Publication date: Available online 11 September 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Veronica Alonso, Alberto Sanchez- Abuin, Cristina Duran, Oscar Gomez, Lorena Miguez, Maria E. MolinaABSTRACTThe incidence of postoperative fistula following primary cleft palate repair ranges from 0% to 58%. The reported recurrence rate is between 33% to 37%, and the prognosis of a successful closure declines with each reoperation.Closure of palatal fistulas can be achieved...
Thu Sep 12, 2019 13:08
Publication date: Available online 11 September 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Sandra M. Carrera Fernández, Paula Gabaldon Massé, Fabiana Wilder, Diego Preciado, Hugo A. RodriguezAbstractObjectiveVoice disorders are very common in the pediatric population, with 6% and 23 % of all children presenting with some form of dysphonia [1,2]. For many years, these patients have been underdiagnosed. There has been increasing awareness and interest in the study...
Thu Sep 12, 2019 13:08
Publication date: Available online 11 September 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Sara Elawady, Omayma Afsah, Wessam Elshawaf, Tamer Abou-ElsaadAbstractBackgroundAuditory performance outcome of children with hearing impairment has been widely studied, and the related factors of the performance have been explored among different age groups for English speaking hearing impaired children.ObjectivesThe objective of this study was to construct Arabic questionnaires...
Thu Sep 12, 2019 13:08
Publication date: Available online 11 September 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Emma S. Campisi, Jane E. Schneiderman, Blythe Owen, Theo J. Moraes, Paolo CampisiAbstractIntroductionExercise-induced laryngeal obstruction (EILO) affects 2-3% of the general population and 5.1% of elite athletes. Symptoms arise during high-intensity exercise and resolve at rest. EILO is often misdiagnosed as exercise-induced asthma as both conditions can present with dyspnea,...
Thu Sep 12, 2019 13:08
Related ArticlesCorrection to: Is there a relation between sudden sensorineural hearing loss and white matter lesions? Eur Arch Otorhinolaryngol. 2019 Sep 10;: Authors: Fusconi M, Attanasio G, Capitani F, Di Porto E, Diacinti D, Musy I, Ralli M, Ralli G, Greco A, de Vincentiis M, Colonnese C Abstract In the original publication, fifth author's surname was incorrectly published as "Diacinto". The correct surname should read as "Diacinti".PMID: 31506841...
Thu Sep 12, 2019 13:09
Related ArticlesCalmodulin-dependent signalling pathways are activated and mediate the acute inflammatory response of injured skeletal muscle. J Physiol. 2019 Sep 11;: Authors: Hu J, Shi D, Ding M, Huang T, Gu R, Xiao J, Xian CJ, Dong J, Wang L, Liao H Abstract KEY POINTS: There is a close relationship between skeletal muscle physiology and Ca2+ /CaM signalling. Despite the effects of Ca2+ /CaM signalling on immune and inflammatory responses have been...
Thu Sep 12, 2019 13:09
Abstract Cushing's disease (CD) is caused by a pituitary tumor that secretes adrenocorticotropin (ACTH) autonomously, leading to excess cortisol secretion from the adrenal glands. The condition is associated with increased morbidity and mortality that can be mitigated by treatments that result in sustained endocrine remission. Transsphenoidal pituitary surgery (TSS) remains the mainstay of treatment for CD but requires considerable neurosurgical expertise and experience in order to optimize...
Wed Sep 11, 2019 18:28
Related ArticlesMicroscopic study of chronic charcot arthropathy foot bones contributes to understanding pathogenesis - A preliminary report. Histol Histopathol. 2019 Sep 11;:18162 Authors: Dharmadas S, Kumar H, Pillay M, Jojo A, Tessy PJ, Sukumaran Mangalanandan T, Vivek L, Pavithran Praveen V, Bal A Abstract INTRODUCTION: Charcot arthropathy (CA) is non-infective, chronic destructive condition affecting the pes architecture of long standing diabetic...
Thu Sep 12, 2019 14:40
Related ArticlesMaintenance Therapy in HER2-Negative Metastatic Breast Cancer: A New Approach for an Old Concept. Clin Drug Investig. 2019 Jul;39(7):595-606 Authors: Ciruelos E, Pérez-García JM, Gavilá J, Rodríguez A, de la Haba-Rodriguez J Abstract The aim of this article is to discuss the role of maintenance therapy with chemotherapy, endocrine therapy, or bevacizumab-based combination therapy in patients with human epidermal growth factor receptor...
Thu Sep 12, 2019 13:12
Related ArticlesHead and neck cancer survivors' preferences for and evaluations of a post-treatment dietary intervention. Nutr J. 2019 Sep 10;18(1):57 Authors: Crowder SL, Douglas KG, Frugé AD, Carroll WR, Spencer SA, Locher JL, Demark-Wahnefried W, Rogers LQ, Arthur AE Abstract BACKGROUND: Dietary preferences vary depending on cancer type. The purpose of this study was to report dietary intervention preferences and a study program evaluation from post-treatment...
Thu Sep 12, 2019 13:12
Related ArticlesCetuximab in the management of nasopharyngeal carcinoma - a narrative review. J Laryngol Otol. 2019 Sep 11;:1-13 Authors: Iqbal MS, Wilkinson D, Tin A, Bossi P, Gradwell-Nelson L, Kovarik J, O'Hara J, Kelly C Abstract BACKGROUND: Concurrent chemotherapy with radiotherapy is the standard treatment for locoregionally advanced nasopharyngeal cancer. Cetuximab can be used in the treatment of head and neck squamous cell carcinoma. However,...
Thu Sep 12, 2019 13:12
Related ArticlesEmerging drugs to target lower urinary tract symptomatology (LUTS)/benign prostatic hyperplasia (BPH): focus on the prostate. World J Urol. 2019 Sep 10;: Authors: Ückert S, Kedia GT, Tsikas D, Simon A, Bannowsky A, Kuczyk MA Abstract OBJECTIVES: The benign prostatic syndrome, comprising lower urinary tract symptomatology secondary to benign prostatic hyperplasia/enlargement, represents a major health care issue in westernized countries....
Thu Sep 12, 2019 13:12
Related ArticlesDilemmas in diagnosis and management of hemophagocytic lymphohistiocytosis in children. World J Pediatr. 2019 Sep 10;: Authors: Xu XJ, Tang YM Abstract BACKGROUND: Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening entity which is characterized by severe hyperinflammation. Now the HLH-2004 protocol has been widely accepted and clinically used; however, many questions still remain in clinical practice. In this review, we discuss...
Thu Sep 12, 2019 13:12
Related ArticlesDiscovery of Novel Biomarkers of Therapeutic Responses in Han Chinese Pemetrexed-Based Treated Advanced NSCLC Patients. Front Pharmacol. 2019;10:944 Authors: Zhang X, Zhang D, Huang L, Li G, Chen L, Ma J, Li M, Wei M, Zhou W, Zhou C, Zhu J, Wang Z, Qin S Abstract Pemetrexed, one of the most commonly used drugs in advanced non-small cell lung cancer (NSCLC) therapies, often leads to various therapeutic responses in patients. These therapeutic...
Thu Sep 12, 2019 15:07
Related ArticlesMRI Atlas of the Human Deep Brain. Front Neurol. 2019;10:851 Authors: Lemaire JJ, De Salles A, Coll G, El Ouadih Y, Chaix R, Coste J, Durif F, Makris N, Kikinis R Abstract Mastering detailed anatomy of the human deep brain in clinical neurosciences is challenging. Although numerous pioneering works have gathered a large dataset of structural and topographic information, it is still difficult to transfer this knowledge into practice, even...
Thu Sep 12, 2019 15:07
Related ArticlesCongenital mesoblastic nephroma: a single-centre series. Ann R Coll Surg Engl. 2019 Sep 11;:1-4 Authors: Pachl M, Arul GS, Jester I, Bowen C, Hobin D, Morland B Abstract BACKGROUND: Congenital mesoblastic nephroma is a rare disease. Treatment is surgical in the first instance. Chemotherapy has traditionally been thought not to have a role. Recent literature suggests a 50% mortality rate for recurrent/metastatic disease. MATERIALS...
Thu Sep 12, 2019 15:07
Related ArticlesREPLATINUM Phase III randomized study: RRx-001 + platinum doublet versus platinum doublet in third-line small cell lung cancer. Future Oncol. 2019 Sep 11;: Authors: Oronsky B, Reid TR, Larson C, Caroen S, Quinn M, Burbano E, Varner G, Thilagar B, Brown B, Coyle A, Ferry L, Abrouk N, Oronsky A, Scribner CL, Carter CA Abstract RRx-001 is a cysteine-directed anticancer alkylating agent with activity in a Phase II study in platinum refractory...
Thu Sep 12, 2019 15:07
Related ArticlesSensitivity and Specificity of the Modified Epworth Sleepiness Scale in Children With Craniopharyngioma. J Clin Sleep Med. 2019 Sep 11;: Authors: Crabtree VM, Klages KL, Sykes A, Wise MS, Lu Z, Indelicato D, Merchant TE, Avent Y, Mandrell BN Abstract STUDY OBJECTIVES: Children with craniopharyngioma are at risk for excessive daytime sleepiness (EDS). Multiple Sleep Latency Testing (MSLT) is the gold standard for objective evaluation of...
Thu Sep 12, 2019 15:07
Related ArticlesGonadal Tissue Cryopreservation for Children with Differences of Sex Development. Horm Res Paediatr. 2019 Sep 11;:1-8 Authors: Johnson EK, Finlayson C, Finney EL, Harris CJ, Tan SY, Laronda MM, Lockart BA, Chen D, Rowell EE, Cheng EY, Yerkes EB Abstract INTRODUCTION: Infertility is common for individuals with differences of sex development (DSD) and is a significant concern to these individuals. Fertility potential in many DSD conditions...
Thu Sep 12, 2019 15:07
Related ArticlesOral administration of a potassium bromate dosage: Determination and evaluation of accumulated bromate on the liver of male mice. Drug Chem Toxicol. 2019 Sep 10;:1-6 Authors: Germoush MO, Alsohaimi IH, Alqadami AA, Alothman ZA, Ali HM, Algamdi MS, Aldawsari AM Abstract In this work, we developed a simple spectrophotometric strategy for BrO3- ions determination as a major water disinfection constituents in the mice's liver tissues by using...
Thu Sep 12, 2019 13:21
Related ArticlesAssociation of the Lung Immune Prognostic Index With Immune Checkpoint Inhibitor Outcomes in Patients With Advanced Non-Small Cell Lung Cancer. JAMA Oncol. 2018 Mar 01;4(3):351-357 Authors: Mezquita L, Auclin E, Ferrara R, Charrier M, Remon J, Planchard D, Ponce S, Ares LP, Leroy L, Audigier-Valette C, Felip E, Zerón-Medina J, Garrido P, Brosseau S, Zalcman G, Mazieres J, Caramela C, Lahmar J, Adam J, Chaput N, Soria JC, Besse B Abstract ...
Thu Sep 12, 2019 13:21
Related ArticlesDichloroacetic acid (DCA) synergizes with the SIRT2 inhibitor Sirtinol and AGK2 to enhance anti-tumor efficacy in non-small cell lung cancer. Cancer Biol Ther. 2018;19(9):835-846 Authors: Ma W, Zhao X, Wang K, Liu J, Huang G Abstract Combination chemotherapy is a potentially promising approach to enhance anticancer activity, overcome drug resistance, and improve disease-free and overall survival. The current study investigates the antitumor...
Thu Sep 12, 2019 13:21
Related ArticlesMicroRNA-506 inhibits the proliferation and invasion of mantle cell lymphoma cells by targeting B7H3. Biochem Biophys Res Commun. 2019 01 22;508(4):1067-1073 Authors: Zhu XW, Wang J, Zhu MX, Wang YF, Yang SY, Ke XY Abstract BACKGROUND: Aberrant expression of B7 homologue 3 (B7H3) has been observed in various malignancies. Our previous study demonstrated that knocking down of B7H3 inhibited cell proliferation, invasion and enhanced the...
Thu Sep 12, 2019 13:21
In Vitro Characterization of a Potent p53-MDM2 Inhibitor, RG7112 in Neuroblastoma Cancer Cell Lines.
Related ArticlesIn Vitro Characterization of a Potent p53-MDM2 Inhibitor, RG7112 in Neuroblastoma Cancer Cell Lines. Cancer Biother Radiopharm. 2019 May;34(4):252-257 Authors: Al-Ghabkari A, Narendran A Abstract Background: Neuroblastoma (NB) is one of the most aggressive and common solid tumors in pediatrics. Development of effective new therapeutics for NB is in progress to help reduce mortality and morbidity of the disease, particularly in relapsed...
Thu Sep 12, 2019 13:21
Related ArticlesSide Effects of Curcumin: Epigenetic and Antiproliferative Implications for Normal Dermal Fibroblast and Breast Cancer Cells. Antioxidants (Basel). 2019 Sep 09;8(9): Authors: Cianfruglia L, Minnelli C, Laudadio E, Scirè A, Armeni T Abstract BACKGROUND: Curcumin is a yellow-orange pigment obtained from the plant Curcuma longa, which is known to exert beneficial effects in several diseases, including cancer. However, at high doses, it may...
Thu Sep 12, 2019 13:21
Related ArticlesRadiation effects on early phase of NT2/D1 neural differentiation in vitro. Int J Radiat Biol. 2019 Sep 11;:1-36 Authors: Stanisavljevic D, Popovic J, Petrovic I, Davidovic S, Atkinson MJ, Anastasov N, Stevanovic M Abstract PURPOSE: Widespread medical use of radiation in diagnostic, imaging and treatment of different central nervous system malignancies lead to various consequences. Aim of this study was to further elucidate mechanism...
Thu Sep 12, 2019 14:22
Related ArticlesUM-Chor1: establishment and characterization of the first validated clival chordoma cell line. J Neurosurg. 2018 03;128(3):701-709 Authors: Owen JH, Komarck CM, Wang AC, Abuzeid WM, Keep RF, McKean EL, Sullivan S, Fan X, Prince MEP Abstract OBJECTIVE Chordomas are rare malignant tumors thought to arise from remnants of the notochord. They can be located anywhere along the axial skeleton but are most commonly found in the clival and sacrococcygeal...
Thu Sep 12, 2019 13:21
Related ArticlesBullous Pemphigoid-like Skin Lesions and Overt Eosinophilia in a Patient With Melanoma Treated With Nivolumab: Case Report and Review of the Literature. J Immunother. 2018 04;41(3):164-167 Authors: Anastasopoulou A, Papaxoinis G, Diamantopoulos P, Christofidou E, Benopoulou O, Stratigos A, Gogas H Abstract The widespread use of immune checkpoint inhibitors has shed light to several unusual immune-related adverse effects of the drugs....
Thu Sep 12, 2019 13:21
Related Articles[Fibrous hamartoma in childhood. A case description of large size and review of the literature]. Cir Pediatr. 2018 Feb 01;31(1):52-55 Authors: Berenguer B, Lorca-García C, Agra C, Lancharro A, Tomás E Abstract INTRODUCTION: Fibrous hamartoma of infancy is a rare soft tissue tumour that usually appears before 2 years of age, typically in the upper extremities of male infants. CASE REPORT: We report the case of a 2 year old boy...
Thu Sep 12, 2019 13:21
Related ArticlesHealth Survey of Adults with Neurofibromatosis 1 Compared to Population Study Controls. J Genet Couns. 2018 09;27(5):1102-1110 Authors: Fjermestad KW, Nyhus L, Kanavin ØJ, Heiberg A, Hoxmark LB Abstract Neurofibromatosis type 1 (NF1) is a genetic, autosomal dominant multi-organ disease characterized by susceptibility to tumor formation, changes in skin pigmentation, skeletal abnormalities, and neuropsychological deficits. Clinical studies...
Thu Sep 12, 2019 13:21
Related ArticlesThe carnitine system and cancer metabolic plasticity. Cell Death Dis. 2018 02 14;9(2):228 Authors: Melone MAB, Valentino A, Margarucci S, Galderisi U, Giordano A, Peluso G Abstract Metabolic flexibility describes the ability of cells to respond or adapt its metabolism to support and enable rapid proliferation, continuous growth, and survival in hostile conditions. This dynamic character of the cellular metabolic network appears enhanced...
Thu Sep 12, 2019 13:21
Related ArticlesA Preexisting Rare PIK3CAE545K Subpopulation Confers Clinical Resistance to MEK plus CDK4/6 Inhibition in NRAS Melanoma and Is Dependent on S6K1 Signaling. Cancer Discov. 2018 05;8(5):556-567 Authors: Romano G, Chen PL, Song P, McQuade JL, Liang RJ, Liu M, Roh W, Duose DY, Carapeto FCL, Li J, Teh JLF, Aplin AE, Chen M, Zhang J, Lazar AJ, Davies MA, Futreal PA, Amaria RN, Zhang DY, Wargo JA, Kwong LN Abstract Combined MEK and CDK4/6...
Thu Sep 12, 2019 13:21
Related ArticlesErlotinib in the treatment of recurrent or metastatic cutaneous squamous cell carcinoma: A single-arm phase 2 clinical trial. Cancer. 2018 05 15;124(10):2169-2173 Authors: Gold KA, Kies MS, William WN, Johnson FM, Lee JJ, Glisson BS Abstract BACKGROUND: Cutaneous squamous cell carcinoma (CSCC) is a very common malignancy in which most patients present with localized disease. Recurrent and metastatic disease is rare, and there is no...
Thu Sep 12, 2019 13:21
Related ArticlesPrognostic factors in adrenocortical carcinoma: data from a large Polish series. Pol Arch Intern Med. 2018 06 30;128(6):371-378 Authors: Nowak KM, Samsel R, Cichocki A, Ambroziak U, Roszkowska-Purska K, Łebek-Szatańska A, Koperski Ł, Otto M, Zgliczyński W, Papierska L Abstract Introduction Adrenocortical carcinoma (ACC) is a rare malignancy, associated with poor outcome and few therapeutic options. Despite increasing attention, the knowledge...
Thu Sep 12, 2019 13:21
Related Articles[Acute exacerbation of chronic CLL with multiple pathological fractures : A rarity]. Unfallchirurg. 2018 Nov;121(11):930-934 Authors: Zafeiris T, Gothner M, Hempel Overhage C, Heil G, Roetman B Abstract Chronic lymphatic leukaemia (CLL) is one of the most common leukaemic diseases in middle Europe. Pathological fractures are rare findings in patients with CLL. The diagnosis of CLL is in most cases an incidental finding as it often stays...
Thu Sep 12, 2019 13:21
Related ArticlesTargeted Molecular Analysis in Adrenocortical Carcinomas: A Strategy Toward Improved Personalized Prognostication. J Clin Endocrinol Metab. 2018 12 01;103(12):4511-4523 Authors: Lippert J, Appenzeller S, Liang R, Sbiera S, Kircher S, Altieri B, Nanda I, Weigand I, Gehrig A, Steinhauer S, Riemens RJM, Rosenwald A, Müller CR, Kroiss M, Rost S, Fassnacht M, Ronchi CL Abstract Context: Adrenocortical carcinoma (ACC) has a heterogeneous prognosis,...
Thu Sep 12, 2019 13:21
Related ArticlesUsing genomics to guide treatment for glioblastoma. Pharmacogenomics. 2018 10;19(15):1217-1229 Authors: Young JS, Prados MD, Butowski N Abstract Glioblastoma has been shown to have many different genetic mutations found both within and between tumor samples. Molecular testing and genomic sequencing has helped to classify diagnoses and clarify difficult to interpret histopathological specimens. Genomic information also plays a critical...
Thu Sep 12, 2019 13:21
Related ArticlesOcular torsion responses to electrical vestibular stimulation in vestibular schwannoma. Clin Neurophysiol. 2018 11;129(11):2350-2360 Authors: Mackenzie SW, Irving R, Monksfield P, Kumar R, Dezso A, Reynolds RF Abstract OBJECTIVES: We determined if eye movements evoked by Electrical Vestibular Stimulation (EVS) can be used to detect vestibular dysfunction in patients with unilateral vestibular schwannoma (VS). METHODS: Ocular...
Thu Sep 12, 2019 13:21
Related ArticlesImmune Mediated Cerebellar Ataxia: An Unknown Manifestation of Graft-versus-Host Disease. Acta Haematol. 2019;141(1):19-22 Authors: Shargian-Alon L, Raanani P, Rozovski U, Siegal T, Yust-Katz S, Yeshurun M Abstract Neurologic complications of allogeneic hematopoietic cell transplantation (allo-HCT) include infections, cerebrovascular events, therapy-induced neurotoxicity, recurrent malignancies, and neurologic manifestations of graft-versus-host...
Thu Sep 12, 2019 13:21
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