Effect of monoclonal antibodies on olfactory dysfunction caused by chronic rhinosinusitis with nasal polyps: a systematic review and meta-analysis.

Effect of monoclonal antibodies on olfactory dysfunction caused by chronic rhinosinusitis with nasal polyps: a systematic review and meta-analysis.:

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Effect of monoclonal antibodies on olfactory dysfunction caused by chronic rhinosinusitis with nasal polyps: a systematic review and meta-analysis.

Int Forum Allergy Rhinol. 2020 Apr 06;:

Authors: Tsetsos N, Markou K, Konstantinidis I

Abstract

BACKGROUND: Olfactory dysfunction is a common complaint in patients suffering from chronic rhinosinusitis with nasal polyps (CRSwNP). The purpose of this paper is to critically review all published literature regarding the impact of monoclonal antibodies on CRSwNP-related olfactory dysfunction.

METHODOLOGY: An electronic literature search was performed in MEDLINE, ScienceDirect, the Cochrane Library electronic databases and multiple trial registries followed by extensive hand-searching for the retrieval of relevant studies.

RESULTS: Seven trials with a total of 957 patients were eventually identified and systematically reviewed. Six out of seven studies showed that biologic therapy can improve olfactory dysfunction as compared to placebo. Overall, these biologics were considered safe and well-tolerated. No cases of olfactory deterioration or olfactory loss were reported.

CONCLUSIONS: This is the first meta-analysis presenting clinical outcomes regarding olfactory function in CRSwNP patients, who have had treatment with monoclonal antibodies. The positive effect of biologic treatment in the olfactory function of these patients needs further studies, so that the sustainability of results and duration of treatment can be evaluated. This article is protected by copyright. All rights reserved.

PMID: 32250544 [PubMed - as supplied by publisher]