Analytical ChemistryDOI: 10.1021/acs.analchem.9b03176
Wed Sep 18, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03278
Wed Sep 18, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03359
Wed Sep 18, 2019 07:00
Significant variability exists in the sarcopenic indices. All three sarcopenic indices previously described failed to predict post‐operative morbidity. Sarcopenic obesity was the only predictor of post‐operative morbidity. Abstract Background Several indices of sarcopenia (SARC) exist in the literature, however, there is no consensus as to the best SARC index to predict post‐operative morbidity following pancreatic surgery. Methods A prospectively collected database was reviewed in...
Wed Sep 18, 2019 14:53
Wed Sep 18, 2019 14:54
Wed Sep 18, 2019 14:54
The combination of radiation with immune-checkpoint inhibitors was reported in some cancers to have synergic effects both locally and distally. Our aim was to assess this combined therapy on both radiated and non-radiated bladder tumors and to characterize the immune landscape within the tumor microenvironment. Murine bladder cancer cells (MB49) were injected s.c. in both flanks of C57BL/6 mice. Mice were randomly assigned to the following treatments: placebo, antiPD-L1 (4 intra-peritoneal injections...
Wed Sep 18, 2019 20:44
The phosphatidylinositol 3-kinase (PI3K) signaling pathway serves as a central node in regulating cell survival, proliferation and metabolism. PIK3CA, the gene encoding the PI3K catalytic subunit p110-alpha, is commonly altered in breast cancer resulting in the constitutive activation of the PI3K pathway. Using an unbiased cell line screening approach, we tested the sensitivity of breast cancer cell lines to taselisib, a potent PI3K inhibitor, and correlated sensitivity with key biomarkers (PIK3CA,...
Wed Sep 18, 2019 20:44
AZD0156 is a potent and selective, bio-available inhibitor of Ataxia Telangiectasia Mutated (ATM) protein, a signaling kinase involved in the DNA damage response (DDR). We present pre-clinical data demonstrating abrogation of irradiation-induced ATM signaling by low doses of AZD0156, as measured by phosphorylation of ATM substrates. AZD0156 is a strong radio-sensitizer in vitro, and using a lung xenograft model, we show that systemic delivery of AZD0156 enhances the tumor growth inhibitory effects...
Wed Sep 18, 2019 20:44
Poly (ADP-ribose) Polymerase (PARP) inhibitors (PARPi) are approved to treat recurrent ovarian cancer with BRCA1 or BRCA2 mutations, and as maintenance therapy for recurrent platinum sensitive ovarian cancer (BRCA wild-type or mutated) after treatment with platinum. However, the acquired resistance against PARPi remains a clinical hurdle. Here, we demonstrated that PARP inhibitor (olaparib)-resistant epithelial ovarian cancer (EOC) cells exhibited an elevated aldehyde dehydrogenase (ALDH) activity,...
Wed Sep 18, 2019 20:44
Purpose: Pancreatic ductal adenocarcinoma (PDAC) is a predominantly fatal common malignancy with inadequate treatment options. Glycogen synthase kinase 3β (GSK-3β) is an emerging target in human malignancies including PDAC.Experimental Design: Pancreatic cancer cell lines and patient-derived xenografts were treated with a novel GSK-3 inhibitor 9-ING-41 alone or in combination with chemotherapy. Activation of the DNA damage response pathway and S-phase arrest induced by gemcitabine were assessed in...
Wed Sep 18, 2019 17:00
RNA silencing pathways play critical roles in maintaining quiescence of transposons in germ cells to promote genome integrity. However the precise mechanism by which different types of transposons are recognized by these pathways is not fully understood. Furthermore, the location in the germline where this transposition occurs after disruption of transposon silencing was previously unknown. Here we utilize the spatial and temporal organization of the Caenorhabditis elegans germline to demonstrate...
00:45
The usefulness of genomic prediction in crop and livestock breeding programs has prompted efforts to develop new and improved genomic prediction algorithms, such as artificial neural networks and gradient tree boosting. However, the performance of these algorithms has not been compared in a systematic manner using a wide range of datasets and models. Using data of 18 traits across six plant species with different marker densities and training population sizes, we compared the performance of six linear...
00:45
Satellites or tandem repeats are very abundant in many eukaryotic genomes. Occasionally they have been reported to be present in some prokaryotes, but to our knowledge there is no general comparative study on ...
Wed Sep 18, 2019 03:00
Blumeria graminis f. sp. tritici (Bgt), the causal agent of wheat powdery mildew severely affects yield security wheat production in China. Understanding the virulence structure and genetic variations of this pat...
Wed Sep 18, 2019 03:00
Silkmoths and their relatives constitute the ecologically and taxonomically diverse superfamily Bombycoidea, which includes some of the most charismatic species of Lepidoptera. Despite displaying spectacular f...
Wed Sep 18, 2019 03:00
Marine invertebrates are abundant and diverse on the continental shelf in Antarctica, but little is known about their parasitic counterparts. Endoparasites are especially understudied because they often posses...
Wed Sep 18, 2019 03:00
Future Oncology, Ahead of Print.
Wed Sep 18, 2019 06:24
Journal of Neurotrauma, Ahead of Print.
Wed Sep 18, 2019 10:00
Journal of Neurotrauma, Ahead of Print.
Wed Sep 18, 2019 10:00
Journal of Neurotrauma, Ahead of Print.
Wed Sep 18, 2019 10:00
Journal of Neurotrauma, Ahead of Print.
Wed Sep 18, 2019 10:00
Journal of Neurotrauma, Ahead of Print.
Wed Sep 18, 2019 10:00
Journal of Neurotrauma, Ahead of Print.
Wed Sep 18, 2019 10:00
Journal of Neurotrauma, Ahead of Print.
Wed Sep 18, 2019 10:00
Vibration of the vocal folds can disrupt the tissue and induce structural, functional, and molecular changes; the presence or absence of contact between the vocal folds during vibration can affect the type and extent of these changes. The purpose of this study was to characterize vocal fold changes following 2 hours of contact phonation or phonation without vibratory contact.
Wed Sep 18, 2019 03:00
Tissue Engineering Part A, Ahead of Print.
Wed Sep 18, 2019 10:00
Tissue Engineering Part A, Ahead of Print.
Wed Sep 18, 2019 10:00
Thyroid, Volume 29, Issue 9, Page 1316-1326, September 2019.
Tue Sep 17, 2019 10:00
Thyroid, Volume 29, Issue 9, Page 1346-1346, September 2019.
Tue Sep 17, 2019 10:00
Thyroid, Volume 29, Issue 9, Page 1262-1268, September 2019.
Tue Sep 17, 2019 10:00
Thyroid, Volume 29, Issue 9, Page 1255-1261, September 2019.
Tue Sep 17, 2019 10:00
Thyroid, Volume 29, Issue 9, Page 1173-1191, September 2019.
Tue Sep 17, 2019 10:00
Thyroid, Volume 29, Issue 9, Page 1286-1301, September 2019.
Tue Sep 17, 2019 10:00
Thyroid, Volume 29, Issue 9, Page 1237-1243, September 2019.
Tue Sep 17, 2019 10:00
Thyroid, Volume 29, Issue 9, Page 1220-1226, September 2019.
Tue Sep 17, 2019 10:00
Thyroid, Volume 29, Issue 9, Page 1302-1315, September 2019.
Tue Sep 17, 2019 10:00
Thyroid, Volume 29, Issue 9, Page 1347-1347, September 2019.
Tue Sep 17, 2019 10:00
Thyroid, Volume 29, Issue 9, Page 1201-1208, September 2019.
Tue Sep 17, 2019 10:00
Thyroid, Volume 29, Issue 9, Page 1279-1285, September 2019.
Tue Sep 17, 2019 10:00
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