Related ArticlesMiR-20a-3p regulates TGF-β1/Survivin pathway to affect keratinocytes proliferation and apoptosis by targeting SFMBT1 in vitro. Cell Signal. 2018 Sep;49:95-104 Authors: Li R, Qiao M, Zhao X, Yan J, Wang X, Sun Q Abstract Psoriasis is a common immune-mediated chronic inflammatory skin disease characterized by abnormal keratinocyte proliferation, differentiation and apoptosis. However, the exact etiology and pathogenesis are still unclear....
Sat Sep 14, 2019 13:58
Related ArticlesSilver(I) complexes containing diclofenac and niflumic acid induce apoptosis in human-derived cancer cell lines. Arch Physiol Biochem. 2019 Sep 13;:1-11 Authors: Altay A, Caglar S, Caglar B Abstract We investigated the anti-cancer activity of [Ag(μ-dicl)]n 1 and [AgH(nif)2] 2 complexes against human cancer cell lines (MCF-7, HT-29, and HepG2) and mouse fibroblast (3T3-L1) cell line. Anti-proliferative activity was monitored by XTT cell...
Sat Sep 14, 2019 14:58
Related ArticlesDownregulation of thymopoietin by miR-139-5p suppresses cell proliferation and induces cell cycle arrest/apoptosis in pancreatic ductal adenocarcinoma. Oncol Lett. 2019 Oct;18(4):3443-3452 Authors: Zhou H, Zhang L, Tu H Abstract MicroRNAs (miRNAs) serve a pivotal role in tumor development and progression, in which miRNA (miR)-139-5p functions as a tumor suppressor. However, the functions and mechanisms of miR-139-5p in pancreatic ductal...
Sat Sep 14, 2019 14:58
Related ArticlesIron chelation and 2-oxoglutarate-dependent dioxygenase inhibition suppress mantle cell lymphoma's cyclin D1. J Cell Mol Med. 2019 Sep 13;: Authors: Babosova O, Kapralova K, Raskova Kafkova L, Korinek V, Divoky V, Prchal JT, Lanikova L Abstract The patients with mantle cell lymphoma (MCL) have translocation t(11;14) associated with cyclin D1 overexpression. We observed that iron (an essential cofactor of dioxygenases including prolyl...
Sat Sep 14, 2019 14:58
Related ArticlesOridonin inhibits hypoxia-induced epithelial-mesenchymal transition and cell migration by the hypoxia-inducible factor-1α/matrix metallopeptidase-9 signal pathway in gallbladder cancer. Anticancer Drugs. 2019 Oct;30(9):925-932 Authors: Chen K, Ye J, Qi L, Liao Y, Li R, Song S, Zhou C, Feng R, Zhai W Abstract Hypoxia has crucial roles in cancer development and progression. Our previous study indicated that cell migration was increased...
Sat Sep 14, 2019 14:58
Related ArticlesFlavopereirine induces cell cycle arrest and apoptosis via the AKT/p38 MAPK/ERK1/2 signaling pathway in human breast cancer cells. Eur J Pharmacol. 2019 Sep 10;:172658 Authors: Yeh HT, Tsai YS, Chen MS, Li YZ, Lin WC, Lee YR, Tseng YS, Sheu SM Abstract Breast cancer, which is the most frequently diagnosed cancer, is quite heterogeneous. For breast cancer subtypes lacking targeted therapies, it is vitally essential to find novel agents...
Sat Sep 14, 2019 14:58
Related ArticlesDeubiquitination and stabilization of Estrogen Receptor α by Ubiquitin-Specific Protease 7 promotes breast tumorigenesis. Cancer Lett. 2019 Sep 10;: Authors: Xia X, Liao Y, Huang C, Liu Y, He J, Shao Z, Jiang L, Dou QP, Liu J, Huang H Abstract Breast cancer is the most common malignancy in women around the world. Estrogen receptor α (ERα) is expressed in approximately 70% of breast tumors, and considered as one of most effective targets...
Sat Sep 14, 2019 14:58
Related ArticlesPreclinical efficacy of dual mTORC1/2 inhibitor AZD8055 in renal cell carcinoma harboring a TFE3 gene fusion. BMC Cancer. 2019 Sep 13;19(1):917 Authors: Kauffman EC, Lang M, Rais-Bahrami S, Gupta GN, Wei D, Yang Y, Sourbier C, Srinivasan R Abstract BACKGROUND: Renal cell carcinomas (RCC) harboring a TFE3 gene fusion (TfRCC) represent an aggressive subset of kidney tumors. Key signaling pathways of TfRCC are unknown and preclinical in...
Sun Sep 15, 2019 13:11
Related ArticlesAMMECR1 Inhibits Apoptosis and Promotes Cell-cycle Progression and Proliferation of the A549 Human Lung Cancer Cell Line. Anticancer Res. 2019 Sep;39(9):4637-4642 Authors: Ge H, Cheng N, Xu X, Yang Z, Hoffman RM, Zhu J Abstract AIM: The aim of this study was to characterize the role of Alport syndrome, mental retardation, midface hypoplasia, and elliptocytosis chromosomal region gene 1 (AMMECR1) in human lung cancer cell lines. ...
Sun Sep 15, 2019 13:11
Related ArticlesThioredoxin-interacting Protein (TXNIP) Mediates Thioredoxin-dependent Antioxidant Mechanism in Endometrial Cancer Cells Treated With 1α,25-dihydroxyvitamin D3. Anticancer Res. 2019 Sep;39(9):4795-4803 Authors: Kim Y, Kim YS, Kim M, Kim JM, Lee HH, Kim TH Abstract BACKGROUND/AIM: To determine the mechanism of vitamin D3-induced modulation of antioxidant-related factors in endometrial cancer, we investigated their role in apoptosis of...
Sun Sep 15, 2019 13:11
Related ArticlesmTORC1/2 Inhibitor Served as a More Ideal Agent Against the Growth of Mouse Lymphocytic Leukemia Both In Vitro and In Vivo. Anticancer Res. 2019 Sep;39(9):4829-4835 Authors: Liao HF, Lin YZ, Yu CC, Tai TS, Hung SK, Yang CC, Su YC Abstract BACKGROUND/AIM: Chronic lymphocytic leukemia (CLL) still remains an incurable disease as the cells evade apoptosis, which is an obstacle for current therapeutic approaches. Therefore, our aim was to...
Sun Sep 15, 2019 13:11
Related ArticlesAnti-parasitic Drug Ivermectin Exhibits Potent Anticancer Activity Against Gemcitabine-resistant Cholangiocarcinoma In Vitro. Anticancer Res. 2019 Sep;39(9):4837-4843 Authors: Intuyod K, Hahnvajanawong C, Pinlaor P, Pinlaor S Abstract BACKGROUND/AIM: The antiparasitic drug, ivermectin (IVM), exerts anticancer activities in diverse cancer types. However, its anticancer activity against cholangiocarcinoma (CCA), especially the drug-resistant...
Sun Sep 15, 2019 13:11
Related ArticlesCyclin-dependent kinase 1-mediated AMPK phosphorylation regulates chromosome alignment and mitotic progression. J Cell Sci. 2019 Sep 13;: Authors: Stauffer S, Zeng Y, Santos M, Zhou J, Chen Y, Dong J Abstract AMP-activated protein kinase (AMPK), a heterotrimeric serine/threonine kinase and cellular metabolic sensor, has been found to regulate cell cycle checkpoints in cancer cells in response to energetic stress to harmonize proliferation...
Sun Sep 15, 2019 13:11
Related ArticlesFocal Adhesion Kinase Inhibition Contributes to Tumor Cell Survival and Motility in Neuroblastoma Patient-Derived Xenografts. Sci Rep. 2019 Sep 13;9(1):13259 Authors: Stafman LL, Williams AP, Marayati R, Aye JM, Markert HR, Garner EF, Quinn CH, Lallani SB, Stewart JE, Yoon KJ, Whelan K, Beierle EA Abstract Patient-derived xenografts (PDXs) provide an opportunity to evaluate the effects of therapies in an environment that more closely...
Sun Sep 15, 2019 13:11
Related ArticlesBDE-209 induces male reproductive toxicity via cell cycle arrest and apoptosis mediated by DNA damage response signaling pathways. Environ Pollut. 2019 Aug 24;255(Pt 1):113097 Authors: Li X, Zhu Y, Zhang C, Liu J, Zhou G, Jing L, Shi Z, Sun Z, Zhou X Abstract Decabromodiphenyl ether (BDE-209) is commonly used as a flame retardant, usually in products that were utilized in electronic equipment, plastics, furniture and textiles. To identify...
Sun Sep 15, 2019 15:11
Related ArticlesHypofractionated stereotactic radiosurgery: a new treatment strategy for giant cavernous sinus hemangiomas. J Neurosurg. 2018 01;128(1):60-67 Authors: Wang X, Zhu H, Knisely J, Mei G, Liu X, Dai J, Mao Y, Pan L, Qin Z, Wang E Abstract OBJECTIVE Cavernous sinus hemangiomas (CSHs) are rare benign vascular tumors that arise from the dural venous sinuses lateral to the sella. Stereotactic radiosurgery (SRS) has emerged as a principal alternative...
Fri Sep 13, 2019 13:26
Related ArticlesGlossopharyngeal neuralgia treated by Gamma Knife radiosurgery: safety and efficacy through long-term follow-up. J Neurosurg. 2018 05;128(5):1372-1379 Authors: Pommier B, Touzet G, Lucas C, Vermandel M, Blond S, Reyns N Abstract OBJECTIVE Glossopharyngeal neuralgia (GPN) is a rare and disabling condition. Just as for trigeminal neuralgia, Gamma Knife radiosurgery (GKRS) is increasingly proposed as a therapeutic option for GPN. The purpose...
Fri Sep 13, 2019 13:26
Related ArticlesClinical, radiological, and histological features and treatment outcomes of supratentorial extraventricular ependymoma: 14 cases from a single center. J Neurosurg. 2018 05;128(5):1396-1402 Authors: Sun S, Wang J, Zhu M, Beejadhursing R, Gao P, Zhang X, Jiao L, Jiang W, Ke C, Shu K Abstract OBJECTIVE Reports on supratentorial extraventricular ependymoma (STE) are relatively rare. The object of this study was to analyze the clinical, radiological,...
Fri Sep 13, 2019 13:26
Related ArticlesA potential therapy for chordoma via antibody-dependent cell-mediated cytotoxicity employing NK or high-affinity NK cells in combination with cetuximab. J Neurosurg. 2018 05;128(5):1419-1427 Authors: Fujii R, Schlom J, Hodge JW Abstract OBJECTIVE Chordoma is a rare bone tumor derived from the notochord and is resistant to conventional therapies such as chemotherapy, radiotherapy, and targeting therapeutics. Expression of epidermal growth...
Fri Sep 13, 2019 13:26
Related Articles[Current Therapies in Superficial Malignant Tumors]. Klin Monbl Augenheilkd. 2018 Oct;235(10):1138-1147 Authors: Scholz SL, Eckstein A, Dekowski D, Esser J, Westekemper H, Steuhl KP Abstract This article is a review of diagnostic and therapeutic possibilities in common epibulbar malignant tumors, such as basal cell carcinoma, conjunctival lymphoma, squamous cell carcinoma and conjunctival melanoma. Most importantly, for every tumor patient...
Fri Sep 13, 2019 13:26
Related Articles9.4T and 17.6T MRI of Retinoblastoma: Ex Vivo evaluation of microstructural anatomy and disease extent compared with histopathology. J Magn Reson Imaging. 2018 06;47(6):1487-1497 Authors: de Jong MC, de Graaf P, Pouwels PJW, Beenakker JW, Jansen RW, Geurts JJG, Moll AC, Castelijns JA, van der Valk P, van der Weerd L Abstract BACKGROUND: Retinoblastoma is the most common intraocular tumor in childhood with a good prognosis in terms of...
Fri Sep 13, 2019 13:26
Related ArticlesMultiparametric characterization of response to anti-angiogenic therapy using USPIO contrast-enhanced MRI in combination with dynamic contrast-enhanced MRI. J Magn Reson Imaging. 2018 06;47(6):1589-1600 Authors: Kim J, Kim E, Euceda LR, Meyer DE, Langseth K, Bathen TF, Moestue SA, Huuse EM Abstract BACKGROUND: Steady state susceptibility contrast (SSC)-MRI provides information on vascular morphology but is a rarely used method. ...
Fri Sep 13, 2019 13:26
Related ArticlesClinical Activity of Pazopanib in Patients with Advanced Desmoplastic Small Round Cell Tumor. Oncologist. 2018 03;23(3):360-366 Authors: Menegaz BA, Cuglievan B, Benson J, Camacho P, Lamhamedi-Cherradi SE, Leung CH, Warneke CL, Huh W, Subbiah V, Benjamin RS, Patel S, Daw N, Hayes-Jordan A, Ludwig JA Abstract BACKGROUND: Desmoplastic small round cell tumor (DSRCT) is an aggressive, often fatal soft tissue sarcoma that lacks an optimal...
Fri Sep 13, 2019 13:26
Related ArticlesMultiple cranial nerve enhancement as a rare presentation of secondary brain lymphoma. Neurol India. 2018 Jan-Feb;66(1):270-272 Authors: Seilanian-Toosi F, Shams M, Akhavan R, Abbasi B PMID: 29323011 [PubMed - indexed for MEDLINE]
Fri Sep 13, 2019 13:26
Related ArticlesHepatic metastasis from basal cell carcinoma: A rare location with an unreported presentation. Diagn Interv Imaging. 2018 Jul - Aug;99(7-8):513-514 Authors: Dohan A, Arrondeau J, Kramkimel N, Terris B, Barral M, Soyer P, Gaujoux S PMID: 29475776 [PubMed - indexed for MEDLINE]
Fri Sep 13, 2019 13:26
Related ArticlesRhabdomyosarcoma: an overview and nursing considerations. Br J Nurs. 2018 Mar 22;27(6):328-332 Authors: Kerin Ú, Wolohan C, Cooke K Abstract This article aims to provide nurses with a clinical overview of rhabdomyosarcoma, a rare type of soft tissue sarcoma. The causes, clinical features, pathophysiology, diagnostic process, prognosis and treatment will be explored. Some of the main nursing considerations for rhabdomyosarcoma patients...
Fri Sep 13, 2019 13:26
Related ArticlesEvidence for Efficacy of Treatment With the Anti-PD-1 Mab Nivolumab in Radiation and Multichemorefractory Advanced Penile Squamous Cell Carcinoma. J Immunother. 2018 Jul/Aug;41(6):300-305 Authors: Trafalis DT, Alifieris CE, Kalantzis A, Verigos KE, Vergadis C, Sauvage S Abstract Penile squamous cell carcinoma (PeSCC) is a rare tumor and advanced PeSCC is associated with poor survival due to the aggressiveness of the disease and lack...
Fri Sep 13, 2019 13:26
Related ArticlesCavernous Hemangioma Between the Elastomer and Fibrous Capsule of a Breast Implant. Aesthetic Plast Surg. 2018 Oct;42(5):1257-1260 Authors: de Mello Tucunduva TC, Gaziero A, Tostes VS, Stiepcich MMA, Torres US, Ohara P, Andrade WP, Ferreira AHPG, Missrie DR, de Mello GGN Abstract Hemangiomas are described in many locations, but breast hemangioma (BH) is rare, accounting for only 0.4% of all breast tumors. These tumors are difficult to...
Fri Sep 13, 2019 13:26
Related ArticlesThe classification of pediatric and young adult renal cell carcinomas registered on the children's oncology group (COG) protocol AREN03B2 after focused genetic testing. Cancer. 2018 08;124(16):3381-3389 Authors: Cajaiba MM, Dyer LM, Geller JI, Jennings LJ, George D, Kirschmann D, Rohan SM, Cost NG, Khanna G, Mullen EA, Dome JS, Fernandez CV, Perlman EJ Abstract BACKGROUND: Renal cell carcinomas (RCCs) are rare in young patients. Knowledge...
Fri Sep 13, 2019 13:26
Related ArticlesCSF3R Mutations are frequently associated with abnormalities of RUNX1, CBFB, CEBPA, and NPM1 genes in acute myeloid leukemia. Cancer. 2018 08;124(16):3329-3338 Authors: Zhang Y, Wang F, Chen X, Zhang Y, Wang M, Liu H, Cao P, Ma X, Wang T, Zhang J, Zhang X, Lu P, Liu H Abstract BACKGROUND: Mutations in the colony-stimulating factor 3 receptor (CSF3R) gene occur frequently in chronic neutrophilic leukemia and are rare in de novo acute...
Fri Sep 13, 2019 13:26
Related ArticlesEmerging Role of IL-4-Induced Gene 1 as a Prognostic Biomarker Affecting the Local T-Cell Response in Human Cutaneous Melanoma. J Invest Dermatol. 2018 12;138(12):2625-2634 Authors: Ramspott JP, Bekkat F, Bod L, Favier M, Terris B, Salomon A, Djerroudi L, Zaenker KS, Richard Y, Molinier-Frenkel V, Castellano F, Avril MF, Prévost-Blondel A Abstract Several studies have emphasized the importance of immune composition of the melanoma microenvironment...
Fri Sep 13, 2019 13:26
Related Articles[Neurological side effects of checkpoint inhibitors]. Nervenarzt. 2019 Feb;90(2):138-147 Authors: Knauss S, Ginesta Roque L, Hühnchen P, Heinzerling L, Böhmerle W, Endres M Abstract BACKGROUND: In recent years the treatment of many tumor entities has been revolutionized by the use of modern immunotherapies with checkpoint inhibitors; however, good response rates are contrasted by many immune-mediated side effects. Neurological immune-mediated...
Fri Sep 13, 2019 13:26
Related ArticlesMolecular Analysis of Gene Fusions in Bone and Soft Tissue Tumors by Anchored Multiplex PCR-Based Targeted Next-Generation Sequencing. J Mol Diagn. 2018 09;20(5):653-663 Authors: Lam SW, Cleton-Jansen AM, Cleven AHG, Ruano D, van Wezel T, Szuhai K, Bovée JVMG Abstract Molecular assays for translocation detection in bone and soft tissue tumors have gradually been incorporated into routine diagnostics. However, conventional methods such...
Fri Sep 13, 2019 13:26
Related ArticlesDouble hit and double expressors in lymphoma: Definition and treatment. Cancer. 2018 12 15;124(24):4622-4632 Authors: Riedell PA, Smith SM Abstract Emerging biologic subsets and new prognostic markers are significantly and adversely affecting curability after standard chemoimmunotherapy for aggressive B-cell lymphomas. The identification of concurrent MYC and B-cell CLL/lymphoma 2 (BCL2) deregulation, whether at a genomic or protein...
Fri Sep 13, 2019 13:26
Related ArticlesNovel gene mutations in well-differentiated fetal adenocarcinoma of the lung in the next generation sequencing era. Lung Cancer. 2018 10;124:1-5 Authors: Fu Y, Wu Q, Su F, Tang Y, Lin Y, Wang W, Jiang L Abstract OBJECTIVES: Since well-differentiated fetal adenocarcinoma of lung (WDFA) is an extremely rare subtype of invasive lung adenocarcinoma, histologic features, biomarkers and molecular aberrant of it are not fully determined. This...
Fri Sep 13, 2019 13:26
Related ArticlesRare targetable drivers (RTDs) in non-small cell lung cancer (NSCLC): Outcomes with immune check-point inhibitors (ICPi). Lung Cancer. 2018 10;124:117-124 Authors: Dudnik E, Bshara E, Grubstein A, Fridel L, Shochat T, Roisman LC, Ilouze M, Rozenblum AB, Geva S, Zer A, Rotem O, Allen AM, Peled N Abstract OBJECTIVES: Efficacy of immune check-point inhibitors (ICPi) in NSCLC with rare targetable drivers (RTDs) is largely unknown. ...
Fri Sep 13, 2019 13:26
Related ArticlesSolitary pulmonary capillary hemangioma: An under-recognized pulmonary lesion mimicking early lung cancer on computed tomography images. Lung Cancer. 2018 10;124:227-232 Authors: Hsieh MS, Lee YH, Lin MW, Chen JS Abstract OBJECTIVES: Solitary pulmonary capillary hemangioma (SPCH) is a rare lung tumor typically presenting as pure or part-solid ground-glass nodules (GGNs) on computed tomography (CT), which clinically resembles early lung...
Fri Sep 13, 2019 13:26
Related ArticlesProbable hereditary familial overlap syndrome with multiple synchronous lung tumors. Lung Cancer. 2018 10;124:279-282 Authors: Cardona AF, Zatarain-Barrón ZL, Rubio C, Martínez S, Ruiz-Patiño A, Ricaurte L, Serna A, Barrios R, Garzón JC, Navarrete C, Balaguera A, Corrales L, Rojas L, Arrieta O Abstract Here we report a case of a young, never-smoker Hispanic woman with a hereditary familial overlap syndrome (Li-Fraumeni plus CDH1). The...
Fri Sep 13, 2019 13:26
Related ArticlesCarving out another slice of the pie: Exceptional response to single agent imatinib in an asian female never-smoker with advanced NSCLC with a de-novo PDGFR-α N848 K mutation. Lung Cancer. 2018 10;124:86-89 Authors: Klempner SJ, Gowen K, Lee TK, Zhu VW, Schrock AB, Miller VA, Ali SM, Ou SI Abstract Non-small cell lung cancer (NSCLC) has emerged as a paradigm for clinical application of precision medicine as optimal therapy is commonly...
Fri Sep 13, 2019 13:26
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