Related ArticlesPhase transitions beyond post-perovskite in NaMgF3 to 160 GPa. Proc Natl Acad Sci U S A. 2019 Sep 10;: Authors: Dutta R, Greenberg E, Prakapenka VB, Duffy TS Abstract Neighborite, NaMgF3, is used as a model system for understanding phase transitions in ABX3 systems (e.g., MgSiO3) at high pressures. Here we report diamond anvil cell experiments that identify the following phases in NaMgF3 with compression to 162 GPa: NaMgF3 (perovskite)...
Thu Sep 12, 2019 14:15
Related ArticlesThe single-cell transcriptomic landscape of early human diabetic nephropathy. Proc Natl Acad Sci U S A. 2019 Sep 10;: Authors: Wilson PC, Wu H, Kirita Y, Uchimura K, Ledru N, Rennke HG, Welling PA, Waikar SS, Humphreys BD Abstract Diabetic nephropathy is characterized by damage to both the glomerulus and tubulointerstitium, but relatively little is known about accompanying cell-specific changes in gene expression. We performed unbiased...
Thu Sep 12, 2019 14:15
Related ArticlesDiversification of giant and large eukaryotic dsDNA viruses predated the origin of modern eukaryotes. Proc Natl Acad Sci U S A. 2019 Sep 10;: Authors: Guglielmini J, Woo AC, Krupovic M, Forterre P, Gaia M Abstract Giant and large eukaryotic double-stranded DNA viruses from the Nucleo-Cytoplasmic Large DNA Virus (NCLDV) assemblage represent a remarkably diverse and potentially ancient component of the eukaryotic virome. However, their...
Thu Sep 12, 2019 14:15
Related ArticlesChromatin conformation remains stable upon extensive transcriptional changes driven by heat shock. Proc Natl Acad Sci U S A. 2019 Sep 10;: Authors: Ray J, Munn PR, Vihervaara A, Lewis JJ, Ozer A, Danko CG, Lis JT Abstract Heat shock (HS) initiates rapid, extensive, and evolutionarily conserved changes in transcription that are accompanied by chromatin decondensation and nucleosome loss at HS loci. Here we have employed in situ Hi-C to...
Thu Sep 12, 2019 14:15
Related ArticlesThree archetypical classes of macromolecular regulators of protein liquid-liquid phase separation. Proc Natl Acad Sci U S A. 2019 Sep 10;: Authors: Ghosh A, Mazarakos K, Zhou HX Abstract Membraneless organelles, corresponding to the droplet phase upon liquid-liquid phase separation (LLPS) of protein or protein-RNA mixtures, mediate myriad cellular functions. Cells use a variety of biochemical signals such as expression level and posttranslational...
Thu Sep 12, 2019 14:15
Related ArticlesGlobal invasion history of the agricultural pest butterfly Pieris rapae revealed with genomics and citizen science. Proc Natl Acad Sci U S A. 2019 Sep 10;: Authors: Ryan SF, Lombaert E, Espeset A, Vila R, Talavera G, Dincă V, Doellman MM, Renshaw MA, Eng MW, Hornett EA, Li Y, Pfrender ME, Shoemaker D Abstract The small cabbage white butterfly, Pieris rapae, is a major agricultural pest of cruciferous crops and has been introduced to every...
Thu Sep 12, 2019 14:15
Related ArticlesIntracellular redox potential is correlated with miRNA expression in MCF7 cells under hypoxic conditions. Proc Natl Acad Sci U S A. 2019 Sep 10;: Authors: Johnston H, Dickinson P, Ivens A, Buck AH, Levine RD, Remacle F, Campbell CJ Abstract Hypoxia is a ubiquitous feature of cancers, encouraging glycolytic metabolism, proliferation, and resistance to therapy. Nonetheless, hypoxia is a poorly defined term with confounding features described...
Thu Sep 12, 2019 14:15
Related ArticlesReply to Head-Gordon and Paesani: Liquid water, a branched polymer with ∼100-fs short-lived heterogeneous hydrogen bonds. Proc Natl Acad Sci U S A. 2019 Sep 10;: Authors: Naserifar S, Goddard WA PMID: 31506354 [PubMed - as supplied by publisher]
Thu Sep 12, 2019 14:15
Related ArticlesStructural basis for power stroke vs. Brownian ratchet mechanisms of motor proteins. Proc Natl Acad Sci U S A. 2019 Sep 10;: Authors: Hwang W, Karplus M Abstract Two mechanisms have been proposed for the function of motor proteins: The power stroke and the Brownian ratchet. The former refers to generation of a large downhill free energy gradient over which the motor protein moves nearly irreversibly in making a step, whereas the latter...
Thu Sep 12, 2019 14:15
Related ArticlesPremotor cortex implements causal inference in multisensory own-body perception. Proc Natl Acad Sci U S A. 2019 Sep 10;: Authors: Ehrsson HH, Chancel M PMID: 31506356 [PubMed - as supplied by publisher]
Thu Sep 12, 2019 14:15
Related ArticlesOpinion: Putting all foods on the same table: Achieving sustainable food systems requires full accounting. Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18152-18156 Authors: Halpern BS, Cottrell RS, Blanchard JL, Bouwman L, Froehlich HE, Gephart JA, Sand Jacobsen N, Kuempel CD, McIntyre PB, Metian M, Moran DD, Nash KL, Többen J, Williams DR PMID: 31506376 [PubMed - in process]
Thu Sep 12, 2019 14:15
Related ArticlesComments on superconductivity in AE 2CuO4±δ (AE = Sr, Ba). Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18165 Authors: Yamamoto H PMID: 31506377 [PubMed - in process]
Thu Sep 12, 2019 14:15
Related ArticlesReply to Yamamoto: A cuprate superconductor with unconventional features. Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18166-18167 Authors: Li WM, Zhao JF, Cao LP, Hu Z, Huang QZ, Wang XC, Liu Y, Zhao GQ, Zhang J, Liu QQ, Yu RZ, Long YW, Wu H, Lin HJ, Chen CT, Li Z, Gong ZZ, Guguchia Z, Kim JS, Stewart GR, Uemura YJ, Uchida S, Jin CQ PMID: 31506378 [PubMed - in process]
Thu Sep 12, 2019 14:15
Related Articles[New techniques of blood glucose monitoring and treatment in type 1 diabetes]. Zhonghua Yi Xue Za Zhi. 2019 Sep 10;99(34):2641-2645 Authors: Zhou J PMID: 31505711 [PubMed - in process]
Thu Sep 12, 2019 14:16
Related Articles[Enlightenment coming from HAPO study to HAPO follow-up study]. Zhonghua Yi Xue Za Zhi. 2019 Sep 10;99(34):2646-2649 Authors: Wu HH PMID: 31505712 [PubMed - in process]
Thu Sep 12, 2019 14:16
Related Articles[Clinical implications of the crosstalk between islet endothelial cells and β cells]. Zhonghua Yi Xue Za Zhi. 2019 Sep 10;99(34):2650-2653 Authors: Le YY, Yang J, Hong TP PMID: 31505713 [PubMed - in process]
Thu Sep 12, 2019 14:16
Related Articles[Awareness of preconceptional care and its related factors in women of child-bearing age with type 1 diabetes]. Zhonghua Yi Xue Za Zhi. 2019 Sep 10;99(34):2654-2659 Authors: Zheng XY, Yang DZ, Ai HY, Qiu LL, Ling P, Wu ZK, Wei XY, Lin QY, Lü J, Yan JH, Yao B, Weng JP, Luo SH Abstract Objective: To investigate the awareness of preconception care among women of child-bearing age with type 1 diabetes (T1DM) and their self-management status,...
Thu Sep 12, 2019 14:16
Related Articles[Changes and clinical significance of serum proteinase 3 in latent autoimmune diabetes in adults]. Zhonghua Yi Xue Za Zhi. 2019 Sep 10;99(34):2660-2664 Authors: Yu Y, Liu LL, Xiao XY, Wang YD, Xu AM, Tu YT, Liu LJ, Xiao Y, Zhou ZG Abstract Objective: To investigate the changes of circulating proteinase 3 (PR3) in latent autoimmune diabetes mellitus in adults (LADA) patients, type 2 diabetes mellitus (T2DM) patients, obese patients without...
Thu Sep 12, 2019 14:16
Related Articles[Association of insulin resistance with dyslipidemia in adults with type 1 diabetes]. Zhonghua Yi Xue Za Zhi. 2019 Sep 10;99(34):2665-2669 Authors: Luo SH, Yang DZ, Wei XY, Ai HY, Lin QY, Liu ZY, Ling P, Lü J, Yan JH, Yao B, Weng JP, Zheng XY Abstract Objective: To investigate the relationship between insulin resistance (IR) and dyslipidemia in adults with type 1 diabetes (T1DM) and provide more insights on diabetes-related cardiovascular...
Thu Sep 12, 2019 14:16
Related Articles[The expression of VHL/HIF signaling pathway in the erythroid progenitor cells with chronic mountain sickness]. Zhonghua Yi Xue Za Zhi. 2019 Sep 10;99(34):2670-2674 Authors: Liu HH, Su J, Ma J, Li ZQ, Cui S, Ji LH, Geng H, Tang F, Ge RL Abstract Objective: To investigate the expression and interaction of VHL/HIF-α pathways including HIF-1α, HIF-2α as well as VHL in erythroid progenitor cells of bone marrow from chronic mountain sickness...
Thu Sep 12, 2019 14:16
Related Articles[Sacral neuromodulation preliminary outcomes in male patients with idiopathic dysuria]. Zhonghua Yi Xue Za Zhi. 2019 Sep 10;99(34):2675-2680 Authors: Meng LF, Zhang W, Zhang YG, Wang JY, Liao LM, Chen GQ, Ling Q, Zhang P, Wei ZQ, Chen Q Abstract Objective: To assess the effectiveness and safety of sacral neuromodulation (SNM) therapy for men with idiopathic dysuria. Methods: From January 2012 to December 2016, a total of 26 patients treated...
Thu Sep 12, 2019 14:16
Related Articles[Epithelial-mesenchymal transition of small airway epithelium in patients receiving lung tumor surgery with normal lung function and chronic obstructive pulmonary disease]. Zhonghua Yi Xue Za Zhi. 2019 Sep 10;99(34):2681-2686 Authors: Zhu JY, Zhou F, Yu L, Zhang J Abstract Objective: To investigate the phenomenon of small airway epithelial-mesenchymal transition (EMT) in patients with normal pulmonary function and chronic obstructive...
Thu Sep 12, 2019 14:16
Related Articles[Relationship between systolic blood pressure load and sleep stability in patients with essential hypertension]. Zhonghua Yi Xue Za Zhi. 2019 Sep 10;99(34):2687-2690 Authors: Zhu YQ, Jia YK, Chen LP, Yang Y, He MY, Guo YT, Zhang M, Wei YL, Tang B Abstract Objective: To explore the relationship between blood pressure load and sleep stability in hypertensive patients by cardiopulmonary coupling monitoring (CPC) and 24-hour ambulatory blood...
Thu Sep 12, 2019 14:16
Related Articles[Clinical features of atrial fibrillation complicated with occult pulmonary embolism]. Zhonghua Yi Xue Za Zhi. 2019 Sep 10;99(34):2691-2695 Authors: Yu QH, Qian HY, Peng HY Abstract Objective: To investigate the clinical features of patients with atrial fibrillation (AF) and occult pulmonary embolism (PE). Methods: Clinical data of 67 AF patients complicated with PE (AP group) admitted to the Tianjin Chest hospital from January 2014 to...
Thu Sep 12, 2019 14:16
Related Articles[Clinical characteristics of lung NK/T cell lymphoma misdiagnosed as pneumonia]. Zhonghua Yi Xue Za Zhi. 2019 Sep 10;99(34):2696-2700 Authors: Wu J, Qiu YJ, Xu AG, Xing LH, Zhang QX Abstract Objective: To investigate the clinical features of lung natural killer (NK)/T cell lymphoma. Methods: The clinical data of patients with lung NK/T-cell lymphoma confirmed by pathology who were hospitalized due to lung shadow and initially treated...
Thu Sep 12, 2019 14:16
Related Articles[Mouse models for human colorectal cancer with liver metastasis]. Zhonghua Yi Xue Za Zhi. 2019 Sep 10;99(34):2701-2705 Authors: Huang XD, Zheng YB, Yang YJ, Yang C, Li HL, Cheng HR Abstract Objective: To established Apc(loxp/loxp)+Kras(LSL-G12D/-)+Smad4(loxp/loxp) transgenic mouse model that mimick the occurrence and development of human sporadic colorectal cancer(CRC) and its liver metastasis. Methods: C57BL/6-Apc(tm1Tyj)/J(Apc(loxP)),...
Thu Sep 12, 2019 14:16
Related Articles[Biomechanical study of bridge-link type combined internal fixation system with mixed-rod in the treatment of long segmental comminuted fracture of femoral shaft]. Zhonghua Yi Xue Za Zhi. 2019 Sep 10;99(34):2706-2710 Authors: Wang L, Yu JN, Huang ZZ, Gu WD, Wang R Abstract Objective: To observe the biomechanical characteristics of bridge-link type combined internal fixation system (BCFS) with mixed-rod in the treatment of long segmental...
Thu Sep 12, 2019 14:16
New therapies targeting metabolic vulnerabilities of specific tumor types have created wide interest in recent years. Through research now reported in the Journal by Gantner et al. metabolic precision therapy may become possible in patients with a rare eye disease, macular telangiectasia type 2,…
Wed Sep 11, 2019 03:00
Understanding the pathophysiology of diseases with complex genetic inheritance patterns is challenging. Macular telangiectasia type 2, which has a prevalence of 0.0045% to 0.06%, is a rare macular disease that leads to loss of central vision, with the onset of symptoms occurring in the fifth or…
Wed Sep 11, 2019 03:00
To the Editor: Pennsylvania legalized medical marijuana in 2016, and since then its use has skyrocketed. The doses of the active ingredients of marijuana — tetrahydrocannabinol (THC) and cannabidiol (CBD) — are not standardized, product concentrations are not regulated, and prescribing practices…
Thu Sep 12, 2019 03:00
The effect of diet and/or rotating light cycles on gastric vagal afferent satiety signaling and food intake. Abstract Background Gastric vagal afferents (GVAs) respond to mechanical stimulation, initiating satiety. These afferents exhibit diurnal fluctuations in mechanosensitivity, facilitating food intake during the dark phase in rodents. In humans, desynchrony of diurnal rhythms (eg, shift work) is associated with a higher risk of obesity. To test the hypothesis that shift work disrupts...
Wed Sep 11, 2019 18:08
86 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: ALCOHOL These pubmed results were generated on 2019/09/12PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Thu Sep 12, 2019 14:23
Related ArticlesRecent Advances in Medicinal Chemistry to Treat Filariasis and Helminthiasis. Curr Top Med Chem. 2019;19(14):1189-1190 Authors: Srivastava SK AbstractPMID: 31509098 [PubMed - in process]
Thu Sep 12, 2019 14:26
Related ArticlesBioactive Natural and Synthetic Peroxides for the Treatment of Helminth and Protozoan Pathogens: Synthesis and Properties. Curr Top Med Chem. 2019;19(14):1201-1225 Authors: Vil' VA, Terent'ev AO, Mulina OM Abstract The significant spread of helminth and protozoan infections, the uncontrolled intake of the known drugs by a large population, the emergence of resistant forms of pathogens have prompted people to search for alternative drugs....
Thu Sep 12, 2019 14:26
Related ArticlesAdvances in Dopamine D1 Receptor Ligands for Neurotherapeutics. Curr Top Med Chem. 2019 Jul 12;: Authors: Felsing DE, Jain MK, Allen JA Abstract The dopamine D1 receptor (D1R) is essential for neurotransmission in various brain pathways where it modulates key functions including voluntary movement, memory, attention and reward. Not surprisingly, the D1R has been validated as a promising drug target for over 40 years and selective activation...
Thu Sep 12, 2019 14:26
Related ArticlesLearning brain aneurysm microsurgical skills in a human placenta model: predictive validity. J Neurosurg. 2018 03;128(3):846-852 Authors: de Oliveira MMR, Ferrarez CE, Ramos TM, Malheiros JA, Nicolato A, Machado CJ, Ferreira MT, de Oliveira FB, de Sousa CFPM, Costa PHV, Gusmao S, Lanzino G, Maestro RD Abstract OBJECTIVE Surgery for brain aneurysms is technically demanding. In recent years, the process to learn the technical skills necessary...
Thu Sep 12, 2019 13:00
Related ArticlesHSP27-Mediated Extracellular and Intracellular Signaling Pathways Synergistically Confer Chemoresistance in Squamous Cell Carcinoma of Tongue. Clin Cancer Res. 2018 03 01;24(5):1163-1175 Authors: Zheng G, Zhang Z, Liu H, Xiong Y, Luo L, Jia X, Peng C, Zhang Q, Li N, Gu Y, Lu M, Song Y, Pan H, Liu J, Liu W, He Z Abstract Purpose: Squamous cell carcinoma of tongue (SCCT) is the most common type of oral cavity carcinoma. Chemoresistance...
Thu Sep 12, 2019 13:00
Related ArticlesExcess Mucin Impairs Subglottic Epithelial Host Defense in Mechanically Ventilated Patients. Am J Respir Crit Care Med. 2018 08 01;198(3):340-349 Authors: Powell J, Garnett JP, Mather MW, Cooles FAH, Nelson A, Verdon B, Scott J, Jiwa K, Ruchaud-Sparagano MH, Cummings SP, Perry JD, Wright SE, Wilson JA, Pearson J, Ward C, Simpson AJ Abstract RATIONALE: Aspiration of infective subglottic secretions causes ventilator-associated pneumonia...
Thu Sep 12, 2019 13:00
Related ArticlesErlotinib in the treatment of recurrent or metastatic cutaneous squamous cell carcinoma: A single-arm phase 2 clinical trial. Cancer. 2018 05 15;124(10):2169-2173 Authors: Gold KA, Kies MS, William WN, Johnson FM, Lee JJ, Glisson BS Abstract BACKGROUND: Cutaneous squamous cell carcinoma (CSCC) is a very common malignancy in which most patients present with localized disease. Recurrent and metastatic disease is rare, and there is no...
Thu Sep 12, 2019 13:00
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