IJMS, Vol. 20, Pages 4340: Inhibition of Tyrosine-Phosphorylated STAT3 in Human Breast and Lung Cancer Cells by Manuka Honey is Mediated by Selective Antagonism of the IL-6 Receptor International Journal of Molecular Sciences doi: 10.3390/ijms20184340 Authors: Priyanka Aryappalli Khadija Shabbiri Razan J. Masad Roadha H. Al-Marri Shoja M. Haneefa Yassir A. Mohamed Kholoud Arafat Samir Attoub Otavio Cabral-Marques Khalil B. Ramadi Maria J. Fernandez-Cabezudo Basel...
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IJMS, Vol. 20, Pages 4337: Exosomes in Systemic Sclerosis: Messengers Between Immune, Vascular and Fibrotic Components? International Journal of Molecular Sciences doi: 10.3390/ijms20184337 Authors: Colletti Galardi Santis Guidelli Giannatale Luigi Antinozzi : Systemic sclerosis (SSc) is a rare autoimmune disease, characterized by vasculopathy and fibrosis of the skin and internal organs. This disease is still considered incurable and is associated with a high...
Wed Sep 04, 2019 03:00
IJMS, Vol. 20, Pages 4338: Function and Transcriptional Regulation of Bovine TORC2 Gene in Adipocytes: Roles of C/EBP, XBP1, INSM1 and ZNF263 International Journal of Molecular Sciences doi: 10.3390/ijms20184338 Authors: Khan Raza Junjvlieke Xiaoyu Garcia Elnour Hongbao Linsen The TORC2 gene is a member of the transducer of the regulated cyclic adenosine monophosphate (cAMP) response element binding protein gene family, which plays a key role in metabolism...
Wed Sep 04, 2019 03:00
IJMS, Vol. 20, Pages 4339: YaeB, Expressed in Response to the Acidic pH in Macrophages, Promotes Intracellular Replication and Virulence of Salmonella Typhimurium International Journal of Molecular Sciences doi: 10.3390/ijms20184339 Authors: Huan Zhang Xiaorui Song Peisheng Wang Runxia Lv Shuangshuang Ma Lingyan Jiang Salmonella enterica serovar Typhimurium is a facultative intracellular pathogen that infects humans and animals. Survival and growth in host macrophages...
Wed Sep 04, 2019 03:00
IJMS, Vol. 20, Pages 4336: Iron Release Profile of Silica-Modified Zero-Valent Iron NPs and Their Implication in Cancer Therapy International Journal of Molecular Sciences doi: 10.3390/ijms20184336 Authors: Li-Xing Yang Ya-Na Wu Pei-Wen Wang Wu-Chou Su Dar-Bin Shieh To evaluate the iron ion release profile of zero-valent iron (ZVI)-based nanoparticles (NPs) and their relationship with lysosomes in cancer cells, silica and mesoporous silica-coated ZVI NPs (denoted as ZVI@SiO2...
Wed Sep 04, 2019 03:00
IJMS, Vol. 20, Pages 4334: RNA-Seq de Novo Assembly and Differential Transcriptome Analysis of Chaga (Inonotus obliquus) Cultured with Different Betulin Sources and the Regulation of Genes Involved in Terpenoid Biosynthesis International Journal of Molecular Sciences doi: 10.3390/ijms20184334 Authors: Fradj Gonçalves dos Santos de Montigny Awwad Boumghar Germain Desgagné-Penix Chaga (Inonotus obliquus) is a medicinal fungus used in traditional medicine of Native...
Wed Sep 04, 2019 03:00
IJMS, Vol. 20, Pages 4333: Cyclobutane-Containing Scaffolds as Useful Intermediates in the Stereoselective Synthesis of Suitable Candidates for Biomedical Purposes: Surfactants, Gelators and Metal Cation Ligands International Journal of Molecular Sciences doi: 10.3390/ijms20184333 Authors: Illa Serra Ardiaca Herrero Closa Ortuño Efficient and versatile synthetic methodologies are reported for the preparation of products that are suitable candidates to be used as...
Wed Sep 04, 2019 03:00
IJMS, Vol. 20, Pages 4335: Mapping and Identifying a Candidate Gene Plr4, a Recessive Gene Regulating Purple Leaf in Rice, by Using Bulked Segregant and Transcriptome Analysis with Next-Generation Sequencing International Journal of Molecular Sciences doi: 10.3390/ijms20184335 Authors: Ju Gao Gaoxing Dai Weiyong Zhou Haifu Liang Juan Huang Dongjin Qing Weiwei Chen Hao Wu Xinghai Yang Danting Li Lijun Gao Guofu Deng The anthocyanin biosynthesis of rice...
Wed Sep 04, 2019 03:00
IJMS, Vol. 20, Pages 4331: Molecular Docking: Shifting Paradigms in Drug Discovery International Journal of Molecular Sciences doi: 10.3390/ijms20184331 Authors: Luca Pinzi Giulio Rastelli Molecular docking is an established in silico structure-based method widely used in drug discovery. Docking enables the identification of novel compounds of therapeutic interest, predicting ligand-target interactions at a molecular level, or delineating structure-activity relationships (SAR), without...
Wed Sep 04, 2019 03:00
IJMS, Vol. 20, Pages 4329: Molecular Characteristics and Treatment of Endothelial Dysfunction in Patients with COPD: A Review Article International Journal of Molecular Sciences doi: 10.3390/ijms20184329 Authors: Botond Szucs Csilla Szucs Mate Petrekanits Janos T. Varga Patients with chronic obstructive pulmonary disease (COPD) show systemic consequences, such as chronic systemic inflammation leading to changes in the airway, airway penetrability, and endothelial function. Endothelial...
Wed Sep 04, 2019 03:00
IJMS, Vol. 20, Pages 4332: The Role of Exosomes in Pancreatic Cancer International Journal of Molecular Sciences doi: 10.3390/ijms20184332 Authors: Bin Lan Siyuan Zeng Robert Grützmann Christian Pilarsky Pancreatic cancer remains one of the deadliest cancers in the world, as a consequence of late diagnosis, early metastasis and limited response to chemotherapy, under which conditions the potential mechanism of pancreatic cancer progression requires further study. Exosomes are...
Wed Sep 04, 2019 03:00
IJMS, Vol. 20, Pages 4328: Differing Membrane Interactions of Two Highly Similar Drug-Metabolizing Cytochrome P450 Isoforms: CYP 2C9 and CYP 2C19 International Journal of Molecular Sciences doi: 10.3390/ijms20184328 Authors: Ghulam Mustafa Prajwal P. Nandekar Neil J. Bruce Rebecca C. Wade The human cytochrome P450 (CYP) 2C9 and 2C19 enzymes are two highly similar isoforms with key roles in drug metabolism. They are anchored to the endoplasmic reticulum membrane by their N-terminal...
Wed Sep 04, 2019 03:00
IJMS, Vol. 20, Pages 4327: Nitric Oxide Is Involved in Heavy Ion-Induced Non-Targeted Effects in Human Fibroblasts International Journal of Molecular Sciences doi: 10.3390/ijms20184327 Authors: Megumi Hada Premkumar B. Saganti Francis A. Cucinotta Previously, we investigated the dose response for chromosomal aberration (CA) for exposures corresponding to less than one particle traversal per cell nucleus by high energy and charge (HZE) particles, and showed that the dose responses...
Wed Sep 04, 2019 03:00
IJMS, Vol. 20, Pages 4330: Systematic Identification of Characteristic Genes of Ovarian Clear Cell Carcinoma Compared with High-Grade Serous Carcinoma Based on RNA-Sequencing International Journal of Molecular Sciences doi: 10.3390/ijms20184330 Authors: Saya Nagasawa Kazuhiro Ikeda Kuniko Horie-Inoue Sho Sato Atsuo Itakura Satoru Takeda Kosei Hasegawa Satoshi Inoue Objective: Ovarian cancer has the highest mortality among gynecological cancers. High-grade serous...
Wed Sep 04, 2019 03:00
IJMS, Vol. 20, Pages 4326: Multi-Staged Regulation of Lipid Signaling Mediators during Myogenesis by COX-1/2 Pathways International Journal of Molecular Sciences doi: 10.3390/ijms20184326 Authors: Chenglin Mo Zhiying Wang Lynda Bonewald Marco Brotto Cyclooxygenases (COXs), including COX-1 and -2, are enzymes essential for lipid mediator (LMs) syntheses from arachidonic acid (AA), such as prostaglandins (PGs). Furthermore, COXs could interplay with other enzymes such as lipoxygenases...
Wed Sep 04, 2019 03:00
IJMS, Vol. 20, Pages 4325: Study on the Role of Cytc in Response to BmNPV Infection in Silkworm, Bombyx mori (Lepidoptera) International Journal of Molecular Sciences doi: 10.3390/ijms20184325 Authors: Xue-Yang Wang Kang-Hui Wu Hui-Lin Pang Ping-Zhen Xu Mu-Wang Li Guo-Zheng Zhang Bombyx mori nucleopolyhedrovirus (BmNPV) is one of the primary pathogens of the silkworm. Cytochrome c (cytc) showed a significant response to BmNPV infection in our previous transcriptome study....
Wed Sep 04, 2019 03:00
IJMS, Vol. 20, Pages 4324: Mutagenic Study of Benzimidazole Derivatives with (+S9) and without (−S9) Metabolic Activation International Journal of Molecular Sciences doi: 10.3390/ijms20184324 Authors: Nurul Hafizan Azahar Siti Soleha Ab dullah Rozaini Abdullah Norizan Ahmat Abdah Md Akim Hasiah Ab Hamid Benzimidazole derivatives have a diverse range of biological activities, including antiulcer, antihypertensive, antiviral, antifungal, anti-inflammatory, and anticancer....
Wed Sep 04, 2019 03:00
JCM, Vol. 8, Pages 1386: The Outcomes of Pancreatic Transplantation from Pediatric Donors–A Single Institution Experience Journal of Clinical Medicine doi: 10.3390/jcm8091386 Authors: Ito Kenmochi Aida Kurihara Kawai Suzuki Shibata Hiratsuka Hasegawa Objectives: The aim of this study was to compare the outcomes of pancreatic transplantation from pediatric donors younger than 15 years of age to the outcomes of pancreatic transplantation from adult donors....
Wed Sep 04, 2019 03:00
JCM, Vol. 8, Pages 1385: Relationship Between Oxidative Stress, ER Stress, and Inflammation in Type 2 Diabetes: The Battle Continues Journal of Clinical Medicine doi: 10.3390/jcm8091385 Authors: Burgos-Morón Abad-Jiménez Marañón Iannantuoni Escribano-López López-Domènech Salom Jover Mora Roldan Solá Rocha Víctor Type 2 diabetes (T2D) is a metabolic disorder characterized by hyperglycemia and insulin resistance in which oxidative stress...
Wed Sep 04, 2019 03:00
JCM, Vol. 8, Pages 1384: Prevalence of Early Chronic Kidney Disease and Main Associated Factors in Spanish Population: Populational Study Journal of Clinical Medicine doi: 10.3390/jcm8091384 Authors: Carmen Expósito Guillem Pera Lluís Rodríguez Ingrid Arteaga Alba Martínez Alba Alumà María Doladé Pere Torán Llorenç Caballeria The aim of this study was to determine the prevalence of early chronic kidney disease (EKD) (stages 1 and 2) and the factors associated....
Wed Sep 04, 2019 03:00
JoF, Vol. 5, Pages 83: Minimal Inhibitory Concentration (MIC)-Phenomena in Candida albicans and Their Impact on the Diagnosis of Antifungal Resistance Journal of Fungi doi: 10.3390/jof5030083 Authors: Ulrike Binder Maria Aigner Brigitte Risslegger Caroline Hörtnagl Cornelia Lass-Flörl Michaela Lackner Antifungal susceptibility testing (AFST) of clinical isolates is a tool in routine diagnostics to facilitate decision making on optimal antifungal therapy. The minimal inhibitory...
Wed Sep 04, 2019 03:00
JoF, Vol. 5, Pages 82: A Week of Oral Terbinafine Pulse Regimen Every Three Months to Treat all Dermatophyte Onychomycosis Journal of Fungi doi: 10.3390/jof5030082 Authors: Anarosa B. Sprenger Katia Sheylla Malta Purim Flávia Sprenger Flávio Queiroz-Telles Terbinafine has proved to treat numerous fungal infections, including onychomycosis, successfully. Due to its liver metabolization and dependency on the cytochrome P450 enzyme complex, undesirable drug interaction are highly...
Wed Sep 04, 2019 03:00
JoF, Vol. 5, Pages 81: Candida albicans and Staphylococcus aureus Pathogenicity and Polymicrobial Interactions: Lessons beyond Koch’s Postulates Journal of Fungi doi: 10.3390/jof5030081 Authors: Olivia A. Todd Brian M Peters While Koch’s Postulates have established rules for microbial pathogenesis that have been extremely beneficial for monomicrobial infections, new studies regarding polymicrobial pathogenesis defy these standards. The explosion of phylogenetic sequence...
Wed Sep 04, 2019 03:00
J. Imaging, Vol. 5, Pages 74: Measurement of Vibrating Tympanic Membrane in an In Vivo Mouse Model Using Doppler Optical Coherence Tomography Journal of Imaging doi: 10.3390/jimaging5090074 Authors: Jeon Kim Jeon Kim Optical coherence tomography (OCT) has a micro-resolution with a penetration depth of about 2 mm and field of view of about 10 mm. This makes OCT well suited for analyzing the anatomical and internal structural assessment of the middle ear. To study the vibratory...
Wed Sep 04, 2019 03:00
Medicina, Vol. 55, Pages 567: PAI-1 Level Differences in Malignant Plural Effusion, Parapneumonic Pleuritis, and Cardiac Hydrothorax Medicina doi: 10.3390/medicina55090567 Authors: Zentina Stukena Krams Lejnieks Background and Objectives: Plasminogen activator inhibitor-1 (PAI-1) is a fibrinolytic system enzyme whose role in various fibrinolytic processes is currently unknown. In clinical manifestations of pleural liquids of diverse etiology, various levels of fibrinolytic...
Wed Sep 04, 2019 03:00
Medicines, Vol. 6, Pages 93: Cervical Cancer Prevention in Racially Disparate Rural Populations Medicines doi: 10.3390/medicines6030093 Authors: Patti Olusola Kia Ousley Harrison Ndetan Karan P. Singh Hirendra Nath Banerjee Santanu Dasgupta Background: Undergoing a timely Pap smear, high-risk human papilloma virus (HPV)- and colposcopy-based testing can reduce HPV-associated cervical cancer (CC) development in women. However, in rural areas, women and minorities without...
Wed Sep 04, 2019 03:00
Metabolites, Vol. 9, Pages 175: Erratum: Chen, F. et al. Advances of Metabolomics in Fungal Pathogen–Plant Interactions. Metabolites 2019, 9, 169 Metabolites doi: 10.3390/metabo9090175 Authors: Fangfang Chen Ruijing Ma Xiao-Lin Chen The authors wish to make the following corrections to this paper [...]
Wed Sep 04, 2019 03:00
Metabolites, Vol. 9, Pages 174: Non-Targeted UHPLC-Q-TOF/MS-Based Metabolomics Reveals a Metabolic Shift from Glucose to Glutamine in CPB Cells during ISKNV Infection Cycle Metabolites doi: 10.3390/metabo9090174 Authors: Xiaozhe Fu Xixi Guo Shiwei Wu Qiang Lin Lihui Liu Hongru Liang Yinjie Niu Ningqiu Li Infectious spleen and kidney necrosis virus (ISKNV) has caused serious economic losses in the cultured mandarin fish (Siniperca chuatsi) industry in China. Host...
Wed Sep 04, 2019 03:00
MPs, Vol. 2, Pages 77: An Enhanced Self-Care Protocol for People Affected by Moderate to Severe Lymphedema Methods and Protocols doi: 10.3390/mps2030077 Authors: Janet Douglass Hayley E. Mableson Sarah Martindale Louise A. Kelly-Hope Lymphedema is a chronic skin disease that has many causes and leads to significant disfigurement and disability worldwide. Recommendations for lymphedema self-care vary by setting and the World Health Organization guidelines for people affected...
Wed Sep 04, 2019 03:00
Microorganisms, Vol. 7, Pages 317: Cyclospora cayetanensis and Cyclosporiasis: An Update Microorganisms doi: 10.3390/microorganisms7090317 Authors: Sonia Almeria Hediye N. Cinar Jitender P. Dubey Cyclospora cayetanensis is a coccidian parasite of humans, with a direct fecal–oral transmission cycle. It is globally distributed and an important cause of foodborne outbreaks of enteric disease in many developed countries, mostly associated with the consumption of contaminated...
Wed Sep 04, 2019 03:00
Microorganisms, Vol. 7, Pages 318: Probiotic and Triticale Silage Fermentation Potential of Pediococcus pentosaceus and Lactobacillus brevis and Their Impacts on Pathogenic Bacteria Microorganisms doi: 10.3390/microorganisms7090318 Authors: Ilavenil Soundharrajan Dahye Kim Palaniselvam Kuppusamy Karanan Muthusamy Hyun Jeong Lee Ki Choon Choi The purpose of this study was to identify potent lactic acid bacteria that could have a great impact on triticale silage fermentation...
Wed Sep 04, 2019 03:00
Microorganisms, Vol. 7, Pages 316: Rhodotorula mucilaginosa C2.5t1 Modulates Carotenoid Content and CAR Genes Transcript Levels to Counteract the Pro-Oxidant Effect of Hydrogen Peroxide Microorganisms doi: 10.3390/microorganisms7090316 Authors: Sara Landolfo Rossella Chessa Giacomo Zara Severino Zara Marilena Budroni Ilaria Mannazzu In order to contribute to the elucidation of the biological role of carotenoids, the cellular response to hydrogen peroxide was analyzed in...
Wed Sep 04, 2019 03:00
Microorganisms, Vol. 7, Pages 315: Dual RNA-Seq Analysis of the Pine-Fusarium circinatum Interaction in Resistant (Pinus tecunumanii) and Susceptible (Pinus patula) Hosts Microorganisms doi: 10.3390/microorganisms7090315 Authors: Erik A. Visser Jill L. Wegrzyn Emma T. Steenkamp Alexander A. Myburg Sanushka Naidoo Fusarium circinatum poses a serious threat to many pine species in both commercial and natural pine forests. Knowledge regarding the molecular basis of pine-F. circinatum...
Wed Sep 04, 2019 03:00
Molecules, Vol. 24, Pages 3228: Synthesis, Structural Confirmation, and Biosynthesis of 22-OH-PD1n-3 DPA Molecules doi: 10.3390/molecules24183228 Authors: Jannicke Irina Nesman Karoline Gangestad Primdahl Jørn Eivind Tungen Fransesco Palmas Jesmond Dalli Trond Vidar Hansen PD1n-3 DPA belongs to the protectin family of specialized pro-resolving lipid mediators. The protectins are endogenously formed mediators that display potent anti-inflammatory properties and pro-resolving...
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Molecules, Vol. 24, Pages 3226: Epicatechin Provides Antioxidant Protection to Bovine Spermatozoa Subjected to Induced Oxidative Stress Molecules doi: 10.3390/molecules24183226 Authors: Eva Tvrda Peter Straka Drahomir Galbavy Peter Ivanic Epicatechin (EPI) is a natural flavonoid with antibacterial, anti-inflammatory and anti-cancer properties. Furthermore, the molecule exhibits powerful reactive oxygen species (ROS) scavenging and metal-chelating properties. In this study, we...
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Molecules, Vol. 24, Pages 3227: Synthesis with Immobilized Lipases and Downstream Processing of Ascorbyl Palmitate Molecules doi: 10.3390/molecules24183227 Authors: Carolina Tufiño Claudia Bernal Carminna Ottone Oscar Romero Andrés Illanes Lorena Wilson Ascorbyl palmitate is a fatty acid ester endowed with antioxidant properties, used as a food additive and cosmetic ingredient, which is presently produced by chemical synthesis. Ascorbyl palmitate was synthesized from ascorbic...
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Molecules, Vol. 24, Pages 3225: Inhibition of Pancreatic α-amylase by Resveratrol Derivatives: Biological Activity and Molecular Modelling Evidence for Cooperativity between Viniferin Enantiomers Molecules doi: 10.3390/molecules24183225 Authors: Luce M. Mattio Mauro Marengo Chiara Parravicini Ivano Eberini Sabrina Dallavalle Francesco Bonomi Stefania Iametti Andrea Pinto To improve the current understanding of the role of stilbenoids in the management of diabetes,...
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Molecules, Vol. 24, Pages 3223: Ionic Liquids Enhanced Alkynyl Schiff Bases Derivatives of Fipronil Synthesis and Their Cytotoxicity Studies Molecules doi: 10.3390/molecules24183223 Authors: Liu Huang Chen Li Yan Jin Xu To obtain highly selective toxic derivatives of fipronil, a series of Schiff bases with an alkynyl group (3a–3k) were designed and synthesized from 4-ethynylbenzaldehyde (2) and 4-substituted 5-amino-N-arylpyrazole (1a–1k)...
Wed Sep 04, 2019 03:00
Molecules, Vol. 24, Pages 3220: Quality Evaluation of Ophiopogonis Radix from Two Different Producing Areas Molecules doi: 10.3390/molecules24183220 Authors: Mengxia Tan Jiali Chen Chengcheng Wang Lisi Zou Shuyu Chen Jingjing Shi Yuqi Mei Lifang Wei Xunhong Liu Ophiopogonis Radix, also known as Mai-dong in Chinese, was a commonly used traditional Chinese medicine (TCM) and functional health food. Two products of Ophiopogonis Radix are largely produced in the Sichuan...
Wed Sep 04, 2019 03:00
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