This article summarizes the milestones in the development of selinexor leading to this first approval for RRMM. (Source: Drugs)
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Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, EarlyView. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
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This article contributes to distributive environmental justice (EJ) research on air pollution by analyzing racial/ethnic and related intra-categorical disparities in health risk from exposure to on-road hazardous air pollutants (HAPs) in Harris County, Texas. Previous studies in this urban area have not examined intra-ethnic heterogeneity in EJ outcomes or disproportionate exposure to vehicular pollutants. Our goal was to determine how the EJ implications of cancer risk from exposure to on-road HAP...
23h
We appreciate the interest that Roncati and Piscioli showed in our recent publication, in which we evaluated the risk of sentinel lymph node (SLN) metastases in nonulcerated, T1b melanoma by the new 8th edition American Joint Committee on Cancer (AJCC) staging criteria.1 The authors propose a model of melanoma progression based on the transition from a radial growth phase to a vertical growth phase (VGP) that can predict biologic aggressiveness and propensity to metastasize. (Source: Journal of the...
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In comparison with the 7th Edition, the 8th Edition of the American Joint Committee on Cancer (AJCC) staging system for melanoma no longer considers the mitotic count in the a or b T1 categorization, but it adopts a sub-stratification based on Breslow depth: T1a ≤ 0.8 mm without ulceration and T1b ≤ 0.8 mm with ulceration or 0.8 to 1 mm with or without ulceration. Skin melanoma can be subdivided by Breslow depth into thin melanoma (≤1 mm) or thick melanoma (>1 mm). According to the AJCC 8th Edition,...
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Pulmonary embolism (PE) is one of the most common causes of cardiovascular death. The most often PE etiology is a deep vein thrombosis (DVT) of the lower extremities, but embolic material can arise in pelvic or upper extremity veins as well as in right heart chambers. There is growing number of evidences of atrial fibrillation (AF) involvement in PE. The presence of AF in patients with PE may be both the cause and the consequence of PE. The PE association with AF should be considered in patients...
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In the biomedical field, there is growing interest in using human stem cell-derived neurons as in vitro models for pharmacological and toxicological screening of bioactive compounds extracted from natural products. Lignosus rhinocerus (Tiger Milk Mushroom) is used by indigenous communities in Malaysia as a traditional medicine to treat various diseases. The sclerotium of L. rhinocerus has been reported to have medicinal properties, including various bioactivities such as neuritogenic, anti-inflammatory,...
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We previously demonstrated that angiotensin-(1-7) (Ang-(1-7)), an essential endocrine factor, inhibits the NLRP3 inflammasome by regulating reactive oxygen species (ROS) in fibrotic livers. We also demonstrated that the NLRP3 inflammasome contributes to the liver damage induced by pyroptosis after heatstroke. However, the role of Ang-(1-7) in the hepatocytes under heat stress remains uncertain. We aimed to examine the change in angiotensin peptides in the livers affected by heatstroke and the effect...
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Diabetic foot ulcer (DFU) is a complication experienced by diabetic patients and does not heal well in an altered wound environment. Although diverse microbes in DFU were detected, little is known about their influences on diabetic foot wound (DFW) and the association with the skin microbiota in normal tissue from the same patients according to clinical features. We aimed to analyze the microbiota in normal skin and DFW tissue from the same subject and predict their roles based on clinical features....
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Objective. This study aimed to examine the effect of pelvic floor muscle training on the irisin (Ir) concentration in overweight or obese elderly women with stress urinary incontinence. Methods. The number of participants included in analysis was 49: 28 women in the experimental group and 21 women in the control group. The experimental group (EG) underwent pelvic floor muscle training, whereas no therapeutic intervention was applied to the control group (CG). Irisin concentration, severity of urinary...
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Periodontal bone regeneration relies on coupled and cooperative bone formation and resorption. Accordingly a novel strategy on concurrent use of platelet-rich fibrin (PRF) (anabolic agent) and 1% alendronate (ALN) (anticatabolic agent) was proposed recently in regenerative periodontal treatment. It was supposed to enhance bone formation and reduce bone resorption simultaneously. However, there is a lack of evidence-based studies to answer whether this concurrent application was superior to single...
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Objective. The blood of cancer patients is in a state of hypercoagulability, easily leading to thrombosis. Anemia is also a complication of tumors. Anemia and thrombosis affect the treatment of tumor patients. Methods. Ginsenosides Rb were extracted from the stems and leaves of American ginseng using water-saturated ethanol and ethyl acetate in silica gel column. Tumor mice model was established by injecting H22 hepatocellular carcinoma cells into the axilla of mice. Mice were randomly divided into...
20h
The incidence and rates of diagnosis of drug-induced liver injury (DILI) have been increasing in recent years as findings from basic research and the examination of clinical databases reveal information about the clinical course, etiology, and prognosis of this complex disease. The prevalence of metabolic comorbidities (e.g., diabetes mellitus, fatty liver, obesity, and metabolic syndrome (MetS)) has been increasing during the same period. The results of preclinical and clinical research studies...
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Cdc2-like kinases (CLKs) play a crucial role in the alternative splicing of eukaryotic pre-mRNAs through the phosphorylation of serine/arginine-rich proteins (SR proteins). Dysregulation of this processes is linked with various diseases including cancers, neurodegenerative diseases, and many genetic diseases. Thus, CLKs have been regarded to have a potential as a therapeutic target and significant efforts have been exerted to discover an effective inhibitor. In particular, the small molecule CX-4945,...
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Although significant advances have been made in synthetic nerve conduits and surgical techniques, complete regeneration following peripheral nerve injury (PNI) remains far from optimized. The repair of PNI is a highly heterogeneous process involving changes in Schwann cell phenotypes, the activation of macrophages, and the reconstruction of the vascular network. At present, the efficacy of MSC-based therapeutic strategies for PNI can be attributed to paracrine secretion. Exosomes, as a product of...
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Diffusion-weighted imaging (DWI) of the breast offers enormous future potential...Read more on AuntMinnieEurope.comRelated Reading: Use DWI to streamline breast MRI protocols Breast MRI can identify positive tumor margins Dutch shed light on pros and cons of breast MRI Kuhl brings the curtain down in Montreal Breast MRI equally proficient at 1.5T and 3T
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Background. Control of anemia can be achieved with early detection of pallor by parents at home. However, most parents lack the capacity to recognize pallor; thus most cases of anaemia are detected during hospital visit due to other symptoms. This study aimed to evaluate parental ability to detect pallor when aided with the anaemia screening tool. Methods. In the study information on the symptoms of illness and parental knowledge on anaemia. Their ability to detect anaemia aided with the Home-Base...
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The Jordan decomposition of matrix is a typical scientific and engineering computational task, but such computation involves enormous computing resources for large matrices, which is burdensome for the resource-limited clients. Cloud computing enables computational resource-limited clients to economically outsource such problems to the cloud server. However, outsourcing Jordan decomposition of large-scale matrix to the cloud brings great security concerns and challenges since the matrices usually...
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Introduction. In cranioplasty, pinwheel-shaped titanium mini plates are frequently used to cover bone defects produced by burr holes, and it is common to insert screws through only a few of the holes in cranial flap fixation. Presentation of Case. A 69-year-old man who had undergone clipping surgery for subarachnoid hemorrhage 16 years previously visited our clinic because a titanium plate had penetrated his scalp one month after he was hit on the head by a wall cabinet. Imaging studies revealed...
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A novel systematic framework, infrared thermography- (IRT-) based method, for rotating machinery fault diagnosis under nonstationary running conditions is presented in this paper. In this framework, IRT technique is first applied to obtain the thermograph. Then, the fault features are extracted using bag-of-visual-word (BoVW) from the IRT images. In the end, support vector machine (SVM) is utilized to automatically identify the fault patterns of rotating machinery. The effectiveness of proposed method...
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A new internal substructure method for seismic wave input in soil-structure systems was recently proposed. This method simplifies the calculation of equivalent input seismic loads and avoids the participation of artificial boundaries in the process of seismic wave input. However, in previous research and applications, the internal substructures are usually intercepted down from the free surface, which forms large substructures and increases the computational effort for data management on the substructure...
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Objectives. The aim of this study was to analyse the composition of amyloid mass and the plasmacytic infiltrate of localized amyloidosis of the upper aerodigestive tract. Methods. Biopsy materials were studied by light microscopy, immunohistochemistry (IHC), and mRNA in situ hybridization (mRNA-ISH). The amyloid mass was also analysed with high-performance liquid chromatography mass spectrometry- (HPLC-MS-) based proteomics. Results. Nodular and diffuse forms of amyloid deposition were detected....
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In pathology or under damaging conditions, the properties of cell-free DNA (cfDNA) change. An example of such change is GC enrichment, which drastically alters the biological properties of cfDNA. GC-rich cfDNA is a factor of stress signaling, whereas genomic cfDNA is biologically inactive. GC-rich cfDNA stimulates TLR9-MyD88-NF-κB signaling cascade, leading to an increase in proinflammatory cytokine levels in the organism. In addition, GC-rich DNA is prone to oxidation and oxidized cfDNA can stimulate...
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Patients with end-stage renal disease (ESRD) have an increased risk of both impaired cognitive function and peripheral artery disease (PAD) than the general population. The association between PAD and dementia is recognized, but there are limited studies in patients with ESRD. The aim of this study was to evaluate the relationship between ankle-brachial index (ABI) and brachial-ankle pulse wave velocity (baPWV) and cognitive impairment in patients receiving hemodialysis (HD). We enrolled 136 prevalent...
2h
We constitute some necessary and sufficient conditions for the system ,,,,, to have a solution over the quaternion skew field in this paper. A novel expression of general solution to this system is also established when it has a solution. The least norm of the solution to this system is also researched in this article. Some former consequences can be regarded as particular cases of this article. Finally, we give determinantal representations (analogs of Cramer’s rule) of the least norm solution to...
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The mechanical properties of the water-assisted injection molded tube can be enhanced by the increase in the short fiber circumferential orientation (SFCO). Thus, the numerical method verified by experiments is used to simulate the SFCO distribution in the overflow water-assisted injection molding (OWAIM), with the mechanism of short fiber orientation analyzed as well. The effect of parameters (filling time, melt temperature, mold temperature, delay time, water pressure, and water temperature) on...
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Introduction. Abortion is termination of pregnancy before the viability of the pregnancy. It is one of the major causes for maternal mortality in the world and in Ethiopia. Unintended pregnancies which end up in abortion occur due to contraception method nonuse or misuse. To limit unintended pregnancies and avoid repeated abortions promoting immediate postabortion contraception is crucial. Objective. To assess the proportion of postabortion contraception acceptance among women who got abortion care...
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Ground penetrating radar (GPR), as a kind of fast, effective, and nondestructive tool, has been widely applied to nondestructive testing of road quality. The finite-difference time-domain method (FDTD) is the common numerical method studying the GPR wave propagation law in layered structure. However, the numerical accuracy and computational efficiency are not high because of the Courant-Friedrichs-Lewy (CFL) stability condition. In order to improve the accuracy and efficiency of FDTD simulation model,...
7h
The classical Bertrand game is assumed that players are perfectly rational. However, many empirical researches indicate that people have bounded rational behavior with fairness concern, which is important in the two-person game and has attracted much attention. In this paper, fairness concern is incorporated into the Bertrand game with two homogeneous products and the effect of fairness concern on this extended Bertrand game is explored. Nash bargaining solution of player is applied to be his own...
7h
The accurate identification of recurrent bottlenecks has been an important assumption of many studies on traffic congestion analysis and management. As one of the most widely used traffic detection devices, loop detectors can provide reliable multidimensional data for traffic bottleneck identification. Although great efforts have been put on developing bottleneck identification methods based on loop detector data, the existing studies are less informative with respect to providing accurate position...
17h
Dengue fever caused by dengue virus is a common tropical infection transmitted by the mosquitos Aedes aegypti and Aedes albopictus. Four strains of the genus flavivirus is responsible for the epidemics of varying severity. Hepatitis A caused by hepatitis A virus is spread by faecal-oral route. The culprit virus is a hepatovirus. Coinfection with dengue virus and hepatitis A virus is rare and is a diagnostic as well as management challenge to the medical professional. We report a patient who presented...
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This study was conducted to investigate the microbiological, physicochemical, and visual quality of dried persimmons (Diospyros kaki Thunb. cv. Cheongdo-Bansi) during storage at various temperatures in order to determine the shelf-life. Two commercial dried persimmon samples were evaluated for changes in weight, moisture content, color, texture (hardness and gumminess), and microbial populations during storage at different temperatures (−20, 5, 12, and 25°C) for 70 days. Overall, dried persimmon-2...
18h
This work reports an efficient method for the oxidation reaction of aliphatic, aromatic allylic, and benzylic alcohols into aldehydes catalyzed by the cyclopentadienyl ruthenium(II) complex (RuCpCl(PPh3)2) with bubbled O2. Through further optimizing controlled studies, the tendency order of oxidation reactivity was determined as follows: benzylic alcohols > aromatic allylic alcohols >> aliphatic alcohols. In addition, this method has several advantages, including a small amount of catalyst...
18h
Channel state information (CSI) feedback in massive MIMO systems is too large due to large pilot overhead. It is due to the large channel matrix dimension which depends on the number of base station (BS) antennas and consumes the majority of scarce radio resources. To solve this problem, we proposed a scheme for efficient CSI acquisition and reduced pilot overhead. It is based on the separation mechanism for the channel matrix. The spatial correlation among multiuser channel matrices in the virtual...
18h
Internet of things (IoT) is a new challenging paradigm for connecting heterogeneous networks. However, an explosive increase in the number of IoT cognitive users requires a mass of sensing reporting; thus, it increases complexity of the system. Moreover, bandwidth utilization, reporting time, and communication overhead arise. To realize spectrum sensing, how to collect sensing results by reducing the communication overhead and the reporting time is a problem of major concern in future wireless networks....
18h
In this paper, we develop a framework to estimate network flow length distributions in terms of the number of packets. We model the network flow length data as a three-way array with day-of-week, hour-of-day, and flow length as entities where we observe a count. In a high-speed network, only a sampled version of such an array can be observed and reconstructing the true flow statistics from fewer observations becomes a computational problem. We formulate the sampling process as matrix multiplication...
18h
In healthcare, the analysis of patients’ activities is one of the important factors that offer adequate information to provide better services for managing their illnesses well. Most of the human activity recognition (HAR) systems are completely reliant on recognition module/stage. The inspiration behind the recognition stage is the lack of enhancement in the learning method. In this study, we have proposed the usage of the hidden conditional random fields (HCRFs) for the human activity recognition...
19h
The bat algorithm (BA) is a heuristic algorithm that globally optimizes by simulating the bat echolocation behavior. In order to improve the search performance and further improve the convergence speed and optimization precision of the bat algorithm, an improved algorithm based on chaotic map is introduced, and the improved bat algorithm of Levy flight search strategy and contraction factor is proposed. The optimal chaotic map operator is selected based on the simulation experiments results. Then,...
19h
This paper focuses on an in-plane instability analysis of fixed arches under a linear temperature gradient field and a uniformly distributed radial load, which has not been reported in the literature. Combining a linear temperature gradient field and uniformly distributed radial load leads to the changes in axial expansion and curvature of arches, producing the complex in-plane nonuniform bending moment and axial force. Therefore, it is necessary to explore the in-plane thermoelastic mechanism behavior...
19h
In this paper, a digital elevation model (DEM) was produced for Lop Nur playa produced with the data from TanDEM-X mission. The spatial resolution is 10 m. It covers an area of 38,000 km2 for orthometric height from 785 m to 900 m above sea level, which is composed of 42 interferometric synthetic aperture radar (InSAR) scenes. A least-square adjustment approach was used to reduce the systematic errors in each DEM scene. The DEM produced was validated with data from other sensors including Ice, Cloud,...
19h
Background. Malaria remains a major worldwide public health problem leading to death of millions of people. Spread and emergence of antimalarial drug resistance are the major challenge in malaria control. Medicinal plants are the key source of new effective antimalarial agents. Cordia africana (Lam.) is widely used for traditional management of malaria by local people in different parts of Ethiopia. The present study aimed to evaluate in vivo antimalarial effects of leaf extracts and solvent fractions...
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Rheumatoid arthritis (RA) is a common chronic systemic autoimmune disease. Recent studies show that gut flora plays an important role in regulating the systemic immune response, and gut dysbacteria are linked with systemic chronic inflammation in the development of RA. Our previous results found that Qingluo Tongbi decoction (QLT) can treat RA effectively. The present study explored the effect of QLT on gut flora in an adjuvant-induced arthritis (AA) rat model. Thirty rats were divided randomly into...
19h
Adenoid cystic carcinomas of the Bartholin’s gland are extremely rare and are often misdiagnosed. There are currently no definite treatment guidelines. This article describes the case of a 33-year-old female who was managed at our centre for adenoid cystic carcinoma of the Bartholin’s gland. She presented with a prolonged history of a vulvar lesion which was eventually diagnosed as adenoid cystic carcinoma of the Bartholin’s gland. She was subsequently treated with wide local excision of the primary...
19h
Recovery of waste electrical and electronic equipment (WEEE) plays an important role in protecting environment and conserving resources. Design of a more efficient WEEE recovery system is an imperative need for the relevant decision-makers, such as alleviation of overcapacity or insufficient recycling in many developing countries. In this paper, we optimize the WEEE recovery network which is associated with recycling prices and government subsidies by a nonlinear mixed integer programming approach....
19h
Introduction. Rhythmic auditory stimulation (RAS) has successfully helped regulate gait for people with Parkinson’s disease. However, the way in which different auditory cues and types of movements affect entrainment, synchronization, and pacing stability has not been directly compared in different aged people with and without Parkinson’s. Therefore, this study compared music and metronomes (cue types) in finger tapping, toe tapping, and stepping on the spot tasks to explore the potential of RAS...
21h
Organophosphates are commonly used in rural, agricultural communities worldwide. Poisoning in Nepal is commonly a result of suicide attempt via ingestion with a mortality rate of 41 times higher than in the United States even after appropriate treatment. The patient discussed in this case is a 46-year-old Nepalese female with a complicated psychosocial history that presented with a suicide attempt via organophosphate ingestion. She required higher doses and greater lengths of treatment of atropine...
21h
In the last years the reputation of medical, economic, and scientific expertise has been strongly damaged by a series of false predictions and contradictory studies. The lax application of statistical principles has certainly contributed to the uncertainty and loss of confidence in the sciences. Various assumptions, generally held as valid in statistical treatments, have proved their limits. In particular, since some time it has emerged quite clearly that even slightly departures from normality and...
22h
There has been an increasing interest in the search for colour indicators of natural origin for titrimetric analysis. This is due to some challenges associated with the currently used synthetic ones. This study evaluates and validates the acid-base indicator property of plumbagin isolated from Plumbago zeylanica Linn. Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) was isolated from the roots of Plumbago zeylanica Linn using silica gel chromatography and characterized using spectroscopic methods...
23h
The aim of this paper consists in the derivation of an analytic formula for the hydraulic resistance of capillaries, taking into account the tube hematocrit level. The consistency of the derived formula is verified using Finite Element simulations. Such an effective formula allows for assigning resistances, depending on the hematocrit level, to the edges of networks modeling biological capillary systems, which extends our earlier models of blood flow through large capillary networks. Numerical simulations...
23h
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