This study was aimed to explore the prognosis-related biomarkers in glioblastoma and guide the therapy. The gene expression profile of glioblastoma samples with different prognosis outcomes was downloaded from National Center of Biotechnology Information Gene Expression Omnibus. The differently expressed genes (DEGs) among different samples were identified through pairwise comparison via Limma package of R. The DEGs were clustered using the Mfuzz package of R. The clusters with gene expression increasing...
Mon Sep 16, 2019 03:00
Immune checkpoint inhibitors (ICIs) represent a new standard of care for patients with advanced nonsmall cell lung cancer, improving overall survival compared with standard chemotherapy. However, a new pattern of response to ICIs characterized by accelerated tumor growth has been recently described, termed hyperprogressive disease (HPD). We report the case of a 73-year-old patient with advanced lung adenocarcinoma who developed HPD following treatment with a unique dose of atezolizumab for a skin...
Mon Sep 16, 2019 03:00
Anal canal adenocarcinoma is generally treated like rectal cancer. Surgery is the standard treatment in early stages and neoadjuvant chemoradiation in locally advanced tumors. Local recurrences treatment paradigm often depends on the previous therapies of either surgery or radiotherapy or systemic therapy. We present the case of a patient with tubulovillous adenocarcinoma of the anal canal which relapsed after chemoradiation. The patient refused salvage surgery and was treated with definitive electrochemotherapy...
Mon Sep 16, 2019 03:00
Small-vessel vasculitis is an uncommon diagnosis associated with many causes, including certain medication. Characteristic findings are immune complex deposition, vessel wall damage, and erythrocyte extravasation. We present a case of a 77-year-old man with advanced hepatocellular carcinoma who was treated with sorafenib. Twenty days post introduction to sorafenib, the patient experienced high fever and painful purpura on the lower limbs. The results of the skin biopsy confirmed the diagnosis. More...
Mon Sep 16, 2019 03:00
Tenosynovial giant cell tumour (TGCT) is a group of rare soft tissues neoplasia affecting synovial joints, bursae and tendon sheaths and is classified as localized type or diffuse type. The diffuse type (TGCT-D), also known as ‘pigmented villonodular (teno)synovitis’ is characterized by local aggressivity, with invasion and destruction of adjacent soft-tissue structures, and high local recurrence rate. Radical surgery remains the standard therapy while adjuvant radiotherapy may help to control local...
Mon Sep 16, 2019 03:00
Heavily pretreated ovarian cancer patients become progressively chemoresistant, and thereafter, only scant treatments potentially accord reasonable, albeit limited clinical efficacy. We describe a case involving a 67-year-old ovarian cancer patient who underwent multiple lines of chemotherapy and presented with recurrent disease and a CA-125 of 4112 U/mL. Thenceforth, she was treated with GL-ONC1 oncolytic viral therapy that was administered laparoscopically in accordance with a clinical trial. The...
Mon Sep 16, 2019 03:00
Abstract Objective To analyze the prevalence of high‐risk HPV in the oral cavity of HIV‐positive men who have sex with men (MSM) and to assess the concordance between oral and anal sites. Patients and Methods The study group consisted of 82 HIV‐infected MSM attending an anal cancer screening program. Sociodemographic, behavioral and medical‐analytical data were collected. Oral (rinse technique) and anal samples (brush technique) were taken from each patient. HPV‐DNA was extracted (QIAcube...
Tue Sep 17, 2019 18:24
Abstract Objective Oral healthcare professionals are frequently confronted with patients using drugs on a daily basis. These drugs can cause taste disorders as adverse effect. The literature that discusses drug‐induced taste disorders is fragmented. This article aims to support oral healthcare professionals in their decision making whether a taste disorder can be due to use of drugs by providing a comprehensive overview of drugs with taste disorders as an adverse effect. Materials and Methods...
Wed Sep 18, 2019 21:03
Abstract Globally, chronic pain is a major therapeutic challenge and affects more than 15% of the population. As patients with painful terminal diseases may face unbearable pain, there is a need for more potent analgesics. Although opioid-based therapeutic agents received attention to manage severe pain, their adverse drug effects and mortality rate associated with opioids overdose are the major concerns. Evidences from clinical trials showed therapeutic benefits of cannabis, especially...
Wed Sep 18, 2019 03:00
Abstract Purpose Sugammadex is used to reverse neuromuscular block induced by rocuronium or vecuronium by forming a stable complex. If the binding capacity of any substance to sugammadex is large enough, this molecule will displace rocuronium or vecuronium from the complex. For drugs used in anesthesia, the binding affinity of remifentanil for sugammadex was highest. The aim of the current study was to investigate the decrease in the reversal...
Wed Sep 18, 2019 03:00
The ancestor of some of the largest flying birds ever has been found in Waipara, New Zealand.
Wed Sep 18, 2019 02:36
During the late 10th century BCE, the emerging Edomite Kingdom of the southern Levant experienced a 'leap' in technological advancement.
Wed Sep 18, 2019 21:08
Surgical reconstruction of large soft tissue defects of the upper back is challenging. Although the usefulness of free perforator flaps has been demonstrated, local options remain limited. The dorsal intercost...
Tue Sep 17, 2019 03:00
Three-dimensional co-culture spheroid angiogenesis assay system is designed to mimic the physiologic angiogenesis. Co-culture spheroids are formed by two human vascular cell precursors, ECFCs and MSCs, and embedded in collagen gel. The new system is effective for evaluating angiogenic modulators, and provides more relevant information to the in vivo study.
Wed Sep 18, 2019 19:55
Presented here is a protocol for performing single-molecule Förster resonance energy transfer to study HJ resolution. Two-color alternating excitation is used for determining the dissociation constants. Single-color time lapse smFRET is then applied in real-time cleavage assays to obtain the dwell time distribution prior to HJ resolution.
Wed Sep 18, 2019 20:55
We describe an in vivo method to investigate the functional loss of a specific gene in satellite cells by using a combination of cardiotoxin mediated injury of skeletal muscle and the injection of a self-delivering siRNA.
Wed Sep 18, 2019 21:55
Blood-brain barrier integrity is critical for nervous system function. In Drosophila melanogaster, the blood-brain barrier is formed by glial cells during late embryogenesis. This protocol describes methods to assay for blood-brain barrier formation and maintenance in D. melanogaster embryos and third instar larvae.
Wed Sep 18, 2019 22:55
Abstract Background Airway structural changes are important in asthma pathology and require further investigations. Objective We sought to evaluate which computed tomography (CT) indices, bronchial histological traits, or blood and bronchoalveolar lavage (BAL) biomarkers correlate best with lung function abnormalities in asthma. Methods In 105 white adult asthmatics (53 with a component of fixed airflow obstruction) we determined airway cross‐sectional geometry of two proximal (the...
Wed Sep 18, 2019 21:39
A new form of gene therapy termed genetic editing or gene targeting has become possible owing to advances in genetic engineering technology. The intent of genetic editing is to alter the DNA code in cells with single base-pair specificity, and thus it can be considered to be an ultimate form of…
Wed Sep 11, 2019 03:00
Airway narrowing can be idiopathic or can occur as a result of airway tumors, hematomas, infections, and other pathologic conditions. Endoscopic management variously involves balloon dilatation, stent placement, laser vaporization of pathologic tissue, microdebridement, and other interventions, using either a rigid or a flexible bronchoscope. Jet ventilation is frequently used in such settings, especially when the presence of an endotracheal tube would interfere with the procedure. In desperate cases,...
Wed Sep 18, 2019 03:00
The introduction of peptide receptor radionuclide therapy (PRRT) represents a step change in the management of neuroendocrine tumours (NETs). The recently published NETTER-1 trial reported a significant improvement in progression free (PFS) and overall survival in those patients with small bowel NETs receiving lutetium oxodotreotide ([177Lu]DOTATATE) compared to single agent octreotide, giving confirmation to a theranostic field that has been active for the past 20 years but lacked a definitive study...
Wed Sep 18, 2019 03:00
Wed Sep 18, 2019 03:00
Mucosal Immunology, Published online: 18 September 2019; doi:10.1038/s41385-019-0204-yNon-hematopoietic STAT6 induces epithelial tight junction dysfunction and promotes intestinal inflammation and tumorigenesis
Wed Sep 18, 2019 03:00
A proper rehabilitation program targeting gait is mandatory to maintain the quality of life of patients with Myotonic dystrophy type 1 (DM1). Assuming that gait and balance impairment simply depend on the degr...
Wed Sep 18, 2019 03:00
Autologous breast reconstruction, on its own, is a complex microsurgical procedure. However, this operation is usually just one of a series of steps along a patient's reconstructive journey. This includes not just a primary major surgical event, but also the consequent recovery, potential complications and secondary surgeries required to optimise the final outcome. Unfortunately, there is limited information of what patients can expect of this reconstructive journey in the literature. The aim of...
Wed Sep 18, 2019 03:00
New England Journal of Medicine, Ahead of Print.
Wed Sep 18, 2019 12:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b07267
Wed Sep 18, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b07979
Wed Sep 18, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b09861
Wed Sep 18, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b05991
Wed Sep 18, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b07301
Wed Sep 18, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b05148
Wed Sep 18, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b10072
Wed Sep 18, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b06910
Wed Sep 18, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b08238
Wed Sep 18, 2019 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.9b07732
Wed Sep 18, 2019 07:00
J Neurol Surg BDOI: 10.1055/s-0039-1694051 Objective A novel technique is described for transpalatal hypophysectomy as an option for sellar region surgery using a microscope and/or endoscope. Technique A straight submucosal tunnel (approximately 20 mm in diameter; 40–50 mm long—half the length required by conventional transsphenoidal hypophysectomy) is dissected in favorable alignment with the main tumor axis, providing a direct view that allows the surgeon to operate on...
Wed Sep 18, 2019 02:00
J Neurol Surg BDOI: 10.1055/s-0039-1694054 Objective Neurofibromatosis type 2 (NF2) patients report that swallowing and speech problems significantly affect their quality of life, but the etiology of these phenomena is poorly understood. Swallowing and speech deficits may arise due to the neuropathy of involved nerves, due to posterior fossa tumor growth, or as iatrogenic effects from neurosurgical procedures to remove these tumors. This study aims to identify the natural history of...
Wed Sep 18, 2019 02:00
J Neurol Surg BDOI: 10.1055/s-0039-1696706 Objectives The main purpose of this article is to examine a single-center cohort of patients with nasopharyngeal adenoid cystic carcinoma (ACC) for pathologic features, skull base invasion, overall survival, and disease-free survival, with a focus on response to proton beam radiation therapy. Design, Setting, and Participants Single-center institutional cancer registry was used to retrospectively identify and analyze outcomes for...
Wed Sep 18, 2019 02:00
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου