Genes, Vol. 10, Pages 623: Integration of Transcriptomes, Small RNAs, and Degradome Sequencing to Identify Putative miRNAs and their Targets Related to Eu-Rubber Biosynthesis in Eucommia ulmoides Genes doi: 10.3390/genes10080623 Authors: Jing Ye Wenjing Han Ruisheng Fan Minhao Liu Long Li Xiaoming Jia Eucommia ulmoides has attracted much attention as a valuable natural rubber (Eu-rubber) production tree. As a strategic material, Eu-rubber plays a vital role in general...
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Genes, Vol. 10, Pages 622: The Molecular Evolution of Circadian Clock Genes in Spotted Gar (Lepisosteus oculatus) Genes doi: 10.3390/genes10080622 Authors: Yi Sun Chao Liu Moli Huang Jian Huang Changhong Liu Jiguang Zhang John H. Postlethwait Han Wang Circadian rhythms are biological rhythms with a period of approximately 24 h. While canonical circadian clock genes and their regulatory mechanisms appear highly conserved, the evolution of clock gene families is still...
1h
Genes, Vol. 10, Pages 621: The Role of the HOXA Gene Family in Acute Myeloid Leukemia Genes doi: 10.3390/genes10080621 Authors: Si-Liang Chen Zhe-Yuan Qin Fang Hu Yun Wang Yu-Jun Dai Yang Liang The HOXA gene family is associated with various cancer types. However, the role of HOXA genes in acute myeloid leukemia (AML) have not been comprehensively studied. We compared the transcriptional expression, survival data, and network analysis of HOXA-associated signaling pathways...
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Genes, Vol. 10, Pages 620: Transcriptome Landscape Variation in the Genus Thymus Genes doi: 10.3390/genes10080620 Authors: Aboozar Soorni Tahereh Borna Ali Alemardan Manohar Chakrabarti Arthur G. Hunt Aureliano Bombarely Among the Lamiaceae family, the genus Thymus is an economically important genera due to its medicinal and aromatic properties. Most Thymus molecular research has focused on the determining the phylogenetic relationships between different species, but no...
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Genes, Vol. 10, Pages 619: Cloning and Functional Analysis of Lignin Biosynthesis Genes Cf4CL and CfCCoAOMT in Cryptomeria fortunei Genes doi: 10.3390/genes10080619 Authors: Zhenhao Guo Hui Hua Jin Xu Jiaxing Mo Hui Zhao Junjie Yang Cryptomeria fortunei, also known as the Chinese cedar, is an important timber species in southern China. The primary component of its woody tissues is lignin, mainly present in secondary cell walls. Therefore, continuous lignin synthesis is...
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Genes, Vol. 10, Pages 617: Global Investigation of Cytochrome P450 Genes in the Chicken Genome Genes doi: 10.3390/genes10080617 Authors: Junxiao Ren Liyu Yang Quanlin Li Qinghe Zhang Congjiao Sun Xiaojun Liu Ning Yang Cytochrome P450 (CYP) superfamily enzymes are broadly involved in a variety of physiological and toxicological processes. However, genome-wide analysis of this superfamily has never been investigated in the chicken genome. In this study, genome-wide analyses...
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Genes, Vol. 10, Pages 618: Host Invasion by Pathogenic Amoebae: Epithelial Disruption by Parasite Proteins Genes doi: 10.3390/genes10080618 Authors: Abigail Betanzos Cecilia Bañuelos Esther Orozco The epithelium represents the first and most extensive line of defence against pathogens, toxins and pollutant agents in humans. In general, pathogens have developed strategies to overcome this barrier and use it as an entrance to the organism. Entamoeba histolytica, Naegleria fowleri...
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Genes, Vol. 10, Pages 616: Molecular Characterization and Expression of SPP1, LAP3 and LCORL and Their Association with Growth Traits in Sheep Genes doi: 10.3390/genes10080616 Authors: Yongfu La Xiaoxue Zhang Fadi Li Deyin Zhang Chong Li Futao Mo Weimin Wang The SPP1, LAP3, and LCORL are located on chromosome 6 of sheep and a domain of 36.15-38.56 Mb, which plays an essential role in tissue and embryonic growth. In this study, we cloned the complete coding sequences...
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Genes, Vol. 10, Pages 615: Transcriptomic Analysis of Porcine Granulosa Cells Overexpressing Retinol Binding Protein 4 Genes doi: 10.3390/genes10080615 Authors: Zhao Li Zhou Retinol binding protein 4 (RBP4), mainly secreted by the liver and adipocytes, is a transporter of vitamin A. RBP4 has been shown to be involved in several pathophysiological processes, such as obesity, insulin resistance, and cardiovascular risk. Reports have indicated the high expression levels of RBP4...
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Genes, Vol. 10, Pages 612: Identification of Key Genes and Pathways in Pancreatic Cancer Gene Expression Profile by Integrative Analysis Genes doi: 10.3390/genes10080612 Authors: Wenzong Lu Ning Li Fuyuan Liao Background: Pancreatic cancer is one of the malignant tumors that threaten human health. Methods: The gene expression profiles of GSE15471, GSE19650, GSE32676 and GSE71989 were downloaded from the gene expression omnibus database including pancreatic cancer and normal samples....
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Genes, Vol. 10, Pages 613: Meta-Analysis of Cancer Triploidy: Rearrangements of Genome Complements in Male Human Tumors Are Characterized by XXY Karyotypes Genes doi: 10.3390/genes10080613 Authors: Ninel M. Vainshelbaum Pawel Zayakin Regina Kleina Alessandro Giuliani Jekaterina Erenpreisa Triploidy in cancer is associated with poor prognosis, but its origins remain unclear. Here, we attempted to differentiate between random chromosomal and whole-genome origins of cancer triploidy....
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Genes, Vol. 10, Pages 614: A Critical Review of Animal Models Used in Acute Myeloid Leukemia Pathophysiology Genes doi: 10.3390/genes10080614 Authors: Hala Skayneh Batoul Jishi Rita Hleihel Maguy Hamieh Nadine Darwiche Ali Bazarbachi Marwan El Sabban Hiba El Hajj Acute myeloid leukemia (AML) is one of the most frequent, complex, and heterogeneous hematological malignancies. AML prognosis largely depends on acquired cytogenetic, epigenetic, and molecular abnormalities....
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Genes, Vol. 10, Pages 611: Multi-Objective Optimized Fuzzy Clustering for Detecting Cell Clusters from Single-Cell Expression Profiles Genes doi: 10.3390/genes10080611 Authors: Saurav Mallik Zhongming Zhao Rapid advance in single-cell RNA sequencing (scRNA-seq) allows measurement of the expression of genes at single-cell resolution in complex disease or tissue. While many methods have been developed to detect cell clusters from the scRNA-seq data, this task currently remains a main...
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Genes, Vol. 10, Pages 608: DNILMF-LDA: Prediction of lncRNA-Disease Associations by Dual-Network Integrated Logistic Matrix Factorization and Bayesian Optimization Genes doi: 10.3390/genes10080608 Authors: Yan Li Junyi Li Naizheng Bian Identifying associations between lncRNAs and diseases can help understand disease-related lncRNAs and facilitate disease diagnosis and treatment. The dual-network integrated logistic matrix factorization (DNILMF) model has been used for drug–target...
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Genes, Vol. 10, Pages 606: Transcriptomic Analysis of the Influence of Methanol Assimilation on the Gene Expression in the Recombinant Pichia pastoris Producing Hirudin Variant 3 Genes doi: 10.3390/genes10080606 Authors: Li Ma Xu Wang Wang Shao Yang Huang Liu Hirudin and its variants, as strong inhibitors against thrombin, are present in the saliva of leeches and are recognized as potent anticoagulants. However, their yield is far from the clinical requirement...
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Genes, Vol. 10, Pages 609: Cellular and Molecular Mechanisms in the Pathogenesis of Classical, Vascular, and Hypermobile Ehlers‒Danlos Syndromes Genes doi: 10.3390/genes10080609 Authors: Nicola Chiarelli Marco Ritelli Nicoletta Zoppi Marina Colombi The Ehlers‒Danlos syndromes (EDS) constitute a heterogenous group of connective tissue disorders characterized by joint hypermobility, skin abnormalities, and vascular fragility. The latest nosology recognizes 13 types caused by pathogenic...
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Genes, Vol. 10, Pages 607: The Hot QTL Locations for Potassium, Calcium, and Magnesium Nutrition and Agronomic Traits at Seedling and Maturity Stages of Wheat under Different Potassium Treatments Genes doi: 10.3390/genes10080607 Authors: Shen Yuan Zhang Guo Zhao Li Kong Potassium (K) is one of the most important mineral nutrients for wheat. In this study, the effects of low K (LK) treatments and the quantitative trait loci (QTLs) for K, calcium (Ca), and magnesium...
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Genes, Vol. 10, Pages 610: Identification of Maize CC-Type Glutaredoxins That Are Associated with Response to Drought Stress Genes doi: 10.3390/genes10080610 Authors: Ding He Tang Du Wang Global maize cultivation is often adversely affected by drought stress. The CC-type glutaredoxin (GRX) genes form a plant-specific subfamily that regulate plant growth and respond to environmental stresses. However, how maize CC-type GRX (ZmGRXCC) genes respond to drought stress remains...
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Abstract Background To evaluate the prognostic role of interleukin-6 (IL-6) in renal cell carcinoma (RCC). Method Relevant research articles were obtained from literature databases. Data were extracted from study reports which reported IL-6 levels in relevance to RCC prognosis and random-effects meta-analyses were performed to estimate IL-6 levels, percentage...
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Background Follow-up with computed tomographic angiography is recommended after endovascular aneurysm repair, exposing patients to significant levels of radiation and iodine contrast medium. Dual-energy computed tomography allows virtual noncontrast (VNC) images to be reconstructed from contrast-enhanced images using a software algorithm. If the VNC images are a good-enough approximation of true noncontrast (TNC) images, a reduction in radiation dose can be ensured through omitting a TNC scan. ...
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Abstract Background High survival rates of 80‐90% have been reported in recent clinical trials of reduced‐intensity chemotherapies for children with acute myeloid leukemia and Down syndrome (AML‐DS). However, a certain number of children with AML‐DS have complicating comorbidities, including congenital heart disease (CHD), and are therefore ineligible for enrolment in clinical trials. Methods We retrospectively analyzed the clinical characteristics and outcomes of children with AML‐DS who...
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Abstract Background The role of local analgesics for lumbar punctures (LPs) in pediatric oncology patients has not been specifically studied. Aim To compare the efficacy of eutectic mixture of local anesthetics (EMLA) cream to 1% lidocaine injection for LPs. Method This was a retrospective observational study of all patients receiving either EMLA cream (EMLA group) or 1% lidocaine subcutaneous injection (lidocaine group) in addition to fentanyl and propofol for LPs over 18 months....
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Abstract Retinoblastoma is an ocular tumor that occurs in young children, in either heritable or sporadic manner. The relative rarity of retinoblastoma, and the need for expensive equipment, anesthesia, and pediatric ophthalmologic expertise, are barriers for effective treatment in developing countries. Also, with an average age‐adjusted incidence of two to five cases per million children, patient number limits development of local expertise in countries with small populations. Lebanon is a small...
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Opinion statementIn 2017, the World Health Organization (WHO) classification for pancreatic NET was updated to include a new category of well-differentiated high-grade (Ki 67> 20%) pancreatic tumors (NET G3), distinct from high-grade poorly differentiated neuroendocrine carcinoma (NEC). NET G3 are considered a molecularly, radiologically, and prognostically distinct entity compared to NEC and NET G1/G2. The optimal first-line management in NET G3 and sequencing therapies remains a challenge awaiting...
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Abstract Purpose We aimed to determine the safety, feasibility and efficacy of interventional radiology method for the management of esophagogastric anastomotic leakage. Methods We retrospectively assessed the medical records of 23 consecutive patients with esophagogastric anastomotic leakage treated using intervention protocol. Patients received three-tube...
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Abstract Objectives We aimed to analyze the baseline features and clinical outcomes of patients younger than 80 years undergoing transfemoral transcatheter aortic valve implantation (TAVI) or surgical aortic valve replacement (SAVR) enrolled in the OBservational Study of Effectiveness of SAVR‐TAVR procedures for severe Aortic steNosis Treatment (OBSERVANT) real‐world study, focusing on variables guiding Heart Team decision toward TAVI. Background Patients treated with TAVI, independently...
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Abstracts Background Data concerning the impact of stent generation on long‐term outcomes in ST‐segment elevation myocardial infarction (STEMI) patients with multivessel disease (MVD) who underwent primary percutaneous coronary intervention (PCI) with culprit‐only PCI (C‐PCI) or multivessel PCI (M‐PCI) are limited. Methods A total of 7,266 patients were separated into the two groups, a C‐PCI (n = 4,901) or M‐PCI group (n = 2,365). The primary endpoint was the occurrence of major adverse...
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A photoredox benzyl activation was developed via formidable C(sp3)‐C(sp3) bond dissociation of 1‐aryl acetone oxime esters, which were easily perapared from benzyl ketones. Further coupling with O‐ and N‐ nuclophiles successfully forged important benzyl ether and amines derivatives in one pot. In this process, different substitutions on oxime esters were found compatible and various primary, secondary alcohols and amines as well as amides showed good performance as nuclophiles. Mechanistic studies...
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An interaction of N‐(cyanomethyl)pyridinium salts with vinamidinium perchlorates or enaminones proceeds as a pseudo‐three component process and results in the formation of 3‐ or 2‐substituted pyrido[2,3‐b]indolizine‐10‐carbonitriles, respectively. Optical properties of these compounds have been evaluated, revealing effective green light emission with fluorescence quantum yields of up to 0.81.
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Abstract As claimed by Robert Gilles et al., “Images are more than pictures, they are data”. This statement refers to the power of imaging to provide large amounts of quantitative features for improving diagnosis, prognosis and therapy response. The conversion of digital medical images into high-dimensional mineable data is called radiomics. Radiomics analysis is based on data-characterisation algorithms which have the potential to uncover disease heterogeneity characteristics...
40m
Abstract Background Inconsistent results are reported so far in the literature on the relationship between subjective memory complaints (SMC) and objective memory performance. Mixed findings triggered the need to investigate whether other potential mediating variables, such as mood and non-memory domains, affect the relationship between SMC and memory performance. Aims ...
2h
Abstract The surgical approach for hypophysectomy has undergone sweeping revolution in the past three decades. With the advent of endoscopes, better instrumentation, better illumination and viewing cameras, endoscopic endo-nasal trans-sphenoidal approach to sella has now largely become the norm. The aim of this study is to present our experience, analysing the surgical outcomes of this approach in patients with pituitary adenoma, pertaining to entirety of tumor removal, alleviation...
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Abstract Swallowing is a complicated, multilevel and neuromuscular physiological function. Transcutaneous neuromuscular electrical stimulation is a relatively new therapeutic intervention for the treatment of swallowing disorders. The aim was to administer and focus on pre and post therapy effects of traditional dysphagia therapy and electrical stimulation (TENS) in 2 participants with posterior stroke. Electrical current along with traditional dysphagia therapy on regular intervals...
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Pharmaceutics, Vol. 11, Pages 418: Rationally Designed Dendritic Silica Nanoparticles for Oral Delivery of Exenatide Pharmaceutics doi: 10.3390/pharmaceutics11080418 Authors: Muhammad Mustafa Abeer Anand Kumar Meka Naisarg Pujara Tushar Kumeria Ekaterina Strounina Rute Nunes Ana Costa Bruno Sarmento Sumaira Z. Hasnain Benjamin P. Ross Amirali Popat Type 2 diabetes makes up approximately 85% of all diabetic cases and it is linked to approximately one-third...
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Brain Sciences, Vol. 9, Pages 204: Pro-Nerve Growth Factor Induces Activation of RhoA Kinase and Neuronal Cell Death Brain Sciences doi: 10.3390/brainsci9080204 Authors: Marina Sycheva Jake Sustarich Yuxian Zhang Vaithinathan Selvaraju Thangiah Geetha Marla Gearing Jeganathan Ramesh Babu We have previously shown that the expression of pro-nerve growth factor (proNGF) was significantly increased, nerve growth factor (NGF) level was decreased, and the expression of p75NTR...
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Two statements from APA officials make it clear that they don't see any substantial link between mental illness and gun violence.Decades of studies show that there is no conclusive evidence to this knee jerk rhetoric.Officials reiterate the argument that the easy access to guns is to blame.In the wake of the latest mass shootings throughout the United States, the American Psychiatric Association (APA) has pushed back against politicians linking mental illness to the issue. The country's largest organization...
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Researchers find a new state of matter called "topological superconductivity".The state can lead to important advancements in quantum computing.Utilizing special particles that emerge during this state can lead to error-free data storage and blazing calculation speed.NoneA group of physicists has discovered a new state of matter that can lead to significant advancements in quantum computing and device storage. The state is called topological superconductivity and can be utilized to tremendously speed...
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IJERPH, Vol. 16, Pages 2974: The Moderation of Obesity Penalty on Job Market Outcomes by Employment Efforts International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16162974 Authors: Rosemary Ahn Tae Hyun Kim Euna Han The current study explores the moderation of the relationship between obesity and labor market outcomes by direct employment efforts such as job hunting and job training of young adults. The study used data provided by the Korean Education...
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IJERPH, Vol. 16, Pages 2879: Physiological Demands of Extreme Obstacle Course Racing: A Case Study International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16162879 Authors: Timothy Baghurst Steven L. Prewitt Tyler Tapps Obstacle course races are a popular source of recreation in the United States, providing additional challenges over traditional endurance events. Despite their popularity, very little is known about the physiological or cognitive demands...
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IJERPH, Vol. 16, Pages 2973: European Rural Development Policy Approaching Health Issues: An Exploration of Programming Schemes International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16162973 Authors: Antonella Samoggia Aldo Bertazzoli Arianna Ruggeri Malnutrition, obesity, type 2 diabetes, micronutrient deficiencies, and the increase in non-communicable diseases are among the future European key challenges in health and welfare. Agriculture and rural...
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IJERPH, Vol. 16, Pages 2970: The Water–Energy–Food Nexus as a Tool to Transform Rural Livelihoods and Well-Being in Southern Africa International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16162970 Authors: Tafadzwanashe Mabhaudhi Luxon Nhamo Sylvester Mpandeli Charles Nhemachena Aidan Senzanje Nafisa Sobratee Pauline Paidamoyo Chivenge Rob Slotow Dhesigen Naidoo Stanley Liphadzi Albert Thembinkosi Modi About 60% of southern Africa’s...
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IJERPH, Vol. 16, Pages 2971: Air Pollution and Suicide in Mexico City: A Time Series Analysis, 2000–2016 International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16162971 Authors: Claudia Iveth Astudillo-García Laura Andrea Rodríguez-Villamizar Marlene Cortez-Lugo Julio César Cruz-De la Cruz Julián Alfredo Fernández-Niño The association between air pollution and suicide has recently been under examination, and the findings continue to be contradictory....
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IJERPH, Vol. 16, Pages 2972: The Impact of Social Disparities on Microbiological Quality of Drinking Water Supply in Ugu District Municipality of Kwazulu-Natal Province, South Africa International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16162972 Authors: C. M. N. Khabo-Mmekoa M. N. B. Momba This study was undertaken to highlight the social disparity between rural and urban areas in terms of housing patterns, provision of safe drinking water, access to...
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IJERPH, Vol. 16, Pages 2969: Health-Related Participatory Research in American Indian and Alaska Native Communities: A Scoping Review International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16162969 Authors: R. Brian Woodbury Scott Ketchum Vanessa Y. Hiratsuka Paul Spicer A scoping review was conducted to assess the state of the literature on health-related participatory research involving American Indian and Alaska Native communities. Online databases...
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IJERPH, Vol. 16, Pages 2968: Vehicular Air Pollution in Houston, Texas: An Intra-Categorical Analysis of Environmental Injustice International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16162968 Authors: Michel G. Loustaunau Jayajit Chakraborty This article contributes to distributive environmental justice (EJ) research on air pollution by analyzing racial/ethnic and related intra-categorical disparities in health risk from exposure to on-road hazardous...
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IJERPH, Vol. 16, Pages 2967: Adjustment Disorder and Suicidal Behaviours Presenting in the General Medical Setting: A Systematic Review International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16162967 Authors: Joanne Fegan Anne M. Doherty Background: Adjustment disorder (AD) is a condition commonly encountered by clinicians in emergency departments and liaison psychiatry settings and has been frequently reported among patients presenting with suicidal...
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