Related ArticlesChanging Cardiopulmonary Resuscitation to Cardiocerebral Resuscitation: The Reason We Push Hard and Fast. Crit Care Med. 2018 05;46(5):823-825 Authors: Maciel CB, Hirsch LJ PMID: 29652712 [PubMed - indexed for MEDLINE]
Thu Sep 12, 2019 13:54
Related ArticlesLesson of the month 1: Sodium valproate-induced encephalopathy. Clin Med (Lond). 2018 10;18(5):430-432 Authors: Camilleri L Abstract A 69-year-old man developed reduced consciousness of sudden onset. Examination and parameters were normal, except for a Glasgow Coma Scale (GCS) score of six. Brain imaging and blood tests were also normal, except for high plasma ammonia. His past medical history included epilepsy, hypertension and colitis....
Thu Sep 12, 2019 13:54
Related ArticlesMyoclonic epilepsy, parkinsonism, schizophrenia and left-handedness as common neuropsychiatric features in 22q11.2 deletion syndrome. J Med Genet. 2019 Sep 10;: Authors: Fanella M, Frascarelli M, Lambiase C, Morano A, Unolt M, Liberati N, Fattouch J, Buzzanca A, Accinni T, Ceccanti M, Viganò A, Biondi M, Colonnese C, Giallonardo AT, Di Fabio F, Pizzuti A, Di Bonaventura C, Berardelli A Abstract BACKGROUND: 22q11.2 deletion syndrome (22q11.2DS)...
Thu Sep 12, 2019 13:54
Related ArticlesDevelopment of Ontology for Self-limited Epilepsy with Centrotemporal Spikes and Application of Data Mining Algorithms to Identify New Subtypes. Isr Med Assoc J. 2019 Jul;21(7):503 Authors: Porat Rein A, Kramer U, Mitelpunkt A Abstract BACKGROUND: Benign rolandic epilepsy or benign childhood epilepsy with centrotemporal spikes (BCECTS) is a common childhood epileptic syndrome. The syndrome resolves in adolescence, but 1-7% of patients...
Thu Sep 12, 2019 13:54
Related ArticlesVagus Nerve Stimulation-Induced Laryngeal Motor Evoked Potentials: A Possible Biomarker of Effective Nerve Activation. Front Neurosci. 2019;13:880 Authors: Vespa S, Stumpp L, Bouckaert C, Delbeke J, Smets H, Cury J, Ferrao Santos S, Rooijakkers H, Nonclercq A, Raedt R, Vonck K, El Tahry R Abstract Vagus nerve stimulation (VNS) therapy is associated with laryngeal muscle activation and induces voice modifications, well-known side effects...
Thu Sep 12, 2019 15:19
Related ArticlesDetrimental Effects of HMGB-1 Require Microglial-Astroglial Interaction: Implications for the Status Epilepticus -Induced Neuroinflammation. Front Cell Neurosci. 2019;13:380 Authors: Rosciszewski G, Cadena V, Auzmendi J, Cieri MB, Lukin J, Rossi AR, Murta V, Villarreal A, Reinés A, Gomes FCA, Ramos AJ Abstract Temporal Lobe Epilepsy (TLE) is the most common form of human epilepsy and available treatments with antiepileptic drugs are not...
Thu Sep 12, 2019 15:19
Related ArticlesThe Effects of a Single Oral Dose of Pyridoxine on Alpha-Aminoadipic Semialdehyde, Piperideine-6-Carboxylate, Pipecolic Acid, and Alpha-Aminoadipic Acid Levels in Pyridoxine-Dependent Epilepsy. Front Pediatr. 2019;7:337 Authors: Wang J, Xue J, Gong P, Wu M, Yang W, Jiang S, Wu Y, Jiang Y, Zhang Y, Yuzyuk T, Li H, Yang Z Abstract Purpose: To evaluate the effects of a single oral dose of pyridoxine on lysine metabolites including α-aminoadipic...
Thu Sep 12, 2019 15:19
Related ArticlesA cascade of care for people with epilepsy: learning from "HIV/AIDS 90-90-90". Gates Open Res. 2019;3:1502 Authors: Mateen F Abstract Epilepsy is now more prevalent in many countries than HIV/AIDS. Building upon the advances of global policymaking for HIV/AIDS and creating a framework for countries and organizations to monitor progress in epilepsy care will help direct and justify much-needed novel programming. Given the clarity of the...
Thu Sep 12, 2019 15:19
Related ArticlesResponsive neurostimulation targeting anterior thalamic nucleus in generalized epilepsy. Ann Clin Transl Neurol. 2019 Sep 11;: Authors: Herlopian A, Cash SS, Eskandar EM, Jennings T, Cole AJ Abstract Responsive neurostimulation (RNS) has emerged as an adjunctive treatment modality for patients with intractable focal epilepsy who are not surgical candidates or have more than one ictal onset focus. We report a 34-year-old patient with intractable,...
Thu Sep 12, 2019 15:19
Related ArticlesLetter from the Executive Director Dr. John Cho. Mil Med. 2019 Sep 10;: Authors: PMID: 31506675 [PubMed - as supplied by publisher]
Thu Sep 12, 2019 13:59
Related ArticlesAn anatomical study of the superior transverse scapular ligament of Jining population. Surg Radiol Anat. 2019 Sep 10;: Authors: Long R, Wang N, Liu W, Liu Z, Cheng S, Zhang X, Geng X, Liu C, Wang J, Ding M, Tian Z, Li J Abstract PURPOSE: The aim of this study was to determine the anatomical variations of the superior transverse scapular ligament (STSL) for better understanding the possible predisposing factors for suprascapular nerve...
Thu Sep 12, 2019 14:06
Related ArticlesFine-Needle Aspiration Cytology of Cellular Basaloid Neoplasms of the Salivary Gland. Arch Pathol Lab Med. 2019 Sep 11;: Authors: Cantley RL Abstract CONTEXT.—: Cellular basaloid neoplasms of the salivary gland represent a diverse group of benign and malignant neoplasms with significant cytomorphologic overlap on fine-needle aspiration cytology. All are marked by the presence of monotonous and usually bland basaloid epithelium. Distinction...
Thu Sep 12, 2019 16:05
Related ArticlesA Clinicopathologic and Molecular Update of Pancreatic Neuroendocrine Neoplasms With a Focus on the New World Health Organization Classification. Arch Pathol Lab Med. 2019 Sep 11;: Authors: Fang JM, Shi J Abstract CONTEXT.—: According to the 2017 World Health Organization classification, pancreatic neuroendocrine neoplasms (PanNENs) include a new category of pancreatic neuroendocrine tumor, grade 3, which is often difficult to differentiate...
Thu Sep 12, 2019 16:05
Related ArticlesHistologic Evaluation of Malignant Polyps and Low-Stage Colorectal Carcinoma. Arch Pathol Lab Med. 2019 Sep 11;: Authors: Hagen CE, Farooq A Abstract CONTEXT.—: With widespread screening for colorectal cancer, the number of early-stage colorectal cancers is increasing. Local excision of pT1 tumors is associated with considerably less morbidity and mortality, but this must be weighed against risk of lymph node metastases. OBJECTIVE.—:...
Thu Sep 12, 2019 16:05
Related ArticlesEvaluation of the Anyplex II HPV28 Assay in the Detection of Human Papillomavirus in Archival Samples of Oropharyngeal Carcinomas. Arch Pathol Lab Med. 2019 Sep 11;: Authors: Rollo F, Donà MG, Pichi B, Pellini R, Covello R, Benevolo M Abstract CONTEXT.—: The improved survival and better response to treatments of human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) highlight the need for effective tools in...
Thu Sep 12, 2019 16:05
Related ArticlesCorrelation of ROS1 Immunohistochemistry With ROS1 Fusion Status Determined by Fluorescence In Situ Hybridization. Arch Pathol Lab Med. 2019 Sep 11;: Authors: Huang RSP, Smith D, Le CH, Liu WW, Ordinario E, Manohar C, Lee M, Rajamani J, Truong H, Li J, Choi C, Li J, Pati A, Bubendorf L, Buettner R, Kerr KM, Lopez-Rios F, Marchetti A, Marondel I, Nicholson AG, Ãz AB, Pauwels P, Penault-Llorca F, Rossi G, Thunnissen E, Newell AH, Pate G, Menzl I ...
Thu Sep 12, 2019 16:05
Publication date: Available online 11 September 2019Source: Sleep MedicineAuthor(s): Vladimir Svetnik, Ellen S. Snyder, Peining Tao, Thomas Roth, Christopher Lines, W. Joseph HerringAbstractObjectiveThe determinants of sleep quality (sQUAL) are poorly understood. We evaluated how well a large number of objective polysomnography (PSG) parameters can predict sQUAL in insomnia patients with and without medications.MethodsPSG recordings over multiple nights from two clinical drug development programs...
Thu Sep 12, 2019 14:13
Publication date: Available online 11 September 2019Source: Sleep MedicineAuthor(s): Tetyana Kendzerska, Richard Leung, Clare Atzema, George Chandy, Moussa Meteb, Atul Malhotra, Gillian Hawker, Andrea S. GershonAbstractObjective/Background: Evidence on sex differences in the association between obstructive sleep apnea (OSA) and cardiovascular outcomes is limited and controversial. We conducted a historical cohort study to investigate this relationship.Patients/MethodsClinical data on adults who underwent...
Thu Sep 12, 2019 14:13
Publication date: Available online 11 September 2019Source: Sleep MedicineAuthor(s): Rasintra Siriwat, Neepa Gurbani, Yuanfang Xu, Md Monir Hossain, Narong SimakajornboonAbstractStudy ObjectivesTo describe sleep manifestations, polysomnographic findings, and specific sleep disorders in children with Eosinophilic Esophagitis (EoE).MethodsThis retrospective study included children with EoE who were referred to sleep clinics. Clinical manifestations, polysomnographic variables, and diagnosis of sleep...
Thu Sep 12, 2019 14:13
Update on the Pharmacologic Management of Narcolepsy: Mechanisms of Action and Clinical Implications
Publication date: Available online 11 September 2019Source: Sleep MedicineAuthor(s): Michael J. Thorpy, Richard K. BoganAbstractNarcolepsy is a chronic, debilitating neurological disorder of sleep-wake state instability. This instability underlies all narcolepsy symptoms, including excessive daytime sleepiness (EDS), symptoms of REM sleep dysregulation (i.e., cataplexy, hypnagogic/hypnopompic hallucinations, sleep paralysis), and disrupted nighttime sleep. Several neurotransmitter systems promote...
Thu Sep 12, 2019 14:13
Publication date: Available online 12 September 2019Source: Sleep MedicineAuthor(s): Naoki Toyama, Daisuke Ekuni, Ayano Taniguchi-Tabata, Toshiki Yoneda, Kota Kataoka, Aya Yokoi, Yoko Uchida, Daiki Fukuhara, Hikari Saho, Islam Md Monirul, Nanami Sawada, Yukiho Nakashima, Yoshiaki Iwasaki, Manabu MoritaAbstractObjectiveSleep bruxism, a major sleep disorder that causes serious harm to oral health, is considered a multifactorial disease. Sleep bruxism can be induced by smoking, which also adversely...
Thu Sep 12, 2019 14:13
Publication date: Available online 12 September 2019Source: Gene Expression PatternsAuthor(s): Jeffrey G. Daniel, Jennifer R. PanizziAbstractRecent human next-generation sequencing (NGS) studies indicate a correlation between ANKEF1 (ankyrin repeat and EF-hand domain containing protein 1) expression and cilia formation or function. Additionally, a single study conducted in the African clawed frog (Xenopus laevis) showed ankef1 is down-regulated after pharmacological fibroblast growth factor (FGF)...
Thu Sep 12, 2019 14:14
Thu Sep 12, 2019 03:00
Thu Sep 12, 2019 03:00
Thu Sep 12, 2019 03:00
Thu Sep 12, 2019 03:00
Thu Sep 12, 2019 03:00
Thu Sep 12, 2019 03:00
Nature Communications, Published online: 12 September 2019; doi:10.1038/s41467-019-12137-1Respiratory syncytial virus (RSV) is a leading cause of infant hospitalization. Here, the authors isolate a human monoclonal antibody that binds to a highly conserved epitope on the RSV fusion protein, neutralizes RSV A and B subtypes equipotently and is protective in the cotton rat model.
Thu Sep 12, 2019 03:00
Nature Communications, Published online: 12 September 2019; doi:10.1038/s41467-019-12073-0A common complication of cisplatin-based chemotherapy is hearing loss. Here, Park et al. show that glutathione transferase α4 (GSTA4) contributes to reducing cisplatin toxicity in the inner ear of female mice by removing 4-hydroxynonenal (4-HNE).
Thu Sep 12, 2019 03:00
Nature Communications, Published online: 12 September 2019; doi:10.1038/s41467-019-12139-zThe hidden matching communication problem features an exponential classical-quantum gap, but a demonstration is extremely challenging. Here, the authors define a more feasible variant called sampling matching problem, and realise a proof-of-principle implementation beating the best known classical protocol.
Thu Sep 12, 2019 03:00
Nature Communications, Published online: 12 September 2019; doi:10.1038/s41467-019-12099-4While energy metabolism has been repeatedly linked to ALS, motor neuron metabolism remains poorly studied. Here, authors show that human iPSCs rewire specific metabolic routes when they differentiate into functional motor neurons and that ALS-causing mutations in FUS do not affect energy metabolism.
Thu Sep 12, 2019 03:00
Nature Communications, Published online: 12 September 2019; doi:10.1038/s41467-019-12183-9Irrigation buffers crop yields from extreme weather, but comes at environmental costs. Here the authors show that in India irrigation has improved wheat yield and reduced its sensitivity to heat, yet further increases are unlikely to offset the impact of warming.
Thu Sep 12, 2019 03:00
Nature Communications, Published online: 12 September 2019; doi:10.1038/s41467-019-12226-1Survival and proliferation of vascular cells in the presence of DNA damage is a characteristic of pulmonary arterial hypertension. Here the authors show that the phosphatase EYA3 contributes to vascular remodeling by promoting survival of damaged cells, and present results of genetic and pharmacological EYA3 inhibition.
Thu Sep 12, 2019 03:00
Nature Communications, Published online: 12 September 2019; doi:10.1038/s41467-019-12087-8The authors present an in vitro gut microbiome model that maintains the functional and compositional profiles of individual gut microbiomes, as assessed by metaproteomics. Gut microbiome responses to metformin in this model correlate with those shown in mice fed a high-fat diet.
Thu Sep 12, 2019 03:00
Nature Communications, Published online: 12 September 2019; doi:10.1038/s41467-019-12122-8The underlying transcriptional and cellular events mediating the reduction of dendritic spines on medium spiny neurons of the nucleus accumbens (NAc) remains unknown. Here, authors demonstrate that heroin self-administration negatively regulates the actin-binding protein drebrin in the NAc, which is shown to be transcriptionally repressed by the histone modifier HDAC2, and that overexpression of drebrin is sufficient...
Thu Sep 12, 2019 03:00
Related ArticlesPhase transitions beyond post-perovskite in NaMgF3 to 160 GPa. Proc Natl Acad Sci U S A. 2019 Sep 10;: Authors: Dutta R, Greenberg E, Prakapenka VB, Duffy TS Abstract Neighborite, NaMgF3, is used as a model system for understanding phase transitions in ABX3 systems (e.g., MgSiO3) at high pressures. Here we report diamond anvil cell experiments that identify the following phases in NaMgF3 with compression to 162 GPa: NaMgF3 (perovskite)...
Thu Sep 12, 2019 14:15
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου