiber Recording and Intact Dorsal Root Ganglion with Attached Sciatic Nerve to Examine the Mechanism of Conduction Failure

  Single-fiber recording is an effective electrophysiological technique that is applicable to the central and peripheral nervous systems. Along with the preparation of intact DRG with the attached sciatic nerve, the mechanism of conduction failure is examined. Both protocols improve the understanding of the peripheral nervous system's relationship with pain.

  JoVE: Journal of Visualized Experiments

  Tue Aug 27, 2019 10:39
• Eradicating Otomycosis with Terbinafine Solution: Basic and Clinical Investigation

  Background: Otomycosis still remains intractable in clinical practice, likely because topical antifungal agents lack efficacy or are potentially toxic to the inner ear end organs. Objectives: The aim of this study was to investigate whether terbinafine solution is a potential candidate for treating intractable otomycosis in humans. In addition, the toxic effect on the inner ear was also assessed by animal models treated with terbinafine. Methods

  Audiology and neurotology

  Tue Aug 27, 2019 06:41
• Radiotherapy for painful benign skeletal disorders

  Abstract Purpose The aim of this retrospective clinical quality assessment was to evaluate the efficacy of low-dose radiotherapy (RT) for painful benign skeletal disorders. Methods Patients with different painful benign skeletal disorders (arthrosis and enthesopathies) were recruited for this retrospectiv

  Strahlentherapie und Onkologie

  Mon Aug 26, 2019 17:00
• Wnt Signaling Modulates Routes of Retinoic Acid-Induced Differentiation of Embryonic Stem Cells

  Stem Cells and Development, Ahead of Print.

  Stem Cells and Development

  Tue Aug 27, 2019 00:00
• Method for Recording Broadband High Resolution Emission Spectra of Laboratory Lightning Arcs

  Emission spectroscopy techniques have traditionally been used to analyze inherently random lightning arcs occurring in nature. In this paper, a method developed to obtain the emission spectroscopy from reproducible lightning arcs generated within a laboratory environment is described.

  JoVE: Journal of Visualized Experiments

  Tue Aug 27, 2019 09:38
• Daily briefing: Press pause on facial-recognition technology

  Nature - Issue - nature.com science feeds

  Mon Aug 26, 2019 17:00
• [ASAP] Observation of Proton Transfer Coupled Spin Transition and Trapping of Photoinduced Metastable Proton Transfer State in an Fe(II) Complex

  Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b07204

  Journal of the American Chemical Society: Latest Articles (ACS Publications)

  Mon Aug 26, 2019 21:00
• [ASAP] Spotlights on Recent <italic toggle="yes">JACS</italic> Publications

  Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b09244

  Journal of the American Chemical Society: Latest Articles (ACS Publications)

  Mon Aug 26, 2019 21:00
• [ASAP] Desymmetrization of Phosphinic Acids via Pd-Catalyzed Asymmetric Allylic Alkylation: Rapid Access to <italic toggle="yes">P</italic>-Chiral Phosphinates

  Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b07340

  Journal of the American Chemical Society: Latest Articles (ACS Publications)

  Mon Aug 26, 2019 21:00
• [ASAP] Fast Ionic Conductivity in the Most Lithium-Rich Phosphidosilicate Li₁₄SiP₆

  Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b05301

  Journal of the American Chemical Society: Latest Articles (ACS Publications)

  Mon Aug 26, 2019 21:00
• [ASAP] Enantioselective Imine Reduction Catalyzed by Phosphenium Ions

  Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b07293

  Journal of the American Chemical Society: Latest Articles (ACS Publications)

  Mon Aug 26, 2019 21:00
• Unique Uses of Cooling Strategies

  Therapeutic Hypothermia and Temperature Management, Ahead of Print.

  Therapeutic Hypothermia and Temperature Management

  Tue Aug 27, 2019 00:00
• Procedural memory consolidation is associated with heart rate variability and sleep spindles

  Abstract Sleep and memory studies often focus on overnight rather than long‐term memory changes, traditionally associating overnight memory change (OMC) with sleep architecture and sleep patterns such as spindles. In addition, (para‐)sympathetic innervation has been associated with OMC after a daytime nap using heart rate variability (HRV). In this study we investigated overnight and long‐term performance changes for procedural memory and evalua

  Journal of Sleep Research

  Tue Aug 27, 2019 07:08
• Households’ age, country of birth, and marital status, stronger predictor variables than education in the prevalence of dental sealants, restorations, and caries among US children 5–19 years of age, NHANES 2005–2010

  Abstract Background The aim of this study is to use data representative of the U.S. population to determine if households (HHs) age, birth country, and marital status, are strong predictors as HHs education for dental sealants, restorations, and caries in children 5 to 19 years of age. Methods

  Latest Results for BMC Oral Health

  Mon Aug 26, 2019 17:00
• Cartilage on a Chip to Identify New Treatments for Osteoarthritis

  Researchers from the Polytechnic University of Milan and the University Hospital of Basel have developed a microfluidic chip containing cartilage, which can be subjected to mechanical stress. The procedure mimics the conditions of osteoarthritis and could help in developing new treatments. Osteoarthritis is relatively common among people over 60, with 20% of women and 10% of men suffering its effects at this age. However, perhaps s

  Medgadget

  Tue Aug 27, 2019 08:41
• Arms race between parasites and their victims

  Acanthocephala are parasitic worms that reproduce in the intestines of various animals, including fish. However, only certain species of fish are suitable as hosts. A study now shows how the parasites succeed in preferably infecting these types.

  Evolutionary Biology News -- ScienceDaily

  Tue Aug 27, 2019 06:52
• The making of 'Fancy Mouse'

  For the past few hundred years, the colorful hair and unique patterns of the so-called 'Fancy Mouse' have made them the stars of pet shows in Japan and beyond. Now, scientists have finally revealed the true cause of the genetic mutation responsible for the iconic black pigmentation in the popular East Asian pet.

  Evolutionary Biology News -- ScienceDaily

  Tue Aug 27, 2019 06:50
• Η παχυσαρκία εξασθενεί τη γεύση

  Η παχυσαρκία συνδέεται με μειωμένη ανταπόκριση στην αίσθηση της γεύσης, σύμφωνα με νέα έρευνα του Πανεπιστημίου της Νέας Υόρκης Binghampton που δημοσιεύθηκε στο Frontiers in Integrative Neuroscience. Μέχρι τώρα ήταν ήδη γνωστό πως ο τρόπος με τον οποίο αντιλαμβάνεται κανείς τη γεύση τροποποιείται με την παχυσαρκία. Η παρούσα μελέτη, όμως, είναι η πρώτη που διερεύνησε τις νευρωνικές αλλαγές που κρύβονται πίσω από αυτή την κατάσταση. «Είναι εντυπ

  Επιστημονικές Εξελίξεις – ygeiamou | Το αξιόπιστο site για την Υγεία, τη Διατροφή και την Ευεξία

  Tue Aug 27, 2019 05:35
• Αυτός ο παράγοντας προβλέπει τη σωματική αδυναμία

  Τα χαμηλά επίπεδα συγκεκριμένων βιταμινών και αντιοξειδωτικών στον οργανισμό των ηλικιωμένων σχετίζονται με σωματική αδυναμία, σύμφωνα με ιρλανδική μελέτη που δημοσιεύθηκε στο Journal of the American Medical Directors Association. Η γεροντική αδυναμία αποτελεί ένα συχνό χρόνιο σύνδρομο που επηρεάζει έως και το 25% των ενηλίκων άνω των 65 ετών και σχεδόν τους μισούς άνω των 80 ετών. Χαρακτηρίζεται από μια γενική φθορά στη σωματική λειτουργία και

  Επιστημονικές Εξελίξεις – ygeiamou | Το αξιόπιστο site για την Υγεία, τη Διατροφή και την Ευεξία

  Tue Aug 27, 2019 05:34
• Cancers, Vol. 11, Pages 1256: Baseline and Early Predictors of Good Patient Candidates for Second-Line after Sorafenib Treatment in Unresectable Hepatocellular Carcinoma

  Cancers, Vol. 11, Pages 1256: Baseline and Early Predictors of Good Patient Candidates for Second-Line after Sorafenib Treatment in Unresectable Hepatocellular Carcinoma Cancers doi: 10.3390/cancers11091256 Authors: Takada Kurosaki Tsuchiya Komiyama Itakura Takahashi Nakanishi Yasui Tamaki Maeyashiki Kaneko Takaura Higuchi Okada Wang Osawa Sekiguchi Hayakawa Yamashita

  Cancers

  Mon Aug 26, 2019 17:00
• Cancers, Vol. 11, Pages 1257: PD-L1 Induction by Cancer-Associated Fibroblast-Derived Factors in Lung Adenocarcinoma Cells

  Cancers, Vol. 11, Pages 1257: PD-L1 Induction by Cancer-Associated Fibroblast-Derived Factors in Lung Adenocarcinoma Cells Cancers doi: 10.3390/cancers11091257 Authors: Inoue Miki Saito Hata Abe Sato Okada Sasano Cancer-associated fibroblasts (CAFs) exert various effects upon biological behaviours of cancer. In this study, we examined the correlation of CAFs with the intra-tumoural immune system in the lu

  Cancers

  Mon Aug 26, 2019 17:00
• Smartphone and Paper Microfluidic Device for Norovirus Detection

  Researchers at the University of Arizona have developed a simple and inexpensive method that can be used to detect tiny traces of norovirus in water samples. The technique involves a smartphone camera and a paper microfluidics device, and could help to identify sources of norovirus before it can cause illness. In the US, norovirus causes approximately 20 million cases of food poisoning annually. However, the virus isn’t just r

  Medgadget

  Tue Aug 27, 2019 08:26
• Self-Rolling Sensor Measures Electrical Activity of Heart Organoids

  Researchers from Carnegie Mellon University and Nanyang Technological University in Singapore have developed a new microfabricated sensor array that performs 3D electrophysiology of cellular organoids. Their work demonstrates that the device can be designed to wrap around small organoids and measure voltage changes across the surface of the organoids without leading to significant loss of viability of the cells. This is an exciting development t

  Medgadget

  Tue Aug 27, 2019 08:06
• Optimizing outcomes and treatment sequences in EGFR mutation-positive non-small-cell lung cancer: recent updates

  Future Oncology, Ahead of Print.

  Future Oncology

  Tue Aug 27, 2019 03:18
• Nomograms for predicting the survival rate for cervical cancer patients who undergo radiation therapy: a SEER analysis

  Future Oncology, Ahead of Print.

  Future Oncology

  Tue Aug 27, 2019 02:42
• How scientific mobility can help current and future radiology research: a radiology trainee’s perspective

  Abstract One of the ways in which modern radiology is manifesting itself in higher education and research is through the increasing importance of scientific mobility. This article seeks to provide an overview and a prospective of radiology fellows in their last year of training about the current trends and policy tools for promoting mobility among young radiologists, especially inside the European Union. Nowadays, the need to

  Imaging

  Mon Aug 26, 2019 17:00
• Memo to Italy’s president: your researchers need you

  Nature - Issue - nature.com science feeds

  Mon Aug 26, 2019 17:00
• VR Simulation Leads to Enhanced Procedural Confidence for Surgical Trainees

  Publication date: Available online 26 August 2019Source: Journal of Surgical EducationAuthor(s): Heather Lesch, Evan Johnson, Jörg Peters, Juan C. CendánObjectiveActive learning techniques result in greater knowledge acquisition compared to passive methods. For medical students with limited hands-on operative experiences, virtual reality platforms represent active learning and may enhance procedural training. We hypothesize that virtual reality s

  Journal of Surgical Education

  Tue Aug 27, 2019 07:52
• Propagating the “SEAD”: Exploring the Value of an Overnight Call Shift in the Surgical Exploration and Discovery (SEAD) Program

  Publication date: Available online 26 August 2019Source: Journal of Surgical EducationAuthor(s): Teresa Ziegler, Alexander Adibfar, Aram Abbasian, Shirley Xue Jiang, James T Rutka, Nada GawadObjectiveAttrition of general surgery residents highlights a need to support well-informed specialty selection. This study evaluated preclerkship medical students’ perception of overnight call shifts in surgical career exploration.DesignA mixed-methods design

  Journal of Surgical Education

  Tue Aug 27, 2019 07:52
• The Value of Surgical Graduate Medical Education (GME) Programs Within An Integrated Health Care System

  Publication date: Available online 26 August 2019Source: Journal of Surgical EducationAuthor(s): Claire I. Lauer, Mohsen M. Shabahang, Brian Restivo, Samantha Lane, Sarah Hayek, James Dove, Halle B. Ellison, Erin Pica, Evan J. RyerOBJECTIVESurgical graduate medical education (GME) programs add both significant cost and complexity to the mission of teaching hospitals. While expenses tied directly to surgical training programs are well tracked, ove

  Journal of Surgical Education

  Tue Aug 27, 2019 07:52
• Halt the use of facial-recognition technology until it is regulated

  Nature, Published online: 27 August 2019; doi:10.1038/d41586-019-02514-7Until appropriate safeguards are in place, we need a moratorium on biometric technology that identifies individuals, says Kate Crawford.

  Nature - Issue - nature.com science feeds

  Mon Aug 26, 2019 17:00