CD47 promotes cell growth and motility in epithelial ovarian cancer

Publication date: November 2019Source: Biomedicine & Pharmacotherapy, Volume 119Author(s): Chiu-Lin Wang, Ming-Jie Lin, Chia-Yi Hsu, Hsiao-Yun Lin, Hung-Pei Tsai, Cheng-Yu Long, Eing-Mei Tsai, Tsung-Hua Hsieh, Chin-Hu WuAbstractEndometriosis is considered a high risk factor for the development of ovarian carcinoma, including clear cell and endometrioid malignancies. The mechanism by which endometriosis-associated ovarian cancer (EAOC) avoids anti-tumor immune surveillance by macrophages remains...

Biomedicine & Pharmacotherapy

Wed Sep 04, 2019 19:03

Enhancement of anticancer activity of docetaxel by combination with Fuzheng Yiliu decoction in a mouse model of castration-resistant prostate cancer

Publication date: October 2019Source: Biomedicine & Pharmacotherapy, Volume 118Author(s): Wei Fu, Zhiming Hong, Xujun You, Jing Din, Baishu Chen, Beibei Zhao, Gengyan Yuan, Qixin LiAbstractDocetaxel (Doc) is the gold standard of care for castration-resistant prostate cancer (CRPC) patients, although the therapeutic effects are modest. Fuzheng Yiliu decoction (FZYL) comprises multiple herbs, and has been used for >10 years to treat various cancers, including hepatocellular tumors, malignant...

Biomedicine & Pharmacotherapy

Wed Sep 04, 2019 19:03

Practical robustness evaluation in radiotherapy – A photon and proton-proof alternative to PTV-based plan evaluation

Publication date: Available online 3 September 2019Source: Radiotherapy and OncologyAuthor(s): Erik W. Korevaar, Steven J.M. Habraken, Daniel Scandurra, Roel G.J. Kierkels, Mirko Unipan, Martijn G.C. Eenink, Roel J.H.M. Steenbakkers, Stephanie G. Peeters, Jaap D. Zindler, Mischa Hoogeman, Johannes A. LangendijkAbstractBackground and purposeA planning target volume (PTV) in photon treatments aims to ensure that the clinical target volume (CTV) receives adequate dose despite treatment uncertainties....

Radiotherapy and Oncology

Wed Sep 04, 2019 18:18

Effect of L1-79 on Core Symptoms of Autism Spectrum Disorder: A Case Series

Publication date: Available online 3 September 2019Source: Clinical TherapeuticsAuthor(s): John Rothman, Eric J. Bartky, Francis Peter HalasAbstractPurposeThis study examines the effects of the tyrosine hydroxylase inhibitor L1-79, a racemic formulation of α-methylparatyrosine, in patients with autism spectrum disorder (ASD) in a prospective case series. The l-isomer formulation of α-methylparatyrosine, metyrosine, is approved for the management of patients with pheochromocytoma.MethodsSix male and...

Clinical Therapeutics

Wed Sep 04, 2019 15:15

Comment on “Photodynamic therapy in the treatment of basal cell carcinoma: A systematic review and meta-analysis”

Publication date: Available online 3 September 2019Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Chen Fu, Li Qin, Xian-Yu Zeng, Bi-Cheng Wang

ScienceDirect Publication: Photodiagnosis and Photodynamic Therapy

Wed Sep 04, 2019 15:02

Butylphthalide ameliorates airway inflammation and mucus hypersecretion <em>via</em> NF-κB in a murine asthma model

Publication date: November 2019Source: International Immunopharmacology, Volume 76Author(s): Zhiwang Wang, Nan Yao, Xiaoyan Fu, Lingxia Wei, Maopeng Ding, Yarong Pang, Dongling Liu, Yuan Ren, Mei GuoAbstractButylphthalide (NBP) is a phthalide compound contained in Angelicae Sinensis Radix which is one of the most widely used traditional Chinese medicines. This study aims to explore the therapeutic effect of NBP on airway inflammation, mucus hypersecretion and their possible mechanism in asthma mice....

ScienceDirect Publication: International Immunopharmacology

Wed Sep 04, 2019 13:53

Myocarditis following the use of different immune checkpoint inhibitor regimens: A real-world analysis of post-marketing surveillance data

Publication date: November 2019Source: International Immunopharmacology, Volume 76Author(s): Qianqian Fan, Yang Hu, Changqing Yang, Bin ZhaoAbstractBackgroundsAlthough myocarditis has been reported in patients treated with immune checkpoint inhibitors (ICIs), there are few real-world studies to compare the occurrences and characteristics of myocarditis after different ICI regimens.MethodsDisproportionality analysis and Bayesian analysis were utilized for data mining of the suspected adverse events...

ScienceDirect Publication: International Immunopharmacology

Wed Sep 04, 2019 13:53

Glycyrrhetinic acid pretreatment attenuates liver ischemia/reperfusion injury via inhibiting TLR4 signaling cascade in mice

Publication date: November 2019Source: International Immunopharmacology, Volume 76Author(s): Xujie Jiang, Ge Kuang, Xia Gong, Rong Jiang, Tianjun Xie, Hongtao Tie, Shengwang Wu, Ting Wang, Jingyuan Wan, Bin WangAbstractGlycyrrhetinic acid (GA), the main bioactive substances of glycyrrhiza uralensis Fisch, has been reported to exhibit hepatoprotective and anti-inflammatory properties. However, the effects and underlying mechanisms of GA in liver ischemia/reperfusion (I/R) injury remain elusive. In...

ScienceDirect Publication: International Immunopharmacology

Wed Sep 04, 2019 13:53

Peripheral blood mononuclear cellular viability and its correlation with long-term pulmonary complications after sulfur mustard exposure

Publication date: November 2019Source: International Immunopharmacology, Volume 76Author(s): Ensie Sadat Mirsharif, Jalaledin Shams, Faramarz Falahi, Mohamad Reza Sedighi Moghadam, Ali Mohamad Mohseni Majd, Razieh Dilmaghanian, Tooba GhazanfariAbstractIntroductionSulfur mustard (SM) as a chemical warfare agent has short- and long-term complications on its victims. Complications of exposure to SM depend on the level of contamination. Long-term pulmonary complications are the most serious problems....

ScienceDirect Publication: International Immunopharmacology

Wed Sep 04, 2019 13:53