Depression is a common co-morbid, disabling disorder that affects 10–25% of cancer patients. It causes substantial functional impairment and lowers survival rate of breast cancer patients. Therefore, the aim o...
7h
Identification of specific needs in patients with cancer is very important for the provision of patient-centered medical service. The aim of this study was to investigate the unmet needs and related factors of...
7h
Blood counting and the liver function tests, as the routine examinations, can reflect the immune and nutritional status of the body, our aim is to assess the prognostic significance of serum gamma-glutamyltran...
7h
Adrenal tumors in patients with previous/synchronous extra-adrenal malignancy are diverse and are a dilemma in clinical practice. This study investigated the differentiation of adrenal malignant and benign tum...
7h
In the U.S., lung cancer accounts for 14% of cancer diagnoses and 28% of cancer deaths annually. Since no cure exists for advanced lung cancer, the main treatment goal is to prolong survival. Chemotherapy regi...
7h
Gavi, the Vaccine Alliance, which is part funded by the UK, should stop giving Pfizer and GlaxoSmithKline special funding for the pneumonia vaccine and instead focus on finding a cheaper version,...
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Gavi, the Vaccine Alliance, which is part funded by the UK, should stop giving Pfizer and GlaxoSmithKline special funding for the pneumonia vaccine and instead focus on finding a cheaper version,...
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Doctors should ask patients with symptoms that could be due to meningococcal infection about recent travel, Public Health England has warned after three cases of ciprofloxacin resistant meningococcal...
15h
The studyA Rodger, V Cambiano, T Bruun, et al. Risk of HIV transmission through condomless sex in serodifferent gay couples with the HIV-positive partner taking suppressive antiretroviral therapy...
15h
I recently experienced a first in my career: while presenting at a conference, I shed tears.To put things in context, I was talking at a session on preventing suicide in the NHS. Before mine, we...
15h
Doctors should ask patients with symptoms that could be due to meningococcal infection about recent travel, Public Health England has warned after three cases of ciprofloxacin resistant meningococcal...
18h
The studyA Rodger, V Cambiano, T Bruun, et al. Risk of HIV transmission through condomless sex in serodifferent gay couples with the HIV-positive partner taking suppressive antiretroviral therapy...
20h
I recently experienced a first in my career: while presenting at a conference, I shed tears.To put things in context, I was talking at a session on preventing suicide in the NHS. Before mine, we...
20h
[Should the results of the LACC trial modify French practices for the choice of surgical approach for the treatment of early-stage cervical cancer ? The point of view of the CNGOF Cancer Commission]. Bull Cancer. 2019 Aug 21;: Authors: Canlorbe G, Levêque J, Koskas M PMID: 31445672 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
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Background Although the benefits of palliative care for patients with cancer has been well established, the current utilization pattern remains largely unknown. The authors investigated the temporal trends and service settings of palliative care among Medicare beneficiaries with newly diagnosed, metastatic non–small‐cell lung cancer (NSCLC). Methods In total, 69,414 patients with NSCLC were identified between January 1, 2001 and December 31, 2013 from the Surveillance, Epidemiology, and End...
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Background There is a need for guidelines on patient navigation activities to promote both the quality of patient navigation and the standards of reimbursement for these services because a lack of reimbursement is a major barrier to the implementation, maintenance, and sustainability of these programs. Methods A broad community‐based participatory research process was used to identify the needs of patients for navigation. A panel of stakeholders of clinical providers was convened to identify...
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Background Cancer survivors face an increased risk of cardiovascular events compared with the general population. Adopting a healthy lifestyle may reduce these risks, and guidelines encourage health‐promotion counseling for cancer survivors, but the extent of physician adherence is unclear. Methods This mixed‐method study surveyed 91 physicians, including 30 primary care physicians (PCPs), 30 oncologists, and 31 specialists (urologists, dermatologists, and gynecologists). Interviews also were...
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Abstract Purpose Tumors of the inner quadrants of the breast are associated with poorer survival than those of the upper-outer quadrant. It is unknown whether racial differences in breast cancer outcomes are modified by breast quadrant, in addition to comparisons among Asian subgroups. Methods Using the Surveillance, Epidemiology, and End Results database,...
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ConclusionsDifferences in breast cancer survival by race could not be attributed to tumor locations. Understanding the cultural, biological, and lifestyle factors that vary between White, African American, and ethnic subgroups of Asian American women may help explain these survival differences. (Source: Cancer Causes and Control)
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ConclusionsThe present cohort study suggests a protective effect of green tea against hematologic neoplasms, especially acute myeloid leukemias. (Source: Cancer Causes and Control)
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Award marks University of Miami's commitment to research and community outreach.
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Glioblastomas are highly lethal cancers, containing self-renewing glioblastoma stem cells (GSCs). Here, we show that GSCs, differentiated glioblastoma cells (DGCs), and non-malignant brain cultures all displayed robust circadian rhythms, yet GSCs alone displayed exquisite dependence on core clock transcription factors, BMAL1 and CLOCK, for optimal cell growth. Downregulation of BMAL1 or CLOCK in GSCs induced cell cycle arrest and apoptosis. Chromatin immunoprecipitation revealed BMAL1 preferentially...
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Cancer Gene Therapy, Published online: 27 August 2019; doi:10.1038/s41417-019-0131-9Synergistic antitumor effect on cervical cancer by rational combination of PD1 blockade and CRISPR-Cas9-mediated HPV knockout (Source: Cancer Gene Therapy)
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Cancer Gene Therapy, Published online: 27 August 2019; doi:10.1038/s41417-019-0132-8SGPL1321 mutation: one main trigger for invasiveness of pediatric alveolar rhabdomyosarcoma
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Cancer Gene Therapy, Published online: 27 August 2019; doi:10.1038/s41417-019-0131-9Synergistic antitumor effect on cervical cancer by rational combination of PD1 blockade and CRISPR-Cas9-mediated HPV knockout
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Publication date: Available online 26 August 2019Source: Cancer LettersAuthor(s): Michael Torsten Meister, Cathinka Boedicker, Benedikt Linder, Donat Kögel, Thomas Klingebiel, Simone FuldaAbstractIn the present study, we show that concomitant inhibition of Hedgehog (HH) signaling by the Glioma-Associated Oncogene Homolog1 (GLI1)-targeting agent GANT61 and the antiapoptotic BCL-2 protein family member MCL-1 by A-1210477 synergistically induces cell death in HH-driven cancers, i.e. rhabdomyosarcoma...
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Publication date: Available online 26 August 2019Source: Cancer LettersAuthor(s): Judit López-Luque, Esther Bertran, Eva Crosas-Molist, Oscar Maiques, Andrea Malfettone, Laia Caja, Teresa Serrano, Emilio Ramos, Victoria Sanz-Moreno, Isabel FabregatAbstractThe Epidermal Growth Factor Receptor (EGFR) and the Transforming Growth Factor-beta (TGF-β) are key regulators of hepatocarcinogenesis. Targeting EGFR was proposed as a promising therapy; however, poor success was obtained in human hepatocellular...
17h
In conclusion, for all diseases where hypofractionation was demonstrated efficient, it must be fully implemented. Invoice procedures must be adapted to maintain a sufficient level of reimbursement of radiotherapy centers. PMID: 31444076 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
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[Project management of the implementation of intracranial stereotactic body radiotherapy at the "Centre finistérien de radiothérapie et d'oncologie"]. Cancer Radiother. 2019 Aug 20;: Authors: Ponsard N, Lasserre L, Caradec A, Couppa É Abstract The Centre Finistérien de radiothérapie et d'oncologie, based in Brest (France), wanted to expand its activity by offering intracranial stereotactic radiation therapy to improve patient care. The desire of the Centre was to invest in...
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This article focuses on the specific features of stereotactic body radiotherapy for liver treatments and the results of published studies of liver stereotactic body radiotherapy performed with classic linear accelerators and dedicated radiosurgery units. PMID: 31444078 [PubMed - as supplied by publisher] (Source: Cancer Radiotherapie)
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Reactive oxygen species play an important role in cancer, however, their promiscuous reactivity, low abundance and short-lived nature limits our ability to study them in real time in living subjects with conventional non-invasive imaging methods. Photoacoustic imaging is an emerging modality for in vivo visualization of molecular processes with deep tissue penetration and high spatio-temporal resolution. Here, we describe the design and synthesis of a targeted, activatable probe for photoacoustic...
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Related ArticlesThe Immunobiology of Hepatocellular Carcinoma in Humans and Mice: Basic Concepts and Therapeutic Implications. J Hepatol. 2019 Aug 23;: Authors: Hou J, Zhang H, Sun B, Karin M Abstract Basic and clinical studies have demonstrated the efficacy of immunotherapy, a technical and conceptual breakthrough that has revolutionized cancer treatment. Hepatocellular carcinoma (HCC), a deadly malignancy with etiologic diversity and a chronic course,...
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Related ArticlesConsiderations for best practices in studies of fiber or other dietary components and the intestinal microbiome. Am J Physiol Endocrinol Metab. 2018 12 01;315(6):E1087-E1097 Authors: Klurfeld DM, Davis CD, Karp RW, Allen-Vercoe E, Chang EB, Chassaing B, Fahey GC, Hamaker BR, Holscher HD, Lampe JW, Marette A, Martens E, O'Keefe SJ, Rose DJ, Saarela M, Schneeman BO, Slavin JL, Sonnenburg JL, Swanson KS, Wu GD, Lynch CJ Abstract A 2-day...
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Collecting ducts carcinoma is a malignant epithelial tumor arising from the principal cells of distal segment of the collecting ducts of Bellini in the renal medulla [1]. CDC is a rare tumor, accounting for only 1% of renal tumors with distinct clinical, histological and pathological characteristics [2–4], first recognized by Mancilla-Jimenez et al. in 1976 [5] and then further described by Fleming and Lewi in 1986 [6].
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The US Food and Drug Administration recently approved gilteritinib (Xospata), in addition to final trial data from the phase 3 ADMIRAL trial, making it the new standard of care for acute myeloid leukemia. (Source: CancerNetwork)
12h
Brain metatstasis is common in breast cancer and often has a poor prognosis, but there are several ways to manage brain metastasis in breast cancer including focal therapies as well as systemic options for specific populations, including emerging and novel therapies. (Source: CancerNetwork)
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Atezolizumab is an immune-checkpoint inhibitor, which has been approved by the US Food and Drug Administration (FDA) in various combinations for a number of cancer types in recent years. (Source: CancerNetwork)
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Prostate cancer is the most frequent cancer found in American men, and the second leading cause of cancer death in this population. Currently, scores of reputable clinical trials are underway and recruiting patients. (Source: CancerNetwork)
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The increasing utilization of these immune checkpoint inhibitors has presented new of immune-related adverse events that have proven to be extremely challenging to manage. (Source: CancerNetwork)
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Cancers, Vol. 11, Pages 1258: Neurokinin-1 Receptor Antagonists against Hepatoblastoma Cancers doi: 10.3390/cancers11091258 Authors: Miguel Muñoz Marisa Rosso Rafael Coveñas Hepatoblastoma (HB) is the most common malignant liver tumor that occurs during childhood. The prognosis of children with HB is favorable when a complete surgical resection of the tumor is possible, but for high-risk patients, the prognosis is much worse. New anti-HB strategies must be urgently developed. The...
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Cancers, Vol. 11, Pages 1259: Predictors of Outcomes in Patients with EGFR-Mutated Non-Small Cell Lung Cancer Receiving EGFR Tyrosine Kinase Inhibitors: A Systematic Review and Meta-Analysis Cancers doi: 10.3390/cancers11091259 Authors: Carlo Buonerba Simona Iaccarino Pasquale Dolce Martina Pagliuca Michela Izzo Luca Scafuri Ferdinando Costabile Vittorio Riccio Dario Ribera Brigitta Mucci Simone Carrano Fernanda Picozzi Davide Bosso Luigi Formisano Roberto...
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Cancers, Vol. 11, Pages 1256: Baseline and Early Predictors of Good Patient Candidates for Second-Line after Sorafenib Treatment in Unresectable Hepatocellular Carcinoma Cancers doi: 10.3390/cancers11091256 Authors: Takada Kurosaki Tsuchiya Komiyama Itakura Takahashi Nakanishi Yasui Tamaki Maeyashiki Kaneko Takaura Higuchi Okada Wang Osawa Sekiguchi Hayakawa Yamashita Enomoto Izumi : Background: Recent advances...
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Cancers, Vol. 11, Pages 1257: PD-L1 Induction by Cancer-Associated Fibroblast-Derived Factors in Lung Adenocarcinoma Cells Cancers doi: 10.3390/cancers11091257 Authors: Inoue Miki Saito Hata Abe Sato Okada Sasano Cancer-associated fibroblasts (CAFs) exert various effects upon biological behaviours of cancer. In this study, we examined the correlation of CAFs with the intra-tumoural immune system in the lung adenocarcinoma microenvironment. We studied 27 and...
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Cancers, Vol. 11, Pages 1254: 3D Quantitative and Ultrastructural Analysis of Mitochondria in a Model of Doxorubicin Sensitive and Resistant Human Colon Carcinoma Cells Cancers doi: 10.3390/cancers11091254 Authors: Claudia Moscheni Emil Malucelli Sara Castiglioni Alessandra Procopio Clara De Palma Andrea Sorrentino Patrizia Sartori Laura Locatelli Eva Pereiro Jeanette A. Maier Stefano Iotti Drug resistance remains a major obstacle in cancer treatment. Because...
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Cancers, Vol. 11, Pages 1255: Lithocholic Acid, a Metabolite of the Microbiome, Increases Oxidative Stress in Breast Cancer Cancers doi: 10.3390/cancers11091255 Authors: Patrik Kovács Tamás Csonka Tünde Kovács Zsanett Sári Gyula Ujlaki Adrien Sipos Zsolt Karányi Dóra Szeőcs Csaba Hegedűs Karen Uray Laura Jankó Máté Kiss Borbála Kiss Damya Laoui László Virág Gábor Méhes Péter Bai Edit Mikó In breast cancer patients, the diversity of the...
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Cancers, Vol. 11, Pages 1253: Acute Myeloid and Lymphoblastic Leukemia Cell Interactions with Endothelial Selectins: Critical Role of PSGL-1, CD44 and CD43 Cancers doi: 10.3390/cancers11091253 Authors: Caroline Spertini Bénédicte Baïsse Marta Bellone Milica Gikic Tatiana Smirnova Olivier Spertini Acute myeloid and lymphoblastic leukemia are poor prognosis hematologic malignancies, which disseminate from the bone marrow into the blood. Blast interactions with selectins...
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This study investigated the survival of lung cancer patients among female never-smokers. Methods The female never-smokers, who had lived for many years in Xuanwei and Fuyuan counties, with lung cancer newly-diagnosed between July 2006 to March 2010, were followed up through the end of 2016. Age-standardized relative survival for all cases was calculated using local life table. The Kaplan-Meier method and Log-rank test were used to analyze the relationship between the variables and the prognosis in...
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Conclusion Crizotinib can be used for the treatment of advanced NSCLC with ALK fusion/translocation. It is highly effective and well tolerated.
DOI: 10.3779/j.issn.1009-3419.2019.08.02 (Source: Chinese Journal of Lung Cancer)
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We report a case of LM from NSCLC, who received the intrathecal chemotherapy with pemetrexed by Ommaya reservoir after prior targeted therapies. This local treatment improved the quality of life, and obtained the clearing of CSF cytology and stable lesions of LM without any notable side effects. After confirmation of LM, the patient has survived 17 months until now. Here we report the first case to demonstrate the potential effectiveness of intrathecal pemetrexed by Ommaya reservoir for the treatment...
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Brain is the most frequent site for distant metastases of non-small cell lung cancer (NSCLC). Brain metastasis (BM) is also the leading cause of disabilities and death in advanced NSCLC. In recent years, the application and effectiveness of small-molecule tyrosine kinase inhibitors has formed the basis for the treatment of NSCLC brain metastases with driver gene mutations. With the development of programmed cell death protein 1 (PD-1)/programmed cell death protein ligand 1 (PD-L1) inhibitors and...
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Targeted therapy and immunotherapy are important treatments for non-small cell lung cancer (NSCLC). At present, the clinical and basic research of epidermal growth factor receptor (EGFR) mutation NSCLC is still in the exploratory stage, needing to optimize the efficacy, combination, sequence and dosage of immunotherapy and other treatments, to clarify the relationship between EGFR mutation, immune microenvironment and the efficacy of immunotherapy. In this review, we summarized the newly updated...
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This article focuses on the research progress of pulmonary function changes in NSCLC patients after video-assisted thoracoscopic segmentectomy.
DOI: 10.3779/j.issn.1009-3419.2019.08.10 (Source: Chinese Journal of Lung Cancer)
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Lung cancer is the malignant tumor with the highest morbidity and mortality in China. Non-small cell lung cancer is the main pathological type. Lymph node metastasis is the most common and primary metastatic pathway in non-small cell lung cancer. Acknowledged as the major factor determining tumor staging and prognosis. Unfortunately, it's presently hard to make an accurate preoperative judgment on the lymph node metastasis of early stage non-small cell lung cancer. Consequently, there has been a...
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The mortality rate of lung cancer has been high all over the world. In recent years, targeted drugs have become a new and effective method for the treatment of advanced lung cancer, but the early diagnosis and long-term effective treatment are still great challenges in lung cancer. Circular RNA (circRNA) is a unique RNA molecule with ring structure, which exhibits excellent stability and expression specificity. Increasing studies found that the expression of several circRNAs in tumors were abnormal....
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Conclusion NSCLC-NED is different from simple NSCLC or pulmonary neuroendocrine tumors. Males, ≤70 years old, severely smoking, and patients with lower tumor differentiation often have NED, and most of them are stage IV. This type of patient-driven gene positive proportion is lower than the general adenocarcinoma population, less sensitive to chemotherapy, and the overall survival is shorte r, indicating a poor prognosis.
DOI: 10.3779/j.issn.1009-3419.2019.08.05 (Source: Chinese Journal of Lung...
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Lung cancer is a worldwide malignancy with high morbidity and mortality in the world. With the application of low-dose spiral computed tomography in the screening and diagnosis of lung cancer, more lung cancers are detected at an early stage and cured by surgical treatment. Anatomical lobectomy has long been the standard procedure for the treatment of early stage non-small cell lung cancer. However, whether intentional segmentectomy can be more used remains controversial. And this paper focuses on...
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Background and objective Bronchopulmonary carcinoid (BPC) is a rare neuroendocrine tumor, the clinical studies on treatment and prognostic factors of BPC are somewhat controversial. Our purpose was to evaluate the clinical efficacy of surgery on BPC, and to analyze the prognostic factors affecting the survival of BPC. Methods We retrospectively collected the clinical data of patients with BPC admitted to the Chinese PLA General Hospital between January 2000 and December 2017. The Kaplan-Meier method...
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This study analyzed the clinical characteristics and prognosis of patients with sub-centimeter lung adenocarcinoma in orde r to provide the basis for the diagnosis and treatment of such patients. Methods A retrospective study was performed to analyze patients with sub-centimeter lung adenocarcinoma who underwent VATS in Peking University People’s Hospital from January 2012 to December 2016. Patients were divided into pure ground-glass nodules (pGGN) group, mixed ground-glass nodules (mGGN) group...
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Purpose: Immunotherapy with interleukin (IL)-2, granulocyte-macrophage colony-stimulating factor (GM-CSF), and an anti-disialoganglioside (GD2) antibody significantly increases event-free survival in children with high-risk neuroblastoma. However, therapy failure in one-third of these patients and IL-2-related toxicities pose a major challenge. We compared the immunoadjuvant effects of IL-15 with those of IL-2 for enhancing antibody-dependent cell-mediated cytotoxicity (ADCC) in neuroblastoma. Experimental...
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Purpose: The majority of broad-panel tumor genomic profiling has used a gene-centric approach, although much of that data is unused in clinical decision-making. We hypothesized that a pathway-centric approach using next-generation sequencing, combined with conventional clinicopathologic features, may better predict disease-free survival (DFS) in early-stage lung adenocarcinoma. Experimental Design: Utilizing our prospectively maintained database, we analyzed 492 patients with primary, untreated,...
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Purpose: Regulatory T-cells (Tregs) expressing CC chemokine receptor 4 (CCR4) can suppress antitumor immune responses and are associated with poor prognoses in several cancers. We assessed the safety and efficacy of combined mogamulizumab (anti-CCR4 antibody) and nivolumab (anti-programmed death-1 [PD-1] antibody) in immunotherapy-naive patients with advanced/metastatic solid tumors. Experimental Design: This study (NCT02476123) comprised dose-escalation (3+3 design) and expansion parts. Patients...
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Purpose: To determine the pharmacokinetics and skin toxicity profile of sorafenib in children with refractory/relapsed malignancies. Experimental Design: Sorafenib was administered concurrently or sequentially with clofarabine and cytarabine (Clo/AraC) to leukemia patients or with bevacizumab and cyclophosphamide (Bev/Cyclo) to patients with solid tumor malignancies. The population pharmacokinetics (PPK) of sorafenib and its metabolites and skin toxicities were evaluated. Results: In PPK analysis,...
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Purpose: Intratumoral injection of oncolytic adenovirus Delta-24-RGDOX induces efficacious anti-glioma immunity in syngeneic glioma mouse models. We hypothesized that localized treatment with the virus is effective against disseminated melanomas. Experimental Design: We tested the therapeutic effect of injecting Delta-24-RGDOX into primary subcutaneous (s.c.) B16-Red-FLuc tumors in s.c./s.c. and s.c./intracranial (i.c.) melanoma models in C57BL/6 mice. Tumor growth and in vivo luciferase-expressing...
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