Κυριακή 15 Σεπτεμβρίου 2019


Impact of Hyperventilation and Sleep Deprivation Upon Visual Evoked Potentials in Patients with Epilepsy.
Related ArticlesImpact of Hyperventilation and Sleep Deprivation Upon Visual Evoked Potentials in Patients with Epilepsy. Neurol India. 2019 Jul-Aug;67(4):1027-1032 Authors: Dziadkowiak E, Podemski R Abstract Objectives: The diagnosis of epilepsy can cause many problems, especially when the routine electrophysiological tests are inconclusive. The aim of the present study was to assess the visual evoked potential (VEP) in patients with epilepsy using...
pubmed: epilepsy treatment
Fri Sep 13, 2019 14:13
Drug-responsive versus drug-refractory mesial temporal lobe epilepsy: a single-center prospective outcome study.
Related ArticlesDrug-responsive versus drug-refractory mesial temporal lobe epilepsy: a single-center prospective outcome study. Postgrad Med. 2019 Sep 12;:1-7 Authors: Stefanatou M, Gatzonis S, Peskostas A, Paraskevas G, Koutroumanidis M Abstract Objectives: To evaluate clinical, electrophysiological, and neuroradiological factors which correlate with the prognosis in patients with mesial temporal lobe epilepsy (MTLE). Methods: This was a single-center...
pubmed: epilepsy treatment
Fri Sep 13, 2019 14:13
Inhibition of gap junctional intercellular communication by an anti-migraine agent, flunarizine.
Related ArticlesInhibition of gap junctional intercellular communication by an anti-migraine agent, flunarizine. PLoS One. 2019;14(9):e0222326 Authors: Yeo JH, Choi EJ, Lee J Abstract Gap junctions (GJs), which consist of proteins called connexins, are intercellular channels that allow the passage of ions, second messengers, and small molecules. GJs and connexins are considered as emerging therapeutic targets for various diseases. Previously, we screened...
pubmed: epilepsy treatment
Fri Sep 13, 2019 14:13
Comparative analysis of monotherapy versus duotherapy antiseizure drug management for postoperative seizure control in patients undergoing an awake craniotomy.
Related ArticlesComparative analysis of monotherapy versus duotherapy antiseizure drug management for postoperative seizure control in patients undergoing an awake craniotomy. J Neurosurg. 2018 06;128(6):1661-1667 Authors: Eseonu CI, Eguia F, Garcia O, Kaplan PW, Quiñones-Hinojosa A Abstract OBJECTIVE Postoperative seizures are a common complication in patients undergoing an awake craniotomy, given the cortical manipulation during tumor resection and...
pubmed: epilepsy treatment
Sat Sep 14, 2019 13:05
Decreased post-synaptic density-95 protein expression on dendrites of newborn neurons following CX3CR1 modulation in the epileptogenic adult rodent brain.
Related ArticlesDecreased post-synaptic density-95 protein expression on dendrites of newborn neurons following CX3CR1 modulation in the epileptogenic adult rodent brain. Cell Mol Immunol. 2018 Apr;15(4):414-417 Authors: Ali I, Avdic U, Chugh D, Ekdahl CT PMID: 29082919 [PubMed - indexed for MEDLINE]
pubmed: epilepsy treatment
Sat Sep 14, 2019 13:05
Double match of 18F-fluorodeoxyglucose-PET and iomazenil-SPECT improves outcomes of focus resection surgery.
Related ArticlesDouble match of 18F-fluorodeoxyglucose-PET and iomazenil-SPECT improves outcomes of focus resection surgery. Acta Neurochir (Wien). 2018 09;160(9):1875-1882 Authors: Fujimoto A, Okanishi T, Kanai S, Sato K, Itamura S, Baba S, Nishimura M, Masui T, Enoki H Abstract BACKGROUND: When the results of electroencephalography (EEG), magnetic resonance imaging (MRI), and seizure semiology are discordant or no structural lesion is evident on MRI,...
pubmed: epilepsy treatment
Sat Sep 14, 2019 13:05
Diffuse vasospasm after transcortical temporal lobectomy for intractable epilepsy.
Related ArticlesDiffuse vasospasm after transcortical temporal lobectomy for intractable epilepsy. Acta Neurochir (Wien). 2018 09;160(9):1883-1887 Authors: Dickerson JC, Hidalgo JA, Smalley ZS, Shiflett JM Abstract Cerebral delayed ischemia due to arterial vasospasm is a rare complication following epilepsy surgery. Here we report the third known case and first of diffuse vasospasm. A 48-year-old woman underwent a transcortical anterior left temporal...
pubmed: epilepsy treatment
Sat Sep 14, 2019 13:05
Efficacy and tolerability of perampanel in patients with genetic generalized epilepsy (GGE): A retrospective, single-center study from the United Arab Emirates (UAE).
Related ArticlesEfficacy and tolerability of perampanel in patients with genetic generalized epilepsy (GGE): A retrospective, single-center study from the United Arab Emirates (UAE). Epilepsy Behav Rep. 2019;12:100330 Authors: Alsaadi T, Kassie SA, Servano R Abstract •52.4% achieved seizure freedom at six months from baseline in our cohort of PWE from the UAE.•38.1% achieved ≥50% reduction in seizure frequency at six months from baseline.•90.5% remained...
pubmed: epilepsy treatment
Sat Sep 14, 2019 14:31
Relationship between Status Epilepticus Severity Score and etiology in adult NCSE patients.
Related ArticlesRelationship between Status Epilepticus Severity Score and etiology in adult NCSE patients. Ideggyogy Sz. 2019 Jul 30;72(7-8):257-263 Authors: Genç F, Erdal A, Akça G, Karaçay E, Göksu EÖ, Kutlu G, Gömceli YB Abstract Background and purpose: Nonconvulsive status epilepticus (NCSE) is a heterogeneous, severe neurological disorder of different etiologies. In this study, the outcomes of NCSE episodes was assessed in a large series of adult...
pubmed: epilepsy treatment
Sat Sep 14, 2019 14:31
The potential effects of anticonvulsant drugs on neuropeptides and neurotrophins in pentylenetetrazol kindled seizures in the rat.
Related ArticlesThe potential effects of anticonvulsant drugs on neuropeptides and neurotrophins in pentylenetetrazol kindled seizures in the rat. Int J Neurosci. 2019 Sep 13;:1-12 Authors: Tekgul H, Simsek E, Erdoğan MA, Yiğittürk G, Erbaş O, Taşkıran D Abstract Purpose: Neuropeptides and neurotrophic factors are thought to be involved in epileptogenesis. This study aims to investigate the potential effects of anticonvulsant drugs on neuropeptides (galanin...
pubmed: epilepsy treatment
Sat Sep 14, 2019 14:31
Drug-drug interactions and pharmacodynamics of concomitant clobazam and cannabidiol or stiripentol in refractory seizures.
Related ArticlesDrug-drug interactions and pharmacodynamics of concomitant clobazam and cannabidiol or stiripentol in refractory seizures. Epilepsy Behav. 2019 Sep 10;:106459 Authors: Klein P, Tolbert D, Gidal BE Abstract OBJECTIVE: The goal of this study was to characterize the drug-drug interactions between clobazam and 2 antiseizure drugs, cannabidiol and stiripentol, for treatment of refractory seizures through the use of pharmacokinetic modeling....
pubmed: epilepsy treatment
Sun Sep 15, 2019 13:23
[Fast track concepts in total knee arthroplasty: use of tranexamic acid and local intra-articular anesthesia technique].
Related Articles[Fast track concepts in total knee arthroplasty: use of tranexamic acid and local intra-articular anesthesia technique]. Oper Orthop Traumatol. 2019 Sep 13;: Authors: Petersen W, Bierke S, Hees T, Karpinski K, Häner M Abstract OBJECTIVE: Fast track concepts are used to reduce the risk of perioperative and postoperative complications after total knee arthroplasty. INDICATIONS: The described concepts are used for patients with...
pubmed: epilepsy treatment
Sun Sep 15, 2019 13:23
Prescription patterns of antiepileptic drugs in Kazakhstan in 2018: A retrospective study of 57,959 patients.
Related ArticlesPrescription patterns of antiepileptic drugs in Kazakhstan in 2018: A retrospective study of 57,959 patients. Epilepsy Behav. 2019 Sep 11;99:106445 Authors: Jacob L, Kerimbaeva Z, Kalyapin A, Kostev K Abstract AIM: The goal of this retrospective study was to analyze prescription patterns of antiepileptic drugs (AEDs) in Kazakhstan in 2018. METHODS: This study used prescription data of patients with epilepsy who received AEDs...
pubmed: epilepsy treatment
Sun Sep 15, 2019 14:38
Optimized SEEG-guided radiofrequency thermocoagulation for mesial temporal lobe epilepsy with hippocampal sclerosis.
Related ArticlesOptimized SEEG-guided radiofrequency thermocoagulation for mesial temporal lobe epilepsy with hippocampal sclerosis. Seizure. 2019 Aug 30;71:304-311 Authors: Fan X, Shan Y, Lu C, An Y, Wang Y, Du J, Wang D, Wei P, Fisher RS, Wang Y, Ren L, Zhao G Abstract PURPOSE: Concerns about the impact of open surgery for drug-resistant mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) have driven interest in minimally invasive techniques....
pubmed: epilepsy treatment
Sun Sep 15, 2019 14:38
Trastuzumab use in older patients with HER2-positive metastatic breast cancer: outcomes and treatment patterns in a whole-of-population Australian cohort (2003-2015).
Related ArticlesTrastuzumab use in older patients with HER2-positive metastatic breast cancer: outcomes and treatment patterns in a whole-of-population Australian cohort (2003-2015). BMC Cancer. 2019 Sep 11;19(1):909 Authors: Daniels B, Kiely BE, Tang M, Tervonen H, Pearson SA Abstract BACKGROUND: Older patients with HER2-positive metastatic breast (HER2 + MBC) cancer are underrepresented in clinical trials. We aim to describe the treatment patterns...
pubmed: her2-positive breast...
Fri Sep 13, 2019 13:04
Long-term survival analysis of adjuvant chemotherapy with or without trastuzumab in patients with T1, node-negative HER2-positive breast cancer.
Related ArticlesLong-term survival analysis of adjuvant chemotherapy with or without trastuzumab in patients with T1, node-negative HER2-positive breast cancer. Clin Cancer Res. 2019 Sep 12;: Authors: He X, Ji J, Tian M, Esteva FJ, Hortobagyi GN, Yeung SJ Abstract PURPOSE: Adjuvant therapy for small, node-negative HER2-positive breast cancer (HER2+ BC) is controversial. We aimed to identify the subgroup that would benefit most from adjuvant chemotherapy...
pubmed: her2-positive breast...
Sat Sep 14, 2019 13:16
Interaction between molecular subtypes, stromal immune infiltration before and after treatment in breast cancer patients treated with neoadjuvant chemotherapy.
Related ArticlesInteraction between molecular subtypes, stromal immune infiltration before and after treatment in breast cancer patients treated with neoadjuvant chemotherapy. Clin Cancer Res. 2019 Sep 12;: Authors: Hamy AS, Bonsang-Kitzis H, De Croze D, Laas E, Darrigues L, Topciu L, Menet E, Vincent-Salomon A, Lerebours F, Pierga JY, Brain E, Feron JG, Benchimol G, Lam GT, Lae M, Reyal F Abstract PURPOSE: High levels of tumor-infiltrating lymphocytes...
pubmed: her2-positive breast...
Sat Sep 14, 2019 13:16
Imaging and Clinicopathologic Features Associated With Pathologic Complete Response in HER2-positive Breast Cancer Receiving Neoadjuvant Chemotherapy With Dual HER2 Blockade.
Related ArticlesImaging and Clinicopathologic Features Associated With Pathologic Complete Response in HER2-positive Breast Cancer Receiving Neoadjuvant Chemotherapy With Dual HER2 Blockade. Clin Breast Cancer. 2019 Aug 21;: Authors: Yoon GY, Chae EY, Cha JH, Shin HJ, Choi WJ, Kim HH, Kim JE, Kim SB Abstract BACKGROUND: In human epidermal growth factor receptor 2-positive (HER2+) breast cancer, the incorporation of a dual HER2 blockade into neoadjuvant...
pubmed: her2-positive breast...
Sun Sep 15, 2019 13:23
Need for positive airway pressure re-titration with changes in mask style.
Related ArticlesNeed for positive airway pressure re-titration with changes in mask style. Sleep Med. 2018 01;41:100-101 Authors: Ebben MR PMID: 29174795 [PubMed - indexed for MEDLINE]
pubmed: sleep apnea
Fri Sep 13, 2019 14:10
Japanese Sleep Questionnaire for Elementary Schoolers (JSQ-ES): validation and population-based score distribution.
Related ArticlesJapanese Sleep Questionnaire for Elementary Schoolers (JSQ-ES): validation and population-based score distribution. Sleep Med. 2018 01;41:69-77 Authors: Kuwada A, Mohri I, Asano R, Matsuzawa S, Kato-Nishimura K, Hirata I, Mitsuhosi T, Kagitani-Shimono K, Nakanishi M, Tachibana M, Ohno Y, Taniike M Abstract OBJECTIVE: The Japanese Sleep Questionnaire for Elementary Schoolers (JSQ-ES) was developed to measure the sleep habits and disturbances...
pubmed: sleep apnea
Fri Sep 13, 2019 14:10
[Respiratory muscle testing and its value in diagnosis and treatment of sleep disordered breathing].
Related Articles[Respiratory muscle testing and its value in diagnosis and treatment of sleep disordered breathing]. Zhonghua Yi Xue Za Zhi. 2019 Jul 23;99(28):2163-2165 Authors: Luo YM, Liang SF PMID: 31434386 [PubMed - indexed for MEDLINE]
pubmed: sleep apnea
Fri Sep 13, 2019 14:10
Pathophysiologic mechanisms, neuroimaging and treatment in wake-up stroke.
Related ArticlesPathophysiologic mechanisms, neuroimaging and treatment in wake-up stroke. CNS Spectr. 2019 Sep 12;:1-8 Authors: Elfil M, Eldokmak M, Baratloo A, Ahmed N, Amin HP, Koo BB Abstract Wake-up stroke (WUS) or ischemic stroke occurring during sleep accounts for 14%-29.6% of all ischemic strokes. Management of WUS is complicated by its narrow therapeutic time window and attributable risk factors, which can affect the safety and efficacy of administering...
pubmed: sleep apnea
Fri Sep 13, 2019 14:10
Novel Insights Into Sleep Disorder and Atrial Fibrillation Risk: More Than Sleep Apnea.
Related ArticlesNovel Insights Into Sleep Disorder and Atrial Fibrillation Risk: More Than Sleep Apnea. Chest. 2019 Sep;156(3):421-423 Authors: Mehra R, Marcus GM PMID: 31511147 [PubMed - in process]
pubmed: sleep apnea
Fri Sep 13, 2019 14:10
New organisation for follow-up and assessment of treatment efficacy in sleep apnoea.
Related ArticlesNew organisation for follow-up and assessment of treatment efficacy in sleep apnoea. Eur Respir Rev. 2019 Sep 30;28(153): Authors: Suarez-Giron M, Bonsignore MR, Montserrat JM Abstract Obstructive sleep apnoea (OSA) is a highly prevalent disease, and there is an increased demand for OSA diagnosis and treatment. However, resources are limited compared with the growing needs for OSA diagnosis and management, and alternative strategies need...
pubmed: sleep apnea
Fri Sep 13, 2019 14:10
Drug-induced sleep endoscopy compared with systematic adenotonsillectomy in the management of obstructive sleep apnoea in children: a systematic review and meta-analysis protocol.
Related ArticlesDrug-induced sleep endoscopy compared with systematic adenotonsillectomy in the management of obstructive sleep apnoea in children: a systematic review and meta-analysis protocol. BMJ Open. 2019 Sep 11;9(9):e028242 Authors: Prévost AS, Hylands M, Gervais M, Praud JP, Battista MC, Déziel-Malouin S, Lachance M, Lamontagne F Abstract INTRODUCTION: Obstructive sleep apnoea affects up to 6% of children worldwide. Although current guidelines...
pubmed: sleep apnea
Fri Sep 13, 2019 14:10
Obstructive sleep apnea treatment in adults.
Related ArticlesObstructive sleep apnea treatment in adults. Kaohsiung J Med Sci. 2019 Sep 12;: Authors: Chang HP, Chen YF, Du JK Abstract Sleep-related breathing disorders are complex problems that decrease quality of life and increase morbidity and mortality in patients. Comprehensive evaluation is essential for selecting and planning obstructive sleep apnea (OSA) treatments. However, the many proposed OSA treatments are rarely compared in the literature....
pubmed: sleep apnea
Fri Sep 13, 2019 14:10
Update on Research and Practices in Major Sleep Disorders: Part I. Obstructive Sleep Apnea Syndrome.
Related ArticlesUpdate on Research and Practices in Major Sleep Disorders: Part I. Obstructive Sleep Apnea Syndrome. J Nurs Scholarsh. 2019 Sep;51(5):500-508 Authors: Chaiard J, Weaver TE Abstract PURPOSE: The purpose of this first of two review articles providing an update on sleep disorders was to examine the pathophysiology, epidemiology, and treatment of obstructive sleep apnea (OSA). OSA is a common sleep disorder whose prevalence is similar to...
pubmed: sleep apnea
Fri Sep 13, 2019 14:10
Association of Obstructive Sleep Apnea With the Risk of Affective Disorders.
Related ArticlesAssociation of Obstructive Sleep Apnea With the Risk of Affective Disorders. JAMA Otolaryngol Head Neck Surg. 2019 Sep 12;: Authors: Kim JY, Ko I, Kim DK Abstract Importance: Obstructive sleep apnea (OSA) is a common subtype of sleep breathing disorder; however, the association between OSA and the psychological health of affected individuals has not been fully evaluated. Objective: To investigate the association between OSA and...
pubmed: sleep apnea
Fri Sep 13, 2019 14:10
Respiratory-Related Displacement of the Trachea in Obstructive Sleep Apnea.
Related ArticlesRespiratory-Related Displacement of the Trachea in Obstructive Sleep Apnea. J Appl Physiol (1985). 2019 Sep 12;: Authors: Tong J, Jugé L, Burke PGR, Knapman F, Eckert DJ, Bilston LE, Amatoury J Abstract Tracheal displacement is thought to be the primary mechanism by which changes in lung volume influence upper airway patency. Caudal tracheal displacement during inspiration may help preserve the integrity of the upper airway in response...
pubmed: sleep apnea
Fri Sep 13, 2019 14:10
Evolution and Predictive Factors of Improvement of Obstructive Sleep Apnea in an Obese Population After Bariatric Surgery.
Related ArticlesEvolution and Predictive Factors of Improvement of Obstructive Sleep Apnea in an Obese Population After Bariatric Surgery. J Clin Sleep Med. 2019 Sep 12;: Authors: Magne F, Gomez E, Marchal O, Malvestio P, Reibel N, Brunaud L, Ziegler O, Quilliot D, Chabot F, Chaouat A Abstract INTRODUCTION: Our objectives were to determine in an obese population (body mass index > 35 kg/m²) the number of patients, after gastric bypass (GBP), who no...
pubmed: sleep apnea
Fri Sep 13, 2019 14:10
Prevalence, Characteristics and Association of Obstructive Sleep Apnea with Blood Pressure Control in Patients with Resistant Hypertension.
Related ArticlesPrevalence, Characteristics and Association of Obstructive Sleep Apnea with Blood Pressure Control in Patients with Resistant Hypertension. Ann Am Thorac Soc. 2019 Sep 13;: Authors: Sapiña-Beltrán E, Torres G, Benitez I, Fortuna-Gutiérrez AM, Ponte Márquez P, Masa JF, Corral-Peñafiel J, Drager LF, Cabrini M, Félez M, Vázquez S, Abad J, Lee CH, Aung AT, García-Río F, Casitas R, Sanchez-de-la-Torre M, Michela Gaeta A, Barbé F, Dalmases M Abstract...
pubmed: sleep apnea
Sat Sep 14, 2019 13:49
Is the 2013 American Thoracic Society CPAP-tracking system algorithm useful for managing non-adherence in long-term CPAP-treated patients?
Related ArticlesIs the 2013 American Thoracic Society CPAP-tracking system algorithm useful for managing non-adherence in long-term CPAP-treated patients? Respir Res. 2019 Sep 12;20(1):209 Authors: Rotty MC, Mallet JP, Suehs CM, Martinez C, Borel JC, Rabec C, Bourdin A, Molinari N, Jaffuel D Abstract BACKGROUND: Whereas telemedicine usage is growing, the only clinical algorithm for Continuous Positive Airway Pressure (CPAP) adherence management is that...
pubmed: sleep apnea
Sat Sep 14, 2019 13:49
Improving surgical results in velopharyngeal surgery: our experience in the last decade.
Related ArticlesImproving surgical results in velopharyngeal surgery: our experience in the last decade. Acta Otorrinolaringol Esp. 2019 Sep 09;: Authors: Martínez Ruiz de Apodaca P, Carrasco Llatas M, Valenzuela Gras M, Dalmau Galofre J Abstract BACKGROUND AND PURPOSE: The surgical techniques used to treat velopharyngeal collapse in obstructive sleep apnoea patients have evolved over recent years. Our aim was to determine whether these new techniques...
pubmed: sleep apnea
Sat Sep 14, 2019 13:49
In obstructive sleep apnea patients, automatic determination of respiratory arrests by photoplethysmography signal and heart rate variability.
Related ArticlesIn obstructive sleep apnea patients, automatic determination of respiratory arrests by photoplethysmography signal and heart rate variability. Australas Phys Eng Sci Med. 2019 Sep 12;: Authors: Bozkurt MR, Uçar MK, Bozkurt F, Bilgin C Abstract Obstructive sleep apnea is a disease that occurs in connection to pauses in respiration during sleep. Detection of the disease is achieved using a polysomnography device, which is the gold standard...
pubmed: sleep apnea
Sat Sep 14, 2019 13:49
Multimodal anesthesia management of a morbidly obese spinal muscular atrophy patient with obstructive sleep apnea.
Related ArticlesMultimodal anesthesia management of a morbidly obese spinal muscular atrophy patient with obstructive sleep apnea. Kaohsiung J Med Sci. 2019 Sep 12;: Authors: Gau TP, Chen GY, Su MP, Cheng KI PMID: 31515939 [PubMed - as supplied by publisher]
pubmed: sleep apnea
Sat Sep 14, 2019 13:49
Respiratory presentation of diffuse idiopathic skeletal hyperostosis (DISH): Management and review of the literature.
Related ArticlesRespiratory presentation of diffuse idiopathic skeletal hyperostosis (DISH): Management and review of the literature. Cranio. 2019 Sep 13;:1-4 Authors: Dell'Era V, Garzaro M, Farri F, Gorris C, Rosa MS, Toso A, Aluffi Valletti P Abstract Background: Diffuse idiopathic skeletal hyperostosis (DISH) is characterized by the ossification of entheses. When localized in the cervical paravertebral region, typical signs and symptoms include stiffness,...
pubmed: sleep apnea
Sat Sep 14, 2019 15:13
Magnitude of Nonalcoholic Fatty Liver Disease: Western Perspective.
Related ArticlesMagnitude of Nonalcoholic Fatty Liver Disease: Western Perspective. J Clin Exp Hepatol. 2019 Jul-Aug;9(4):497-505 Authors: Samji NS, Verma R, Satapathy SK Abstract The incidence of nonalcoholic fatty liver disease (NAFLD) is continuing to rise worldwide, and it is estimated that this disquieting trend will continue for another 10-15 years before prevalence begins to decrease. NAFLD is the hepatic manifestation of metabolic syndrome. As...
pubmed: sleep apnea
Sat Sep 14, 2019 15:13
Pathogenesis and Consequences of Disordered Sleep in PCOS.
Related ArticlesPathogenesis and Consequences of Disordered Sleep in PCOS. Clin Med Insights Reprod Health. 2019;13:1179558119871269 Authors: Sam S, Ehrmann DA Abstract Polycystic ovary syndrome (PCOS) is a common hormonal disorder that is characterized by hyperandrogenism and menstrual irregularity. Affected women have a high prevalence of insulin resistance and related metabolic complications. The frequency of sleep disturbances appears to be increased...
pubmed: sleep apnea
Sat Sep 14, 2019 15:13
Resolution of Idiopathic Intracranial Hypertension Symptoms by Surgery for Obstructive Sleep Apnea in a Pediatric Patient.
Related ArticlesResolution of Idiopathic Intracranial Hypertension Symptoms by Surgery for Obstructive Sleep Apnea in a Pediatric Patient. J Pediatr Neurosci. 2019 Apr-Jun;14(2):110-112 Authors: Onder H, Aksoy M PMID: 31516635 [PubMed]
pubmed: sleep apnea
Sat Sep 14, 2019 15:13

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