Related ArticlesThe Incremental Risk of Pancreatic Cancer According to Fasting Glucose Levels: Nationwide Population-Based Cohort Study. J Clin Endocrinol Metab. 2019 Oct 01;104(10):4594-4599 Authors: Koo DH, Han KD, Park CY Abstract CONTEXT: It has been unclear whether the risk of pancreatic cancer is different according to glucose levels. OBJECTIVE: To determine the association between fasting glucose levels and pancreatic cancer risk using...
Tue Sep 10, 2019 15:18
Related ArticlesCord Blood Metabolomics: Association With Newborn Anthropometrics and C-Peptide Across Ancestries. J Clin Endocrinol Metab. 2019 Oct 01;104(10):4459-4472 Authors: Kadakia R, Talbot O, Kuang A, Bain JR, Muehlbauer MJ, Stevens RD, Ilkayeva OR, Lowe LP, Metzger BE, Newgard CB, Scholtens DM, Lowe WL, HAPO Study Cooperative Research Group Abstract CONTEXT: Newborn adiposity is associated with childhood obesity. Cord blood metabolomics is one...
Tue Sep 10, 2019 15:18
Related ArticlesIRF6 polymorphisms in Brazilian patients with non-syndromic cleft lip with or without palate. Braz J Otorhinolaryngol. 2019 Jun 08;: Authors: Bezerra JF, Silva HPVD, Bortolin RH, Luchessi AD, Ururahy MAG, Loureiro MB, Gil-da-Silva-Lopes VL, Almeida MDG, Amaral VSD, Rezende AA Abstract INTRODUCTION: Non-syndromic orofacial clefts have a complex etiology due to the contribution from both genetic and environmental risk factors, as well as...
Tue Sep 10, 2019 13:12
Publication date: Available online 10 September 2019Source: American Journal of OtolaryngologyAuthor(s): Zachary G. Schwam, Rocco Ferrandino, Vivian Z. Kaul, Maura K. Cosetti, George B. WannaAbstractPurposeTo determine the risk factors for unanticipated readmission, prolonged index admission, and discharge to a facility after vestibular schwannoma surgery.Materials and methodsRetrospective cohort study of those undergoing surgery for vestibular schwannoma in the Nationwide Readmissions Database (2013–2014)....
Tue Sep 10, 2019 13:11
Publication date: Available online 10 September 2019Source: American Journal of OtolaryngologyAuthor(s): Orly Yariv, Aron Popovtzer, Oshri Wasserzug, Narin Carmel Neiderman, Doron Halperin, Yonatan Lahav, Gil Lahav, Moshe YehudaAbstractPurposeTo assess the clinical value of ultrasound (US) and fine needle aspiration (FNA) of salivary gland lesions prior to surgery, for preoperative decision-making and long-term follow-up/outcome.Materials & methodsWe retrospectively analyzed the medical charts...
Tue Sep 10, 2019 13:11
Publication date: Available online 9 September 2019Source: American Journal of OtolaryngologyAuthor(s): Alfonso Scarpa, Massimo Ralli, Claudia Cassandro, Federico Maria Gioacchini, Matteo Alicandri-Ciufelli, Pasquale Viola, Giuseppe Chiarella, Marco de Vincentis, Ettore CassandroAbstractPurposeThere are many therapeutic options for Meniere disease (MD); intratympanic (IT) gentamicin has been proposed for intractable cases although controversy about dosage and method exists. The purpose of this study...
Tue Sep 10, 2019 13:11
Publication date: Available online 9 September 2019Source: American Journal of OtolaryngologyAuthor(s): Mickie Hamiter, Brian Manzi, Anil GungorAbstractObjectiveExamination of the outcomes of needle aspiration (NA) under sedation as the primary surgical treatment for pediatric deep neck space abscesses (DNSA) to determine its adequacy, safety, and cost.Study designRetrospective chart review.Methods10 consecutive pediatric patients (age 4–48 months) that were diagnosed with DNSA starting from August...
Tue Sep 10, 2019 13:11
Publication date: Available online 9 September 2019Source: American Journal of OtolaryngologyAuthor(s): Lei Zhou, Na Shen, Guangyao Li, Jiaye Ding, Danzheng Liu, Xinsheng HuangAbstractObjectiveTo investigate whether the racial/ethnical disparity of nasopharyngeal carcinoma exists among the four major ethical groups in the United States named Asians, Caucasians, African Americans and Hispanics between the years of 1973 to 2013 using the Surveillance, Epidemiology, and End Result (SEER) database.MethodsThe...
Tue Sep 10, 2019 13:11
Publication date: Available online 9 September 2019Source: American Journal of OtolaryngologyAuthor(s): Tristan Allsopp, Alexandrea H. Kim, Alexa M. Robbins, Joshua C. Page, John L. DornhofferAbstractPurposeThis study was performed to evaluate the effectiveness and impact on quality of life in patients undergoing plugging of superior semicircular canal dehiscence using the transmastoid approach.Materials and methodsRetrospective chart review with prospective outcomes assessment, using validated quantitative...
Tue Sep 10, 2019 13:11
Publication date: Available online 9 September 2019Source: American Journal of OtolaryngologyAuthor(s): Allison G. Chisholm, Madhankumar Sathyamoorthy, Samantha R. Seals, Jeffrey D. CarronAbstractObjectivePostoperative pain control is of significant interest in pediatric otolaryngology given the safety concerns with opioid use. We sought to determine if addition of intraoperative intravenous acetaminophen decreases perioperative morphine use in pediatric tonsillectomy.MethodsThis study is a retrospective...
Tue Sep 10, 2019 13:11
Publication date: Available online 9 September 2019Source: American Journal of OtolaryngologyAuthor(s): Edward Westfall, Benton Nelson, Dominic Vernon, Mohamad Z. Saltagi, Avinash V. Mantravadi, Cecelia Schmalbach, Jonathan Y. Ting, Taha Z. ShipchandlerAbstractObjectiveTo determine radiologic preferences of practicing otolaryngologists regarding isolated nasal bone fractures.Study designAn 8-question survey on isolated nasal bone fractures was designed.SettingSurveys were sent to all otolaryngology...
Tue Sep 10, 2019 13:11
Related ArticlesEfficacy of fibre-optic laryngeal potassium titanyl phosphate laser surgery under local anaesthesia for the treatment of vocal polyps: A prospective study of 65 patients. Clin Otolaryngol. 2018 12;43(6):1617-1621 Authors: Ban MJ, Park JH, Ban WW, Kim JW, Park KN, Lee SW PMID: 30027628 [PubMed - indexed for MEDLINE]
Tue Sep 10, 2019 13:11
Related ArticlesXenon exerts anti-seizure and neuroprotective effects in kainic acid-induced status epilepticus and neonatal hypoxia-induced seizure. Exp Neurol. 2019 Sep 06;:113054 Authors: Zhang Y, Zhang M, Liu S, Zhu W, Yu J, Cui Y, Pan X, Gao X, Wang Q, Sun H Abstract Xenon is an inhalation anesthetic with a favorable safety profile, and previous studies have demonstrated its neuroprotective efficacy. However, whether xenon plays a role in the treatment...
Tue Sep 10, 2019 14:35
Related ArticlesNo prevention or cure of epilepsy as yet. Neuropharmacology. 2019 Sep 06;:107762 Authors: Klein P, Tyrlikova I Abstract Approximately 20% of all epilepsy is caused by acute acquired injury such as traumatic brain injury, stroke and CNS infection. The known onset of the injury which triggers the epileptogenic process, early presentation to medical care, and a latency between the injury and the development of clinical epilepsy present an...
Tue Sep 10, 2019 14:35
Related ArticlesRisk factors for the development of epilepsy in patients with brain metastasis. Neuro Oncol. 2019 Sep 10;: Authors: Wolpert F, Lareida A, Terziev R, Grossenbacher B, Neidert MC, Roth P, Poryazova R, Imbach L, Le Rhun E, Weller M Abstract BACKGROUND: Current guidelines do not recommend primary prophylactic anti-epileptic drug therapy for patients with brain metastases (BM). Yet, subgroups of patients at high seizure risk might still benefit...
Tue Sep 10, 2019 14:35
Related ArticlesClinical outcomes of eslicarbazepine acetate monotherapy for focal-onset seizures: a multicenter audit. Acta Neurol Scand. 2019 Sep 09;: Authors: Giráldez BG, Garamendi-Ruiz I, Zurita J, García A, Querol R, Campos D, Cabeza-Alvarez C, Serrano P, López-González FJ, Molins A, Serratosa JM Abstract OBJECTIVE: To assess the effectiveness and tolerability of eslicarbazepine acetate (ESL) monotherapy in routine clinical practice for the treatment...
Tue Sep 10, 2019 14:35
Related ArticlesTreatment of vagus nerve stimulator-induced sleep-disordered breathing: A case series. Epilepsy Behav Rep. 2019;12:100325 Authors: Oh DM, Johnson J, Shah B, Bhat S, Nuoman R, Ming X Abstract Objective: Vagus nerve stimulation (VNS) is a treatment option for patients with drug-resistant seizures, but it is also associated with sleep-disordered breathing (SDB). We present four patients with VNS who underwent polysomnography (PSG) concurrently...
Tue Sep 10, 2019 14:35
Related ArticlesThe Role of Phlebotomy (Fasd) and Cupping in the Treatment of Epilepsy from Perspective of Persian Medicine. Iran J Public Health. 2019 Jul;48(7):1392-1394 Authors: Eghbalian F, Mohammadi Kenari H, Kordafshari G, Karimi M, Atyabi A, Shirbeigi L PMID: 31497568 [PubMed]
Tue Sep 10, 2019 14:35
Related ArticlesParenteral hydroxocobalamin dose intensification in five patients with different types of early onset intracellular cobalamin defects: Clinical and biochemical responses. JIMD Rep. 2019 Sep;49(1):70-79 Authors: Scalais E, Osterheld E, Geron C, Pierron C, Chafai R, Schlesser V, Borde P, Regal L, Laeremans H, van Gassen KLI, van den Heuvel LB, De Meirleir L Abstract Intracellular cobalamin metabolism (ICM) defects can be present as autosomal...
Tue Sep 10, 2019 14:35
Related ArticlesDravet Syndrome: An Overview. Cureus. 2019 Jun 26;11(6):e5006 Authors: Anwar A, Saleem S, Patel UK, Arumaithurai K, Malik P Abstract Dravet syndrome (DS), also known as severe myoclonic epilepsy of infancy (SMEI), is one of the rare early childhood intractable epileptic encephalopathies associated with pleomorphic seizure activity, cognitive decline, motor, and behavioral abnormalities. The convulsive seizure is the most common type seen...
Tue Sep 10, 2019 14:35
Related ArticlesHeart Rate Variability and Vagus Nerve Stimulation in Epilepsy Patients. Transl Neurosci. 2019;10:223-232 Authors: Constantinescu V, Matei D, Constantinescu I, Cuciureanu DI Abstract Background: Vagus nerve stimulation (VNS) exerts a cortical modulating effect through its diffuse projections, especially involving cerebral structures related to autonomic regulation. The influence of VNS on cardiovascular autonomic function in drug-resistant...
Tue Sep 10, 2019 14:35
Related ArticlesPresence of cerebrospinal fluid antibodies associated with autoimmune encephalitis of humans in dogs with neurologic disease. J Vet Intern Med. 2019 Sep 08;: Authors: Stafford EG, Kortum A, Castel A, Green L, Lau J, Early PJ, Muñana KR, Mariani CL, Yoder JA, Olby NJ Abstract BACKGROUND: Presumed autoimmune diseases affecting the central nervous system (CNS) of dogs are common. In people, antibodies against neuronal cell surface antigens...
Tue Sep 10, 2019 13:10
Related ArticlesOpportunities for Electroceuticals in Epilepsy. Trends Pharmacol Sci. 2019 Sep 05;: Authors: Kavehei O, Hamilton TJ, Truong ND, Nikpour A Abstract Epilepsy is a neurological disorder that affects ~1% of the world population. Nearly 30% of epilepsy patients suffer from pharmacoresistant epilepsy that cannot be treated with antiepileptic drugs. Depending on seizure type, a diverse range of therapies are available, including surgery, vagus...
Tue Sep 10, 2019 13:10
Related ArticlesBlocking TrkB's Effectors Reveal Benefits of the Road Not Taken. Epilepsy Curr. 2019 Sep 09;:1535759719872503 Authors: Danzer SC Abstract TrkB-Shc Signaling Protects Against Hippocampal Injury Following Status Epilepticus Huang YZ, He XP, Krishnamurthy K, McNamara JO. J Neurosci. 2019;39(23):4624-4630. doi:10.1523/JNEUROSCI.2939-18.2019. Epub March 29, 2019. PMID: 30926745 Temporal lobe epilepsy (TLE) is a common and commonly devastating...
Tue Sep 10, 2019 13:10
Related ArticlesAdverse drug reactions associated with six commonly used antiepileptic drugs in southern China from 2003 to 2015. BMC Pharmacol Toxicol. 2019 Jan 14;20(1):7 Authors: Du Y, Lin J, Shen J, Ding S, Ye M, Wang L, Wang Y, Wang X, Xia N, Zheng R, Chen H, Xu H Abstract BACKGROUND: This active, open observational study aimed to investigate adverse drug reactions (ADRs) associated with six commonly used antiepileptic drugs (AEDs) in southern...
Tue Sep 10, 2019 13:10
Related ArticlesTherapeutic monitoring of antiepileptic drugs in comatose patients. Tunis Med. 2018 Feb;96(2):129-134 Authors: Charfi R, Mizouri R, Ben Sassi M, Eljebari H, Jebabli N, Ben Salem F, Zerei S, Mrabet A, Daghfous R, Klouz A, Salouage I, Gaies E, Trabelsi S Abstract OBJECTIVE: In this study, we aimed to analyze the trough plasmatic levels (C0) of the antiepileptic drugs (AED) administered by nasogastric tubes (NGT) in comatose patients and...
Tue Sep 10, 2019 13:10
Related ArticlesHello from the other side: Parental reflections on the patient-parent-family physician triadic relationship. Can Fam Physician. 2018 04;64(Suppl 2):S76-S78 Authors: MacGregor L, Martin J PMID: 29650749 [PubMed - indexed for MEDLINE]
Tue Sep 10, 2019 13:10
Related ArticlesEpilepsy surgery in infants : Safety issues and developmental outcome. Wien Klin Wochenschr. 2018 May;130(9-10):341-348 Authors: Gröppel G, Dorfer C, Dressler A, Mühlebner A, Porsche B, Czech T, Prayer D, Feucht M Abstract PURPOSE: To evaluate the efficacy and safety of epilepsy surgery in infants. METHODS: Included were patients with epilepsy onset during the first year of life, epilepsy surgery before the age of 36 months...
Tue Sep 10, 2019 13:10
Related ArticlesCortical Structures Associated With Human Blood Pressure Control. JAMA Neurol. 2018 02 01;75(2):194-202 Authors: Lacuey N, Hampson JP, Theeranaew W, Zonjy B, Vithala A, Hupp NJ, Loparo KA, Miller JP, Lhatoo SD Abstract Importance: A better understanding of the role of cortical structures in blood pressure control may help us understand cardiovascular collapse that may lead to sudden unexpected death in epilepsy (SUDEP). Objective:...
Tue Sep 10, 2019 13:10
Related ArticlesPostoperative Epileptic Seizures in Children: Is the Brain Incision a Risk Factor? Neurosurgery. 2018 04 01;82(4):465-472 Authors: Massimi L, Battaglia D, Bianchi F, Peraio S, Peppucci E, Di Rocco C Abstract BACKGROUND: Postoperative seizures (PSs) after neurosurgical operations are common but little is known about the role of surgical brain incision on their genesis. This topic has not been addressed so far. OBJECTIVE: To verify...
Tue Sep 10, 2019 13:10
Related ArticlesProduction of E. coli-expressed Self-Assembling Protein Nanoparticles for Vaccines Requiring Trimeric Epitope Presentation. J Vis Exp. 2019 Aug 21;(150): Authors: Karch CP, Burkhard P, Matyas GR, Beck Z Abstract Self-assembling protein nanoparticles (SAPNs) function as repetitive antigen displays and can be used to develop a wide range of vaccines for different infectious diseases. In this article we demonstrate a method to produce a...
Tue Sep 10, 2019 15:05
Related ArticlesMurine Surgical Model of Topical Elastase Induced Descending Thoracic Aortic Aneurysm. J Vis Exp. 2019 Aug 24;(150): Authors: Tyerman Z, Dahl J, Shannon A, Johnston WF, Pope NH, Lu G, Upchurch GR, Ailawadi G, Salmon M Abstract According to the Center for Disease Control, aortic aneurysms (AAs) were considered a leading cause of death in all races and both sexes from 1999-2016. An aneurysm forms as a result of progressive weakening and...
Tue Sep 10, 2019 15:05
Related ArticlesSemiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy. J Vis Exp. 2019 Aug 25;(150): Authors: Gui B, Zhang Y, Liang B, Kwok YKY, Lui WT, Yeung QSY, Kong L, Xuan L, Chung JPW, Choy KW Abstract Chromosomal aneuploidy, one of the main causes leading to embryonic development arrest, implantation failure, or pregnancy loss, has been well documented in human embryos. Preimplantation genetic testing for aneuploidy (PGT-A)...
Tue Sep 10, 2019 15:05
Related ArticlesUse of Drosophila S2 Cells for Live Imaging of Cell Division. J Vis Exp. 2019 Aug 23;(150): Authors: Dewey EB, Parra AS, Johnston CA Abstract Drosophila S2 cells are an important tool in studying mitosis in tissue culture, providing molecular insights into this fundamental cellular process in a rapid and high-throughput manner. S2 cells have proven amenable to both fixed- and live-cell imaging applications. Notably, live-cell imaging...
Tue Sep 10, 2019 15:05
Related ArticlesMeasurement of Chitinase Activity in Biological Samples. J Vis Exp. 2019 Aug 22;(150): Authors: Amick AK, Liu Q, Gautam S, Chupp G, Dela Cruz CS, Sharma L Abstract Chitinases are the enzymes that cleave chitin. Even in the absence of chitin, mammalians have significant amounts of chitinases present in the body including at baseline. The precise role of chitinase is not known, however it was believed to play important role in digestion...
Tue Sep 10, 2019 15:05
Related ArticlesPreparation of High-Quality Fermented Fish Product. J Vis Exp. 2019 Aug 23;(150): Authors: Yang F, Zhu LL, Diao YD, Gao P, Yu DW, Yu PP, Jiang QX, Xu YS, Xia WS, Zhan XB Abstract This protocol provides a method for preparation of industrialized fermented fish product with sturgeon (Aquilaria sinensis) meat product. The procedures were: (1) pretreatment of farmed sturgeon including decapitation, evisceration, skinning-off, cleaning and...
Tue Sep 10, 2019 15:05
Related ArticlesCortisol Measurement in Koala (Phascolarctos cinereus) Fur. J Vis Exp. 2019 Aug 23;(150): Authors: Charalambous R, Narayan E Abstract Optimal methods of hormone extraction used to measure stress in animals across sample types are not always the same. Australia's iconic marsupial species, the koala (Phascolarctos cinereus), faces prolonged exposure to anthropogenic-induced stressors and assessment of chronic stress in wild populations...
Tue Sep 10, 2019 15:05
Related ArticlesIsolation of Tissue Extracellular Vesicles from the Liver. J Vis Exp. 2019 Aug 21;(150): Authors: Ishiguro K, Yan IK, Patel T Abstract Extracellular vesicles (EVs) can be released from many different cell types and detected in most, if not all, body fluids. EVs can participate in cell-to-cell communication by shuttling bioactive molecules such as RNA or protein from one cell to another. Most studies of EVs have been performed in cell...
Tue Sep 10, 2019 15:05
Related ArticlesRapid Evaluation of Toxicity of Chemical Compounds Using Zebrafish Embryos. J Vis Exp. 2019 Aug 25;(150): Authors: Aspatwar A, Hammaren MM, Parikka M, Parkkila S Abstract The zebrafish is a widely used vertebrate model organism for the disease and phenotype-based drug discovery. The zebrafish generates many offspring, has transparent embryos and rapid external development. Zebrafish embryos can, therefore, also be used for the rapid evaluation...
Tue Sep 10, 2019 15:05
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