IJMS, Vol. 20, Pages 4209: The Human Ovary and Future of Fertility Assessment in the Post-Genome Era
IJMS, Vol. 20, Pages 4209: The Human Ovary and Future of Fertility Assessment in the Post-Genome Era International Journal of Molecular Sciences doi: 10.3390/ijms20174209 Authors: Emna Ouni Didier Vertommen Christiani A. Amorim Proteomics has opened up new avenues in the field of gynecology in the post-genome era, making it possible to meet patient needs more effectively and improve their care. This mini-review aims to reveal the scope of proteomic applications through an overview...
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IJMS, Vol. 20, Pages 4207: Fine Tuning: Effects of Post-Translational Modification on Hsp70 Chaperones International Journal of Molecular Sciences doi: 10.3390/ijms20174207 Authors: Alijah A. Griffith William Holmes The discovery of heat shock proteins shaped our view of protein folding in the cell. Since their initial discovery, chaperone proteins were identified in all domains of life, demonstrating their vital and conserved functional roles in protein homeostasis. Chaperone proteins...
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IJMS, Vol. 20, Pages 4208: A Cyclic Pentamethinium Salt Induces Cancer Cell Cytotoxicity through Mitochondrial Disintegration and Metabolic Collapse International Journal of Molecular Sciences doi: 10.3390/ijms20174208 Authors: Radovan Krejcir Lucie Krcova Pavlina Zatloukalova Tomas Briza Philip J. Coates Martin Sterba Petr Muller Jarmila Kralova Pavel Martasek Vladimir Kral Borivoj Vojtesek Cancer cells preferentially utilize glycolysis for ATP production...
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IJMS, Vol. 20, Pages 4206: Artificial Neural Network Approach for Modelling of Mercury Ions Removal from Water Using Functionalized CNTs with Deep Eutectic Solvent International Journal of Molecular Sciences doi: 10.3390/ijms20174206 Authors: Seef Saadi Fiyadh Mohamed Khalid AlOmar Wan Zurina Binti Jaafar Mohammed Abdulhakim AlSaadi Sabah Saadi Fayaed Suhana Binti Koting Sai Hin Lai Ming Fai Chow Ali Najah Ahmed Ahmed El-Shafie Multi-walled carbon nanotubes...
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IJMS, Vol. 20, Pages 4205: Alteration of Phenolic Composition in Lettuce (Lactuca sativa L.) by Reducing Nitrogen Supply Enhances its Anti-Proliferative Effects on Colorectal Cancer Cells International Journal of Molecular Sciences doi: 10.3390/ijms20174205 Authors: Weiwei Zhou Xin Liang Peibin Dai Yao Chen Yuxue Zhang Miao Zhang Lingli Lu Chongwei Jin Xianyong Lin Consumption of vegetables rich in phenolic compounds has become a useful method to reduce the risk...
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IJMS, Vol. 20, Pages 4204: Multifunctional Peptides from Spanish Dry-Cured Pork Ham: Endothelial Responses and Molecular Modeling Studies International Journal of Molecular Sciences doi: 10.3390/ijms20174204 Authors: Sara María Martínez-Sánchez Horacio Pérez-Sánchez José Antonio Gabaldón José Abellán-Alemán Silvia Montoro-García Food peptides contain a very wide range of diversified structures, which explains their diverse range of functional activities. Proatherogenic endothelium...
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IJMS, Vol. 20, Pages 4203: Physiologically Relevant Oxygen Concentration (6% O2) as an Important Component of the Microenvironment Impacting Melanoma Phenotype and Melanoma Response to Targeted Therapeutics In Vitro International Journal of Molecular Sciences doi: 10.3390/ijms20174203 Authors: Marta Osrodek Mariusz L. Hartman Malgorzata Czyz Cancer cell phenotype largely depends on oxygen availability. The atmospheric oxygen concentration (21%) used in in vitro studies is much...
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IJMS, Vol. 20, Pages 4201: Magnetorheological Hybrid Elastomers Based on Silicone Rubber and Magnetorheological Suspensions with Graphene Nanoparticles: Effects of the Magnetic Field on the Relative Dielectric Permittivity and Electric Conductivity International Journal of Molecular Sciences doi: 10.3390/ijms20174201 Authors: Bica Bunoiu Hybrid magnetorheological elastomers (hMREs) were manufactured based on silicone rubber, silicone oil, carbonyl iron microparticles, graphene nanoparticles...
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IJMS, Vol. 20, Pages 4202: Hydrogen Sulfide Prevents Elastin Loss and Attenuates Calcification Induced by High Glucose in Smooth Muscle Cells through Suppression of Stat3/Cathepsin S Signaling Pathway International Journal of Molecular Sciences doi: 10.3390/ijms20174202 Authors: Ye-Bo Zhou Hong Zhou Li Li Ying Kang Xu Cao Zhi-Yuan Wu Lei Ding Gautam Sethi Jin-Song Bian Vascular calcification can be enhanced by hyperglycemia. Elastin loss in tunica media promotes...
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IJMS, Vol. 20, Pages 4200: Circularly Permuted Fluorescent Protein-Based Indicators: History, Principles, and Classification International Journal of Molecular Sciences doi: 10.3390/ijms20174200 Authors: Alexander I. Kostyuk Aleksandra D. Demidovich Daria A. Kotova Vsevolod V. Belousov Dmitry S. Bilan Genetically encoded biosensors based on fluorescent proteins (FPs) are a reliable tool for studying the various biological processes in living systems. The circular permutation...
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IJMS, Vol. 20, Pages 4199: Mechanistic Insights into Arbuscular Mycorrhizal Fungi-Mediated Drought Stress Tolerance in Plants International Journal of Molecular Sciences doi: 10.3390/ijms20174199 Authors: Ali Bahadur Asfa Batool Fahad Nasir Shengjin Jiang Qin Mingsen Qi Zhang Jianbin Pan Yongjun Liu Huyuan Feng Arbuscular mycorrhizal fungi (AMF) establish symbiotic interaction with 80% of known land plants. It has a pronounced impact on plant growth, water absorption,...
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IJMS, Vol. 20, Pages 4197: Triple-Negative Breast Cancer with High Levels of Annexin A1 Expression Is Associated with Mast Cell Infiltration, Inflammation, and Angiogenesis International Journal of Molecular Sciences doi: 10.3390/ijms20174197 Authors: Maiko Okano Masanori Oshi Ali Linsk Butash Eriko Katsuta Kazunoshin Tachibana Katsuharu Saito Hirokazu Okayama Xuan Peng Li Yan Koji Kono Toru Ohtake Kazuaki Takabe Annexin A1 (ANXA1) is a phospholipid-linked...
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IJMS, Vol. 20, Pages 4198: N-Heterocyclic Carbene-Platinum Complexes Featuring an Anthracenyl Moiety: Anti-Cancer Activity and DNA Interaction International Journal of Molecular Sciences doi: 10.3390/ijms20174198 Authors: Sébastien Harlepp Edith Chardon Mathilde Bouché Georges Dahm Mounir Maaloum Stéphane Bellemin-Laponnaz A platinum (II) complex stabilized by a pyridine and an N-heterocyclic carbene ligand featuring an anthracenyl moiety was prepared. The compound was...
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IJMS, Vol. 20, Pages 4195: The Role of Fibroblast Growth Factor 23 in Inflammation and Anemia International Journal of Molecular Sciences doi: 10.3390/ijms20174195 Authors: Brian Czaya Christian Faul In patients with chronic kidney disease (CKD), adverse outcomes such as systemic inflammation and anemia are contributing pathologies which increase the risks for cardiovascular mortality. Amongst these complications, abnormalities in mineral metabolism and the metabolic milieu are associated...
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IJMS, Vol. 20, Pages 4196: Supplementation with Nicotinamide Riboside Reduces Brain Inflammation and Improves Cognitive Function in Diabetic Mice International Journal of Molecular Sciences doi: 10.3390/ijms20174196 Authors: Hee Jae Lee Soo Jin Yang The purpose of this study is to investigate whether nicotinamide riboside (NR) can improve inflammation and cognitive function in diabetic mice. ICR male mice were fed for 14 weeks with either high-fat chow diet (HF, 60% kcal fat) or standard...
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IJMS, Vol. 20, Pages 4194: Conformation and Domain Movement Analysis of Human Matrix Metalloproteinase-2: Role of Associated Zn2+ and Ca2+ Ions International Journal of Molecular Sciences doi: 10.3390/ijms20174194 Authors: Leah Voit-Ostricki Sándor Lovas Charles R. Watts Matrix metaloproteinase-2 (MMP-2) is an extracellular Zn2+ protease specific to type I and IV collagens. Its expression is associated with several inflammatory, degenerative, and malignant diseases. Conformational...
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IJMS, Vol. 20, Pages 4192: Liver X Receptors and Their Implications in the Physiology and Pathology of the Peripheral Nervous System International Journal of Molecular Sciences doi: 10.3390/ijms20174192 Authors: Venkat Krishnan Sundaram Charbel Massaad Julien Grenier Recent research in the last decade has sought to explore the role and therapeutic potential of Liver X Receptors (LXRs) in the physiology and pathologies of the Peripheral Nervous System. LXRs have been shown to be...
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IJMS, Vol. 20, Pages 4191: Development of Multi-Target Chemometric Models for the Inhibition of Class I PI3K Enzyme Isoforms: A Case Study Using QSAR-Co Tool International Journal of Molecular Sciences doi: 10.3390/ijms20174191 Authors: Amit Kumar Halder M. Natália Dias Soeiro Cordeiro The present work aims at establishing multi-target chemometric models using the recently launched quantitative structure–activity relationship (QSAR)-Co tool for predicting the activity of...
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IJMS, Vol. 20, Pages 4193: Quality Analysis of Minerals Formed by Jaw Periosteal Cells under Different Culture Conditions International Journal of Molecular Sciences doi: 10.3390/ijms20174193 Authors: Marina Danalache Sophie-Maria Kliesch Marita Munz Andreas Naros Siegmar Reinert Dorothea Alexander Previously, we detected a higher degree of mineralization in fetal calf serum (FCS) compared to serum-free cultured jaw periosteum derived osteoprogenitor cells (JPCs). By Raman...
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IJMS, Vol. 20, Pages 4187: Homology Modeling-Based in Silico Affinity Maturation Improves the Affinity of a Nanobody International Journal of Molecular Sciences doi: 10.3390/ijms20174187 Authors: Xin Cheng Jiewen Wang Guangbo Kang Min Hu Bo Yuan Yingtian Zhang He Huang Affinity maturation and rational design have a raised importance in the application of nanobody (VHH), and its unique structure guaranteed these processes quickly done in vitro. An anti-CD47 nanobody,...
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IJMS, Vol. 20, Pages 4189: Hypoxic Regulation of Neutrophils in Cancer International Journal of Molecular Sciences doi: 10.3390/ijms20174189 Authors: Daniel Triner Yatrik M. Shah Neutrophils have been well-characterized for their role in the host anti-microbial response. However, it is now appreciated that neutrophils have a critical role in tumorigenesis and tumor progression in the majority of solid tumors. Recent studies have indicated a critical role for hypoxia in regulating...
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IJMS, Vol. 20, Pages 4190: Correlation of Autophagosome Formation with Degradation and Endocytosis Arabidopsis Regulator of G-Protein Signaling (RGS1) through ATG8a International Journal of Molecular Sciences doi: 10.3390/ijms20174190 Authors: Yue Jiao Miroslav Srba Jingchun Wang Wenli Chen Damaged or unwanted cellular proteins are degraded by either autophagy or the ubiquitin/proteasome pathway. In Arabidopsis thaliana, sensing of D-glucose is achieved by the heterotrimeric...
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IJMS, Vol. 20, Pages 4186: Structure Determination by Single-Particle Cryo-Electron Microscopy: Only the Sky (and Intrinsic Disorder) is the Limit International Journal of Molecular Sciences doi: 10.3390/ijms20174186 Authors: Emeka Nwanochie Vladimir N. Uversky Traditionally, X-ray crystallography and NMR spectroscopy represent major workhorses of structural biologists, with the lion share of protein structures reported in protein data bank (PDB) being generated by these powerful...
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IJMS, Vol. 20, Pages 4188: Inhibition of Phosphoinositide 3-Kinase/Protein Kinase B Signaling Hampers the Vasopressin-dependent Stimulation of Myogenic Differentiation International Journal of Molecular Sciences doi: 10.3390/ijms20174188 Authors: Silvia Sorrentino Alessandra Barbiera Gabriella Proietti Gigliola Sica Sergio Adamo Bianca Maria Scicchitano Arginine-vasopressin (AVP) promotes muscle differentiation, hypertrophy, and regeneration through the combined activation...
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Dendritic cell (DC)-based vaccines pulsed with high hydrostatic pressure (HHP)-inactivated tumor cells have been demonstrated to be a promising immunotherapy for solid tumors. We focused on sole injection of tumor cells that were inactivated by HHP and their combination with local radiotherapy (RTx) for in vivo induction of anti-tumor immune responses. HHP-treatment of tumor cells resulted in predominantly necrotic cells with degraded DNA. We confirmed that treatments at 200 MPa or higher completely...
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Background and purpose: Glioblastomas are the most aggressive of all gliomas. The prognosis of these gliomas, which are classified as grade IV tumors by the World Health Organization (WHO), is poor. Combination therapy, including surgery, radiotherapy, and chemotherapy has variable outcomes and is expensive. In light of rising healthcare costs, there are societal demands for the justification of medical expenses. Therefore, we calculated the cost-effectiveness of follow-up [18F] fluoroethyl-L-tyrosine...
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Purpose: Prostatectomy is one of the main therapeutic options for prostate cancer (PCa). Studies proved the benefit of adjuvant radiotherapy (aRT) on clinical outcomes, with more toxicities when compared to salvage radiotherapy. A better assessment of the likelihood of biochemical recurrence (BCR) would rationalize performing aRT. Our goal was to assess the prognostic value of MRI-derived radiomics on BCR for PCa with high recurrence risk. Methods: We retrospectively selected patients with...
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The toxicity and side effects of traditional chemotherapeutic drugs are the main causes of chemotherapy failure. To improve the specificity and selectivity of chemotherapeutic drugs for tumor cells, a novel redox-sensitive polymer prodrug, polyethylene glycol-poly (β-benzyl-L-aspartate) (PEG-PBLA)-SS-paclitaxel (PPSP), was designed and synthesized in this study. PPSP was synthesized successfully and PPSP micelle was manufactured via high-speed dispersion stirring and dialysis. The inhibitory effect...
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Following the introduction of the molecular classification of gliomas by the WHO in 2016, molecularly-proven lineage conversion during glioma recurrence has never been reported. The reported two cases were initially diagnosed as oligodendroglioma with 1p/19q-codeletion and mutation of isocitrate dehydrogenase 1 (IDH1)-R132H. The recurrent tumors showed loss of alpha-thalassemia/mental retardation X-linked (ATRX) expression, strong P53 positivity, and 1p/19q-nondeletion. Next generation sequencing...
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Abstract Calcium contents of demineralised human cortical bone determined by titrimetric assay and atomic absorption spectrophotometry technique were verified by comparing to neutron activation analysis which has high recovery of more than 90%. Conversion factors determined from the comparison is necessary to correct the calcium content for each technique. Femurs from cadaveric donors were cut into cortical rings and demineralised in 0.5 M hydrochloric acid for varying immersion...
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Gallbladder cancer is an aggressive cancer that continues to be an important health care issue in certain regions of the world such as Southeast Asia and Latin America. Most patients are diagnosed at an advanced, unresectable stage and systemic therapy is their only option. Gallbladder cancer patients have traditionally been included in clinical trials for biliary tract cancer. Thus, systemic chemotherapy options for this cancer are similar to those for cholangiocarcinoma, including gemcitabine and...
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Locally advanced gallbladder cancer poor prognosis due to a high distant metastatic rate and poor overall disease control. The impact of standard therapeutic options is unfortunately modest. Due to the rarity of the disease, evidence-based management continues to evolve. The goal of this review is to highlight the contemporary landscape of radiation therapy for gallbladder cancer. First, the rationale for radiation therapy is described. This includes the risk of locoregional recurrence following...
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India is a high incidence area for gallbladder cancer (GBC) and contributes to about 10% of the global GBC burden. Within India, the incidence is high in North, North-East, Central and Eastern India, and less common in South and West India. The incidence has been on a steady rise in both genders. The presentation is often with advanced disease and carries dismal prognosis. GBC in India usually affects younger patients in the 5th and 6th decade in contrast to the west. Gallstones are present in 80%...
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Gallbladder cancer (GBC) is a form of hepatobiliary malignancy that develops from the mucosal lining of the gallbladder. The early development of gallbladder cancer is usually asymptomatic and gallbladder cancer has a high propensity to metastatic dissemination, thus most patients are diagnosed at intermediate to advanced stages for which there is no curative treatment. Consequently, gallbladder cancer is highly lethal. Though the overall global incidence of gallbladder cancer is low, there is marked...
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The incidence and the mortality of gallbladder cancer (GBC) show significant variation worldwide, with high age-standardized rates in western South America (SA). Due to the lack of effective measures for prevention, the late diagnosis and the small benefit of systemic treatment, GBC has an ominous prognosis and became an important public health problem in this part of the continent, where the most important risk factors are gallstone disease, female gender, age, ethnic groups, and low socioeconomic...
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Background: The extent of liver resection for gallbladder cancer (GBC) is still debated. We evaluated the post-operative and oncological outcomes of patients with GBC who underwent liver wedge excision. Methods: Patients who underwent an upfront radical cholecystectomy (with a liver wedge excision of 2.5– 3 centimetres) from June 2010 to December 2015 were retrospectively analysed. Results: In total, 558 patients underwent surgery for GBC of which 97 cases of primary GBC who underwent upfront radical...
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Gallbladder carcinoma is a rare, aggressive biliary tract malignancy, with a 5-year survival of less than 5%. It is the 6th most common gastrointestinal malignancy in the United States and more commonly found in women. While some risk factors include gallstones, porcelain gallbladder, and smoking, gallbladder carcinoma is often found incidentally following cholecystectomy or percutaneous image guided biopsy. Patients frequently present in a late disease state when they are no longer surgical candidates...
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Thank you for your interest in this special edition of Chinese Clinical Oncology, and welcome to this in-depth discussion and analysis of data on gallbladder cancer. This special edition would not have been possible without the dedication and contributions of all our dear colleagues from every corner of the planet, and thus represents a very global perspective and series of insights on this disease.
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