Related ArticlesIdentification of key modules and prognostic markers in adrenocortical carcinoma by weighted gene co-expression network analysis. Oncol Lett. 2019 Oct;18(4):3673-3681 Authors: Zou Y, Jing L Abstract Adrenocortical carcinoma (ACC) is a rare and aggressive cancer with a high relapse rate and limited treatment options. Therefore, the identification of potential prognostic markers in patients with ACC may improve early detection, survival...
Sat Sep 14, 2019 14:31
Related ArticlesTOX3 is a favorable prognostic indicator and potential immunomodulatory factor in lung adenocarcinoma. Oncol Lett. 2019 Oct;18(4):4144-4152 Authors: Zeng, Lin H, Cui J, Liang W Abstract Thymocyte selection-associated high mobility group box (TOX) genes represent a novel family of genes. Deregulated expression of TOXs has been reported in a variety of cancer types, including lung cancer. It has also been reported that TOXs are crucial...
Sat Sep 14, 2019 14:31
Related ArticlesMalignant pleural effusion and cancer of unknown primary site: a review of literature. Ann Transl Med. 2019 Aug;7(15):353 Authors: Awadallah SF, Bowling MR, Sharma N, Mohan A Abstract Malignant pleural effusions (MPE) are most frequently (50-65%) noted from lung and breast cancers. They are commonly unilateral and are reflective of poorer prognosis. Cancer of unknown primary (CUP) account for 4-5% of all invasive cancers. These are metastatic...
Sat Sep 14, 2019 14:31
Related ArticlesCardiotoxicity from immune checkpoint inhibitors. Int J Cardiol Heart Vasc. 2019 Dec;25:100420 Authors: Michel L, Rassaf T, Totzeck M Abstract Immune checkpoint inhibitor (ICI) therapy has greatly improved treatment of various advanced cancers but increasing use of ICI therapy has exposed the risk of ICI-related cardiovascular side effects. Immune checkpoints are inhibitory regulators of T cell activation and mediate T cell effector functions...
Sat Sep 14, 2019 14:31
Related ArticlesPredicting lymph node metastasis in early gastric cancer patients: development and validation of a model. Future Oncol. 2019 Sep 13;: Authors: Mu J, Jia Z, Yao W, Song J, Cao X, Jiang J, Wang Q Abstract Aim: To develop and validate a model to predict possibility of lymph node metastasis (LNM) in early gastric cancer. Materials & methods: An LNM prediction model was developed by logistic regression based on the demographics or characteristics...
Sat Sep 14, 2019 14:31
Related ArticlesChoosing Words Wisely: Residents' Use of Rhetorical Appeals in Conversations About Unnecessary Tests. Acad Med. 2019 Sep 10;: Authors: Tseng EK, Mukerji G, Weinerman A, Fuller J, McLeod A, Wong BM, Kuper A, Stroud LS Abstract PURPOSE: To characterize how residents employ rhetorical appeals (i.e., the strategic use of communication to achieve specifiable goals) when discussing unnecessary diagnostic tests with patients. METHOD:...
Sat Sep 14, 2019 14:31
Related ArticlesHighly durable response to capecitabine in patient with metastatic estrogen receptor positive breast cancer: A case report. Medicine (Baltimore). 2019 Sep;98(37):e17135 Authors: Barchiesi G, Krasniqi E, Barba M, Giulia MD, Pizzuti L, Massimiani G, Ciliberto G, Vici P Abstract RATIONALE: In estrogen receptor-positive HER2-negative (ER+HER2-) metastatic breast cancer, chemotherapy should be offered only to patients who develop endocrine...
Sat Sep 14, 2019 14:31
Related ArticlesExploring the Needs of Adolescents With Sickle Cell Disease to Inform a Digital Self-Management and Transitional Care Program: Qualitative Study. JMIR Pediatr Parent. 2018 Sep 25;1(2):e11058 Authors: Kulandaivelu Y, Lalloo C, Ward R, Zempsky WT, Kirby-Allen M, Breakey VR, Odame I, Campbell F, Amaria K, Simpson EA, Nguyen C, George T, Stinson JN Abstract BACKGROUND: Accessible self-management interventions are critical for adolescents...
Sat Sep 14, 2019 14:31
Related ArticlesAmidino-Rocaglates: A Potent Class of eIF4A Inhibitors. Cell Chem Biol. 2019 Sep 09;: Authors: Chu J, Zhang W, Cencic R, Devine WG, Beglov D, Henkel T, Brown LE, Vajda S, Porco JA, Pelletier J Abstract Rocaglates share a common cyclopenta[b]benzofuran core that inhibits eukaryotic translation initiation by modifying the behavior of the RNA helicase, eIF4A. Working as interfacial inhibitors, rocaglates stabilize the association between...
Sun Sep 15, 2019 13:17
Related ArticlesTreatment Algorithm for Patients With Gastric Adenocarcinoma: An Austrian Consensus on Systemic Therapy. Anticancer Res. 2019 Sep;39(9):4589-4596 Authors: Wöll E, Eisterer W, Gerger A, Kühr T, Prager GW, Rumpold H, Ulrich-Pur H, Vogl U, Winder T, Weiss L, Greil R Abstract Despite recent advances in the treatment of gastric cancer, mortality related to this disease is still substantial. Surgery and chemotherapy represent the cornerstones...
Sun Sep 15, 2019 13:17
Related ArticlesIntrauterine Progestin Therapy as a New Approach to Premalignant Endometrial Polyps: A Prospective Observational Study. Anticancer Res. 2019 Sep;39(9):4897-4903 Authors: Sletten ET, Arnes M, Vereide AB, Ørbo A Abstract BACKGROUND/AIM: Endometrial hyperplastic polyps (EHP) may progress to endometrial carcinoma (EC) if left untreated. We aimed to prospectively investigate the efficacy of the low-dose levonorgestrel intrauterine system (LNG-IUS)...
Sun Sep 15, 2019 13:17
Related ArticlesCancer biology as revealed by the research autopsy. Nat Rev Cancer. 2019 Sep 13;: Authors: Iacobuzio-Donahue CA, Michael C, Baez P, Kappagantula R, Hooper JE, Hollman TJ Abstract A research autopsy is a post-mortem medical procedure performed on a deceased individual with the primary goal of collecting tissue to support basic and translational research. This approach has increasingly been used to investigate the pathophysiological mechanisms...
Sun Sep 15, 2019 13:17
Related ArticlesA Pilot Study of a TeleHealth Family-Focused Melanoma Preventive Intervention for Children with a Family History of Melanoma. Psychooncology. 2019 Sep 13;: Authors: Wu YP, Boucher K, Hu N, Hay J, Kohlmann W, Aspinwall LG, Bowen DJ, Parsons BG, Nagelhout ES, Grossman D, Mooney K, Leachman SA, Tercyak KP Abstract OBJECTIVE: Melanoma preventive interventions for children with familial risk are critically needed, because ultraviolet radiation...
Sun Sep 15, 2019 13:17
Related ArticlesCurrent management of limited-stage SCLC and CONVERT trial impact: Results of the EORTC Lung Cancer Group survey. Lung Cancer. 2019 Aug 13;136:145-147 Authors: Levy A, Hendriks LEL, Le Péchoux C, Falk S, Besse B, Novello S, Dingemans AC, Hasan B, Reck M, Berghmans T, Faivre-Finn C, EORTC Lung Cancer Group (EORTC LCG) Abstract OBJECTIVES: The CONVERT trial showed that twice-daily (BD) concurrent chemoradiotherapy should continue to be...
Sun Sep 15, 2019 15:06
Related ArticlesDevelopment and validation of the protocol for the evaluation of voice in patients with hearing impairment (PEV-SHI). Braz J Otorhinolaryngol. 2019 Jul 03;: Authors: Coelho AC, Brasolotto AG, Bahmad F Abstract INTRODUCTION: The voice of individuals with hearing impairment has been widely described, and can be compromised in all levels of the phonatory system. OBJECTIVE: To develop and validate an instrument for evaluating the...
Sun Sep 15, 2019 13:17
Related ArticlesReplacement of the heme axial lysine as a test of conformational adaptability in the truncated hemoglobin THB1. J Inorg Biochem. 2019 Sep 04;201:110824 Authors: Nye DB, Johnson EA, Mai MH, Lecomte JTJ Abstract Amino acid replacement is a useful strategy to assess the roles of axial heme ligands in the function of native heme proteins. THB1, the protein product of the Chlamydomonas reinhardtii THB1 gene, is a group 1 truncated hemoglobin...
Fri Sep 13, 2019 14:28
Related ArticlesIdentification of a haptoglobin-hemoglobin complex in human blood plasma. J Inorg Biochem. 2019 Aug 19;201:110802 Authors: Sarpong-Kumankomah S, Gailer J Abstract Blood plasma metalloproteins that contain copper (Cu), iron (Fe), zinc (Zn) and/or other metals/metalloids are potential disease biomarkers because the bloodstream is in permanent contact with organs. Their quantification and/or the presence of additional metal-entities or the...
Fri Sep 13, 2019 14:28
Related ArticlesSynthesis, characterization, anti-tumor activity, photo-luminescence and BHb/HHb/Hsp90 molecular docking of zinc(II) hydroxyl-terpyridine complexes. J Inorg Biochem. 2019 Jul 22;201:110790 Authors: Huang L, Liu R, Li J, Liang X, Lan Q, Shi X, Pan L, Chen H, Ma Z Abstract Six zinc(II) complexes [Zn(Br)2L1] (1), [Zn(Br)2L2] (2) and [Zn(Br)2L3] (3), [Zn(I)2L1] (4), [Zn(I)2L2] (5) and [Zn(I)2L3] (6) have been obtained by the reactions of...
Sat Sep 14, 2019 15:48
Related ArticlesSynthesis and anticancer evaluation of benzo-N-heterocycles transition metal complexes against esophageal cancer cell lines. J Inorg Biochem. 2019 Sep 06;201:110816 Authors: Zhi S, Li Y, Qiang J, Hu J, Song W, Zhao J Abstract Three novel transition metal complexes, Cu(p-2-bmq)Cl2 (1), Zn(p-2-bmq)Cl2 (2) and [Co(p-2-bmq)Cl2]2 (3) (where p-2-bmq = 2-((1-(pyridin-2-yl)-1H-benzoimidazol-2-yl)methyl) quinolone, have been synthesized. The complexes...
Sat Sep 14, 2019 15:48
Related ArticlesCoordination properties of Cu(II) ions towards the peptides based on the His-Xaa-His motif from Fusobacterium nucleatum P1 protein. J Inorg Biochem. 2019 Sep 02;201:110819 Authors: Krupa K, Korabik M, Kowalik-Jankowska T Abstract The coordination capacity of the copper(II) ions with peptides (fragments of the P1 protein - one of the outer membrane protein from Fusobacterium nucleatum) based on the His-Xaa-His motif was carried out using...
Sat Sep 14, 2019 15:48
Related ArticlesBioMOF@cellulose fabric composites for bioactive molecule delivery. J Inorg Biochem. 2019 Sep 05;201:110818 Authors: Noorian SA, Hemmatinejad N, Navarro JAR Abstract This work describes in situ synthesis and application of the zinc glutamate Bio Metal-Organic Framework (BioMOF) supported on cellulose fabrics as a dual material for nitric oxide (NO) and 5-fluorouracil (5FU) controlled delivery for wound and/or skin cancer therapy. In situ...
Sat Sep 14, 2019 15:48
Related ArticlesSynthesis and in vitro antitumor activity evaluation of copper(II) complexes with 5-pyridin-2-yl-[1,3]dioxolo[4,5-g]isoquinoline derivatives. J Inorg Biochem. 2019 Sep 02;201:110820 Authors: Zhang YL, Deng CX, Zhou WF, Zhou LY, Cao QQ, Shen WY, Liang H, Chen ZF Abstract Seven Cu(II) complexes with 5-pyridin-2-yl-[1,3]dioxolo[4,5-g]isoquinoline derivatives as ligands: [Cu2(L1)2Cl4] (1), [Cu(L2)Cl2] (2), [Cu(L1)(NO3)2] (3), [Cu(L2)(NO3)2]...
Sat Sep 14, 2019 15:48
Related ArticlesArtificial bioinorganic clusters of dinuclear 3d-transition metal ions coordinated by an inorganic coordination ligand. J Inorg Biochem. 2019 Sep 05;201:110821 Authors: Sugiarto, Kawamoto K, Hayashi Y Abstract A new biologically relevant cubane-type artificial inorganic ligand was developed to support 3d-transition metal ions of Mn(II), Co(II), Ni(II), Zn(II), Fe(III), and also In(III). All of the reactions produce dinuclear cationic...
Sun Sep 15, 2019 15:20
Related ArticlesVanadium(V) tris-3,5-di-tert-butylcatecholato complex: Links between speciation and anti-proliferative activity in human pancreatic cancer cells. J Inorg Biochem. 2019 Sep 03;201:110815 Authors: Griffin E, Levina A, Lay PA Abstract Vanadium complexes are intensively tested for anti-cancer activities, particularly for the novel treatment protocols involving injections of cytotoxic compounds directly into the tumor. This approach is increasingly...
Sun Sep 15, 2019 15:20
Related ArticlesKinetic analysis of a globin-coupled diguanylate cyclase, YddV: Effects of heme iron redox state, axial ligands, and heme distal mutations on catalysis. J Inorg Biochem. 2019 Sep 06;201:110833 Authors: Lengalova A, Fojtikova-Proskova V, Vavra J, Martínek V, Stranava M, Shimizu T, Martinkova M Abstract Heme-based oxygen sensors allow bacteria to regulate their activity based on local oxygen levels. YddV, a globin-coupled oxygen sensor...
Sun Sep 15, 2019 15:20
Related ArticlesSecondary Corneal Myxoma After DMEK (Descemet Membrane Endothelial Keratoplasty). Am J Case Rep. 2019 Sep 12;20:1350-1355 Authors: Chaussard D, Frouin E, Francois J, Sot M, Paraschiv EA, Perone JM Abstract BACKGROUND This is a clinical case of secondary corneal myxoma, which developed 18 months after Descemet membrane endothelial keratoplasty (DMEK). The DMEK was performed to treat viral endotheliitis and, postoperatively, a diagnosis...
Fri Sep 13, 2019 14:11
Related ArticlesSpinal Epidural Hematoma Following Epidural Catheter Removal in a Patient with Postoperative Urgent Coronary Intervention and Intra-Aortic Balloon Pumping (IABP): A Case Report. Am J Case Rep. 2019 Sep 13;20:1356-1359 Authors: Mimata R, Higashi M, Yasui M, Hirai T, Yamaura K Abstract BACKGROUND It is still challenging to remove an epidural catheter in a postoperative patient receiving urgent antiplatelet and anticoagulation therapy for...
Sat Sep 14, 2019 14:53
Related ArticlesEndometriosis of the Urinary Bladder Causing a Right Hydronephrosis: A Case Report. Am J Case Rep. 2019 Sep 14;20:1360-1363 Authors: Alsinan TA, AlDahleh LA, Alreefi HAA, Albiabi SA, Alsouss YO, Alshayeb FA, Alshurafa ZH, Moukhtar Hammad AA, Altaweel WM Abstract BACKGROUND Endometriosis is a chronic and benign condition in which endometrial glands and stroma are present outside the uterine cavity. The pathogenesis of endometriosis is...
Sun Sep 15, 2019 13:20
Related ArticlesThe long and winding road. Curr Opin Otolaryngol Head Neck Surg. 2018 Dec;26(6):347-348 Authors: Allen JE PMID: 30300213 [PubMed - indexed for MEDLINE]
Fri Sep 13, 2019 14:53
Related ArticlesDiscussion. J Thorac Cardiovasc Surg. 2018 06;155(6):2585-2587 Authors: PMID: 29510936 [PubMed - indexed for MEDLINE]
Sat Sep 14, 2019 13:00
Related ArticlesUltrasound, endoscopy, and the recurrent nerve. J Thorac Cardiovasc Surg. 2018 06;155(6):2588-2590 Authors: Bradley SM PMID: 29530574 [PubMed - indexed for MEDLINE]
Sat Sep 14, 2019 13:00
Related ArticlesINSL5 activates multiple signalling pathways and regulates GLP-1 secretion in NCI-H716 cells. J Mol Endocrinol. 2018 04;60(3):213-224 Authors: Ang SY, Evans BA, Poole DP, Bron R, DiCello JJ, Bathgate RAD, Kocan M, Hutchinson DS, Summers RJ Abstract Insulin-like peptide 5 (INSL5) is a newly discovered gut hormone expressed in colonic enteroendocrine L-cells but little is known about its biological function. Here, we show using RT-qPCR...
Sat Sep 14, 2019 13:00
Related ArticlesHematologic malignancies of the larynx: A single institution review. Am J Otolaryngol. 2019 Sep 04;:102285 Authors: Dewan K, Campbell R, Damrose EJ Abstract BACKGROUND: Primary hematologic malignancies of the larynx are rare diagnoses, accounting for less than 1% of all laryngeal tumors. They most commonly present as submucosal masses of the supraglottis, with symptoms including hoarseness, dysphagia, dyspnea and rarely cervical lymphadenopathy....
Sat Sep 14, 2019 13:00
Related ArticlesA prospective, multicenter DAHANCA study of hyperfractionated, accelerated radiotherapy for head and neck squamous cell carcinoma. Acta Oncol. 2019 Sep 13;:1-7 Authors: Saksø M, Andersen E, Bentzen J, Andersen M, Johansen J, Primdahl H, Overgaard J, Eriksen JG Abstract Background: The study aimed to evaluate Hyperfractionated, Accelerated Radiotherapy (HART) with nimorazole for patients with head and neck squamous cell carcinoma (HNSCC)...
Sun Sep 15, 2019 13:21
Related ArticlesJapanese encephalitis virus prM-E antigen immunization conferred protection against challenge by four different serotypes of Dengue viruses in mice. Appl Microbiol Biotechnol. 2019 Jun;103(12):4977-4986 Authors: Gao N, Li J, Sheng Z, Chen H, Fan D, Wang P, An J Abstract Dengue virus (DENV) and Japanese encephalitis virus (JEV) are closely related mosquito-borne flaviviruses. Together, they caused most arthropod-borne diseases in the...
Fri Sep 13, 2019 14:13
Related ArticlesLong-term health-related quality of life in 262 patients with brain arteriovenous malformation. Neurology. 2019 Sep 11;: Authors: Pohjola A, Oulasvirta E, Roine RP, Sintonen HP, Hafez A, Koroknay-Pál P, Lehto H, Niemelä M, Laakso A Abstract OBJECTIVE: To discover the health-related quality of life (HRQOL) of patients with treated arteriovenous malformation (AVM), we used the self-applicable HRQOL instrument, the 15D, and analyzed the...
Fri Sep 13, 2019 14:13
Related ArticlesComputational chemoproteomics to understand the role of selected psychoactives in treating mental health indications. Sci Rep. 2019 Sep 11;9(1):13155 Authors: Fine J, Lackner R, Samudrala R, Chopra G Abstract We have developed the Computational Analysis of Novel Drug Opportunities (CANDO) platform to infer homology of drug behaviour at a proteomic level by constructing and analysing structural compound-proteome interaction signatures...
Fri Sep 13, 2019 14:13
Related ArticlesTLR7 activation in epilepsy of tuberous sclerosis complex. Inflamm Res. 2019 Sep 11;: Authors: Dombkowski AA, Cukovic D, Bagla S, Jones M, Caruso JA, Chugani HT, Chugani DC Abstract BACKGROUND: Neuroinflammation and toll-like receptors (TLR) of the innate immune system have been implicated in epilepsy. We previously reported high levels of microRNAs miR-142-3p and miR-223-3p in epileptogenic brain tissue resected for the treatment of...
Fri Sep 13, 2019 14:13
Related ArticlesSodium Valproate Reduces Neuronal Apoptosis in Acute Pentylenetetrzole-Induced Seizures via Inhibiting ER Stress. Neurochem Res. 2019 Sep 11;: Authors: Fu J, Peng L, Wang W, He H, Zeng S, Chen TC, Chen Y Abstract Endoplasmic reticulum (ER) stress has been indicated to be involved in the pathogenesis of epilepsy. Sodium valproate (VPA), one of the most commonly used antiepileptic drugs, is reported to regulate ER stress in many neurological...
Fri Sep 13, 2019 14:13
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