Πέμπτη 5 Σεπτεμβρίου 2019


CDX2 Loss With Microsatellite Stable Phenotype Predicts Poor Clinical Outcome in Stage II Colorectal Carcinoma
Current risk factors in stage II colorectal carcinoma are insufficient to guide treatment decisions. Loss of CDX2 has been shown to associate with poor clinical outcome and predict benefit for adjuvant chemotherapy in stage II and III colorectal carcinoma. The prognostic relevance of CDX2 in stage II disease has not been sufficiently validated, especially in relation to clinical risk factors, such as microsatellite instability (MSI) status, BRAF mutation status, and tumor budding. In this study,...
The American Journal of Surgical Pathology - Published Ahead-of-Print
Wed Sep 04, 2019 03:00
Interobserver Agreement in Vascular Invasion Scoring and the Added Value of Immunohistochemistry for Vascular Markers to Predict Disease Relapse in Stage I Testicular Nonseminomas
Vascular invasion has been identified as an informative risk factor for relapse in stage I testicular nonseminomas, used to tailor treatment. We investigated interobserver agreement in vascular invasion reporting and studied the potential additional value of immunohistochemistry for vascular markers for predicting relapse. Patients (n=52) with stage I testicular nonseminomas undergoing surveillance (1993-2006) were included (median follow-up of 66 mo). Two formalin-fixed paraffin-embedded blocks...
The American Journal of Surgical Pathology - Published Ahead-of-Print
Wed Sep 04, 2019 03:00
FOS Expression in Osteoid Osteoma and Osteoblastoma: A Valuable Ancillary Diagnostic Tool
Osteoblastoma and osteoid osteoma together are the most frequent benign bone-forming tumor, arbitrarily separated by size. In some instances, it can be difficult to differentiate osteoblastoma from osteosarcoma. Following our recent description of FOS gene rearrangement in these tumors, the aim of this study is to evaluate the value of immunohistochemistry in osteoid osteoma, osteoblastoma, and osteosarcoma for diagnostic purposes. A total of 337 cases were tested with antibodies against c-FOS: 84...
The American Journal of Surgical Pathology - Published Ahead-of-Print
Wed Sep 04, 2019 03:00
The Role of Histologic Grading and Ki-67 Index in Predicting Outcomes in Pulmonary Carcinoid Tumors
Pulmonary carcinoid tumors are relatively uncommon and have an indolent clinical course. The role of histologic grading and cell proliferation as measured by a Ki-67 index in predicting long-term recurrence in carcinoid tumors of the lung is not defined. We report the largest single-institution study of carcinoid tumors and correlate histologic grade and Ki-67 index with clinical outcome. We reviewed all surgical lung resection cases from 1995 to 2016 with a diagnosis of primary carcinoid tumor....
The American Journal of Surgical Pathology - Published Ahead-of-Print
Wed Sep 04, 2019 03:00
Meningioma-like Tumor of the Skin Revisited: A Distinct CD34: +: Dermal Tumor With an Expanded Histologic Spectrum
The term meningioma-like tumor of the skin (MLTS) was coined in 1993 to designate a particular whorled spindle cell superficial cutaneous tumor. No additional confirmed cases of this entity have been reported to date. Some authors have speculated that these cases might be cellular neurothekeomas. In order to delineate the histologic spectrum and the immunophenotype of this unusual tumor, we studied 5 cases, 2 previously unreported and the 3 original cases. The immunohistochemical findings of case...
The American Journal of Surgical Pathology - Published Ahead-of-Print
Wed Sep 04, 2019 03:00
Anesthesia and Cognitive Outcome in Elderly Patients: A Narrative Viewpoint
Better ways to manage preoperative, intraoperative and postoperative care of surgical patients is the bailiwick of anesthesiologists. Although we care for patients of all ages, protecting the cognitive capacity of elderly patients more frequently requires procedures and practices that go beyond routine care for nonelderly adults. This narrative review will consider current understanding of the reasons that elderly patients need enhanced care, and recommendations for that care based on established...
Journal of Neurosurgical Anesthesiology - Published Ahead-of-Print
Wed Sep 04, 2019 03:00
Surgical, Urinary, and Survival Outcomes of Nerve-sparing Versus Traditional Radical Hysterectomy: A retrospective Cohort Study in China
Purpose: The purpose of this retrospective study was to compare the surgical, urinary, and survival outcomes between nerve-sparing radical hysterectomy (NSRH) and traditional radical hysterectomy (TRH) for stage IB cervical cancer, in which all the primary procedures were performed by a single physician. Methods: Patients with cervical cancer of International Federation of Gynecology and Obstetrics (FIGO) stage IB were included if they received radical hysterectomy of class III or type C...
American Journal of Clinical Oncology - Published Ahead-of-Print
Tue Sep 03, 2019 03:00
Nonsevere combined immunodeficiency T-cell lymphopenia identified through newborn screening
Purpose of review Although severe combined immunodeficiency (SCID) is the primary target condition for newborn screening (NBS), over 25 secondary targets, conditions other than SCID, have been identified. There is no standard method for evaluating neonates with non-SCID T-cell lymphopenia (TCL) and no standard approaches to treatment. We will describe these conditions and discuss recommendations for evaluating and follow-up of non-SCID TCL detected by NBS. Recent findings The birth prevalence...
Current Opinion in Allergy and Clinical Immunology - Published Ahead-of-Print
Tue Sep 03, 2019 03:00
First human ancestors breastfed for longer than contemporary relatives
By analyzing the fossilized teeth of some of our most ancient ancestors, scientists have discovered that the first humans significantly breastfed their infants for longer periods than their contemporary relatives.
Evolutionary Biology News -- ScienceDaily
Thu Aug 29, 2019 18:54
Diversity of Plasmodium falciparum across Sub-Saharan Africa
Scientists have identified the regional character to Plasmodium falciparum across Africa. Malaria, infecting 219 million individuals in 2017, remains a threat to public health and regional stability. Human movement and the introduction of antimalarial drugs were drivers of this genetic diversity. Gene flow between sub-populations could spread resistance from one sub-population to the rest of the continent.
Evolutionary Biology News -- ScienceDaily
Thu Sep 05, 2019 21:54
Bilirubin-Related Differential Striatal [18F]FP-CIT Uptake in Parkinson Disease
Purpose of the Report Oxidative stress is a leading factor in the pathogenesis of idiopathic Parkinson disease (IPD). Two intrinsic antioxidative molecules, bilirubin and uric acid, are known to protect dopaminergic neurons from oxidative stress in IPD. The objective of this study was to determine the relationship between basal serum levels of 2 molecules and dopaminergic deficit assessed by dopamine transporter imaging with 18F-fluorinated-N-3-fluoropropyl-2-β-carboxymethoxy-3-β-(4-iodophenyl)nortropane...
Clinical Nuclear Medicine - Published Ahead-of-Print
Wed Sep 04, 2019 03:00
Incidental Detection of Pleomorphic Sarcoma on 68Ga-PSMA PET/CT in a Patient With Prostate Cancer
68Ga prostate-specific membrane antigen (PSMA) PET/CT is used in the staging, evaluation of biochemical recurrence, and response assessment of patients with prostate cancer. In addition to the PSMA-expressing prostate cancer cells, Ga-PSMA binds to the neovasculaature of various other solid tumors and benign lesions. We report a case of a 72-year-old man with recently diagnosed adenocarcinoma of prostate, incidentally found to have pleomorphic sarcoma on the staging 68Ga-PSMA PET/CT. Received for...
Clinical Nuclear Medicine - Published Ahead-of-Print
Wed Sep 04, 2019 03:00
Radiation-Induced Sarcoma on 18F-FDG PET/CT After Treatment of Gorham-Stout Disease of the Maxilla
Gorham-Stout disease is a rare disorder characterized by proliferation of lymphatic and vascular channels within bone resulting in osteolysis. A 53-year-old man with Gorham-Stout disease involving the left maxilla underwent previous treatment including radiation therapy and intralesional chemotherapeutic injections. He later presented with anemia, facial pain, weight loss, and nasal cavity hemorrhage. CT imaging demonstrated a mass centered within the right maxillary sinus with locoregional involvement....
Clinical Nuclear Medicine - Published Ahead-of-Print
Wed Sep 04, 2019 03:00
Uptake of 18F-FDG in Adrenal Adenomas Is Associated With Unenhanced CT Value and Constituent Cells
Purpose The purposes of this study were to investigate the correlation between unenhanced CT attenuation values and 18F-FDG uptake in adrenal adenomas, and to clarify the mechanism of FDG uptake in adrenal adenomas based on immunohistochemical findings. Materials and Methods In 57 adrenal adenomas, the correlation between SUVmax on 18F-FDG PET and unenhanced CT attenuation was retrospectively investigated. In the 11 surgically resected nodules, the clear cell ratio (CCR) and expression levels...
Clinical Nuclear Medicine - Published Ahead-of-Print
Wed Sep 04, 2019 03:00
Bioinformatics Analysis Suggests the Combined Expression of AURKB and KIF18B Being an Important Event in the Development of Clear Cell Renal Cell Carcinoma
Abstract Clear cell renal cell carcinoma (ccRCC) is the most common type of renal cell carcinoma with high metastatic rate and high mortality rate, needing to find potential therapeutic targets and develop new therapy methods. The bioinformatics analysis was used in this study to find the targets. Firstly, the expression profile of ccRCC obtained from The Cancer Genome Atlas (TCGA) database and GSE53757 dataset were used to identify the significant up-regulated genes. IL20RB, AURKB...
Pathology & Oncology Research
Thu Sep 05, 2019 03:00
Expression and Clinical Significance of Translation Regulatory Long Non-Coding RNA 1 ( TRERNA1 ) in Ependymomas
Abstract Long noncoding RNAs (lncRNA) have emerged as vital molecules governing epithelial-to-mesenchymal transition (EMT) in cancers. Translation regulatory RNA 1 (TRERNA1) is one such lncRNA known to enhance the transcriptional activity of the EMT-transcription factor, Snail. We have previously demonstrated differential upregulation of EMT-transcription factors and cadherin switching across various clinico-pathologic-molecular subclasses of ependymomas (EPN). With an aim to analyze...
Pathology & Oncology Research
Thu Sep 05, 2019 03:00
Expression of hTERT in Oral Submucous Fibrosis and Oral Squamous Cell Carcinoma – an Immunohistochemical Analysis
Abstract Human telomerase reverse transcriptase enzyme, the catalytic subunit of telomerase are seen to be frequently reactivated in cancers including Oral squamous cell carcinoma (OSCC). Increased hTERT expression have been seen in potentially malignant conditions including Oral submucous fibrosis (OSMF). The aim of the study was to evaluate the expression levels in OSMF, OSCC in the background of OSMF and OSCC using immunohistochemistry and also to correlate hTERT expression...
Pathology & Oncology Research
Thu Sep 05, 2019 03:00
Elevated expression of G protein-coupled receptor 30 (GPR30) is associated with poor prognosis in patients with uterine cervical adenocarcinoma.
Related ArticlesElevated expression of G protein-coupled receptor 30 (GPR30) is associated with poor prognosis in patients with uterine cervical adenocarcinoma. Histol Histopathol. 2019 Sep 04;:18157 Authors: Ino Y, Akimoto T, Takasawa A, Takasawa K, Aoyama T, Ueda A, Ota M, Magara K, Tagami Y, Murata M, Hasegawa T, Saito T, Sawada N, Osanai M Abstract Uterine cervical adenocarcinoma has a worse prognosis than that of squamous cell carcinoma and useful...
Cellular and Molecular Biology
02:18
Reduction of Severe Hypoglycaemia in People with Type 2 Diabetes after a Structured Inpatient Intervention
Exp Clin Endocrinol DiabetesDOI: 10.1055/a-0983-1559 Objective The aim of this longitudinal study was to assess outcomes before and one year after participation in a structured inpatient intervention including participation in an education programme for people with type 2 diabetes. Methods In 2014, 81 individuals, who were admitted to optimise insulin therapy, participated in a structured inpatient intervention and were invited to participate in a follow-up visit after one year. Results Seventy...
Experimental and Clinical Endocrinology & Diabetes
Thu Sep 05, 2019 02:00

Δεν υπάρχουν σχόλια:

Δημοσίευση σχολίου

Αρχειοθήκη ιστολογίου