Abstract T cell receptor (TCR) gene-engineered T cells have shown promise in the treatment of melanoma and synovial cell sarcoma, but their application to epithelial cancers has been limited. The identification of novel therapeutic TCRs for the targeting of these tumors is important for the development of new treatments. Here, we describe the preclinical characterization of a TCR directed against Kita-Kyushu Lung Cancer Antigen-1 (KK-LC-1, encoded by CT83), a cancer germline...
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Abstract Background A sequential combination of radiochemotherapy/endocrinotherapy and cytokine-induced killer cell (CIK) infusion has been shown to be an effective therapy for post-mastectomy breast cancer based on statistical analysis of the patient population. However, whether an individual could obtain an improved prognosis from CIK cell-based treatment remains unknown. In the present study, we focused on immune microenvironment...
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Abstract Chromosome 21 abnormalities are the most frequent genetic findings in childhood B cell precursor acute lymphoblastic leukemia (BCP-ALL) cases. Majority of patients are effectively diagnosed with fluorescence in situ hybridization (FISH) and karyotyping; however, some cases may require additional tools to be used. Bone marrow samples of 373 childhood BCP-ALL patients were tested for chromosome 21 copy number variations (CNVs) with Multiplex Ligation-dependent Probe Amplification...
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Title: Men Should be Included in Breast Cancer Clinical Trials: FDACategory: Health NewsCreated: 8/26/2019 12:00:00 AMLast Editorial Review: 8/27/2019 12:00:00 AM
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Title: Childhood Cancer Survivors Struggle With Heart TroublesCategory: Health NewsCreated: 8/26/2019 12:00:00 AMLast Editorial Review: 8/27/2019 12:00:00 AM
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Title: Justice Ruth Bader Ginsburg Treated for Pancreatic CancerCategory: Health NewsCreated: 8/23/2019 12:00:00 AMLast Editorial Review: 8/26/2019 12:00:00 AM (Source: MedicineNet Cancer General)
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Title: aldesleukin (Proleukin)Category: MedicationsCreated: 6/8/1999 12:00:00 AMLast Editorial Review: 8/23/2019 12:00:00 AM (Source: MedicineNet Cancer General)
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Title: More Antibiotics, Higher Odds for Colon Cancer?Category: Health NewsCreated: 8/21/2019 12:00:00 AMLast Editorial Review: 8/22/2019 12:00:00 AM (Source: MedicineNet Cancer General)
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Title: lenalidomide (Revlimid)Category: MedicationsCreated: 3/25/2015 12:00:00 AMLast Editorial Review: 8/22/2019 12:00:00 AM (Source: MedicineNet Cancer General)
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Title: Drug Offers Hope Against a Tough-to-Treat Blood CancerCategory: Health NewsCreated: 8/21/2019 12:00:00 AMLast Editorial Review: 8/22/2019 12:00:00 AM (Source: MedicineNet Cancer General)
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Title: docetaxel (Taxotere, Docefrez)Category: MedicationsCreated: 3/12/2000 12:00:00 AMLast Editorial Review: 8/22/2019 12:00:00 AM (Source: MedicineNet Cancer General)
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Title: nilotinib (Tasigna)Category: MedicationsCreated: 10/14/2011 12:00:00 AMLast Editorial Review: 8/22/2019 12:00:00 AM (Source: MedicineNet Cancer General)
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Title: Health Tip: Risks of Secondhand SmokeCategory: Health NewsCreated: 8/22/2019 12:00:00 AMLast Editorial Review: 8/22/2019 12:00:00 AM (Source: MedicineNet Cancer General)
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Title: sargramostim (Leukine)Category: MedicationsCreated: 9/22/2000 12:00:00 AMLast Editorial Review: 8/22/2019 12:00:00 AM (Source: MedicineNet Cancer General)
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Nature Reviews Cancer, Published online: 27 August 2019; doi:10.1038/s41568-019-0185-xThis Analysis article examines the extent of genetic heterogeneity within several types of untreated cancers, with particular regard to its clinical relevance, and finds that the homogeneity of predicted functional mutations in driver genes is the rule rather than the exception.
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Nature Reviews Cancer, Published online: 27 August 2019; doi:10.1038/s41568-019-0180-2This Review discusses how circulating tumour cell (CTC) analysis at single-cell resolution provides unique insights into tumour heterogeneity that are not revealed by analysis of circulating tumour DNA (ctDNA) derived from liquid biopsies.
18h
Benign paroxysmal positional vertigo (BPPV) is a condition that commonly causes dizziness. Specific head movements may trigger symptoms, but people can usually treat BPPV with exercises and medication. Learn more here.
4h
Eye tracking tests help to distinguish between two subtypes of mild cognitive impairment and their respective risks of becoming Alzheimer's.
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New research shows how subtle natural fluctuations in resting brain activity most likely impact our inclination toward risk taking behaviors.
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Related ArticlesAnthocyanins of Blue Corn and Tortilla Arrest Cell Cycle and Induce Apoptosis on Breast and Prostate Cancer Cells. Nutr Cancer. 2019 Aug 26;:1-10 Authors: Herrera-Sotero MY, Cruz-Hernández CD, Oliart-Ros RM, Chávez-Servia JL, Guzmán-Gerónimo RI, González-Covarrubias V, Cruz-Burgos M, Rodríguez-Dorantes M Abstract Background: Breast and prostate cancer are frequently diagnosed neoplasias in women and men around the world. The signaling...
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Conclusions: This is the first report that suggest that anthocyanins from blue corn have an effect in cell cycle and viability so they could serve as adjuvants for breast and prostate cancer therapies and may prompt to deepen investigations to decipher its molecular properties. Abbreviations AR Androgen Receptor CIDIIR Interdisciplinary Center for Research on Integral Regional Development DHT 5α-Dihydrotestosterone ER Estrogen Receptor PR Progesterone Receptor QBS Amino-N-quinolin-8-yl-benzenesulfonamide....
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. (Source: Nutrition and Cancer)
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Related ArticlesComprehensive Profiling of Gene Copy Number Alterations Predicts Patient Prognosis in Resected Stages I-III Lung Adenocarcinoma. Front Oncol. 2019;9:556 Authors: Han X, Tan Q, Yang S, Li J, Xu J, Hao X, Hu X, Xing P, Liu Y, Lin L, Gui L, Qin Y, Yang J, Liu P, Wang X, Dai W, Lin D, Lin H, Shi Y Abstract Background: Lung adenocarcinoma (LUAD) possesses a poor prognosis with a low 5-year survival rate even for stages I-III resected patients,...
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Related ArticlesCharacterization of DLL3-positive circulating tumor cells (CTCs) in patients with small cell lung cancer (SCLC) and evaluation of their clinical relevance during front-line treatment. Lung Cancer. 2019 Sep;135:33-39 Authors: Messaritakis I, Nikolaou M, Koinis F, Politaki E, Koutsopoulos A, Lagoudaki E, Vetsika EK, Georgoulias V, Kotsakis A Abstract OBJECTIVES: The aim of the study was to characterize and evaluate the presence of DLL3-positive...
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Related ArticlesFatal adverse events in two thymoma patients treated with anti-PD-1 immune check point inhibitor and literature review. Lung Cancer. 2019 Sep;135:29-32 Authors: Konstantina T, Konstantinos R, Anastasios K, Anastasia M, Eleni L, Ioannis S, Sofia A, Dimitris M Abstract OBJECTIVES: Thymomas, as well as thymic carcinomas, are extremely rare tumors that arise from the thymus. The management of these tumors is primarily the complete surgical...
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Related ArticlesTargeting NF-κB-mediated inflammatory pathways in cisplatin-resistant NSCLC. Lung Cancer. 2019 Sep;135:217-227 Authors: Ryan SL, Beard S, Barr MP, Umezawa K, Heavey S, Godwin P, Gray SG, Cormican D, Finn SP, Gately KA, Davies AM, Thompson EW, Richard DJ, O'Byrne KJ, Adams MN, Baird AM Abstract OBJECTIVES: The majority of patients with non-small cell lung cancer (NSCLC) present with advanced stage disease, at which time chemotherapy is...
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Related ArticlesEfficacy and safety of first-line carboplatin-versus cisplatin-based chemotherapy for non-small cell lung cancer: A meta-analysis. Lung Cancer. 2019 Sep;135:196-204 Authors: Griesinger F, Korol EE, Kayaniyil S, Varol N, Ebner T, Goring SM Abstract OBJECTIVES: Platinum-based chemotherapy is the mainstay of first-line (1L) therapy for advanced non-small cell cancer (NSCLC). The objective of this study was to evaluate the relative efficacy,...
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Related ArticlesSafety and efficacy of pembrolizumab monotherapy in elderly patients with PD-L1-positive advanced non-small-cell lung cancer: Pooled analysis from the KEYNOTE-010, KEYNOTE-024, and KEYNOTE-042 studies. Lung Cancer. 2019 Sep;135:188-195 Authors: Nosaki K, Saka H, Hosomi Y, Baas P, de Castro G, Reck M, Wu YL, Brahmer JR, Felip E, Sawada T, Noguchi K, Han SR, Piperdi B, Kush DA, Lopes G Abstract OBJECTIVES: Most lung cancer diagnoses occur...
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Related ArticlesAberrant Expression of Folate Metabolism Enzymes and Its Diagnosis and Survival Prediction in Ovarian Carcinoma. Anal Cell Pathol (Amst). 2019;2019:1438628 Authors: Chen J, Li L Abstract This study was to validate changes in the levels of folate receptor-α (FOLR1), dihydrofolate reductase (DHFR), and methionine synthase reductase (MTRR) in the tissue of OC patients. The expression of FOLR1, DHFR, and MTRR was evaluated in 80 cases of...
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Related ArticlesA new non-dilution rapid desensitization protocol successfully applied to all-grade platinum hypersensitivity. Cancer Chemother Pharmacol. 2018 11;82(5):777-785 Authors: Chung SJ, Kang SY, Kang RY, Kim YC, Lee KH, Kim TY, Han SW, Kang HR Abstract PURPOSE: Desensitization is a safe alternative for patients with hypersensitivity reactions (HSRs) to platinum-based chemotherapeutic agents and widely used in real practice by employing stepwise...
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Related ArticlesClinical Stage IIA-IIC Seminoma: Radiation Therapy versus Systemic Chemotherapy versus Retroperitoneal Lymph Node Dissection. Oncol Res Treat. 2018;41(6):360-363 Authors: von Amsberg G, Hamilton R, Papachristofilou A Abstract BACKGROUND: Clinical stage II (CSII) seminoma is defined by the presence of pure seminoma accompanied by retroperitoneal lymph node metastases. In patients with bulky disease (lymph nodes > 5 cm in diameter),...
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Related ArticlesA giant fibrinoid pericardial mass in a patient with rheumatoid arthritis: a case report. Eur Heart J Case Rep. 2019 Jun 01;3(2): Authors: Cañas F, Lopez Ponce de León JD, Gomez JE, Cañas CA Abstract BACKGROUND : Rheumatoid arthritis (RA) is a chronic inflammatory disease of the joints, which may extend to extra-articular organs. Extra-articular manifestations have been considered as prognostic features in RA, and pericardial disease...
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Related ArticlesMultiple peritricuspidal reentry tachycardias after cardiac infiltration by leukaemia: a case report. Eur Heart J Case Rep. 2019 Jun 01;3(2): Authors: Kawamura I, Fukamizu S, Miyazawa S, Hojo R Abstract BACKGROUND: Cardiac involvement by malignant lymphocytic neoplasms is a rare phenomenon. Little is known concerning cardiotoxicity in the chronic phase after completion of treatment. CASE SUMMARY: A 50-year-old woman with a past...
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Related ArticlesMetastatic squamous cell carcinoma to the heart: an unusual cause of ST elevation-a case report. Eur Heart J Case Rep. 2019 Jun 01;3(2): Authors: Tandon V, Kethireddy N, Balakumaran K, Kim AS Abstract BACKGROUND: Cardiac tumours are typically secondary in nature, and the most common malignancies metastasizing to the heart are cancers of the lung, breast, oesophagus, melanoma, and lymphoma. We present a unique case of squamous cell carcinoma...
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Related ArticlesManagement of rare epithelial ovarian cancers. Clin Adv Hematol Oncol. 2019 Aug;17(8):444-446 Authors: Gershenson DM PMID: 31449512 [PubMed - in process]
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Related ArticlesSafety and Efficacy of Venting Gastrostomy in Malignant Bowel Obstruction: A Systematic Review. J Palliat Care. 2019 Aug 25;:825859719864915 Authors: Thampy S, Mullan D, Najran P, Laasch HU Abstract Malignant bowel obstruction (MBO) is a common manifestation in patients with advanced intra-abdominal malignancy. It is especially common with bowel or gynecological cancers and produces distressing symptoms, including nausea, vomiting, and...
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Related ArticlesRadiation-induced angiosarcoma of the breast: A review. Breast J. 2019 Aug 25;: Authors: Bonito FJP, de Almeida Cerejeira D, Dahlstedt-Ferreira C, Oliveira Coelho H, Rosas R Abstract Angiosarcoma is a rare, aggressive malignant vascular neoplasm with poor prognosis that has a predilection for skin and superficial soft tissue. It can arise spontaneously or in association with factors like chronic lymphedema or radiation therapy. Radiotherapy...
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Related ArticlesTwo-year disease remission of an unresectable basaloid thymic carcinoma with second line chemotherapy drugs: report of a case. Pan Afr Med J. 2019;33:53 Authors: Buero A, Quadrelli S, Pankl LG, Vigovich F Abstract Thymic carcinomas are extremely infrequent neoplasms (15% of all thymic epithelial tumors). Basaloid carcinoma is a peculiar tumor that represents no more than 2% of those infrequent thymic carcinomas. Surgical excision is the...
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Related Articles[Intramedullary lipoma: about a case]. Pan Afr Med J. 2018;31:244 Authors: Wakrim S, Touil N, Traore O, Kacimi O, Chikhaoui N Abstract Intramedullary lipomas are rare benign lesions accounting for approximately 1% of bone marrow cancers. We report a new case of histologically confirmed non-dysraphic intramedullary lipoma. The study involved a 46-year old female patient who had undergone surgical biopsy for medullary lipoma 6 months before...
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Related ArticlesLung cancers associated with cystic airspaces: CT features and pathologic correlation. Lung Cancer. 2019 Sep;135:110-115 Authors: Shen Y, Xu X, Zhang Y, Li W, Dai J, Jiang S, Wu T, Cai H, Sihoe A, Shi J, Jiang G Abstract OBJECTIVE: Lung cancer associated with cystic airspaces (LCCA) is a rare entity. The diagnosis and treatment is often delayed due to lack of comprehension of this disease. We aimed to elucidate LCCA's clinicopathological...
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Related Articles[Collision tumor in the hypopharynx: a case report]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Aug;33(8):775-777 Authors: Wen F, Shen H, Zhao NM Abstract SummaryA collision tumor consists of two different histologically distinct and topographically independent tumors merging in the same mass. In the head and neck area, they are rare and only a few cases have been reported in the hypopharynx. It is difficult to choose to treat...
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Related ArticlesClinical and etiologic characteristics of de novo uveitis in patients aged 60 years and above: experience of a French tertiary center. Graefes Arch Clin Exp Ophthalmol. 2019 Sep;257(9):1971-1979 Authors: Grumet P, Kerever S, Gilbert T, Kodjikian L, Gerfaud-Valentin M, De Parisot A, Jamilloux Y, Sève P Abstract PURPOSE: To describe the characteristics of de novo uveitis in patients â¥â60 years old. METHODS: Retrospective review...
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Related ArticlesIntraoperative tumor lysis syndrome in a giant teratoma: a case report. BMC Surg. 2019 Jun 14;19(1):62 Authors: Pindak D, Rejlekova K, Tomas M, Aziri R, Rovenska E, Puskacova J, Mego M Abstract BACKGROUND: Tumor lysis syndrome is an unusual metabolic emergency in solid tumors. Perioperative occurrence of this syndrome is extremely rare but may have fatal consequences if not detected and treated on time. CASE REPORT: We report...
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Related Articles[Clinicopathological analysis of 40 cases of salivary duct carcinoma]. Zhonghua Kou Qiang Yi Xue Za Zhi. 2019 Jun 09;54(6):416-419 Authors: Lin N, Cai JH, Xu MJ, Kang P, Cheng ZF, He W Abstract Objective: To investigate the clinical manifestations and pathological changes of salivary duct carcinoma (SDC) and the relationship between them, so as to provide reference for the diagnosis of SDC. Methods: In this retrospective analysis 40...
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Related ArticlesBasal Ganglionic Germinoma With Syncytiotrophoblastic Giant Cells Mimicking a Growing Hematoma. J Craniofac Surg. 2019 Jun;30(4):e306-e308 Authors: Yan J, Zhang Y, Yang Y, Yuan X, Xiao H, Niu J, Gu Y Abstract Basal ganglionic germinoma (BGG) with syncytiotrophoblastic giant cells (STGC) is a rare type of ectopic germ cell tumors with mild elevation of human chorionic gonadotropin level. Intratumoral hemorrhage is not uncommon for BGG,...
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Related ArticlesCervical Thymic Cyst Around Hypoglossal Nerve. J Craniofac Surg. 2019 Jun;30(4):e295-e297 Authors: Atalay F, Kars A, Ãnder MOK, Gözeler MS, Demirci E Abstract Cervical thymic cyst is rare lesions leading to cervical mass. As it is a rare entity, it might be confused with other congenital neck masses or neoplastic lesions. Preoperative diagnosis is almost impossible. In the present study, a patient who was operated with prediagnosis...
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Related ArticlesHemangiomatosis of the greater omentum - a case report. Rozhl Chir. 2019;98(4):178-180 Authors: VyÄÃtal O, LiÅ¡ka V, Hadravská Å , TÅeÅ¡ka V Abstract Cavernous hemangiomas are benign tumours of mesodermal origin. Even though various localizations of hemangioma have been described in the literature, its occurrence in the greater omentum is very rare. Only symptomatic hemangiomas are indicated for surgical treatment. There are case...
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Related ArticlesLiver abscess as a rare complication of PEG. Rozhl Chir. 2019;98(5):219-222 Authors: Smolár M, MikolajÄÃk A, Dedinská I, HoÅ¡ala M, Laca Ľ Abstract INTRODUCTION: Percutaneous endoscopic gastrostomy (PEG) is one of the most effective methods of providing long-term enteral nutrition in patients with the impossibility of oral intake. Complications are relatively common. The most common is peristomal wound infection at the site of the...
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Related ArticlesRare causes of acute appendicitis. Rozhl Chir. 2019;98(5):189-193 Authors: ÅÃha I, TÅeÅ¡ka V, Nosek J, Å mÃd D, SluneÄko R Abstract INTRODUCTION: A clinical diagnosis of acute appendicitis does not necessarily imply only inflammatory changes found upon histopathological examination. Even though appendiceal tumors are very rare, accounting for less than 4% of all gastrointestinal tumors‚ they need to be taken into account and require...
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Related ArticlesDetection of NRG1 Gene Fusions in Solid Tumors. Clin Cancer Res. 2019 Aug 15;25(16):4966-4972 Authors: Jonna S, Feldman RA, Swensen J, Gatalica Z, Korn WM, Borghaei H, Ma PC, Nieva JJ, Spira AI, Vanderwalde AM, Wozniak AJ, Kim ES, Liu SV Abstract PURPOSE: NRG1 gene fusions are rare but potentially actionable oncogenic drivers that are present in some solid tumors. Details regarding the incidence of these gene rearrangements are lacking....
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Related ArticlesA Rare Case of Liver Tumor. Gastroenterology. 2019 08;157(2):e5-e7 Authors: Zhuang BW, Wang W, Xie XY PMID: 30959030 [PubMed - indexed for MEDLINE]
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Related ArticlesSUCCESSFUL TREATMENT OF A PROLACTINOMA (CASE REPORT). Georgian Med News. 2019 Feb;(287):26-29 Authors: Pasyechko N, Naumova L, Krytskyy T, Kulchinska V Abstract Currently, lots of young couples are facing infertility. One of the relatively rare causes of female infertility is prolactinoma - hormonally active pituitary tumor that secretes excessive quantity of prolactin. Excessive prolactin production is leading to anovulation and women...
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Related ArticlesDroplet digital PCR as a novel system for the detection of microRNAâ34b/c methylation in circulating DNA in malignant pleural mesothelioma. Int J Oncol. 2019 Jun;54(6):2139-2148 Authors: Sato H, Soh J, Aoe K, Fujimoto N, Tanaka S, Namba K, Torigoe H, Shien K, Yamamoto H, Tomida S, Tao H, Okabe K, Kishimoto T, Toyooka S Abstract Malignant pleural mesothelioma (MPM) is a rare malignancy arising from the pleura that is difficult to diagnose,...
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Related ArticlesPainless Skin Nodule on the Finger of an 18-Year-Old: Answer. Am J Dermatopathol. 2019 Apr;41(4):312-313 Authors: Olofson AM, Yan S, Linos K PMID: 30893079 [PubMed - indexed for MEDLINE]
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Related ArticlesHighly multiplexed profiling of cell surface proteins on single circulating tumor cells based on antibody and cellular barcoding. Anal Bioanal Chem. 2019 Aug;411(21):5373-5382 Authors: Wang C, Yang L, Wang Z, He J, Shi Q Abstract Circulating tumor cells (CTCs) are extraordinarily rare in blood samples and represent a real-time "liquid biopsy" of tumors. Although genetic and transcriptional sequencing of single CTCs has been reported,...
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Related ArticlesNew onset transverse myelitis diagnostic accuracy and patient experiences. Mult Scler Relat Disord. 2019 May;30:42-44 Authors: Greenberg BM, Krishnan C, Harder L Abstract IMPORTANCE: Patients afflicted with rare diseases often have a delay in diagnosis and treatment. Understanding the prevalence and impact of delayed diagnosis in transverse myelitis could trigger directed educational initiatives to increase clinician awareness and improve...
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Related Articles[Molecular cytogenetic characterization of five patients with myeloid leukemia and t(12;22)(p13;q12)]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2019 Feb 10;36(2):112-115 Authors: Shao H, Yang Q, Gong Y, Bai S, Zhang J, Wang Y, Shen J, Wu C, Qiu H, Chen S, Pan J Abstract OBJECTIVE: To explore the clinical and laboratory characteristics of 5 patients with myeloid leukemia and t(12;22)(p13;q12). METHODS: Bone marrow cells were cultured...
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Related ArticlesCannabidiol modulates phosphorylated rpS6 signalling in a zebrafish model of Tuberous Sclerosis Complex. Behav Brain Res. 2019 05 02;363:135-144 Authors: Serra I, Scheldeman C, Bazelot M, Whalley BJ, Dallas ML, de Witte PAM, Williams CM Abstract Tuberous sclerosis complex (TSC) is a rare disease caused by mutations in the TSC1 or TSC2 genes and is characterized by widespread tumour growth, intractable epilepsy, cognitive deficits and...
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Related ArticlesPatterns of infiltration and local recurrences of various types of cutaneous sarcomas following three-dimensional histology. J Dtsch Dermatol Ges. 2018 Dec;16(12):1434-1442 Authors: Welsch K, Breuninger H, Metzler G, Sickinger F, Eberle FC, Häfner HM, Schnabl SM Abstract BACKGROUND: Cutaneous sarcomas are rare and characterized by pathogenetic heterogeneity. Knowledge about local infiltration patterns and recurrence rates may be useful...
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Related ArticlesBoosting care and knowledge about hereditary cancer: European Reference Network on Genetic Tumour Risk Syndromes. Fam Cancer. 2019 04;18(2):281-284 Authors: Vos JR, Giepmans L, Röhl C, Geverink N, Hoogerbrugge N, ERN GENTURIS Abstract Approximately 27-36 million patients in Europe have one of the ~â5.000-8.000 known rare diseases. These patients often do not receive the care they need or they have a substantial delay from diagnosis...
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Related ArticlesTubular apocrine adenoma: A rare and controversial tumor. J Dermatol. 2019 Jan;46(1):e45-e46 Authors: Cortés-Pinto C, SanmartÃn Novell V, Vilardell Vilellas F, Casanova Seuma JM PMID: 29863779 [PubMed - indexed for MEDLINE]
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Related ArticlesPalmoplantar lichen planus-like eruption in a patient with graft-versus-host disease: Is it rare presentation of chronic graft-versus-host disease? J Dermatol. 2018 Dec;45(12):e330-e331 Authors: Hwang S, Oh SH, Lee SH PMID: 29781533 [PubMed - indexed for MEDLINE]
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Related ArticlesAnti-PD-1 Therapy Leads to Near-Complete Remission in a Patient with Metastatic Basal Cell Carcinoma. Oncol Res Treat. 2018;41(6):391-394 Authors: Fischer S, Ali OH, Jochum W, Kluckert T, Flatz L, Siano M Abstract BACKGROUND: Metastatic basal cell carcinoma is rare and the prognosis is poor, with a lack of established treatment options for patients progressing on or after treatment with inhibitors of the hedgehog signaling pathway....
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Related ArticlesGenome sequencing in the clinic: the past, present, and future of genomic medicine. Physiol Genomics. 2018 08 01;50(8):563-579 Authors: Prokop JW, May T, Strong K, Bilinovich SM, Bupp C, Rajasekaran S, Worthey EA, Lazar J Abstract Genomic sequencing has undergone massive expansion in the past 10 yr, from a rarely used research tool into an approach that has broad applications in a clinical setting. From rare disease to cancer, genomics...
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Related ArticlesThree-dimensional microfluidic chip with twin-layer herringbone structure for high efficient tumor cell capture and release via antibody-conjugated magnetic microbeads. Electrophoresis. 2018 06;39(12):1452-1459 Authors: Zhang L, Xu Z, Kang Y, Xue P Abstract Harvesting rare circulating tumor cells (CTCs) from human blood is distinctly substantial to monitor tumor stage and evaluate therapeutic efficacy. As a proof-of-concept study, a microfluidic...
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Related Articles[Pai syndrome: Two new cases with unusual manifestations]. Arch Argent Pediatr. 2018 Apr 01;116(2):e336-e340 Authors: Huckstadt V, Heis Mendoza ME, Moresco A, Obregon MG Abstract Pai syndrome is a very rare congenital disorder characterized by medial cleft lip, nasal and facial cutaneous polyps, and pericallosal lipoma. Broad phenotypic variability exists in this condition. Neurodevelopment is usually normal. Up to date 42 cases have...
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Related Articles[Atypical presentation of a giant prolactinoma in a 15-year-old boy]. Arch Argent Pediatr. 2018 Apr 01;116(2):e325-e330 Authors: Vaiani E, Morales C, Soto F, Blanco Y, Rugilo C, Ciaccio M, Belgorosky A Abstract Giant prolactinomas are rare pituitary adenomas characterized by their great local invasion. In this paper, we report a 15-year-old male with left retro-ocular pain and ipsilateral exophthalmos of 4 months of evolution, secondary...
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Related ArticlesA Unique Case of Dermatofibrosarcoma Protuberans With Melanocytic Differentiation. Am J Dermatopathol. 2019 Apr;41(4):317-319 Authors: Gru AA, Wick MR, Dai H PMID: 29474191 [PubMed - indexed for MEDLINE]
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Related ArticlesSurgical Management of Life Threatening Bleeding after Endoscopic Cystogastrostomy. J Invest Surg. 2018 Dec;31(6):503-508 Authors: George A, Panwar R, Pal S Abstract Postprocedural bleeding is a rare but life threatening complication of endoscopic cystogastrostomy which may require surgical management in some patients. The presence of adhesions and inflammation due to antecedent acute pancreatitis, difficult location of the bleeding...
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Related ArticlesCostal graft as a support for bone regeneration after mandibular juvenile ossifying fibroma resection: An unusual case report. J Stomatol Oral Maxillofac Surg. 2017 Oct;118(5):320-325 Authors: Fauvel F, Pace R, Grimaud F, Marion F, Corre P, Piot B Abstract Spontaneous regeneration of bone tissue after mandibular resection is rare in adults, although it does often take place in children. Periosteum conservation appears to play a major...
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Related ArticlesClassification proposed of malignant intraosseous odontogenic tumors (MIOT). J Stomatol Oral Maxillofac Surg. 2017 Jun;118(3):143-146 Authors: Zwetyenga N, Broly E, Guillier D, Hallier A, Levasseur J, Moris V Abstract Malignant intraosseous odontogenic tumors (MIOT) of the jaws are very rare. The diagnosis is difficult. Clinical, paraclinical and histological diagnostic criteria, strict are well established. But the International Union...
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Related ArticlesNasal glial heterotopia or congenital hemangioma? A case report. J Stomatol Oral Maxillofac Surg. 2017 Oct;118(5):298-301 Authors: Lartizien R, Durand C, Blaise S, Morand B Abstract Nasal glial heterotopia (NGH) is a rare benign tumor of the median line. We describe the case of a child presenting a lateral nasal mass. The characteristics of the prenatal ultrasound and the postnatal clinical examination argued in favor of a congenital...
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Related ArticlesBi-maxillary dentigerous cyst in a non-syndromic child - review of literature with a case presentation. J Stomatol Oral Maxillofac Surg. 2017 Feb;118(1):45-48 Authors: Dhupar A, Yadav S, Dhupar V, Mittal HC, Malik S, Rana P Abstract Dentigerous cysts are the most common developmental odontogenic cysts of the jaw, which usually occur in the second and third decade of life. It is most frequently associated with impacted mandibular third...
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Related ArticlesImaging of spontaneous intraventricular rupture of a septum pellucidum colloid cyst: case report. J Neurosurg. 2017 Jun;126(6):1779-1782 Authors: Westwick HJ, Obaid S, Morin-Roy F, Champagne PO, Bouthillier A Abstract Intraventricular rupture of a colloid cyst is a rare phenomenon and has been proposed as a mechanism for sudden death in patients with colloid cysts. Imaging of a colloid cyst during rupture has been described in only one...
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Related ArticlesEosinophilic meningitis triggered by implanted Gliadel wafers: case report. J Neurosurg. 2017 Jun;126(6):1783-1787 Authors: Saito K, Yamasaki K, Yokogami K, Ivanova A, Takeishi G, Sato Y, Takeshima H Abstract Although carmustine (Gliadel) wafers improve local tumor control and extend the overall survival in patients with malignant glioma, adverse effects have been documented. The authors report the first case of eosinophilic meningitis...
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Bosses like me can fix that -- Read more on ScientificAmerican.com
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The NIH Director showcases a project to develop a brain implant that would restore sight -- Read more on ScientificAmerican.com
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Prescribed burns can remove excess fuel from the forest floor, and algorithms can help fire crews know where to set them -- Read more on ScientificAmerican.com
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E' tornato in Italia Gianpiero Saglimbene. Dopo 50 lunghi giorni trascorsi al Presbyterian Hospital di New York, negli Stati Uniti, dove è stato sottoposto ad un delicatissimo intervento per sconfiggere una grave...
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Cancer control in low and middle income countries: New solutions to evolving challenges - join our collaborators… https://t.co/WXEJ2Dlh6U
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Our new review presents a holistic health services perspective towards managing patients with #melanoma of the skin… https://t.co/pBKOy9yRtb
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