Publication date: Available online 4 September 2019Source: Cancer/RadiothérapieAuthor(s): L. De Marzi, C. Nauraye, P. Lansonneur, F. Pouzoulet, A. Patriarca, T. Schneider, C. Guardiola, H. Mammar, R. Dendale, Y. PrezadoAbstractIn radiation therapy, a renewed interest is emerging for the study of spatially fractionated irradiation. In this article, a few applications using spatial fractionation of the dose will be discussed with a focus on proton minibeam radiation therapy. Examples of calculated...
Thu Sep 05, 2019 12:57
Summary Osimertinib is a key drug for cancer patients with EGFR mutations. However, there is little information about its safety in cancer patients who require hemodialysis (HD) for chronic renal failure, despite notable increases in their numbers. Herein, we examined osimertinib safety in such a patient via pharmacokinetics analysis. A 66-year-old man was diagnosed with relapsed stage IV non-small cell lung cancer with an EGFR mutation in exon 21 (L858R) 2 years after stereotactic...
Thu Sep 05, 2019 03:00
Publication date: Available online 4 September 2019Source: Medical Image AnalysisAuthor(s): Jianing Wang, Jack H. Noble, Benoit M. DawantAbstractCochlear implants (CIs) are surgically implanted neural prosthetic devices that are used to treat severe-to-profound hearing loss. These devices are programmed post implantation and precise knowledge of the implant position with respect to the intra cochlear anatomy (ICA) can help the programming audiologists. Over the years, we have developed algorithms...
Thu Sep 05, 2019 13:03
Publication date: Available online 4 September 2019Source: Behavioural Brain ResearchAuthor(s): Navatha Alugubelly, Afzaal N. Mohammad, Mariola J. Edelmann, Bindu Nanduri, Mohammed Sayed, Juw Won Park, Russell L. Carr
Thu Sep 05, 2019 13:04
Publication date: Available online 4 September 2019Source: Behavioural Brain ResearchAuthor(s): Julie A. Marusich, Elaine A. Gay, Scott L. Watson, Bruce E. BloughAbstractSynthetic cathinones are used for their stimulant-like properties. Stimulant-induced neurochemical changes are thought to occur at different times in different brain regions and neurotransmitter systems. This study sought to examine the behavioral and neurochemical effects of α-pyrrolidinopentiophenone (α-PVP) and mephedrone (4MMC)...
Thu Sep 05, 2019 13:04
Publication date: Available online 4 September 2019Source: Behavioural Brain ResearchAuthor(s): Michael R. Williamson, Theresa A. Jones, Michael R. DrewAbstractThe proliferation and ectopic migration of neural precursor cells (NPCs) in response to ischemic brain injury was first reported two decades ago. Since then, studies of brain injury-induced subventricular zone cytogenesis, primarily in rodent models, have provided insight into the cellular and molecular determinants of this phenomenon and...
Thu Sep 05, 2019 13:04
Abstract This preliminary study provides a combined sound therapeutic strategy (called T‐MIST) for the management of tinnitus patients with normal hearing thresholds. It takes into account individual tinnitus characteristics and personal choices of sounds to provide an efficient intervention. High‐resolution pure tone audiometry was used to measure precise tinnitus pitch and loudness. A Residual Inhibition Test (RIT) was performed using narrow band noise matched to tinnitus frequency at...
Wed Sep 04, 2019 21:39
Publication date: Available online 4 September 2019Source: Academic RadiologyAuthor(s): J.H. Alderson, D.C. O'Neil, C.E. Redmond, D Mulholland, M.J. LeeAims and ObjectivesVaricocele embolization is a growing treatment modality owing to the safety, efficacy, and quick return to work following the procedure. The internet is the most dominant source of information for many. We aimed to assess the quality of information accessible by patients considering treatment.Materials and MethodsA list of applicable,...
Thu Sep 05, 2019 13:24
Publication date: Available online 4 September 2019Source: Academic RadiologyAuthor(s): Erica B. Stein, David M. Williams
Thu Sep 05, 2019 13:24
Publication date: Available online 4 September 2019Source: Academic RadiologyAuthor(s): Sun Kyung Jeon, Jeong Min Lee, Ijin Joo, Jeong Hee Yoon, Dong Ho Lee, Joon Koo HanObjectivesTo investigate the diagnostic performance of liver stiffness (LS) measurements on two-dimensional (2D) shear wave elastography (SWE) for the assessment of hepatic fibrosis using LS measurements on MR elastography (MRE) as the reference standard and the prediction of clinically significant portal hypertension (CSPH).MethodsIn...
Thu Sep 05, 2019 13:24
Publication date: Available online 5 September 2019Source: Academic RadiologyAuthor(s): Yu-ting Peng, Chuan-yang Zhou, Peng Lin, Dong-yue Wen, Xiao-dong Wang, Xiao-zhu Zhong, Deng-hua Pan, Qiao Que, Xin Li, Ling Chen, Yun He, Hong YangRationale and ObjectivesThe purpose of this study was to establish and validate radiomics signatures based on ultrasound (US) medicine images to assess the biological behaviors of intrahepatic cholangiocarcinoma (ICC) in a noninvasive manner.Materials and MethodsThis...
Thu Sep 05, 2019 13:24
Abstract Metabolic reprogramming (including the Warburg effect) is a hallmark of cancer, yet the association between the altered metabolism and chemoresistance remains elusive. Hexokinase II (HKII) is a key metabolic enzyme and is upregulated in multiple cancers. In this study, we examined the impact of targeting metabolism via silencing of HKII on chemoresistance in ovarian cancer (OVCA). In addition, the regulatory molecular mechanism of tumor metabolism was examined using gain‐ and loss‐of‐function...
Wed Sep 04, 2019 19:09
Abstract Lung cancer is one of the most common causes of cancer‐related mortality worldwide, which is partially due to its metastasis. However, the mechanism underlying its metastasis remains elusive. In this study, we showed that a low Krüppel‐like factor 3 (KLF3) expression level is correlated with a poor prognosis and TNM stages in clinical patients with lung cancer and further demonstrated that KLF3 expression is downregulated in lung cancer tissues compared with adjacent normal samples. In...
Thu Sep 05, 2019 12:28
Publication date: Available online 4 September 2019Source: Magnetic Resonance ImagingAuthor(s): Qiang Zhang, Zhensen Chen, Shuo Chen, Xinke Liu, Jia Ning, Yongjun Han, Li Chen, Le He, Xihai Zhao, Yuhui Xiong, Hua Guo, Chun Yuan, Rui Li, Huijun ChenAbstractPurposeTo theoretically compare the MR angiography (MRA) contrast mechanism of Time of Flight (TOF) and Simultaneous Non-contrast Angiography and intraPlaque hemorrhage (SNAP) for intracranial artery imaging with in-vivo validation.MethodsThe contrast...
Thu Sep 05, 2019 13:28
Publication date: Available online 5 September 2019Source: Sleep MedicineAuthor(s): Mariangela Cerasuolo, Francesca Conte, Fiorenza Giganti, Gianluca FiccaAbstractStudies over the last 40 years have mainly investigated sleep structure changes as a result of wake duration, in the frame of the classical sleep regulation theories. However, wake intervals of the same duration can profoundly differ in their intensity, which actually reflects the degree of cognitive and physical activity. Data on how sleep...
Thu Sep 05, 2019 13:28
Publication date: October 2019Source: Cancer Epidemiology, Volume 62Author(s): Erin Kelty, Sarah V Ward, Gemma Cadby, Nina S McCarthy, Peter O’Leary, Eric K Moses, Hooi C. Ee, David B. PreenAbstractAimsThe aim of this study was to examine factors including family history, medical history and comorbidities associated with the risk of colorectal cancer (CRC) in young (18–49 years) and middle-age (50–69 years) individuals.MethodsState records were used to identify individuals born in Western Australia...
Thu Sep 05, 2019 13:39
Publication date: Available online 5 September 2019Source: American Journal of Infection ControlAuthor(s): Eun Jin Kim, So Young Kang, Yee Gyung Kwak, Sung Ran Kim, Myoung Jin Shin, Hyeon Mi Yoo, Su Ha Han, Dong Wook Kim, Young Hwa Choi, the Steering Committee of KONISBackgroundCentral line–associated bloodstream infections (CLABSIs) are preventable health care–associated infections that can lead to increased mortality. Therefore, we investigated trends in CLABSI rates, and the factors associated...
Thu Sep 05, 2019 13:40
Publication date: Available online 5 September 2019Source: American Journal of Infection ControlAuthor(s): Deb Reid, Karen Ternes, Linda Winowiecki, Cheryl Yonke, Brian Riege, Fabian Fregoli, Deborah Passey, Mark Stibich, Russell N OlmstedPortable medical equipment (PME) can be an important reservoir of pathogens causing health care–associated infections. To address this, a novel, portable ultraviolet disinfection pod (UVDP) that allows for full 360-degree disinfection was developed. This investigation...
Thu Sep 05, 2019 13:40
Publication date: Available online 5 September 2019Source: American Journal of Infection ControlAuthor(s): Rodgers Rodriguez Ayebare, Faridah Mayanja
Thu Sep 05, 2019 13:40
Publication date: October 2019Source: European Journal of Cancer, Volume 120Author(s): Hong Sook Kim, Hongui Cha, Jinho Kim, Woong-Yang Park, Yoon-La Choi, Jong-Mu Sun, Jin Seok Ahn, Myung-Ju Ahn, Keunchil Park, Se-Hoon LeeAbstractAimsImmune checkpoint inhibitors (ICIs) induce durable responses, but their clinical benefits apply to only a subset of patients. Therefore, precisely predicting a patient's response before ICI treatment is crucial.MethodsA total of 248 patients with anti-Programmed cell...
Thu Sep 05, 2019 13:44
Publication date: Available online 4 September 2019Source: Ultrasound in Medicine & BiologyAuthor(s): Jeong Ah Hwang, Woo Kyoung Jeong, Kyoung Doo Song, Kyung A Kang, Hyo K. LimAbstractThe aim of this study was to determine the factors influencing stiffness and conspicuity of focal lesions in deep organs by focusing on target properties using 2-D shear wave elastography (SWE). Two normal (4 ± 1 kPa) and cirrhotic (16 ± 2 kPa) liver-mimicking phantoms with spherical inclusions (23 ± 3 kPa) were...
Thu Sep 05, 2019 13:45
Abstract The subendothelial matrix of the artery is a complex mechanical environment where endothelial cells respond to and affect changes upon the underlying substrate. Our recent work has demonstrated that endothelial cell strain heterogeneity increases on a more heterogeneous underlying subendothelial matrix, and these cells display increased focal adhesion presence on stiffer substrate areas. However, the impact of these grouped focal adhesions on endothelial cell strains has not been explored....
Wed Sep 04, 2019 13:04
Abstract The aim of this work was to use a multiscale modeling to study the influence of stent deployment, with generic stents, on flow distributions within the vascular network and the hemodynamic alterations within the cerebral aneurysms pre‐ and post‐stenting. To achieve this goal, two image‐based anatomical cerebral aneurysm models were reconstructed along with the respective aneurysms post‐stenting models after deploying a 16 or 24‐wire stent. The investigation results revealed that the stent...
Wed Sep 04, 2019 19:29
Abstract Areas of disturbed shear that develop following arteriovenous fistula (AVF) creation are believed to trigger the onset of intimal hyperplasia (IH), leading to AVF dysfunction. The presence of helical flow can suppress the flow disturbances that lead to disturbed shear in other areas of the vasculature. However, the relationship between helical flow and disturbed shear remains unevaluated in AVF. In this study, computational fluid dynamics (CFD) is used to evaluate the relationship between...
Wed Sep 04, 2019 21:19
Publication date: Available online 4 September 2019Source: Gait & PostureAuthor(s): C.N. Armitano, H.B. Bennett, J.A. Haegele, S. Morrison
Thu Sep 05, 2019 13:57
Abstract Poor sleep health is associated with numerous health concerns, and sleep problems are exacerbated by cigarette smoking. Although rates of traditional tobacco use are declining, rates of electronic cigarette (e‐cigarette) use are comparatively high and growing. Given that nicotine is a primary mechanism by which smoking negatively impacts sleep health, e‐cigarette use may also be linked to poor sleep health; however, no research has investigated this association. Participants were 1,664...
Wed Sep 04, 2019 19:01
Publication date: Available online 4 September 2019Source: Journal of Surgical EducationAuthor(s): Ioana Baiu, Ashley Titan, Cindy Kin, David A. SpainOBJECTIVEThere is a national epidemic of physician burnout and serious concerns exist regarding the well-being of future physicians. This project seeks to address resident physician health, by creating a sense of support and community during training, as a method to target one of the many facets of burnout.DESIGNWe created a program that allows residents...
Thu Sep 05, 2019 14:17
Publication date: Available online 4 September 2019Source: Archives of Physical Medicine and RehabilitationAuthor(s): Megan K. MacGillivray, Janice J. Eng, Elizabeth Dean, Bonita J. SawatzkyObjectiveTo identify whether motor skill-based training improves wheeling biomechanics in older adults and whether transfer or retention occurs.DesignRandomized Controlled Trial (RCT)SettingHuman mobility laboratoryParticipants34 able-bodied older adults 50 years and older deemed ready to participate in physical...
Thu Sep 05, 2019 14:26
Publication date: Available online 4 September 2019Source: Archives of Physical Medicine and RehabilitationAuthor(s): Jeffrey A. King, Michael A. McCrea, Lindsay D. NelsonAbstractObjectivesTo determine (1) the frequency of neck pain overall and relative to other symptoms in patients presenting to a level I trauma center emergency department (ED) with mild traumatic brain injury (mTBI) and (2) the predictors of primary neck pain in this population.DesignCohort study.SettingLevel I trauma center ED.Participants95...
Thu Sep 05, 2019 14:26
Abstract Objective As the association between obesity and cancer receives increasing attention, studies have begun to examine the potential impact of excess weight on psychosocial domains during treatment and survivorship. The current study will examine the effect of weight status on psychosocial outcomes among patients diagnosed with breast cancer, prostate cancer, and colon cancer. Methods This retrospective study included 4159 patients over the age of 55 who were diagnosed with postmenopausal...
Wed Sep 04, 2019 19:01
Abstract Objective Social support is a critical, yet frequently unmet, need among young adults (YAs) with cancer. YAs desire age‐appropriate resources to connect with peers. Peer‐to‐peer mobile apps are promising interventions to provide social support. Peer‐to‐peer apps will be more effective if development incorporates users’ input for whether app designs (look and function) afford meaningful connections. Methods We interviewed 22 YAs to assess perceptions of a peer‐to‐peer app at a young...
Wed Sep 04, 2019 22:47
Publication date: Available online 4 September 2019Source: Annals of Diagnostic PathologyAuthor(s): Evelyne Pedroza de Andrade, Lucas Novaes Teixeira, Victor Angelo Martins Montalli, Flávio de Melo Garcia, Fabrício Passador Santos, Andresa Borges Soares, Vera Cavalcanti de AraújoAbstractEpithelial membrane antigen (EMA) and DOG1 are used as marker of epithelial cells, particularly the luminal cells, of salivary gland tumours. The aim of this study was to compare the EMA and DOG1 expression in tumours...
Thu Sep 05, 2019 14:42
Abstract Many metaethicists agree that as ordinary people experience morality as a realm of objective truths, we have a prima facie reason to believe that it actually is such a realm. Recently, worries have been raised about the validity of the extant psychological research on this argument’s empirical hypothesis. Our aim is to advance this research, taking these worries into account. First, we propose a new experimental design for measuring folk intuitions about moral objectivity...
Thu Sep 05, 2019 03:00
Related ArticlesGamma-Aminobutyric Acid Levels in the Anterior Cingulate Cortex of Perimenopausal Women With Depression: A Magnetic Resonance Spectroscopy Study. Front Neurosci. 2019;13:785 Authors: Wang D, Wang X, Luo MT, Wang H, Li YH Abstract Objective: The anterior cingulate cortex (ACC) is associated with the processing of negative emotions. Gamma-aminobutyric acid (GABA) metabolism plays an important role in the pathogenesis of mental disorders....
Thu Sep 05, 2019 14:58
Related ArticlesClosed-Loop Implantable Therapeutic Neuromodulation Systems Based on Neurochemical Monitoring. Front Neurosci. 2019;13:808 Authors: Mirza KB, Golden CT, Nikolic K, Toumazou C Abstract Closed-loop or intelligent neuromodulation allows adjustable, personalized neuromodulation which usually incorporates the recording of a biomarker, followed by implementation of an algorithm which decides the timing (when?) and strength (how much?) of stimulation....
Thu Sep 05, 2019 14:58
Related ArticlesLocal Sleep Oscillations: Implications for Memory Consolidation. Front Neurosci. 2019;13:813 Authors: Geva-Sagiv M, Nir Y PMID: 31481865 [PubMed]
Thu Sep 05, 2019 14:58
Related ArticlesLow-Frequency Pulsed Magnetic Field Improves Depression-Like Behaviors and Cognitive Impairments in Depressive Rats Mainly via Modulating Synaptic Function. Front Neurosci. 2019;13:820 Authors: Yang J, Wang L, Wang F, Tang X, Zhou P, Liang R, Zheng C, Ming D Abstract Transcranial magnetic stimulation (TMS) has shown great promise as a medical treatment of depression. The effectiveness of TMS treatment at high frequency has been well investigated;...
Thu Sep 05, 2019 14:58
Related ArticlesResearch on Assisting Clinicians to Operate rTMS Precisely Based on the Coil Magnetic Field Spatial Distribution With Magnetic Resonance Imaging Navigation. Front Neurosci. 2019;13:858 Authors: Li S, Wang Y, Li S, Lv Y, Zhang L, Zou J, Ma L Abstract Objective: To assist clinicians to operate repetitive Transcranial Magnetic Stimulation (rTMS) precisely based on the coil magnetic field spatial distribution with Magnetic Resonance Imaging...
Thu Sep 05, 2019 14:58
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