As a novel orally active multitarget small molecule inhibitor, CS2164 has shown broad antitumor activities against several human tumor xenograft models in immune-compromised mice. However, the ability of CS2164 to modulate antitumor immunity in an immune-competent mouse tumor model remains undefined, although antiangiogenic treatment has been reported to affect immune cell infiltration and remodel the tumor immune microenvironment. In the present study, the subcutaneous and ascites hepatocellular...
Sat Sep 14, 2019 09:56
Aberrant function of RRAS2 drives malignant transformation in a various of cancers. However, little information exists on the function of RRAS2 in tumorigenesis of osteosarcoma. In this study, we investigated the effect of RRAS2 on osteosarcoma progression and its underlying mechanism. The gene expression level and prognostic power of RRAS2 in osteosarcoma were first investigated using the data from the Gene Expression Omnibus database. Then RNA interference was performed to silence the expression...
Sat Sep 14, 2019 09:56
Small-molecule targeted antitumor drugs are considered to be a promising treatment that can improve the efficacy and reduce side effects. PI3K/Akt signaling pathway is constantly activated in various cancers. We recently synthesized a series of novel compounds of PI3K/Akt pathway inhibitors and found the most effective analog to be W934. In this study, we explored the in-vitro and in-vivo antitumor effects of W934 on A549 non-small-cell lung cancer cells and HCT116 colorectal cancer cells. In-vitro...
Sat Sep 14, 2019 09:56
Elderly patients with ovarian cancer are an increasing population and many of them are frailty with an increased risk of postoperative complications, chemotherapy intolerance and mortality. Metronomic chemotherapy is the chronic administration of low, equally spaced, doses of antineoplastic drugs with therapeutic efficacy and low toxicity. Oral metronomic cyclophosphamide has gained increasing interest in recent years in the treatment of patients with recurrent ovarian cancer. We report the case...
Sat Sep 14, 2019 09:56
Chemotherapy is the main treatment for advanced gastric cancer. However, the emergence of multidrug resistance (MDR) has become a major obstacle in chemotherapy in many tumors, including gastric cancer. Epithelial–mesenchymal transition (EMT), which is considered an important process in cancer development, also contributes toward tumor MDR. Salinomycin, an EMT blocker, shows broad-spectrum antitumor and chemosensitization properties. Here, we hypothesized that salinomycin could reverse the MDR of...
Sat Sep 14, 2019 09:56
Osteosarcoma is the most common type of bone malignancies with a poor prognosis. In recent years, targeted therapy has shown great potential in the treatment of osteosarcoma, and more effective therapeutic targets for this disease need to be developed. APLNR is a seven transmembrane G-protein-coupled receptor expressed widely in multiple tissues. As has been reported, APLNR is involved in various physiological and pathological processes. Although APLNR plays a role in the development and progression...
Sat Sep 14, 2019 09:56
Cancer stem cells play a fundamental role in the growth, metastasis, recurrence, and chemoresistance of cancers of various origins; therefore, targeting these cells may prospectively help to eradicate cancer cells from patients. In this study, the effect of tetrandrine on the proliferation of CD133-positive (CD133+) Hep-2 cells was examined to characterize its potential for targeting cancer stem cells in laryngeal cancer. The stem cell population of Hep-2 cells was isolated by magnetic-activated...
Sat Sep 14, 2019 09:56
In the past decade, tumour flare reaction (TFR) was considered as a new side effect associated with immunomodulatory agents (IMiDs) and as a condition of chronic lymphocytic leukaemia (CLL). However, this phenomenon is also observed with immune checkpoint inhibitors in solid tumours. It is still poorly understood and its incidence is underestimated. TFR has been associated with morbidity, therefore, early recognition and management of patients with TFR is critical. An exhaustive literature research...
Sat Sep 14, 2019 09:56
Inflammation is essential for our innate and adaptive immunity, but chronic inflammation can also be detrimental, playing a role in tumor development and subversion of host immunity. A multitude of proteins and cytokines are involved in chronic inflammation; interleukin-1β, in particular, has been recognized as a critical pro-inflammatory cytokine that can trigger a cascade of inflammatory mediators, promoting angiogenesis, tumor invasiveness, and metastasis. The inhibition of interleukin-1β with...
Sat Sep 14, 2019 09:56
Fri Sep 13, 2019 16:56
Abstract Purpose Combined immunotherapy with anti-programmed cell death-ligand 1 (PD-L1) and an inhibitor of cluster of differentiation 47 (CD47) have exhibited preliminary anti-tumor effect. Our study attempted to describe the PD-L1/CD47 expression status in pulmonary sarcomatoid carcinoma (PSC), and explore its survival impact and relevance with cytotoxic T lymphocytes and macrophages infiltration. ...
Sat Sep 14, 2019 03:00
Abstract Background Dental caries and type 1 diabetes are responsible for a large burden of global disease; however, the exact prevalence of dental caries among children and adolescents with type 1 diabetes remains controversial, and no quantitative meta-analysis exists. Thus, we performed a meta-analysis to evaluate the prevalence of dental caries among children and adolescents with type 1 diabetes. ...
Sat Sep 14, 2019 03:00
British Journal of Nursing, Volume 28, Issue 16, Page 1099-1099, September 2019.
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British Journal of Nursing, Volume 28, Issue 16, Page S3-S3, September 2019.
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British Journal of Nursing, Volume 28, Issue 16, Page 1054-1055, September 2019.
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British Journal of Nursing, Volume 28, Issue 16, Page 1096-1096, September 2019.
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British Journal of Nursing, Volume 28, Issue 16, Page 1094-1095, September 2019.
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British Journal of Nursing, Volume 28, Issue 16, Page 1046-1046, September 2019.
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British Journal of Nursing, Volume 28, Issue 16, Page 1092-1093, September 2019.
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British Journal of Nursing, Volume 28, Issue 16, Page 1045-1045, September 2019.
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British Journal of Nursing, Volume 28, Issue 16, Page 1060-1062, September 2019.
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British Journal of Nursing, Volume 28, Issue 16, Page S18-S22, September 2019.
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British Journal of Nursing, Volume 28, Issue 16, Page 1056-1059, September 2019.
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British Journal of Nursing, Volume 28, Issue 16, Page S4-S15, September 2019.
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British Journal of Nursing, Volume 28, Issue 16, Page 1076-1084, September 2019.
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British Journal of Nursing, Volume 28, Issue 16, Page 1063-1068, September 2019.
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British Journal of Nursing, Volume 28, Issue 16, Page S24-S32, September 2019.
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British Journal of Nursing, Volume 28, Issue 16, Page 1086-1090, September 2019.
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British Journal of Nursing, Volume 28, Issue 16, Page 1069-1075, September 2019.
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British Journal of Nursing, Volume 28, Issue 16, Page 1047-1052, September 2019.
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Abstract Colorectal cancer is the fourth cause of death from cancer worldwide mainly due to the high incidence of drug‐resistance. During a screen for new actionable targets in drug‐resistant tumours we recently identified p65BTK ‐ a novel oncogenic isoform of Bruton's tyrosine kinase. Studying three different cohorts of patients here we show that p65BTK expression correlates with histotype and cancer progression. Using drug‐resistant TP53‐null colon cancer cells as a model we demonstrated that...
Fri Sep 13, 2019 19:09
Background and Objectives To evaluate the feasibility of using a novel blue diode laser (blue laser), a thulium fiber laser (Tm laser), and their combination as a directed‐energy surgical tool in laparoscopic partial nephrectomy (LPN). Study Design/Materials and Methods The blue laser emitting at 442 nm, the Tm laser emitting at 1,940 nm wavelengths, and the combination of them were tested. First, cutting and coagulative abilities of the lasers were characterized ex vivo on porcine kidney...
Fri Sep 13, 2019 16:51
Abstract Inhibitors targeting the mitogen‐activated protein kinase (MAPK) pathway and immune checkpoint molecules have dramatically improved the survival of patients with BRAF V600‐mutant melanoma. For BRAF/RAS wild type (WT) melanoma patients, however, immune checkpoint inhibitors remain the only effective therapeutic option with 40% of patients responding to PD‐1 inhibition. In the present study, a large panel of 10 BRAF V600‐mutant and 13 BRAF/RAS WT melanoma cell lines was analyzed to examine...
Fri Sep 13, 2019 19:03
affective reactivity relates to heart rate Abstract The importance of marmosets for comparative and translational science has grown in recent years because of their relatively rapid development, birth cohorts of twins, family social structure, and genetic tractability. Despite this, they remain understudied in investigations of affective processes. In this methodological note, we establish the validity of using noninvasive commercially available equipment to record cardiac physiology and compute...
Thu Sep 12, 2019 19:47
Predicted abundance of nests overlaid with the location of the transects (black lines), location of clusters of nests (red dots), and future location of the mine (pink line). Ronde hill is shown by the green line and rivers are shown by blue lines. Abstract The Boé sector in southeast Guinea‐Bissau harbors a population of western chimpanzees (Pan troglodytes verus) that inhabits a mosaic of forest and savanna. The Boé sector contains a substantial bauxite deposit in a region called Ronde Hill,...
Fri Sep 13, 2019 19:44
Influence of food supplementation on the diet and activity budget of adult brown howler monkeys.Abstract Research on the influence of food supplementation on primate behavior has focused on terrestrial and semiterrestrial species. Its effects on highly arboreal species are poorly known. We assessed the influence of food supplementation on the feeding behavior and activity budget of four adult female and two adult male brown howler monkeys (Alouatta guariba clamitans) belonging to two groups...
Fri Sep 13, 2019 19:44
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