Πέμπτη 5 Σεπτεμβρίου 2019


The Efficacy of Device Designs (Mono-block or Bi-block) in Oral Appliance Therapy for Obstructive Sleep Apnea Patients: A Systematic Review and Meta-Analysis.
Related ArticlesThe Efficacy of Device Designs (Mono-block or Bi-block) in Oral Appliance Therapy for Obstructive Sleep Apnea Patients: A Systematic Review and Meta-Analysis. Int J Environ Res Public Health. 2019 Aug 31;16(17): Authors: Ishiyama H, Hasebe D, Sato K, Sakamoto Y, Furuhashi A, Komori E, Yuasa H Abstract Oral appliance (OAm) therapy has demonstrated efficacy in treating obstructive sleep apnea (OSA). The aim of this systematic review was...
pubmed: snoring
Thu Sep 05, 2019 15:25
Unexpected Finding of Idiopathic REM Sleep Behavior Disorder in a Young Healthy Male With Snoring: A Case Report.
Related ArticlesUnexpected Finding of Idiopathic REM Sleep Behavior Disorder in a Young Healthy Male With Snoring: A Case Report. J Clin Sleep Med. 2019 Aug 19;: Authors: Brock MS, Shirley S, Rohena L, Moore BA, Mysliwiec V Abstract Idiopathic rapid eye movement sleep behavior disorder is characterized by vocalizations and complex motor behaviors during sleep. We report a case of a 44-year-old male with a 20-year history of dream enactment behavior that...
pubmed: snoring
Thu Sep 05, 2019 15:25
Sleep-Disordered Breathing in Pediatric Patients With Rett Syndrome.
Related ArticlesSleep-Disordered Breathing in Pediatric Patients With Rett Syndrome. J Clin Sleep Med. 2019 Aug 30;: Authors: Sarber KM, Howard JJM, Dye TJ, Pascoe JE, Simakajornboon N Abstract STUDY OBJECTIVES: Although respiratory abnormalities occurring during wakefulness are well recognized in patients with Rett syndrome (RS), less has been reported regarding sleep-disordered breathing (SDB) in this population. This study aims to characterize the...
pubmed: snoring
Thu Sep 05, 2019 15:25
Association of possible sleep bruxism with daytime oral habits and sleep behavior in schoolchildren.
Related ArticlesAssociation of possible sleep bruxism with daytime oral habits and sleep behavior in schoolchildren. Cranio. 2019 Sep 04;:1-7 Authors: Duarte J, Souza JF, Cavalcante-Leão B, Todero SRB, Ferreira FM, Fraiz FC Abstract Objective: To Determine whether possible sleep bruxism (PSB) is associated with daytime oral habits and sleep behavior in schoolchildren. Methods: A cross-sectional study was conducted with a representative sample of 8-to-10-year-old...
pubmed: snoring
Thu Sep 05, 2019 15:25
[Epidemiological characteristics and correlated factors of habitual snoring among Chinese aged 30 to 79 year-old].
Related Articles[Epidemiological characteristics and correlated factors of habitual snoring among Chinese aged 30 to 79 year-old]. Zhonghua Liu Xing Bing Xue Za Zhi. 2019 Aug 10;40(8):917-923 Authors: Wei YX, Shen ZW, Yu CQ, Du HD, Lyu J, Guo Y, Bian Z, Pei P, Chen JS, Chen ZM, Li LM, China Kadoorie Biobank Collaborative Group Abstract Objective: To describe the characteristics of habitual snoring among adults from 10 regions engaged in the China Kadoorie...
pubmed: snoring
Thu Sep 05, 2019 15:25
"BMJ Open"[jour]; +45 new citations
45 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "BMJ Open"[jour] These pubmed results were generated on 2019/09/05PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
pubmed: "bmj open"[jour]
Thu Sep 05, 2019 15:29
Resection of liver metastases from differentiated thyroid cancer: who might benefit? A report of 2 cases with review of literature.
Related ArticlesResection of liver metastases from differentiated thyroid cancer: who might benefit? A report of 2 cases with review of literature. Pol Przegl Chir. 2018 Nov 15;91(4):52-56 Authors: Ligocka J, Patkowski W, Szparecki G, Ostrowski T, Wiechno W, Zieniewicz K Abstract BACKGROUND: Liver metastases of differentiated thyroid cancers (DTC) are uncommon. Surgery has proven to be effective in patients with 131I-negative hepatic lesions. Here, we...
radioactive iodine
Thu Sep 05, 2019 15:32
Lesion-based Evaluation Predicts Treatment Response to Lenvatinib For Radioactive Iodine-Refractory Differentiated Thyroid Cancer: A Korean Multicenter Retrospective Study.
Related ArticlesLesion-based Evaluation Predicts Treatment Response to Lenvatinib For Radioactive Iodine-Refractory Differentiated Thyroid Cancer: A Korean Multicenter Retrospective Study. Thyroid. 2019 Sep 04;: Authors: Lee EK, Kim SM, Kim BH, Kim MJ, Lim DJ, Kim MH, Shin DY, Kang HC, Ahn BC, Kim SW, Ahn HY, Park YJ Abstract BACKGROUND: Lenvatinib, a tyrosine kinase inhibitor (TKI) recently approved for treating radioactive iodine-refractory differentiated...
radioactive iodine
Thu Sep 05, 2019 15:32
The long-term outcome of treatment for Graves' hyperthyroidism.
Related ArticlesThe long-term outcome of treatment for Graves' hyperthyroidism. Thyroid. 2019 Sep 04;: Authors: Sjölin G, Holmberg M, Törring O, Byström K, Khamisi S, de Laval D, Abraham-Nordling M, Calissendorff J, Lantz M, Hallengren B, Filipsson Nyström H, Wallin G Abstract BACKGROUND: The treatment efficacy of antithyroid drug therapy(ATD), radioactive iodine(I131) or surgery for Graves' hyperthyroidism is well described. However, there are few reports...
radioactive iodine
Thu Sep 05, 2019 15:32
Vocalization as a novel endpoint of atypical attachment behavior in 2,3,7,8-tetrachlorodibenzo-p-dioxin-exposed infant mice.
Related ArticlesVocalization as a novel endpoint of atypical attachment behavior in 2,3,7,8-tetrachlorodibenzo-p-dioxin-exposed infant mice. Arch Toxicol. 2018 05;92(5):1741-1749 Authors: Kimura E, Tohyama C Abstract Mammalian attachment behaviors, such as crying, are essential for infant survival by receiving food, protection, and warmth from caregivers. Ultrasonic vocalization (USV) of infant rodents functions to promote maternal proximity. Impaired...
Larynx
Thu Sep 05, 2019 15:34
Larynxpapillomatose.
Related ArticlesLarynxpapillomatose. Laryngorhinootologie. 2018 Oct;97(10):670-671 Authors: Nawka T PMID: 30340226 [PubMed - indexed for MEDLINE]
Larynx
Thu Sep 05, 2019 15:34
Postoperative change in wideband absorbance after tympanoplasty in chronic suppurative otitis media.
Related ArticlesPostoperative change in wideband absorbance after tympanoplasty in chronic suppurative otitis media. Auris Nasus Larynx. 2019 Sep 01;: Authors: Park HW, Ahn J, Kang MW, Cho YS Abstract OBJECTIVE: To identify the wideband absorbance (WBA) of reconstructed TM comparing with perforated and normal TM, and to investigate the efficacy of WBA to predict postoperative hearing outcome. METHODS: Ninety-eight adults (128 ears) with normal...
Larynx
Thu Sep 05, 2019 15:34
medical science; +2839 new citations
2839 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: medical science These pubmed results were generated on 2019/09/05PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Medical Science
Thu Sep 05, 2019 15:40
Current practice and barriers of mesh-assisted implant-based breast reconstruction in China: A nationwide cross-sectional survey of 110 hospitals
Publication date: Available online 5 September 2019Source: European Journal of Surgical OncologyAuthor(s): Rong Guo, Lun Li, Yonghui Su, Bingqiu Xiu, Qi Zhang, Jia Wang, Weiru Chi, Benlong Yang, Yingying Zhang, Ayong Cao, Zhimin Shao, Jiong WuAbstractBackgroundThe current National Practice Questionnaire of implant-based breast reconstruction (IBBR) (NPQi) was to assess the clinical practice of mesh-assisted IBBR in China.MethodsA questionnaire was mailed to 110 hospitals in China, which have more...
European Journal of Surgical Oncology (EJSO)
Thu Sep 05, 2019 15:41
Pathological findings following risk-reducing salpingo-oophorectomy in <em>BRCA</em> mutation carriers: A systematic review and meta-analysis
Publication date: Available online 5 September 2019Source: European Journal of Surgical OncologyAuthor(s): Aoshuang Cheng, Lei Li, Ming Wu, Jinghe LangAbstractObjectiveTo evaluate the benefit of risk-reducing salpingo-oophorectomy (RRSO) by estimating the pathological positive rate of occult lesions, including serous tubal intraepithelial carcinoma (STIC) and occult cancers (OCCs).MethodsBRCA1/2 mutation carriers who underwent RRSO in a Chinese study center between 2014 and 2018 were included. A...
European Journal of Surgical Oncology (EJSO)
Thu Sep 05, 2019 15:41
cdc37 is essential for JNK pathway activation and wound closure in Drosophila.
Related Articlescdc37 is essential for JNK pathway activation and wound closure in Drosophila. Mol Biol Cell. 2019 Sep 04;:mbcE18120822 Authors: Lee CW, Kwon YC, Lee Y, Park MY, Choe KM Abstract Wound closure in the Drosophila larval epidermis mainly involves non-proliferative, endocyling epithelial cells. Consequently, it is largely mediated by cell growth and migration. We discovered that both cell growth and migration in Drosophila require the co-chaperone-encoding...
pubmed: "mol biol cell"[jour...
Thu Sep 05, 2019 15:46
Vinculin anchors contractile actin to the cardiomyocyte adherens junction.
Related ArticlesVinculin anchors contractile actin to the cardiomyocyte adherens junction. Mol Biol Cell. 2019 Sep 04;:mbcE19040216 Authors: Merkel CD, Li Y, Raza Q, Stolz DB, Kwiatkowski AV Abstract The adherens junction (AJ) couples the actin cytoskeletons of neighboring cells to allow mechanical integration and tissue organization. The physiological demands of intercellular adhesion require that the AJ be responsive to dynamic changes in force while...
pubmed: "mol biol cell"[jour...
Thu Sep 05, 2019 15:46
FAP57/WDR65 targets assembly of a subset of inner arm dyneins and connects to regulatory hubs in cilia.
Related ArticlesFAP57/WDR65 targets assembly of a subset of inner arm dyneins and connects to regulatory hubs in cilia. Mol Biol Cell. 2019 Sep 04;:mbcE19070367 Authors: Lin J, Le TV, Augspurger K, Tritschler D, Bower R, Fu G, Perrone C, O'Toole ET, Mills KV, Dymek E, Smith E, Nicastro D, Porter ME Abstract Ciliary motility depends on both the precise spatial organization of multiple dynein motors within the 96 nm axonemal repeat, and highly coordinated...
pubmed: "mol biol cell"[jour...
Thu Sep 05, 2019 15:46
DNA damage triggers increased mobility of chromosomes in G1 phase cells.
Related ArticlesDNA damage triggers increased mobility of chromosomes in G1 phase cells. Mol Biol Cell. 2019 Sep 04;:mbcE19080469 Authors: Smith MJ, Bryant EE, Joseph FJ, Rothstein R Abstract During S phase in Saccharomyces cerevisiae, chromosomal loci become mobile in response to DNA double-strand breaks both at the break site (local mobility) and throughout the nucleus (global mobility). Increased nuclear exploration is regulated by the recombination...
pubmed: "mol biol cell"[jour...
Thu Sep 05, 2019 15:46
The mitochondrial intermembrane space facing proteins Mcp2 and Tgl2 are involved in yeast lipid metabolism.
Related ArticlesThe mitochondrial intermembrane space facing proteins Mcp2 and Tgl2 are involved in yeast lipid metabolism. Mol Biol Cell. 2019 Sep 04;:mbcE19030166 Authors: Odendall F, Backes S, Tatsuta T, Weill U, Schuldiner M, Langer T, Herrmann JM, Rapaport D, Dimmer KS Abstract Mitochondria are unique organelles harboring two distinct membranes, the mitochondrial inner and outer membrane (MIM and MOM, respectively). Mitochondria comprise only a...
pubmed: "mol biol cell"[jour...
Thu Sep 05, 2019 15:46
A quantitative screen for metabolic enzyme structures reveals patterns of assembly across the yeast metabolic network.
Related ArticlesA quantitative screen for metabolic enzyme structures reveals patterns of assembly across the yeast metabolic network. Mol Biol Cell. 2019 Sep 04;:mbcE19040224 Authors: Noree C, Begovich K, Samilo D, Broyer R, Monfort E, Wilhelm JE Abstract Despite the proliferation of proteins that can form filaments or phase-separated condensates, it remains unclear how this behavior is distributed over biological networks. We have found that 60 of...
pubmed: "mol biol cell"[jour...
Thu Sep 05, 2019 15:46
Effects of the microtubule nucleator Mto1 on chromosome movement, DNA repair and sister chromatid cohesion in fission yeast.
Related ArticlesEffects of the microtubule nucleator Mto1 on chromosome movement, DNA repair and sister chromatid cohesion in fission yeast. Mol Biol Cell. 2019 Sep 04;:mbcE19050301 Authors: Zhurinsky J, Salas-Pino S, Iglesias-Romero AB, Torres-Mendez A, Knapp B, Flor-Parra I, Wang J, Bao K, Jia S, Chang F, Daga RR Abstract Although the function of microtubules (MTs) in chromosome segregation during mitosis is well characterized, much less is known about...
pubmed: "mol biol cell"[jour...
Thu Sep 05, 2019 15:46
ALCOHOL; +91 new citations
91 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: ALCOHOL These pubmed results were generated on 2019/09/05PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Alcohol
Thu Sep 05, 2019 15:50
Histopathological prognostic factors of recurrence following definitive therapy for atypical and malignant meningiomas.
Related ArticlesHistopathological prognostic factors of recurrence following definitive therapy for atypical and malignant meningiomas. J Neurosurg. 2018 04;128(4):1123-1132 Authors: Kim D, Niemierko A, Hwang WL, Stemmer-Rachamimov AO, Curry WT, Barker FG, Martuza RL, Oh KS, Loeffler JS, Shih HA Abstract OBJECTIVE Patients with atypical and malignant (WHO Grade II and III) meningiomas have a worse prognosis than patients with benign (WHO Grade I) meningiomas....
Skull Base
Thu Sep 05, 2019 15:57
The long-term clinical outcomes of microvascular decompression for treatment of trigeminal neuralgia compressed by the vertebra-basilar artery: a case series review.
Related ArticlesThe long-term clinical outcomes of microvascular decompression for treatment of trigeminal neuralgia compressed by the vertebra-basilar artery: a case series review. BMC Neurol. 2019 Sep 03;19(1):217 Authors: Wang X, Wang H, Chen S, Liang H, Wang H, Xu M, Xu L Abstract BACKGROUND: Microvascular decompression (MVD) is a type of neurosurgery used to treat trigeminal neuralgia (TN) caused by the vertebrobasilar contact/compression. The surgery...
Skull Base
Thu Sep 05, 2019 15:57
Endoscopic Tympanoplasty without Mastoidectomy for Active Mucosal Chronic Otitis Media with Mastoid and Tympanic Antrum Lesions: A Prospective Clinical Study.
Related ArticlesEndoscopic Tympanoplasty without Mastoidectomy for Active Mucosal Chronic Otitis Media with Mastoid and Tympanic Antrum Lesions: A Prospective Clinical Study. ORL J Otorhinolaryngol Relat Spec. 2019 Sep 04;:1-7 Authors: He D, Shou Z, Hsieh Y, Wang C, Wang J, Han Z, Chi FL Abstract OBJECTIVE: This study aims to assess the effectiveness of endoscopic tympanoplasty without mastoidectomy in the management of active mucosal chronic otitis...
Skull Base
Thu Sep 05, 2019 15:57
Palliative Care in Moldova.
Related ArticlesPalliative Care in Moldova. J Pain Symptom Manage. 2018 02;55(2S):S55-S58 Authors: Gherman L, Pogonet V, Soltan V, Isac V Abstract The article describes the important steps of palliative care development in Moldova, the current status, main achievements and challenges to be addressed in the future. It covers background information, policy development, medicines access and availability, education, and training, as well as services' provision....
Oncology
Thu Sep 05, 2019 16:00
Sequencing Pancreatic Juice: Squeezing the Most Out of Surveillance.
Related ArticlesSequencing Pancreatic Juice: Squeezing the Most Out of Surveillance. Clin Cancer Res. 2018 06 15;24(12):2713-2715 Authors: Lipner MB, Yeh JJ Abstract Next-generation sequencing of pancreatic juice can detect and quantify tumor-promoting mutations, supporting imaging and cytology findings to predict the degree of dysplasia in patients at high risk for pancreatic cancer. Future studies are needed to optimize this approach and determine...
Oncology
Thu Sep 05, 2019 16:00
Wnt/β-Catenin Signaling: The Culprit in Pancreatic Carcinogenesis and Therapeutic Resistance.
Related ArticlesWnt/β-Catenin Signaling: The Culprit in Pancreatic Carcinogenesis and Therapeutic Resistance. Int J Mol Sci. 2019 Aug 30;20(17): Authors: Ram Makena M, Gatla H, Verlekar D, Sukhavasi S, K Pandey M, C Pramanik K Abstract Pancreatic ductal adenocarcinoma (PDAC) is responsible for 7.3% of all cancer deaths. Even though there is a steady increase in patient survival for most cancers over the decades, the patient survival rate for pancreatic...
Oncology
Thu Sep 05, 2019 16:00
Analysing Tumour Growth Delay Data from Animal Irradiation Experiments with Deviations from the Prescribed Dose.
Related ArticlesAnalysing Tumour Growth Delay Data from Animal Irradiation Experiments with Deviations from the Prescribed Dose. Cancers (Basel). 2019 Aug 31;11(9): Authors: Karsch L, Beyreuther E, Eger Passos D, Pawelke J, Löck S Abstract The development of new radiotherapy technologies is a long-term process, which requires proof of the general concept. However, clinical requirements with respect to beam quality and controlled dose delivery may not...
Oncology
Thu Sep 05, 2019 16:00
Combination of Proton Therapy and Radionuclide Therapy in Mice: Preclinical Pilot Study at the Paul Scherrer Institute.
Related ArticlesCombination of Proton Therapy and Radionuclide Therapy in Mice: Preclinical Pilot Study at the Paul Scherrer Institute. Pharmaceutics. 2019 Sep 02;11(9): Authors: Müller C, De Prado Leal M, Dominietto MD, Umbricht CA, Safai S, Perrin RL, Egloff M, Bernhardt P, van der Meulen NP, Weber DC, Schibli R, Lomax AJ Abstract Proton therapy (PT) is a treatment with high dose conformality that delivers a highly-focused radiation dose to solid tumors....
Oncology
Thu Sep 05, 2019 16:00
Recent Developments and Therapeutic Strategies against Hepatocellular Carcinoma.
Related ArticlesRecent Developments and Therapeutic Strategies against Hepatocellular Carcinoma. Cancer Res. 2019 Sep 01;79(17):4326-4330 Authors: Yarchoan M, Agarwal P, Villanueva A, Rao S, Dawson LA, Llovet JM, Finn RS, Groopman JD, El-Serag HB, Monga SP, Wang XW, Karin M, Schwartz RE, Tanabe KK, Roberts LR, Gunaratne PH, Tsung A, Brown KA, Lawrence TS, Salem R, Singal AG, Kim AK, Rabiee A, Resar L, Hoshida Y, He AR, Ghoshal K, Ryan PB, Jaffee EM, Guha C, Mishra L,...
Oncology
Thu Sep 05, 2019 16:00
Antibody Responses to Fusobacterium nucleatum Proteins in Prediagnostic Blood Samples are not Associated with Risk of Developing Colorectal Cancer.
Related ArticlesAntibody Responses to Fusobacterium nucleatum Proteins in Prediagnostic Blood Samples are not Associated with Risk of Developing Colorectal Cancer. Cancer Epidemiol Biomarkers Prev. 2019 Sep;28(9):1552-1555 Authors: Butt J, Jenab M, Pawlita M, Overvad K, Tjonneland A, Olsen A, Boutron-Ruault MC, Carbonnel F, Mancini FR, Kaaks R, Kühn T, Boeing H, Trichopoulou A, Karakatsani A, Palli D, Pala VM, Tumino R, Sacerdote C, Panico S, Bueno-de-Mesquita B, van...
Oncology
Thu Sep 05, 2019 16:00
Multimodality Imaging of Prostate Cancer.
Related ArticlesMultimodality Imaging of Prostate Cancer. J Nucl Med. 2019 Sep 03;: Authors: Ghafoor S, Burger IA, Vargas HA Abstract Prostate cancer is a very heterogeneous disease and contemporary management is focused on identification and treatment of the prognostically adverse high-risk tumors while minimizing overtreatment of indolent, low-risk tumors. In recent years, imaging has gained increasing importance in the detection, staging, posttreatment...
Oncology
Thu Sep 05, 2019 16:00
Future of Theranostics: An Outlook on Precision Oncology in Nuclear Medicine.
Related ArticlesFuture of Theranostics: An Outlook on Precision Oncology in Nuclear Medicine. J Nucl Med. 2019 Sep;60(Suppl 2):13S-19S Authors: Langbein T, Weber WA, Eiber M Abstract Molecular alterations in malignant disease result in the expression or upregulations of various targets that can be used for imaging and treatment with radiopharmaceuticals. This theranostic principle has acquired greater importance in personalized medicine in recent years,...
Oncology
Thu Sep 05, 2019 16:00
Radiomics: Data Are Also Images.
Related ArticlesRadiomics: Data Are Also Images. J Nucl Med. 2019 Sep;60(Suppl 2):38S-44S Authors: Hatt M, Le Rest CC, Tixier F, Badic B, Schick U, Visvikis D Abstract The aim of this review is to provide readers with an update on the state of the art, pitfalls, solutions for those pitfalls, future perspectives, and challenges in the quickly evolving field of radiomics in nuclear medicine imaging and associated oncology applications. The main pitfalls...
Oncology
Thu Sep 05, 2019 16:00
The Role of Response-Shift in Studies Assessing Quality of Life Outcomes Among Cancer Patients: A Systematic Review.
Related ArticlesThe Role of Response-Shift in Studies Assessing Quality of Life Outcomes Among Cancer Patients: A Systematic Review. Front Oncol. 2019;9:783 Authors: Ilie G, Bradfield J, Moodie L, Lawen T, Ilie A, Lawen Z, Blackman C, Gainer R, Rutledge RDH Abstract Objective: Response-shift has been cited as an important measurement consideration when assessing patient reported quality of life (QoL) outcomes over time among patients with severe chronic...
Oncology
Thu Sep 05, 2019 16:00
Population pharmacokinetics of siltuximab: impact of disease state.
Related ArticlesPopulation pharmacokinetics of siltuximab: impact of disease state. Cancer Chemother Pharmacol. 2019 Sep 03;: Authors: Nikanjam M, Yang J, Capparelli EV Abstract PURPOSE: To characterize the effects of disease type and clinical characteristics on the pharmacokinetics of siltuximab, an IL-6 inhibiting monoclonal antibody. METHODS: Siltuximab pharmacokinetic data were combined from seven phase I/II clinical trials. A population...
Oncology
Thu Sep 05, 2019 16:00
Immunotherapy in Metastatic Castration-Resistant Prostate Cancer: Past and Future Strategies for Optimization.
Related ArticlesImmunotherapy in Metastatic Castration-Resistant Prostate Cancer: Past and Future Strategies for Optimization. Curr Urol Rep. 2019 Sep 03;20(10):64 Authors: Reimers MA, Slane KE, Pachynski RK Abstract PURPOSE OF REVIEW: To date, prostate cancer has been poorly responsive to immunotherapy. In the current review, we summarize and discuss the current literature on the use of vaccine therapy and checkpoint inhibitor immunotherapy in metastatic...
Oncology
Thu Sep 05, 2019 16:00

Δεν υπάρχουν σχόλια:

Δημοσίευση σχολίου

Αρχειοθήκη ιστολογίου