Publication date: Available online 4 September 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Hirohisa Saito, Harald Renz
Thu Sep 05, 2019 13:18
Publication date: Available online 4 September 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Elien Gevaert, Tim Delemarre, Joyceline De Volder, Nan Zhang, Gabriele Holtappels, Natalie De Ruyck, Emma Persson, Ines Heyndrickx, Kenneth Verstraete, Helena Aegerter, Hans Nauwynck, Savvas N. Savvides, Bart N. Lambrecht, Claus Bachert
Thu Sep 05, 2019 13:18
Publication date: Available online 4 September 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Edwin H. Kim, Luanna Yang, Ping Ye, Rishu Guo, Quefeng Li, Michael D. Kulis, A. Wesley BurksBackgroundPeanut sublingual immunotherapy (SLIT) for 1 year has been shown to induce modest clinical desensitization in allergic children. Studies of oral immunotherapy, epicutaneous immunotherapy, and SLIT have suggested additional benefit with extended treatment.ObjectiveWe sought to investigate...
Thu Sep 05, 2019 13:18
To review the published literature on current and new treatments for chronic spontaneous urticaria (CSU) and to provide guidance on the potential use of these therapeutics.
Thu Sep 05, 2019 03:00
Readily available exome sequencing is revolutionizing clinicians’ ability to establish diagnoses with previously undefined disorders. Exome and genome sequencing have led to the identification of unique gene-disease associations where clinical phenotype has been previously unknown to be associated with a specific genotype. Identification of unique gene-disease associations has led to a change in management in over one-third of newly diagnosed patients.1 Familial Mediterranean Fever (FMF) is an autoinflammatory...
Thu Sep 05, 2019 03:00
To review the state of omics science specific to asthma and allergic diseases and discuss the current and potential applicability of omics in clinical disease prediction, treatment, and management
Thu Sep 05, 2019 03:00
Abstract Purpose of Review Asthma, a common respiratory disease that affects about 10% of the US population, represents a significant public health issue. In the last decade, cumulative evidence has demonstrated sex disparities in asthma, including significant differences in epidemiology, clinical presentation, response to therapies, and health outcomes. Understanding sex-related differences in asthma enables clinicians to provide...
Thu Sep 05, 2019 03:00
Abstract Purpose of Review Chronic rhinosinusitis and nasal polyps (CRSwNP) is a common condition that significantly affects patients’ life. This work aims to provide an up-to-date overview of CRSwNP in older adults, focusing on its aging-related clinical presentations, pathophysiology, and comorbidity associations including asthma. Recent Findings ...
Thu Sep 05, 2019 03:00
Abstract Purpose of Review Asthma is a common inflammatory airway disease, which affects more than 300 million people worldwide. Although conventional drugs are effective for most of the patients with mild-to-moderate asthma, they are less effective for patients with difficult-to-treat or severe asthma. Identification of asthma endotypes and biomarkers will lead to more precise approaches to treat asthma. ...
Thu Sep 05, 2019 03:00
Abstract Purpose of Review Asthma is marked by peculiar pathological features involving airway contraction, an impinging inflammation in the lungs, and an inexorably progressive remodeling of pulmonary architecture. Current medications for management of asthma exacerbations fail to optimally mitigate these pathologies, which is partly due to the intrinsic heterogeneity in the development and progression of asthma within different...
Thu Sep 05, 2019 03:00
Abstract Purpose of Review To examine the role of allergy medications in the treatment of otitis media with effusion (OME), focusing on use of intranasal steroids and antihistamines. Recent Findings There has been ongoing controversy regarding the role of allergy in the development of OME. Treatment of OME with medications commonly used for...
Thu Sep 05, 2019 03:00
Background The sinonasal microbiota has been implicated in chronic rhinosinusitis (CRS) pathogenesis, particularly related to the presence of Staphylococcus aureus. Staphylococcus epidermidis is also prevalent within the sinonasal microbiota and may inhibit S. aureus colonization. We investigated polymerase chain reaction (PCR) primer pairs for measuring absolute abundances of S. aureus and S. epidermidis, then compared bacterial community composition and absolute abundances of these species between...
Wed Sep 04, 2019 18:58
Background Optimizing intranasal distribution and retention of nasal sprays is essential in the management of patients with chronic rhinosinusitis (CRS), including those that have had functional endoscopic sinus surgery (FESS). Despite multiple existing distribution studies, there remains a need for a technique that allows regionalization of particle deposition within a patient's unique 3‐dimensional (3D) geometry without exposing the patient to radiation. Methods Seven participants delivered...
Mon Sep 02, 2019 19:30
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