Publication date: 15 October 2019Source: Biosensors and Bioelectronics, Volume 143Author(s): Jianmei Yang, Xiaotong Huang, Chunfang Gan, Ruo Yuan, Yun XiangAbstractDespite the fact that the identification and detection of circulating tumor cells (CTCs) plays a critical role in cancer monitoring and diagnosis, it remains a major challenge to isolate and detect these cells, due to their extreme scarcity in peripheral blood. In this work, by coupling a dual recognition strategy and the commercial personal...
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Publication date: Available online 27 August 2019Source: Biocatalysis and Agricultural BiotechnologyAuthor(s): Langeswaran K, Suganya N, Sangavi PAbstractAn effort has been initiated to design pharmacophore-based 3D models pertaining to human RACK1 protein, (receptor of activated kinase-1) inhibitors were generated with accurate predictability. Such lead compounds were subsequently validated by screening measures to determine its biological activities and its adaptable stability in the systems. The...
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Publication date: Available online 26 August 2019Source: Journal of Molecular StructureAuthor(s): Esranur Çevik-Yıldız, Neslihan Şahin, Serap Şahin-BölükbaşıAbstractThe aim of this study was to present the synthesis, characterization, and investigation of the antiproliferative activity of new metal N-Heterocyclic Carbene (NHC) salts (1a-c) and their Ag(I) complexes (2a-c). All synthesized compounds were characterized using elemental analysis, LC-MS, FT-IR, 1H NMR, and 13C NMR spectroscopy techniques....
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In this study, we describe the discovery of novel LSD1 inhibitors using computational fragment-based drug design approach. Structure-based screening of the Maybridge Ro3 2000 Diversity Fragment Library had identified two sets of fragments that bind to two different regions within the LSD1 active site. De Novo and Multiple Copy Simultaneous search (MCSS) docking, ligand efficiency (LE), and binding energy calculations (BE) had assisted the selection of the best scoring fragments that were grown to...
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ConclusionsThe increasing incidence of cancer in SSA has led to high rates of poor mental health (anxiety and depression) among FCGs. Specific FCG and ACP factors can help us to identify FCGs at risk of depression and anxiety for early intervention. (Source: International Journal of Africa Nursing Sciences)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Publication date: Available online 26 August 2019Source: Life SciencesAuthor(s): Heba M. Fahmy, Alaa M. Ismail, Amena S. El-Feky, Esraa S. Abu Serea, Wael M. ElshemeyAbstractThis work aimed to characterize normal, benign and malignant excised breast tissues through the analysis of the FTIR spectra of their plasma membrane proteins. Tissue characterization parameters such as peak position, peak intensity, area under the peak, relative peak intensity and relative area under peak were evaluated mainly...
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Publication date: Available online 26 August 2019Source: Life SciencesAuthor(s): Marwa S. Zaghloul, Eman Said, Ghada M. Suddek, Hatem A. SalemAbstractAmongst the various forms of lung injury; pulmonary fibrosis remains the most intricate form with limited therapeutic options to both the patient and the physicians. Bleomycin (BLM) is a chemotherapeutic agent used for the treatment of various carcinomas; however, its therapeutic value is significantly limited by its associated pulmonary fibrosis. The...
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Publication date: Available online 26 August 2019Source: Advances in Biological RegulationAuthor(s): Jordy C.G. van der Zwet, Valentina Cordo, Kirsten Canté-Barrett, Jules P.P. MeijerinkAbstractIn the last decade, tremendous progress in curative treatment has been made for T-ALL patients using high-intensive, risk-adapted multi-agent chemotherapy. Further treatment intensification to improve the cure rate is not feasible as it will increase the number of toxic deaths. Hence, about 20% of pediatric...
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Publication date: 15 January 2020Source: Chemical Engineering Journal, Volume 380Author(s): Fei Yu, Maoshu Zhu, Nini Li, Mingtao Ao, Yang Li, Mengya Zhong, Qian Yuan, Huiyu Chen, Zhongxiong Fan, Yan Wang, Zhenqing Hou, Zhongquan Qi, Yuemao Shen, Xiao Dong ChenAbstractA combination of chemotherapy and photothermal therapy (PTT) against cancer, overcoming the intrinsic limitations of single-modal chemotherapy or PTT, has emerged as a promising strategy to achieve synergistic therapeutic effect. However,...
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Publication date: Available online 26 August 2019Source: Toxicology ReportsAuthor(s): Muhammad Athar Abbasi, Seon-Mi Yu, Aziz-ur-Rehman, Sabahat Zahra Siddiqui, Song Ja Kim, Hussain Raza, Mubashir Hassan, Abdul Rehman Sadiq Butt, Syed Anan Ali Shah, Sung-Yum SeoAbstractIn the study presented here, a novel chlorobenzylated bi-heterocyclic hybrid molecule (7) was synthesized and its structural confirmation was carried out by IR, 1H-NMR, 13C-NMR and CHN analysis data. This compound 7 was subjected to...
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ConclusionsNo significant difference was found in the incidence of 30-day postoperative outcomes between RAMIE and MIE. In comparison to MIE, RAMIE may be considered a feasible but non-superior option for treatment of esophageal cancer. (Source: The American Journal of Surgery)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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ConclusionsWhile acknowledging the limited sample size, no association was seen between PF or postoperative complications and overall or disease-free survival in patients undergoing PD for PDAC. (Source: The Surgeon)
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ConclusionIn spite of often large numbers of spinal operations, the centers perform relatively small numbers of tumor operations, particularly for primary tumors. A nearly three-quarter majority of the departments are integrated into interdisciplinary tumor care. However, there is a marked number that do not belong to an interdisciplinary organisation. Further advances in multidisciplinarity and oncology training are a continuous issue to increase treatment quality in spinal tumor patients. (Source:...
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No abstract available (Source: JCR: Journal of Clinical Rheumatology)
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Authors: Brodhead F Abstract Two studies explore outcomes for low-income, middle-aged adults. PMID: 31449109 [PubMed - in process] (Source: The American Journal of Nursing)
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Authors: Beall L Abstract One woman's truly life-changing experience of caring for a mother with cancer. PMID: 31449133 [PubMed - in process] (Source: The American Journal of Nursing)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Authors: Aschenbrenner DS PMID: 31449116 [PubMed - in process] (Source: The American Journal of Nursing)
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Authors: PMID: 31449110 [PubMed - in process] (Source: The American Journal of Nursing)
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Authors: Santos-Buelga C, González-Paramás AM, Oludemi T, Ayuda-Durán B, González-Manzano S Abstract Phenolic compounds have attracted much attention in recent times as their dietary intake has been associated with the prevention of some chronic and degenerative diseases that constitute major causes of death and incapacity in developed countries, such as cardiovascular diseases, type II diabetes, some types of cancers or neurodegenerative disorders like Alzheimer's and Parkinson's diseases....
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In this study, we evaluate a systematic approach and identify key components of wet bench and bioinformatics strategies to address these challenges. We found that concentration of enrichment oligonucleotides, elements of the library preparation, and the structure of adaptors are critical for achieving high enrichment of target regions, retaining variant allele frequencies accurately throughout all involved steps of library preparation, and obtaining high variant coverage. We developed a dual molecular...
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Authors: Zhang Y, Li J, Wang Y, Jing J, Li J Abstract Osteosarcoma is a malignant tumor that occurs most commonly in the metaphysis of the long bones in the limbs in children and adolescents. Even with surgery and neoadjuvant chemotherapy, the therapeutic effect has reached a peak with 60-70% survival rates. Therefore, new biological targets or molecular mechanisms that enhance the efficacy of osteosarcoma treatments are needed. Circular RNAs (circRNAs) are useful biomarkers that have recently...
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Conclusion: miR-34c-5p can inhibit the proliferation, migration and invasion of osteosarcoma cells. The mechanism may be related to targeting FLOT2, which will provide a new target for the prevention and treatment of osteosarcoma. PMID: 31446795 [PubMed - in process] (Source: Artificial Cells, Nanomedicine and Biotechnology)
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Authors: Reis-Pina P PMID: 31445542 [PubMed - in process] (Source: Acta Medica Portuguesa)
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CONCLUSION: Complex chronic conditions are relevant in the activity and costs regarding pediatric hospitalizations in mainland Portugal. Recognizing this and integrating pediatric palliative care from the moment of diagnosis are essential to promote appropriate hospital use, through the development of effective and sustainable alternatives that meet the needs of children, families, and healthcare professionals. PMID: 31445528 [PubMed - in process] (Source: Acta Medica Portuguesa)
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Authors: Reis-Pina P, Santos RG Abstract Palliative care in oncology is an interdisciplinary approach, centered on patients and their families, carried out along the course of neoplastic diseases, based on symptom control, assertive communication and shared decision-making. Although clinical guidelines recommend a holistic intervention, early integration of palliative care into traditional oncological treatment, research shows a great delay in referral of patients, restricting palliative...
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We report a case of a statin-naive paraneoplastic anti-HMGCR myopathy, who unlike other reported cases, responded to a single dose of 1000 mg of intravenous rituximab and subsequent chemoradiation therapy for an underlying lung cancer, despite failing to completely respond to prior high-dose oral prednisone and methotrexate. (Source: Journal of Clinical Neuromuscular Disease)
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Authors: Csorba C, Pásztor N, Szalma E, Kovács G, Palkó A, Fejes Z Abstract The incidence of endometriosis, including atypical forms of the disease, has been continuously growing, thus increasingly challenging for the imaging specialists as well. We conducted a retrospective study to analyze the results of ultrasound-guided interventions between 2016 and 2018. All interventions were performed in female patients due to uncertain abdominal wall lesions at the University of Szeged, Hungary....
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Publication date: October 2019Source: Hematology/Oncology Clinics of North America, Volume 33, Issue 5Author(s): (Source: Hematology Oncology Clinics of North America)
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Publication date: October 2019Source: Hematology/Oncology Clinics of North America, Volume 33, Issue 5Author(s): Eric A. Gehrie, Edward L. Snyder (Source: Hematology Oncology Clinics of North America)
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Publication date: October 2019Source: Hematology/Oncology Clinics of North America, Volume 33, Issue 5Author(s): (Source: Hematology Oncology Clinics of North America)
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Publication date: October 2019Source: Hematology/Oncology Clinics of North America, Volume 33, Issue 5Author(s): (Source: Hematology Oncology Clinics of North America)
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Publication date: October 2019Source: Hematology/Oncology Clinics of North America, Volume 33, Issue 5Author(s): (Source: Hematology Oncology Clinics of North America)
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Neuroblastoma, a malignancy of the sympathetic nervous system that arises in cells derived from the neural crest, predominantly affects young children. Although survival rates have improved significantly, neuroblastoma remains challenging due, in part, to its biological and clinical heterogeneity. Subsets of children fare well with minimal therapy, with cure rates of close to 100% for children with specific disease characteristics; however, for high-risk patients the cure rates are approximately 50%....
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This narrative review summarizes advances in molecular testing for mutations in non –small cell lung cancer, selection of molecularly targeted therapies based on those mutations, and the use of PD-1 inhibitor immunotherapies for the management of metastatic and stage III nonmetastatic disease. (Source: JAMA)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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To the Editor As part of a study using clinical data linked to comprehensive genomic profiling results obtained from routine care, Dr Singal and colleagues explored programmed death-ligand 1 (PD-L1) status and clinical outcomes among patients with non –small cell lung cancer (NSCLC) who received anti–programmed cell death protein 1 (PD-1)/PD-L1 therapy. They found that PD-L1 status (negative vs positive; 50% staining as cutoff) was not related to overall survival, regardless of treatment line. However,...
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In this narrative medicine essay, a physiatrist recalls his role in telling his wife of her diagnosis of metastatic ovarian cancer, his support during her inexorable decline, and how the experiences of her passing drew his family closer, nurtured his appreciation for relationships, the wonder of nature, and the renewed sense of connection to the world. (Source: JAMA)
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In Reply Dr Yang and colleagues highlight some of the key challenges facing the field of biomarker discovery in general and in particular with the use of PD-L1 metrics to predict immunotherapy response in NSCLC. We agree that there are numerous challenges to interpreting PD-L1 pathological data, including the antibody clone used, intensity of staining, heterogeneity of expression within the tumor, and changes in expression over time and with interval treatments. Ultimately, controlling for all of...
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Publication date: Available online 26 August 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): B. Passmore-Webb, B. Gurney, H.M. Yuen, J. Sloane, J. Lee, M. Proctor, F. Sundram, C. Newlands, S. SharmaAbstractSentinel lymph node biopsy (SLNB) is an accurate staging procedure for malignant melanoma but its use in patients with melanoma of the head and neck has been questioned in the past because of a perceived record of poor safety and accuracy. Technical improvements have sought...
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ConclusionOur study proposes an integration model of experimental, transcriptomic and bioinformatics analyses in the identification of novel therapeutic target of NSCLC from an adjuvant herbal formula BL02. Our findings revealed that inhibition of Rap1/cdc42 signaling by active compounds 5-methylcoumarin-4-cellobioside and mangiferin from BL02 might be potentially effective therapy for NSCLC.Graphical abstract (Source: Pharmacological Research)
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In this study, we developed a potent nanocarrier with an effective photoluminescent emission and MR imaging capacity to deliver the doxorubicin to breast cancer 4T1 cells. The nanocarrier was fabricated by coating of quantum dots (QDs) with mesoporous silica followed by amine functionalization of the silica surface. Then, the doxorubicin was loaded into the silica pores and biheterofunctional PEG was covalently bound to the surface of core-shell quantum dot mesoporous silica nanoparticles. In order...
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Publication date: Available online 26 August 2019Source: International Journal of PharmaceuticsAuthor(s): Xiao-Qing Deng, Hong-Bo Zhang, Gui-Fang Wang, Dong Xu, Wen-Yan Zhang, Qiang-Song Wang, Yuan-Lu CuiAbstractColitis-associated colorectal cancer (CAC) is a common malignancy that develops in chronically inflamed mucosa and is usually accompanied by metastases at other sites. Puerarin, a natural isoflavone isolated from the root of the Pueraria lobata (Willd.) Ohwi, has potential anti-colon cancer...
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CONCLUSION The authors' modifications to the island pedicle flap may be reliably used to reconstruct small- to medium-sized defects of the distal nose in a single stage with minimal risk of complications. (Source: Dermatologic Surgery)
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No abstract available (Source: Dermatologic Surgery)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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CONCLUSION Patients who received Mohs surgery had significantly longer OS when compared with those who received surgical excision. Prospective clinical trials comparing these treatment paradigms are warranted. (Source: Dermatologic Surgery)
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CONCLUSION These data suggest that the combination of surgical resection and ART is a reasonable option for Brigham and Women's T2b/T3 tumors. (Source: Dermatologic Surgery)
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BACKGROUND Staging systems for cutaneous squamous cell carcinoma (CSCC) include Brigham and Women's Hospital (BWH) and American Joint Committee on Cancer staging system, eighth edition (AJCC-8). OBJECTIVE To evaluate and compare AJCC-8 and BWH staging systems for CSCC in immunosuppressed patients. MATERIALS AND METHODS A retrospective cohort study of immunosuppressed patients diagnosed with primary CSCC from 2012 to 2016. The main end point was any poor outcome (PO), which included local...
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Authors: Caroline Spertini Bénédicte Baïsse Marta Bellone Milica Gikic Tatiana Smirnova Olivier Spertini Acute myeloid and lymphoblastic leukemia are poor prognosis hematologic malignancies, which disseminate from the bone marrow into the blood. Blast interactions with selectins expressed by vascular endothelium promote the development of drug resistance and leukostasis. While the role of selectins in initiating leukemia blast adhesion is established, our knowledge of the...
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In conclusion, the use of OR141 as a bona fide ICD inducer led us to unravel both the non-linear relationship between PS concentration and PDT-induced antitumor immune response, and the value of an optimal timing of PDT when co-administered with conventional anticancer therapies. This study therefore stresses the necessity of adapting the clinical use of PDT when the goal is to promote an immune response and identifies PDT-based DC vaccination as a suitable modality to reach such objective. (Source:...
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Chemokine receptors are members of the G protein-coupled receptor superfamily. These receptors are intimately involved in cell movement, and thus play a critical role in several physiological and pathological situations that require the precise regulation of cell positioning. CXCR4 is one of the most studied chemokine receptors and is involved in many functions beyond leukocyte recruitment. During embryogenesis, it plays essential roles in vascular development, hematopoiesis, cardiogenesis and nervous...
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AbstractExtracellular vesicles (EVs) are nanosized, membrane-bound vesicles released from eukaryotic and prokaryotic cells that can transport cargo containing DNA, RNA, lipids and proteins, between cells as a means of intercellular communication. Although EVs were initially considered to be cellular debris deprived of any essential biological functions, emerging literature highlights the critical roles of EVs in the context of intercellular signaling, maintenance of tissue homeostasis, modulation...
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Background Acute Lymphoblastic Leukemia (ALL) is the most common cancer seen in children worldwide and in the Middle East. Although there have been major advances in treatment approaches for childhood ALL, serious toxicities do occur but with significant inter-individual variability. The aim of this study is to measure the frequency of polymorphisms in candidate genes involved in 6-Mercaptopurine (6-MP) disposition in a combined cohort of Middle Eastern Children with ALL, and evaluate whether these...
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Conclusion: One radiomic feature was predictive of BCR and bRFS after prostatectomy helping to guide post-operative management. (Source: Frontiers in Oncology)
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ConclusionsLow baseline LVEF and greater LVEF decline post-anthracycline were both independent predictors of TRC. The other biomarkers did not further improve the ability to predict TRC. (Cardiotoxicity of Adjuvant Trastuzumab [CATS]; NCT00858039)Central Illustration (Source: JACC: Heart Failure)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm...
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Publication date: Available online 21 August 2019Source: Practical Radiation OncologyAuthor(s): James A. Hayman, Andre Dekker, Mary Feng, Sameer R. Keole, Todd R. McNutt, Mitchell Machtay, Neil E. Martin, Charles S. Mayo, Todd Pawlicki, Benjamin D. Smith, Randi Kudner, Samantha Dawes, James B. YuAbstractPurposeIn recent years, the American Society for Radiation Oncology (ASTRO) has received requests for a standard list of data elements from other societies, database architects, Electronic Health...
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ConclusionPatients on Ruxolitinib are at increased risk of developing MTB and AMI. Clinicians should be aware of this risk and consider screening patients for latent MTB prior to initiating Ruxolitinib. (Source: Clinical Lymphoma Myeloma and Leukemia)
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ConclusionDuring front-line CLL treatment, Ibr was associated with longer TTNT, fewer monthly days with outpatient visits, and net monthly total cost reduction versus CIT and BR. (Source: Clinical Lymphoma Myeloma and Leukemia)
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ConclusionIn conclusion, time to entering CR is a predictor factor of OS and DFS for patients with newly diagnosed AML who achieve CR after first induction chemotherapy. Patients achieving CR only after a lengthy time, eg. more than 29 days, should be considered to have high relapse rate and should undergo alloHSCT. (Source: Clinical Lymphoma Myeloma and Leukemia)
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ConclusionsOur results showed that TBI combination might be the best conditioning regimen for young patients undergoing HSCT for acute leukemias in Korea. (Source: Clinical Lymphoma Myeloma and Leukemia)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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ConclusionsOur observations suggest that Ph-like ALL is not uncommon among ALL patients and its presence is associated unfavorable outcome, necessitating more investigations for better therapeutic options.Trial registrationNot applicable. (Source: Clinical Lymphoma Myeloma and Leukemia)
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Objectives: Higher facility surgical volume predicts for improved outcomes in patients with muscle-invasive bladder cancer (MIBC) who undergo radical cystectomy. We investigated the association between facility radiotherapy (RT) case volume and overall survival (OS) for patients with MIBC who received bladder-preserving RT, and the relationship with adherence to National Comprehensive Cancer Network (NCCN) guidelines for bladder preservation. Methods: The National Cancer Database was used to...
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Objectives: Vitamin K antagonists (VKAs) remain one of the most commonly used anticoagulation therapies. The potential anticancer effect of long-term use of VKAs has been a matter of debate with conflicting results. Our goal was to perform a systematic review and meta-analysis examining the association between long-term VKAs use and cancer risk. Methods: Systematic searches of multiple major databases were performed from inception until January 2018. We included studies of adults that compared...
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This study aimed to develop and validate an albumin-bilirubin (ALBI) grade–based prognostic model to stratify survival in patients within Milan criteria undergoing nontransplant therapy. Patients and Methods: A total of 1655 patients were assigned into the derivation and validation cohort according to treatment modalities. Multivariate analysis was used to identify independent predictors of survival in the derivation cohort. An ALBI-based model was evaluated in the validation cohort. Results:...
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Conclusions: Current evidence suggests that prechemotherapy Hgb levels below the threshold of 12 g/dL can potentially predict worse overall survival of OC patients. Future research is required in the field to elucidate whether several independent variables such as the stage and histology of disease and rates of optimal debulking affect the clinical significance of this association. (Source: American Journal of Clinical Oncology)MedWorm Message: If you are looking to buy something in the January...
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Lung cancer is the most common cancer worldwide. It also has the highest malignancy-associated mortality rate. Treatment options are limited by cancer and tumor heterogeneity, resistance to treatment options, and an advanced stage at time of diagnosis, all of which are common. Statins are a class of lipid-lowering medications that have been studied for their antitumor effects in various types of cancers. Multiple mechanisms have been proposed to explain their observed off-target effects. Most of...
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Objectives: Smoking is associated with an increased tumor mutational burden. As tumor mutational burden has been shown to correlate with response to immunotherapy (IO), we hypothesized that a history of smoking may be associated with better response to IO. Methods: We utilized a systematic review with stratified meta-analysis of randomized clinical trials of IO versus standard of care in patients with advanced solid organ malignancies. Results: Among 9 relevant studies, we found no significant...
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No abstract available (Source: American Journal of Clinical Oncology)
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Introduction: Studies have consistently identified an increased risk of pancreatic cancer in diabetics, yet the role hyperglycemia may play in predicting prognosis is less clear. This work aims to evaluate the impact of glycemic state and antidiabetics on outcomes after systemic and local treatment for locoregionally advanced pancreatic cancer. Materials and Methods: This retrospective study consisted of 303 patients with newly diagnosed advanced-stage pancreatic cancer treated from 2004 to...
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Conclusions: An increase in CRC risk, as indicated by the assay in simulated and real-life patients, was associated with a higher likelihood of appropriate patients being referred to diagnostic colonoscopy. (Source: American Journal of Clinical Oncology)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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This study investigated the survival of lung cancer patients among female never-smokers. Methods The female never-smokers, who had lived for many years in Xuanwei and Fuyuan counties, with lung cancer newly-diagnosed between July 2006 to March 2010, were followed up through the end of 2016. Age-standardized relative survival for all cases was calculated using local life table. The Kaplan-Meier method and Log-rank test were used to analyze the relationship between the variables and the prognosis in...
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(Source: Cancer Management and Research)
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ConclusionsDifferences in breast cancer survival by race could not be attributed to tumor locations. Understanding the cultural, biological, and lifestyle factors that vary between White, African American, and ethnic subgroups of Asian American women may help explain these survival differences. (Source: Cancer Causes and Control)
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Alternative splicing (AS) has a critical role in tumor progression and prognosis. Our study aimed to investigate pancreatic cancer-specific AS events using RNA-seq data, gaining systematic insights into potential prognostic predictors. We downloaded 10623 genes with 45313 pancreatic cancer-specific AS events from the Cancer Genome Atlas (TCGA) and SpliceSeq database. Cox univariate analyses of overall survival suggested there was a remarkable association between 6711 AS events and overall survival...
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The pyrogenic property being the first activity described, members of the interleukin-1 superfamily (IL-1α, IL-1β, IL-18, and the newest members: IL-33, IL-36, IL-37, and IL-38) are now known to be involved in several inflammatory diseases such as obesity, atherosclerosis, cancer, viral and parasite infections, and auto-inflammatory syndromes as well as liver diseases. Inflammation processes are keystones of chronic liver diseases, of which the etiology may be viral or toxic, as in alcoholic or non-alcoholic...
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Repair of DNA damage protects genomic integrity, which is key to tissue functional integrity. In cancer, the type and fidelity of DNA damage response is the fundamental basis for clinical response to cytotoxic therapy. Here we consider the contribution of transforming growth factor-beta (TGFβ), a ubiquitous, pleotropic cytokine that is abundant in the tumor microenvironment, to therapeutic response. The action of TGFβ is best illustrated in head and neck squamous cell carcinoma (HNSCC). Survival...
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Future Oncology, Ahead of Print. (Source: Future Oncology)
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Authors: Patrik Kovács Tamás Csonka Tünde Kovács Zsanett Sári Gyula Ujlaki Adrien Sipos Zsolt Karányi Dóra Szeőcs Csaba Hegedűs Karen Uray Laura Jankó Máté Kiss Borbála Kiss Damya Laoui László Virág Gábor Méhes Péter Bai Edit Mikó In breast cancer patients, the diversity of the microbiome decreases, coinciding with decreased production of cytostatic bacterial metabolites like lithocholic acid (LCA). We hypothesized that LCA can modulate...
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Cancer Gene Therapy, Published online: 27 August 2019; doi:10.1038/s41417-019-0131-9Synergistic antitumor effect on cervical cancer by rational combination of PD1 blockade and CRISPR-Cas9-mediated HPV knockout (Source: Cancer Gene Therapy)
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Conclusion: Predictors to satisfy the RESORCE study inclusion criteria were as follows: preserved liver function at baseline, as reflected by albumin or ALBI score, and small deterioration of liver function early during sorafenib therapy, as reflected by Δalbumin or ΔALBI at week 4. Liver function at baseline and degree of change in liver function during sorafenib treatment need to be stricter for better outcomes of liver function with disease progression. (Source: Cancers)
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Recent data revealed the importance of immune reconstitution (IR) for the evaluation of possible biomarkers in NIH-defined cGVHD and its clinical aspects. In this large pediatric study (n=146) we have analyzed whether cellular and humoral parameters of IR in the long-term follow-up (FU) with a special emphasis on B-cell reconstitution correlate with NIH-defined cGVHD criteria. HYPOTHESIS: We were especially interested, whether meaningful cGVHD biomarkers could be defined in a large pediatric cohort....
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In this study, we examined the correlation of CAFs with the intra-tumoural immune system in the lung adenocarcinoma microenvironment. We studied 27 and 113 cases of lung adenocarcinoma tentatively as Cohorts 1 and 2, respectively. The patients in Cohort 1 received epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) for recurrent lung adenocarcinoma. -smooth muscle actin (-SMA), a surrogate marker for CAFs, was examined by immunohistochemistry. We then examined the effects of CAFs...
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Competitive endogenous RNA (ceRNA) networks have emerged as critical regulators of carcinogenesis. Their activity is mediated by various non-coding RNAs (ncRNAs), including long non-coding RNAs and microRNAs, which competitively bind to targets, thereby modulating gene expression and activity of proteins. Of particular interest, ncRNAs encoded by the 8q24 chromosomal region are associated with the development and progression of several human cancers, most prominently lncPVT1. Chemoresistance presents...
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Following the introduction of the molecular classification of gliomas by the WHO in 2016, molecularly-proven lineage conversion during glioma recurrence has never been reported. The reported two cases were initially diagnosed as oligodendroglioma with 1p/19q-codeletion and mutation of isocitrate dehydrogenase 1 (IDH1)-R132H. The recurrent tumors showed loss of alpha-thalassemia/mental retardation X-linked (ATRX) expression, strong P53 positivity, and 1p/19q-nondeletion. Next generation sequencing...
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(Source: Frontiers in Oncology)
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Growth factor independence 1 (GFI1) is known as a DNA binding zinc finger protein which can mediate transcriptional repression mainly by recruiting histone-modifying enzymes to its target genes. GFI1 plays important roles in hematopoiesis, in particular in regulating the function of hematopoietic stem- and precursor cells and the differentiation along myeloid and lymphoid lineages. In recent years, a number of publications provided evidence that GFI1 is involved in the pathogenesis of both acute...
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ConclusionsOur study showed the relationship between PD-L1 expression and CIK therapy and revealed that PD-L1 expression in the tumor is as an indicator of adjuvant CIK therapy for postoperative breast cancer. (Source: Journal for Immunotherapy of Cancer)
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The toxicity and side effects of traditional chemotherapeutic drugs are the main causes of chemotherapy failure. To improve the specificity and selectivity of chemotherapeutic drugs for tumor cells, a novel redox-sensitive polymer prodrug, polyethylene glycol-poly (β-benzyl-L-aspartate) (PEG-PBLA)-SS-paclitaxel (PPSP), was designed and synthesized in this study. PPSP was synthesized successfully and PPSP micelle was manufactured via high-speed dispersion stirring and dialysis. The inhibitory effect...
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