Brain Sciences, Vol. 9, Pages 246: Depressive Symptoms among Economically Disadvantaged African American Older Adults in South Los Angeles Brain Sciences doi: 10.3390/brainsci9100246 Authors: Meghan C. Evans Sharon Cobb James Smith Mohsen Bazargan Shervin Assari Background: Although social, behavioral, and health factors correlate with depressive symptoms, less is known about these links among economically disadvantaged African American (AA) older adults. Objective: To study...
Sun Sep 22, 2019 03:00
Brain Sciences, Vol. 9, Pages 245: Parkinsonism with a Hint of Huntington’s from 29 CAG Repeats in HTT Brain Sciences doi: 10.3390/brainsci9100245 Authors: Sipilä JOT Huntington’s disease is caused by at least 36 cytosine-adenine-guanine (CAG) repeats in an HTT gene allele, but repeat tracts in the intermediate range (27–35 repeats) also display a subtle phenotype. This patient had a slightly elongated CAG repeat tract (29 repeats), a prominent family history of Parkinson’s...
Sun Sep 22, 2019 03:00
Brain Sciences, Vol. 9, Pages 244: C57BL/6 Substrain Differences in Pharmacological Effects after Acute and Repeated Nicotine Administration Brain Sciences doi: 10.3390/brainsci9100244 Authors: Lois S. Akinola Bryan Mckiver Wisam Toma Andy Z. X. Zhu Rachel F. Tyndale Vivek Kumar M. Imad Damaj Tobacco smoking is the major cause of disability and death in the United States and around the world. In addition, tobacco dependence and addiction express themselves as complex...
Sat Sep 21, 2019 03:00
Brain Sciences, Vol. 9, Pages 243: Value of Multimodal Imaging Approach to Diagnosis of Neurosarcoidosis Brain Sciences doi: 10.3390/brainsci9100243 Authors: Ilaria Sammarra Gaetano Barbagallo Angelo Labate Baldassare Mondello Giuseppe Albonico Maurizio Maisano Giuseppe Lucio Cascini Aldo Quattrone Antonio Gambardella Background: Neurosarcoidosis is a highly variable condition with many clinical and radiological manifestations, that can lead to difficult identification...
Sat Sep 21, 2019 03:00
Cancers, Vol. 11, Pages 1416: Tyrosyl-DNA Phosphodiesterase 1 and Topoisomerase I Activities as Predictive Indicators for Glioblastoma Susceptibility to Genotoxic Agents Cancers doi: 10.3390/cancers11101416 Authors: Wenjie Wang Monica Rodriguez-Silva Arlet M. Acanda de la Rocha Aizik L. Wolf Yanhao Lai Yuan Liu William C. Reinhold Yves Pommier Jeremy W. Chambers Yuk-Ching Tse-Dinh Glioblastoma (GBM) patients have an estimated survival of ~15 months with treatment,...
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Cancers, Vol. 11, Pages 1414: Effects of Lidocaine and Src Inhibition on Metastasis in a Murine Model of Breast Cancer Surgery Cancers doi: 10.3390/cancers11101414 Authors: Thomas P. Wall Peter D. Crowley Aislinn Sherwin Andrew G. Foley Donal J. Buggy Breast cancer recurs in 20% of patients following intended curative resection. In vitro data indicates that amide local anaesthetics, including lidocaine, inhibit cancer cell metastasis by inhibiting the tyrosine kinase enzyme...
Sun Sep 22, 2019 03:00
Cancers, Vol. 11, Pages 1412: Theragnostic Use of Radiolabelled Dota-Peptides in Meningioma: From Clinical Demand to Future Applications Cancers doi: 10.3390/cancers11101412 Authors: Riccardo Laudicella Domenico Albano Salvatore Annunziata Diletta Calabrò Giovanni Argiroffi Elisabetta Abenavoli Flavia Linguanti Domenico Albano Antonio Vento Antonio Bruno Pierpaolo Alongi Matteo Bauckneht Meningiomas account for approximately 30% of all new diagnoses of...
Sun Sep 22, 2019 03:00
Cancers, Vol. 11, Pages 1415: Sestrins as a Therapeutic Bridge between ROS and Autophagy in Cancer Cancers doi: 10.3390/cancers11101415 Authors: Sánchez-Álvarez Strippoli Donadelli Bazhin Cordani : The regulation of Reactive Oxygen Species (ROS) levels and the contribution therein from networks regulating cell metabolism, such as autophagy and the mTOR-dependent nutrient-sensing pathway, constitute major targets for selective therapeutic intervention against several...
Sun Sep 22, 2019 03:00
Cancers, Vol. 11, Pages 1413: Proton Beam Therapy Combined with Intra-Arterial Infusion Chemotherapy for Stage IV Adenoid Cystic Carcinoma of the Base of the Tongue Cancers doi: 10.3390/cancers11101413 Authors: Kanako Takayama Takahiro Kato Tatsuya Nakamura Yusuke Azami Takashi Ono Motohisa Suzuki Akinori Takada Hisashi Yamaguchi Ichiro Seto Tatsuhiko Nakasato Hitoshi Wada Yasuhiro Kikuchi Kenji Mitsudo Nobukazu Fuwa Masao Murakami Adenoid cystic...
Sun Sep 22, 2019 03:00
Cancers, Vol. 11, Pages 1411: Programmed Death–Ligand 1 and Vimentin: A Tandem Marker as Prognostic Factor in NSCLC Cancers doi: 10.3390/cancers11101411 Authors: Julien Ancel Philippe Birembaut Maxime Dewolf Anne Durlach Béatrice Nawrocki-Raby Véronique Dalstein Gonzague Delepine Silvia Blacher Gaëtan Deslée Christine Gilles Myriam Polette In non-metastatic non-small-cell lung cancer (NSCLC), outcomes remain poor. Adjuvant chemotherapies provide a limited...
Sun Sep 22, 2019 03:00
Cancers, Vol. 11, Pages 1410: An IKK/NF-κB Activation/p53 Deletion Sequence Drives Liver Carcinogenesis and Tumor Differentiation Cancers doi: 10.3390/cancers11101410 Authors: Michael Svinarenko Sarah-Fee Katz Umesh Tharehalli Medhanie A. Mulaw Harald J. Maier Yoshiaki Sunami Sarah K. Fischer Yuexin Chen Sabine Heurich Lena Erkert Andrea Tannapfel Thomas Wirth Reinhold Schirmbeck Thomas Seufferlein André Lechel Background: Most liver tumors arise...
Sat Sep 21, 2019 03:00
Cancers, Vol. 11, Pages 1409: Radiomics and Texture Analysis in Laryngeal Cancer. Looking for New Frontiers in Precision Medicine through Imaging Analysis Cancers doi: 10.3390/cancers11101409 Authors: Carlos Miguel Chiesa-Estomba Oier Echaniz Ekhiñe Larruscain Jose Angel Gonzalez-Garcia Jon Alexander Sistiaga-Suarez Manuel Graña Radiomics and texture analysis represent a new option in our biomarkers arsenal. These techniques extract a large number of quantitative features,...
Fri Sep 20, 2019 03:00
Cancers, Vol. 11, Pages 1408: Methylation Assessment for the Prediction of Malignancy in Mediastinal Adenopathies Obtained by Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration in Patients with Lung Cancer Cancers doi: 10.3390/cancers11101408 Authors: Virginia Leiro Loretta De Chiara Mar Rodríguez-Girondo Maribel Botana-Rial Diana Valverde Manuel Núñez-Delgado Alberto Fernández-Villar The evaluation of mediastinal lymph nodes is critical for the correct...
Fri Sep 20, 2019 03:00
Cancers, Vol. 11, Pages 1407: Hepatic Stress Response in HCV Infection Promotes STAT3-Mediated Inhibition of HNF4A-miR-122 Feedback Loop in Liver Fibrosis and Cancer Progression Cancers doi: 10.3390/cancers11101407 Authors: Yucel Aydin Ramazan Kurt Kyoungsub Song Dong Lin Hanadi Osman Brady Youngquist John W. Scott Nathan J. Shores Paul Thevenot Ari Cohen Srikanta Dash Hepatitis C virus (HCV) infection compromises the natural defense mechanisms of the liver...
Fri Sep 20, 2019 03:00
Cancers, Vol. 11, Pages 1406: The Emerging Roles of Cancer Stem Cells and Wnt/Beta-Catenin Signaling in Hepatoblastoma Cancers doi: 10.3390/cancers11101406 Authors: Mavila Thundimadathil Hepatoblastoma (HB) is the most common form of primary liver malignancy found in pediatric populations. HB is considered to be clonal and arises from hepatoblasts, or embryonic liver progenitor cells. These less differentiated tumor-initiating progenitor cells, or cancer stem cells (CSCs), may contribute...
Fri Sep 20, 2019 03:00
Cancers, Vol. 11, Pages 1405: Neuroendocrine Differentiation of Prostate Cancer—An Intriguing Example of Tumor Evolution at Play Cancers doi: 10.3390/cancers11101405 Authors: Girijesh Kumar Patel Natasha Chugh Manisha Tripathi Our understanding of neuroendocrine prostate cancer (NEPC) has assumed a new perspective in light of the recent advances in research. Although classical NEPC is rarely seen in the clinic, focal neuroendocrine trans-differentiation of prostate adenocarcinoma...
Fri Sep 20, 2019 03:00
Cancers, Vol. 11, Pages 1404: MET Inhibitors in Small Cell Lung Cancer: From the Bench to the Bedside Cancers doi: 10.3390/cancers11101404 Authors: Max Hardy-Werbin Raúl del Rey-Vergara Miguel Alejandro Galindo-Campos Laura Moliner Edurne Arriola Small cell lung cancer (SCLC) is the most aggressive type of lung cancer. The different systemic treatment approaches attempted in the last 35 years have not improved overall survival in the advanced stage. Targeted therapies assessed...
Fri Sep 20, 2019 03:00
Cells, Vol. 8, Pages 1129: The Core Proteome of Biofilm-Grown Clinical Pseudomonas aeruginosa Isolates Cells doi: 10.3390/cells8101129 Authors: Jelena Erdmann Janne G. Thöming Sarah Pohl Andreas Pich Christof Lenz Susanne Häussler Comparative genomics has greatly facilitated the identification of shared as well as unique features among individual cells or tissues, and thus offers the potential to find disease markers. While proteomics is recognized for its potential to...
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Cells, Vol. 8, Pages 1128: Molecular Mechanisms of Cardiac Remodeling and Regeneration in Physical Exercise Cells doi: 10.3390/cells8101128 Authors: Dominik Schüttler Sebastian Clauss Ludwig T. Weckbach Stefan Brunner Regular physical activity with aerobic and muscle-strengthening training protects against the occurrence and progression of cardiovascular disease and can improve cardiac function in heart failure patients. In the past decade significant advances have been made...
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Cells, Vol. 8, Pages 1127: Mesenchymal Stem Cells in the Adult Human Liver: Hype or Hope? Cells doi: 10.3390/cells8101127 Authors: Irina V. Kholodenko Leonid K. Kurbatov Roman V. Kholodenko Garik V. Manukyan Konstantin N. Yarygin Chronic liver diseases constitute a significant economic, social, and biomedical burden. Among commonly adopted approaches, only organ transplantation can radically help patients with end-stage liver pathologies. Cell therapy with hepatocytes as...
Sun Sep 22, 2019 03:00
Cells, Vol. 8, Pages 1126: A 2-Min Transient Ischemia Confers Cerebral Ischemic Tolerance in Non-Obese Gerbils, but Results in Neuronal Death in Obese Gerbils by Increasing Abnormal mTOR Activation-Mediated Oxidative Stress and Neuroinflammation Cells doi: 10.3390/cells8101126 Authors: Joon Ha Park Ji Hyeon Ahn Minah Song Hyunjung Kim Cheol Woo Park Young Eun Park Tae-Kyeong Lee Jae-Chul Lee Dae Won Kim Choong-Hyun Lee In Koo Hwang Bing Chun Yan Sungwoo...
Sun Sep 22, 2019 03:00
Cells, Vol. 8, Pages 1125: Siglecs in Brain Function and Neurological Disorders Cells doi: 10.3390/cells8101125 Authors: Shoib Sarwar Siddiqui Rachel Matar Maxime Merheb Rawad Hodeify Cijo George Vazhappilly John Marton Syed Azharuddin Shamsuddin Hussain Al Zouabi Siglecs (Sialic acid-binding immunoglobulin-type lectins) are a I-type lectin that typically binds sialic acid. Siglecs are predominantly expressed in immune cells and generate activating or inhibitory...
Sun Sep 22, 2019 03:00
Cells, Vol. 8, Pages 1123: Estrogen-Receptor Expression and Function in Female Reproductive Disease Cells doi: 10.3390/cells8101123 Authors: Zi-Run Tang Rui Zhang Zheng-Xing Lian Shou-Long Deng Kun Yu Estrogen receptors (ER) include ER alpha, ER beta and new membrane receptor G protein-coupled receptor 30 (GPR30). Estrogen receptors are key receptors to maintain ovarian granulosa cell differentiation, follicle and oocyte growth and development, and ovulation function. The...
Sat Sep 21, 2019 03:00
Cells, Vol. 8, Pages 1124: TREM Receptors Connecting Bowel Inflammation to Neurodegenerative Disorders Cells doi: 10.3390/cells8101124 Authors: Gianfranco Natale Francesca Biagioni Carla Letizia Busceti Stefano Gambardella Fiona Limanaqi Francesco Fornai Alterations in Triggering Receptors Expressed on Myeloid cells (TREM-1/2) are bound to a variety of infectious, sterile inflammatory, and degenerative conditions, ranging from inflammatory bowel disease (IBD) to neurodegenerative...
Sat Sep 21, 2019 03:00
Cells, Vol. 8, Pages 1121: Phosphoinositide 3-Kinase P110δ-Signaling Is Critical for Microbiota-Activated IL-10 Production by B Cells that Regulate Intestinal Inflammation Cells doi: 10.3390/cells8101121 Authors: Akihiko Oka Yoshiyuki Mishima Bo Liu Jeremy W. Herzog Erin C. Steinbach Taku Kobayashi Scott E. Plevy R. Balfour Sartor The phosphoinositide 3-kinase catalytic subunit p110δ (PI3Kδ) gene maps to a human inflammatory bowel diseases (IBD)...
Sat Sep 21, 2019 03:00
Cells, Vol. 8, Pages 1122: Upregulation of Lysyl Oxidase Expression in Vitreous of Diabetic Subjects: Implications for Diabetic Retinopathy Cells doi: 10.3390/cells8101122 Authors: Manju L. Subramanian Thor D. Stein Nicole Siegel Steven Ness Marissa G. Fiorello Dongjoon Kim Sayon Roy Animal studies have shown diabetes-induced lysyl oxidase (LOX) upregulation promotes blood-retinal-barrier breakdown and retinal vascular cell loss associated with diabetic retinopathy...
Sat Sep 21, 2019 03:00
Cells, Vol. 8, Pages 1120: Protective Effect of Probiotic Bacteria and Estrogen in Preventing HIV-1-Mediated Impairment of Epithelial Barrier Integrity in Female Genital Tract Cells doi: 10.3390/cells8101120 Authors: Sara Dizzell Aisha Nazli Gregor Reid Charu Kaushic Approximately 40% of global HIV-1 transmission occurs in the female genital tract (FGT) through heterosexual transmission. Epithelial cells lining the FGT provide the first barrier to HIV-1 entry. Previous studies...
Sat Sep 21, 2019 03:00
Cells, Vol. 8, Pages 1117: Meta-Analysis of Human and Mouse Biliary Epithelial Cell Gene Profiles Cells doi: 10.3390/cells8101117 Authors: Verhulst Roskams Sancho-Bru van Grunsven Background: Chronic liver diseases are frequently accompanied with activation of biliary epithelial cells (BECs) that can differentiate into hepatocytes and cholangiocytes, providing an endogenous back-up system. Functional studies on BECs often rely on isolations of an BEC cell population from...
Fri Sep 20, 2019 03:00
Cells, Vol. 8, Pages 1118: The E-Cadherin and N-Cadherin Switch in Epithelial-to-Mesenchymal Transition: Signaling, Therapeutic Implications, and Challenges Cells doi: 10.3390/cells8101118 Authors: Chin-Yap Loh Jian Yi Chai Ting Fang Tang Won Fen Wong Gautam Sethi Muthu Kumaraswamy Shanmugam Pei Pei Chong Chung Yeng Looi Epithelial-to-Mesenchymal Transition (EMT) has been shown to be crucial in tumorigenesis where the EMT program enhances metastasis, chemoresistance...
Fri Sep 20, 2019 03:00
Cells, Vol. 8, Pages 1119: Serine Protease HtrA2/Omi Deficiency Impairs Mitochondrial Homeostasis and Promotes Hepatic Fibrogenesis via Activation of Hepatic Stellate Cells Cells doi: 10.3390/cells8101119 Authors: Hur Kang Kim Lee Kim Nam Rhim Yoon The loss of mitochondrial function impairs intracellular energy production and potentially results in chronic liver disease. Increasing evidence suggests that mitochondrial dysfunction in hepatocytes contributes...
Fri Sep 20, 2019 03:00
Cells, Vol. 8, Pages 1116: Age-Related Alterations Affecting the Chondrogenic Differentiation of Synovial Fluid Mesenchymal Stromal Cells in an Equine Model Cells doi: 10.3390/cells8101116 Authors: Mazzotti Teti Falconi Chiarini Barboni Mazzotti Muttini Osteoarthritis is a degenerative disease that strongly correlates with age and promotes the breakdown of joint cartilage and subchondral bone. There has been a surge of interest in developing cell-based therapies,...
Fri Sep 20, 2019 03:00
Cells, Vol. 8, Pages 1115: CPT1A Supports Castration-Resistant Prostate Cancer in Androgen-Deprived Conditions Cells doi: 10.3390/cells8101115 Authors: Molishree Joshi Gergana E. Stoykova Maren Salzmann-Sullivan Monika Dzieciatkowska Lauren N. Liebman Gagan Deep Isabel R. Schlaepfer Prostate cancer (PCa) is the most common cancer in men, and the global burden of the disease is rising. The majority of PCa deaths are due to metastasis that are highly resistant to current...
Fri Sep 20, 2019 03:00
Cells, Vol. 8, Pages 1114: The Neutrophil-to-Lymphocyte Ratio is Related to Disease Activity in Relapsing Remitting Multiple Sclerosis Cells doi: 10.3390/cells8101114 Authors: Emanuele D’Amico Aurora Zanghì Alessandra Romano Mariangela Sciandra Giuseppe Alberto Maria Palumbo Francesco Patti Background: The role of the neutrophil-to-lymphocyte ratio (NLR) of peripheral blood has been investigated in relation to several autoimmune diseases. Limited studies have addressed...
Fri Sep 20, 2019 03:00
Cells, Vol. 8, Pages 1113: Diverse Roads Taken by 13C-Glucose-Derived Metabolites in Breast Cancer Cells Exposed to Limiting Glucose and Glutamine Conditions Cells doi: 10.3390/cells8101113 Authors: Gkiouli Biechl Eisenreich Otto In cancers, tumor cells are exposed to fluctuating nutrient microenvironments with limiting supplies of glucose and glutamine. While the metabolic program has been related to the expression of oncogenes, only fractional information is available...
Fri Sep 20, 2019 03:00
Cells, Vol. 8, Pages 1112: HtrA4 Protease Promotes Chemotherapeutic-Dependent Cancer Cell Death Cells doi: 10.3390/cells8101112 Authors: Wenta Rychlowski Jarzab Lipinska The HtrA4 human protease is crucial in placentation and embryo implantation, and its altered level is connected with pre-eclampsia. The meta-analyses of microarray assays revealed that the HtrA4 level is changed in brain tumors and breast and prostate cancers, which suggests its involvement in oncogenesis....
Fri Sep 20, 2019 03:00
Challenges, Vol. 10, Pages 36: Social Cohesion and City Green Space: Revisiting the Power of Volunteering Challenges doi: 10.3390/challe10020036 Authors: Viniece Jennings Urban green spaces can facilitate positive social interactions in numerous ways. These interactions may lead to the development of social cohesion among city dwellers. This article provides a viewpoint on the potential role that the presence of green space and volunteering can play in the construct of social cohesion....
Fri Sep 20, 2019 03:00
Clocks & Sleep, Vol. 1, Pages 459-470: Association between Co-Morbidities and the Prevalence of Excessive Daytime Sleepiness over a Four-Year Period Clocks & Sleep doi: 10.3390/clockssleep1040035 Authors: Karunanayake Dosman Fenton Rennie Kirychuk Ramsden Seeseequasis Abonyi Pahwa Team Excessive daytime sleepiness (EDS) is a common problem in general the Canadian population. It can effect day-to-day activities and is also associated with several...
Sun Sep 22, 2019 03:00
Clocks & Sleep, Vol. 1, Pages 435-458: The Cancer Clock Is (Not) Ticking: Links between Circadian Rhythms and Cancer Clocks & Sleep doi: 10.3390/clockssleep1040034 Authors: Monica N. Morgan Sapir Dvuchbabny Chloe-Anne Martinez Bernadette Kerr Peter A. Cistulli Kristina M. Cook Circadian rhythms regulate many physiological and behavioral processes, including sleep, metabolism and cell division, which have a 24-h oscillation pattern. Rhythmicity is generated by a...
Fri Sep 20, 2019 03:00
Clocks & Sleep, Vol. 1, Pages 414-434: 2019 Annual Meeting of the Swiss Society for Sleep Research, Sleep Medicine, and Chronobiology (SSSSC) Clocks & Sleep doi: 10.3390/clockssleep1040033 Authors: Martin Hatzinger We are pleased to present you with this Special Issue of Clocks & Sleep, the abstracts of the 2019 annual meeting of the Swiss Society for Sleep Research, Sleep Medicine, and Chronobiology (SSSSC), which took place in Fribourg, 27 and 28 June [...]
Fri Sep 20, 2019 03:00
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