CONCLUSIONS: The diagnosis and treatment of peritoneal serous papillary carcinoma may be delayed or may not be performed unless Class III findings are detected through uterine mucosal cytology before surgery. Surgeons should not hesitate to perform laparotomy when necessary to identify and appropriately treat patients, even if abnormalities are not detected in the preoperative examination. PMID: 31448396 [PubMed - in process] (Source: Clinical Breast Cancer)
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In this study, protein sequence similarity network (SSN) and evolutionary analysis were performed to understand the enzymes comprehensively. SSN indicated that the proteins in FUC family are mainly present in bacteria, fungi, Metazoa, and plants, but less in archaea. The sequences in bacteria are much diverse compared that in other taxonomic groups. SSN together with phylogenetic tree supported that the proteins in FUC family can be classified into 5 subfamilies. The multiple sequence alignments...
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Conclusions: This is the first report that suggest that anthocyanins from blue corn have an effect in cell cycle and viability so they could serve as adjuvants for breast and prostate cancer therapies and may prompt to deepen investigations to decipher its molecular properties. Abbreviations AR Androgen Receptor CIDIIR Interdisciplinary Center for Research on Integral Regional Development DHT 5α-Dihydrotestosterone ER Estrogen Receptor PR Progesterone Receptor QBS Amino-N-quinolin-8-yl-benzenesulfonamide....
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While a high frequency of Th1 cells in tumors is associated with improved cancer prognosis, this benefit has been attributed mainly to support of cytotoxic activity of CD8+ T cells. By attempting to potentiate antibody-driven immunity, we found a remarkable synergy between CD4+ T cells and tumor-binding antibodies. This surprising synergy was mediated by a small subset of tumor-infiltrating CD4+ T cells that express the high-affinity Fcγ receptor for IgG (FcγRI) in both mouse and human patients....
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Hsp90B enhances MAST1-mediated cisplatin resistance by protecting MAST1 from proteosomal degradation
Microtubule-associated serine/threonine kinase 1 (MAST1) is a central driver of cisplatin resistance in human cancers. However, the molecular mechanism regulating MAST1 levels in cisplatin-resistant tumors is unknown. Through a proteomics screen, we identified the heat shock protein 90 B (hsp90B) chaperone as a direct MAST1 binding partner essential for its stabilization. Targeting hsp90B sensitized cancer cells to cisplatin predominantly through MAST1 destabilization. Mechanistically, interaction...
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Publication date: Available online 25 August 2019Source: European Journal of Surgical OncologyAuthor(s): Talisa Ross, Nikhil PawaAbstractThe question of culpability over decisions made by the multi-disciplinary team (MDT) is a contentious one. Currently, all members present remain responsible for the MDT's decision, but it is unclear whether the onus of decision making lies with the patient's “lead clinician”, and how straight to test pathways (bypassing a consultation with a specialist prior to...
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Conclusions Using a large national surgical database, only 2.4% of women undergoing gynecologic cancer surgery had a concomitant POPUI procedure. Our data suggest that postoperative complications may not increase when concomitant surgery for POPUI is done at the time of gynecologic cancer surgery. (Source: Journal of Pelvic Medicine and Surgery)
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ConclusionThe NSQIP universal surgical risk calculator did not perform with enough accuracy to consider adoption into clinical practice. (Source: World Journal of Urology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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ConclusionAmong two different populations of older adults with different health literacy levels, the preferred strategies for clinicians to discuss stopping screening colonoscopies were highly correlated. Our results can inform effective communication about stopping screening colonoscopies in older adults across different health literacy levels. (Source: Journal of General Internal Medicine)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your...
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We present the case of a 9-year-old child with complete sternal cleft, treated with an innovative sternal prosthesis. Surgery was performed to protect the heart and also, as pulsations was visible, leading to serious esthetical concerns, to enhance school integration, which was difficult. The porous alumina device used was initially designed for sternal reconstruction after refractory deep sternal wound infection or carcinoma. Surgery and early follow-up were simple. There was no complication and...
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Utilization of robotic-assistance for esophagectomy is increasing. The differences in outcomes between robotic-assisted minimally-invasive esophagectomy (RAMIE) and non-robotic minimally-invasive esophagectomy (MIE) for esophageal cancer are unknown. The purpose of this study was to compare 30-day postoperative outcomes between RAMIE and MIE. (Source: American Journal of Surgery)
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Ensuring timely and high-quality surgery must be a key element of breast cancer control efforts in sub-Saharan Africa. We investigated delays in preoperative care and the impact of on-site versus off-site operation on time to operative treatment of patients with breast cancer at Butaro Cancer Center of Excellence in Rwanda. (Source: Surgery)
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To analyze risk factors and patterns of RCC recurrence following percutaneous ablation for stage 1 tumors and develop risk-stratified follow-up imaging protocols. (Source: Urology)
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In this study, we compare the expression and co-expression of stem cell markers ALDH1 and SOX2 in different types of serous ovarian tumors. A total of 215 serous ovarian tumors (161 high-grade serous carcinomas (HGSC), 17 low-grade serous carcinomas (LGSC), 37 atypical proliferative serous tumors (APST)), and 10 cases of serous tubal intraepithelial carcinoma (STIC) were analyzed. Double immunostaining experiments addressed the association of cell proliferation (Ki67) with ALDH1 and the potential...
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Unfortunately, the affiliation for the following authors was incorrectly published in the original publication. (Source: European Spine Journal)
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This study aims to determine rates of spontaneous thelarche (ST) and spontaneous menarche (SM), and prevalence of gonadal tumor and malignancy in girls with TS+Y, to further inform discussions about gonadectomy. (Source: Journal of Pediatric and Adolescent Gynecology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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Journal of Gynecologic Surgery, Ahead of Print. (Source: Journal of Gynecologic Surgery)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
23h
In the UK there are still 42 000 cases of lung cancer diagnosed each year and as the past decade has seen several practice-changing developments in the management of this disease, history has always taught us that patients have their best chance of a good treatment outcome if their cancer is diagnosed at an early stage. In ad dition to smoking cessation, it is the early diagnosis and treatment of lung cancer that is the most effective way to reduce lung cancer mortality at this point in time [1]....
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A standardised classification of malignant skin appendageal (adnexal) tumours and sarcomas is required for improved patient management and prognosis. This has been hindered by considerable morphological variation both within and between tumour types, the use of many synonyms for the same tumour types and variation in classification between pathologists.This update uses the improved classification in the 2018 WHO classification of skin tumours as the basis to discuss malignant skin appendageal tumours,...
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To investigate dosimetric differences and plan qualities between manual plans and automatic plans for nasopharyngeal carcinoma (NPC) in early stage, and provide better options to maximize the benefits. Sixteen cases diagnosed with early NPC were retrospectively investigated. Conventional step and shoot IMRT with 7-fields and full arc volumetric-modulated arc therapy (VMAT) with double arcs were manually generated by experienced planners and automatically generated by Auto-Planning module in Pinnacle3...
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Immunodeficiency can affect different components of the immune system and predispose to different types of opportunistic infections. For example, a defect in neutrophil or humoral immunity increases risk from disseminated infection by extracellular pathogens, whereas a defect in cytotoxic activity by natural killer cells or CD8+ T lymphocytes increases risk from intracellular pathogens. The latter also increases risk from malignancies, due to impairment of normal immunosurveillance against abnormal...
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New diagnoses of CVD, emphysema, osteoporosis identified, often are linked to adverse events (Source: Pulmonary Medicine News - Doctors Lounge)
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Last week, senior NHS bosses were ordered to repeat Prime Minister Boris Johnson’s claim that a no-deal Brexit must be carried out in October if necessary. As reported in The Independent, a controversial government briefing stated that all communications sent by NHS England must be “aligned to this script”. Labour’s Shadow Health Secretary, Jonathan Ashworth MP calls this a “gagging order” on NHS managers. The NHS Confederation have previously outlined several risks to a no-deal Brexit, namely...
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£18m funding for cancer support workers Related items fromOnMedica Better cancer treatment remains a ‘major’ public ‘priority’ Obesity as cause of cancer set to overtake smoking Is the NHS ready for ‘Cutting edge’ CAR T cell immunotherapy? Scotland launches its ‘Detect Cancer Early’ campaign Cancer patients using complementary meds die sooner (Source: OnMedica Latest News)
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Best practice to be shared across cancer networks Related items fromOnMedica Exercise and psychological treatments cut cancer fatigue Cancer patients using complementary meds die sooner Data don ’t support HRT for chronic disease prevention Benefit of Herceptin in more breast cancer cases New breast cancer drug ‘unaffordable’ for NHS (Source: OnMedica Latest News)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best...
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GEORGE ALAGIAH, who ’s best known for presenting BBC News, revealed he’s “in a sort of limbo” at the moment in regards to his health. Just a couple years ago the newsreader was diagnosed with cancer. (Source: Daily Express - Health)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Australian researchers discovered the protein activin-A blocks immune cells, which is thought to be one of the key ways cancer takes hold. This could 'open the door' to new treatments. (Source: the Mail online | Health)
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A potential novel therapy against glioblastoma, a tumor that penetrates brain tissue and hides from radiation, chemotherapy and surgical treatments, targets its circadian clock -- and may lead to new treatment methods. (Source: Health News - UPI.com)
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The treatments that childhood cancer patients receive often save their lives, but they also make survivors prone to heart troubles, a new study finds. (Source: WebMD Health)
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Susanna Hancock, 50, of Sale, Greater Manchester, downloaded the app SkinVision in January this year. She was later diagnosed with basal cell carcinoma and had the mole removed. (Source: the Mail online | Health)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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Tatiana Prowell, MD, has attended many memorial services. But none before the death of the patient — until this summer. Now, she asks: Why wait until a loved one dies to celebrate them?Medscape Medical News (Source: Medscape FamilyMedicine Headlines)
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Alicia Levey, Ph.D., joins as Senior Vice President and Chief Business Officer Two first-in-class Myeloid Tuning antibodies with novel mechanisms in the tumor microenvironment headed for the clinic SOUTH SAN FRANCISCO, Aug. 27, 2019 -- (Healthcare S... Biopharmaceuticals, Oncology, Personnel PIONYR Immunotherapeutics, Myeloid Tuning (Source: HSMN NewsFeed)
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Machavert obtains worldwide exclusive license to small molecule RAL GTPase inhibitors to treat KRAS cancers AURORA, Colo., Aug. 27, 2019 -- (Healthcare Sales & Marketing Network) -- Machavert Pharmaceuticals, a preclinical stage pharmaceutical company ... Biopharmaceuticals, Oncology, Licensing Machavert Pharmaceuticals, KRAS , precision medicine (Source: HSMN NewsFeed)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account....
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TUESDAY, Aug. 27, 2019 -- Few oncologists and specialists recommend health promotion to cancer survivors, according to a study published online Aug. 26 in Cancer. Noting that guidelines encourage health promotion counseling for cancer survivors,... (Source: Drugs.com - Pharma News)
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TUESDAY, Aug. 27, 2019 -- Lung cancer screening (LCS) computed tomography (CT) scans can be used to identify smoking-related conditions that frequently are associated with adverse events, according to a study published in the July issue of Chronic... (Source: Drugs.com - Pharma News)
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PROSTATE cancer is the most common cancer in men in the UK. No one knows how to prevent the disease but certain lifestyle decisions can help to mitigate the risk. One study found eating before a certain time may slash the risk. (Source: Daily Express - Health)
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American computing giant Oracle is working with a Egyptian non-profit organization to accelerate research efforts into cancer cures. (Source: Forbes.com Healthcare News)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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The revised law would reduce penalties for buying generic pharmaceuticals from other countries without waiting for approval, though details are scant. (Source: NYT Health)
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Researchers from Australia plan to explore media coverage of the benefits and...Read more on AuntMinnie.comRelated Reading: AI may help reduce overdiagnosis of breast cancer Lung cancer overdiagnosis varies widely on CT screening Annals: Overdiagnosis must be better defined How serious is the risk of breast cancer overdiagnosis? ACR disputes NEJM paper on overdiagnosis (Source: AuntMinnie.com Headlines)
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Setting volume thresholds does not guarantee that hospitals will adhere to those standards or that patients will have access to hospitals that do, a study of high-risk cancer surgery patients reveals.Reuters Health Information (Source: Medscape Medical News Headlines)
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(Natural News) We’ve all heard stories of heroic dogs saving people’s lives, whether they alerted their sleeping owners to a fire in time for them to escape or they found people who were trapped in disaster areas. However, there’s a growing body of evidence that their life-saving abilities go a lot further than that: They... (Source: NaturalNews.com)
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Study finds that current guidelines exclude too many and test too narrowly, and reveals several new gene-cancer associations with potential to impact patient care.(PRWeb August 27, 2019)Read the full story at https://www.prweb.com/releases/ambry_genetics_data_reveal_that_expanding_genetic_testing_guidelines_could_identify_more_patients_with_increased_risks_of_cancer/prweb16517290.htm (Source: PRWeb: Medical Pharmaceuticals)
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Tatiana Prowell, MD, has attended many memorial services. But none before the death of the patient — until this summer. Now, she asks: Why wait until a loved one dies to celebrate them?Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
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After a long delay in implementing a bill, cancer patients can now defer payment on their student loans without interest accrual.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
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GlaxoSmithKline said an experimental multiple myeloma treatment has shown a meaningful response in patients that have run out of three previous treatment options, in a boost for the British drugmaker's cancer drug business.Reuters Health Information (Source: Medscape Allergy Headlines)
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Title: Justice Ruth Bader Ginsburg Treated for Pancreatic CancerCategory: Health NewsCreated: 8/23/2019 12:00:00 AMLast Editorial Review: 8/26/2019 12:00:00 AM (Source: MedicineNet Cancer General)
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Full Chemo Doses Early On Maximize Breast Cancer Survival (Source: eMedicineHealth.com)
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Title: aldesleukin (Proleukin)Category: MedicationsCreated: 6/8/1999 12:00:00 AMLast Editorial Review: 8/23/2019 12:00:00 AM (Source: MedicineNet Cancer General)
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The increasing utilization of these immune checkpoint inhibitors has presented new of immune-related adverse events that have proven to be extremely challenging to manage. (Source: CancerNetwork)
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