Related ArticlesThe Role of Response-Shift in Studies Assessing Quality of Life Outcomes Among Cancer Patients: A Systematic Review. Front Oncol. 2019;9:783 Authors: Ilie G, Bradfield J, Moodie L, Lawen T, Ilie A, Lawen Z, Blackman C, Gainer R, Rutledge RDH Abstract Objective: Response-shift has been cited as an important measurement consideration when assessing patient reported quality of life (QoL) outcomes over time among patients with severe chronic...
Thu Sep 05, 2019 16:00
Related ArticlesPopulation pharmacokinetics of siltuximab: impact of disease state. Cancer Chemother Pharmacol. 2019 Sep 03;: Authors: Nikanjam M, Yang J, Capparelli EV Abstract PURPOSE: To characterize the effects of disease type and clinical characteristics on the pharmacokinetics of siltuximab, an IL-6 inhibiting monoclonal antibody. METHODS: Siltuximab pharmacokinetic data were combined from seven phase I/II clinical trials. A population...
Thu Sep 05, 2019 16:00
Related ArticlesImmunotherapy in Metastatic Castration-Resistant Prostate Cancer: Past and Future Strategies for Optimization. Curr Urol Rep. 2019 Sep 03;20(10):64 Authors: Reimers MA, Slane KE, Pachynski RK Abstract PURPOSE OF REVIEW: To date, prostate cancer has been poorly responsive to immunotherapy. In the current review, we summarize and discuss the current literature on the use of vaccine therapy and checkpoint inhibitor immunotherapy in metastatic...
Thu Sep 05, 2019 16:00
Related ArticlesRadiosensitizing effects of trabectedin on human A549 lung cancer cells and HT-29 colon cancer cells. Invest New Drugs. 2019 Sep 03;: Authors: Manda K, Präkelt T, Schröder T, Kriesen S, Hildebrandt G Abstract Background and Purpose Trabectedin is a unique alkylating agent with promising effects against a range of solid tumors. In this study, we aimed to examine the cytotoxic and radiosensitizing effects of trabectedin on two human epithelial...
Thu Sep 05, 2019 16:00
Related ArticlesPrediction of outcome in anal squamous cell carcinoma using radiomic feature analysis of pre-treatment FDG PET-CT. Eur J Nucl Med Mol Imaging. 2019 Sep 04;: Authors: Brown PJ, Zhong J, Frood R, Currie S, Gilbert A, Appelt AL, Sebag-Montefiore D, Scarsbrook A Abstract PURPOSE: Incidence of anal squamous cell carcinoma (ASCC) is increasing, with curative chemoradiotherapy (CRT) as the primary treatment of non-metastatic disease. A significant...
Thu Sep 05, 2019 16:00
Related ArticlesClinical Applications of Hyaluronidase. Adv Exp Med Biol. 2019;1148:255-277 Authors: Weber GC, Buhren BA, Schrumpf H, Wohlrab J, Gerber PA Abstract Hyaluronidases are enzymes that degrade hyaluronic acid, which constitutes an essential part of the extracellular matrix. Initially discovered in bacteria, hyaluronidases are known to be widely distributed in nature and have been found in many classes including insects, snakes, fish and mammals....
Thu Sep 05, 2019 16:00
Related ArticlesPregnant surgeon - assessment of potential harm to the woman and her unborn child. Ginekol Pol. 2019;90(8):470-474 Authors: Szczesna A, Grzelak K, Bieniasz M, Kacperczyk-Bartnik J, Dobrowolska-Redo A, Bartnik P, Zareba-Szczudlik J, Romejko-Wolniewicz E Abstract Although most countries developed regulations concerning pregnant women at work, they are not strictly adjusted forevery profession. In the European countries directives prevent...
Thu Sep 05, 2019 16:00
Related ArticlesRecent clinical applications of external beam radiotherapy for hepatocellular carcinoma according to guidelines, major trials and meta-analyses. J Med Imaging Radiat Oncol. 2019 Sep 03;: Authors: Rim CH, Yim HJ, Park S, Seong J Abstract External beam radiotherapy (EBRT) for hepatocellular carcinoma (HCC) has not been widely used due to lack of high-level evidence, despite its potent local therapeutic effect. While clinical evidence has...
Thu Sep 05, 2019 16:00
Related ArticlesThe current status of the clinical utility of liquid biopsies in cancer. Expert Rev Mol Diagn. 2019 Sep 04;: Authors: Snow A, Chen D, Lang JE Abstract Introduction: Liquid biopsies have attracted considerable attention as potential diagnostic, prognostic, predictive, and screening assays in oncology. The term liquid biopsies include circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) in the blood. While many liquid biopsy...
Thu Sep 05, 2019 16:00
Related ArticlesThe use of the V-Care laparoscopic uterine manipulator to facilitate total abdominal hysterectomy: a novel approach and case-series. J Obstet Gynaecol. 2019 Sep 04;:1-4 Authors: Allam MS, El-Sapagh K, Allam MM, Ferguson EJ, Mehasseb MK Abstract Hysterectomy remains mostly performed via the abdominal route in the United Kingdom, despite advances in minimal access techniques and increased training in laparoscopic hysterectomy. The use of...
Thu Sep 05, 2019 16:00
Related ArticlesAutomated extraction of treatment patterns from social media posts: an exploratory analysis in renal cell carcinoma. Future Oncol. 2019 Sep 04;: Authors: Ramagopalan SV, Malcolm B, Merinopoulou E, McDonald L, Cox A Abstract Aim: The use of health-related social media forums by patients is increasing and the size of these forums creates a rich record of patient opinions and experiences, including treatment histories. This study aimed to...
Thu Sep 05, 2019 16:00
Related ArticlesRecent progress in haploidentical transplantation: is this the optimal choice for alternative donor transplantation? Curr Opin Hematol. 2019 Sep 02;: Authors: Watanabe M, Kanda J Abstract PURPOSE: This article is intended to review recent trends and improvements in haploidentical transplantation to understand its current status and future direction. RECENT FINDINGS: The noninferiority of haploidentical donors compared with other...
Thu Sep 05, 2019 16:00
Related ArticlesReal-world outcomes of sipuleucel-T treatment in PROCEED, a prospective registry of men with metastatic castration-resistant prostate cancer. Cancer. 2019 Sep 04;: Authors: Higano CS, Armstrong AJ, Sartor AO, Vogelzang NJ, Kantoff PW, McLeod DG, Pieczonka CM, Penson DF, Shore ND, Vacirca J, Concepcion RS, Tutrone RF, Nordquist LT, Quinn DI, Kassabian V, Scholz MC, Harmon M, Tyler RC, Chang NN, Tang H, Cooperberg MR Abstract BACKGROUND:...
Thu Sep 05, 2019 16:00
Related ArticlesDetection of MYD88 L265P mutation by next-generation deep sequencing in peripheral blood mononuclear cells of Waldenström's macroglobulinemia and IgM monoclonal gammopathy of undetermined significance. PLoS One. 2019;14(9):e0221941 Authors: Nakamura A, Ohwada C, Takeuchi M, Takeda Y, Tsukamoto S, Mimura N, Nagisa OH, Sugita Y, Tanaka H, Wakita H, Aotsuka N, Matsue K, Yokote K, Ohara O, Nakaseko C, Sakaida E Abstract We investigated the...
Thu Sep 05, 2019 16:00
Related ArticlesSafety of light emitting diode-red light on human skin: two randomized controlled trials. J Biophotonics. 2019 Sep 04;:e201960014 Authors: Jagdeo J, Nguyen JK, Ho D, Wang EB, Austin E, Mamalis A, Kaur R, Kraeva E, Schulman JM, Li CS, Hwang ST, Wun T, Maverakis E, Isseroff RR Abstract BACKGROUND: Therapeutic applications of light emitting diode-red light (LED-RL) are expanding, yet data on its clinical effects are lacking. OBJECTIVES:...
Thu Sep 05, 2019 16:00
Health Through Activity: Initial Evaluation of an In-Home Intervention for Older Adults With Cancer.
Related ArticlesHealth Through Activity: Initial Evaluation of an In-Home Intervention for Older Adults With Cancer. Am J Occup Ther. 2019 Sep/Oct;73(5):7305205070p1-7305205070p11 Authors: Lyons KD, Bruce ML, Hull JG, Kaufman PA, Li Z, Stearns DM, Lansigan F, Chamberlin M, Fuld A, Bartels SJ, Whipple J, Bakitas MA, Hegel MT Abstract OBJECTIVE: The objective of this study was to assess the feasibility of conducting a future full-scale trial to test the...
Thu Sep 05, 2019 16:00
Heavy episodic drinking (HED) refers to alcohol consumption that exceeds the recommended threshold for a given episode and increases risk for diverse negative alcohol-related consequences. A pattern of weekly ...
Wed Sep 04, 2019 03:00
Related ArticlesReduced serum osteocalcin in high-risk alcohol using people living with HIV (PLWH) does not correlate with systemic oxidative stress or inflammation: data from the New Orleans Alcohol Use in HIV (NOAH) study. Alcohol Clin Exp Res. 2019 Sep 04;: Authors: Watt J, Schuon J, Davis J, Ferguson TF, Welsh DA, Molina PE, Ronis MJJ Abstract BACKGROUND: HIV infection is now largely a chronic condition as a result of the success of antiretroviral...
Thu Sep 05, 2019 16:06
51 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: upper respiratory tract infection These pubmed results were generated on 2019/09/05PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Thu Sep 05, 2019 16:06
Cancer Informatics, Volume 18, Issue , January-December 2019. The repeatability observed across cancers arising in the same tissue can help understand the evolutionary process of tumour initiation. We recently developed a framework to quantify the local malignant adaptation of genetic clones in tissue-specific environments. In this Commentary, we argue that such a 1-dimensional model can be improved by separating its 2 components to obtain a dual scale: local adaptation, dictating proliferation rates...
Thu Sep 05, 2019 15:21
Related ArticlesAsymmetrical Ocular Manifestations of Nephropathic Cystinosis; A Case Report. Am J Case Rep. 2019 Sep 04;20:1308-1313 Authors: Helmi HA, El Mansoury J, Al Hazzaa S, Al Zoba A, Dirar QS Abstract BACKGROUND Infantile nephropathic cystinosis is the most common and severe variant of cystinosis, which is a rare autosomal recessive condition related to a defect in the transportation of the protein cystine resulting in its deposition in various...
Thu Sep 05, 2019 16:10
Related ArticlesNPA: an R package for computing network perturbation amplitudes using gene expression data and two-layer networks. BMC Bioinformatics. 2019 Sep 03;20(1):451 Authors: Martin F, Gubian S, Talikka M, Hoeng J, Peitsch MC Abstract BACKGROUND: High-throughput gene expression technologies provide complex datasets reflecting mechanisms perturbed in an experiment, typically in a treatment versus control design. Analysis of these information-rich...
Thu Sep 05, 2019 16:12
36 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human homeostasis These pubmed results were generated on 2019/09/05PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Thu Sep 05, 2019 16:13
The standard of care for benign pheochromocytomas and paragangliomas is surgical resection; however, there is no definitive curative or standard therapy for the treatment of malignant pheochromocytomas or paragangliomas. Current therapeutic options include surgical resection, chemotherapy (CVD therapy), MIBG-radiotherapy, somatostatin analogues, and combination targeted therapies such as temozolomide and thalidomide. Although some patients demonstrate short-lived responses to these various therapies,...
Thu Sep 05, 2019 16:05
Related ArticlesOverview of Current Immunotherapies Targeting Mutated KRAS Cancers. Curr Top Med Chem. 2019 Sep 04;: Authors: Hoo WPY, Siak PY, In LLA Abstract The occurrence of somatic substitution mutations of the KRAS proto-oncogene are highly prevalent in certain cancer types, which often leads to constant activation of proliferative pathways and subsequent neoplastic transformation. It is often seen as a gateway mutation in carcinogenesis, and has...
Thu Sep 05, 2019 16:17
23 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Proc Natl Acad Sci U S A"[jour] These pubmed results were generated on 2019/09/05PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Thu Sep 05, 2019 16:19
Related ArticlesImaging Myeloperoxidase in Demyelinating Lesions: Biomarker with Clinical Value for Multiple Sclerosis or Merely a Tool for Animal Research? Radiology. 2019 Sep 03;:191777 Authors: Walczak P PMID: 31483203 [PubMed - as supplied by publisher]
Thu Sep 05, 2019 16:20
Purpose. This study is aimed at determining whether bone mineral density (BMD) values are related to atherogenic indexes (AIs) and could predict the risk of cardiovascular disease (CVD) in southern Taiwanese adults. Methods. Medical records of 3249 adults who underwent health examinations between June 2014 and February 2018 at a regional hospital in southern Taiwan were reviewed. Data collected included health history, anthropomorphic characteristics, exercise habits, diets (vegetarian or nonvegetarian),...
Wed Sep 04, 2019 03:00
Background. The ratio of early mitral inflow velocity to the global diastolic strain rate (E/E’sr) and global longitudinal systolic strain (GLS) of the left ventricle (LV) are emerging indices of diastolic and systolic functions, respectively, for the LV. Their prognostic significance in the prediction of mortality and cardiovascular (CV) outcomes remains underexplored in hemodialysis (HD) patients. Methods. This prospective study included 190 maintenance HD patients. The E/E’sr ratio and GLS were...
Thu Sep 05, 2019 16:05
Related ArticlesFaster, Higher, Farther: Outpacing age-related motor neuron losses. J Physiol. 2019 Sep 03;: Authors: Arnold WD, Clark BC PMID: 31482576 [PubMed - as supplied by publisher]
Thu Sep 05, 2019 16:24
Related ArticlesVirtual signals of head rotation induce gravity-dependent inferences of linear acceleration. J Physiol. 2019 Sep 04;: Authors: Khosravi-Hashemi N, Forbes PA, Dakin CJ, Blouin JS Abstract Considerable debate exists regarding whether electrical vestibular stimuli encoded by vestibular afferents induce a net signal of linear acceleration, rotation or combination of the two. This debate may exist because an isolated signal of head rotation...
Thu Sep 05, 2019 16:24
Related ArticlesSubcutaneous maternal resveratrol treatment increases uterine artery blood flow in the pregnant ewe and increases fetal but not cardiac growth. J Physiol. 2019 Sep 04;: Authors: Darby JRT, Saini BS, Soo JY, Lock MC, Holman SL, Bradshaw EL, McInnes SJP, Voelcker NH, Macgowan CK, Seed M, Wiese MD, Morrison JL Abstract KEY POINTS: Substrate restriction during critical developmental windows of gestation programs offspring for a predisposition...
Thu Sep 05, 2019 16:24
Related ArticlesNonrandom spatial clustering of spontaneous anterior fossa cerebrospinal fluid fistulas and predilection for the posterior cribriform plate. J Neurosurg. 2017 May;126(5):1720-1724 Authors: Murray RD, Friedlander R, Hanz S, Singh H, Anand VK, Schwartz TH Abstract OBJECTIVE The anterior skull base is a common site for the spontaneous development of meningoceles, encephaloceles, and meningoencephaloceles that can lead to cerebrospinal fluid...
Thu Sep 05, 2019 16:27
Related ArticlesA comparative study of bilateral subthalamic nucleus DBS in Parkinson's disease in young versus old: A single institutional study. J Clin Neurosci. 2019 Aug 31;: Authors: Vats A, Amit A, Doshi P Abstract To compare outcome between young [<65 yrs] and old [>65 yrs] patients of Parkinson's disease who underwent bilateral STN DBS a non-randomized retrospective study was done. 20 young (Young group) and 20 elderly (Old group) patients...
Thu Sep 05, 2019 16:28
Related ArticlesPlacement of the Woven EndoBridge (WEB) device via distal transradial access in the anatomical snuffbox: A technical note. J Clin Neurosci. 2019 Aug 31;: Authors: Al Saiegh F, Mouchtouris N, Sweid A, Chalouhi N, Theofanis T, Ghosh R, Tjoumakaris S, Gooch MR, Rosenwasser RH, Jabbour P Abstract The distal transradial access in the anatomical snuffbox for neurovascular procedures is a modification of the radial access with an improved safety...
Thu Sep 05, 2019 16:28
112 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human physiology These pubmed results were generated on 2019/09/05PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Thu Sep 05, 2019 16:29
Related ArticlesComparative Performance of High-Risk Human Papillomavirus RNA and DNA In Situ Hybridization on College of American Pathologists Proficiency Tests. Arch Pathol Lab Med. 2019 Sep 04;: Authors: Keung ES, Souers RJ, Bridge JA, Faquin WC, Graham RP, Hameed MR, Lewis JS, Merker JD, Vasalos P, Moncur JT Abstract CONTEXT.—: Detection of high-risk human papillomavirus (HR-HPV) in squamous cell carcinoma is important for classification and prognostication....
Thu Sep 05, 2019 16:36
Related ArticlesUse of Programmed Death Ligand-1 (PD-L1) Staining to Separate Sarcomatoid Malignant Mesotheliomas From Benign Mesothelial Reactions. Arch Pathol Lab Med. 2019 Sep 04;: Authors: Derakhshan F, Ionescu D, Cheung S, Churg A Abstract CONTEXT.—: The separation of benign from malignant mesothelial proliferations is a difficult morphologic problem. Some mesotheliomas stain for programmed death ligand-1 (PD-L1). OBJECTIVE.—: To determine...
Thu Sep 05, 2019 16:36
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