Microorganisms, Vol. 8, Pages 502: Biochar and Rhizobacteria Amendments Improve Several Soil Properties and Bacterial Diversity Microorganisms doi: 10.3390/microorganisms8040502 Authors: Ren Huang Fernández-García Miesel Yan Lv In the current context, there is a growing interest in reducing the use of chemical fertilizers and pesticides to promote ecological agriculture. The use of biochar and plant growth-promoting rhizobacteria (PGPR) is an environmentally friendly...
Microorganisms, Vol. 8, Pages 503: Small Molecule Inhibitors of the Response Regulator ArsR Exhibit Bactericidal Activity against Helicobacter pylori Microorganisms doi: 10.3390/microorganisms8040503 Authors: González Casado Chueca Salillas Velázquez-Campoy Sancho Lanas Helicobacter pylori is considered the most prevalent bacterial pathogen in humans. The increasing antibiotic resistance evolved by this microorganism has raised alarm bells worldwide due to the...
Microorganisms, Vol. 8, Pages 505: Enhanced Adsorptive Bioremediation of Heavy Metals (Cd2+, Cr6+, Pb2+) by Methane-Oxidizing Epipelon Microorganisms doi: 10.3390/microorganisms8040505 Authors: Faheem Shabbir Zhao Kerr Sultana Jia Cadmium (Cd), chromium (Cr) and lead (Pb) are heavy metals that have been classified as priority pollutants in aqueous environment while methane-oxidizing bacteria as a biofilter arguably consume up to 90% of the produced methane in the...
Microorganisms, Vol. 8, Pages 501: Viruses of Respiratory Tract: an Observational Retrospective Study on Hospitalized Patients in Rome, Italy Microorganisms doi: 10.3390/microorganisms8040501 Authors: Marco Ciotti Massimo Maurici Viviana Santoro Luigi Coppola Loredana Sarmati Gerardo De Carolis Patrizia De Filippis Francesca Pica Respiratory tract infections account for high morbidity and mortality around the world. Fragile patients are at high risk of developing...
Microorganisms, Vol. 8, Pages 500: IL-2 and Mycobacterial Lipoarabinomannan as Targets of Immune Responses in Multiple Sclerosis Patients Microorganisms doi: 10.3390/microorganisms8040500 Authors: Marco Bo Magdalena Niegowska Jessica Frau GianPietro Sechi Giannina Arru Eleonora Cocco Leonardo A. Sechi Interleukin 2 (IL-2) is considered a key player in exacerbating multiple sclerosis (MS). Therapies targeting its receptor have been developed; however, a resolution of...
Microorganisms, Vol. 8, Pages 504: Spheres of Influence: Insights into Salmonella Pathogenesis from Intestinal Organoids Microorganisms doi: 10.3390/microorganisms8040504 Authors: Smriti Verma Stefania Senger Bobby J. Cherayil Christina S. Faherty The molecular complexity of host-pathogen interactions remains poorly understood in many infectious diseases, particularly in humans due to the limited availability of reliable and specific experimental models. To bridge the gap between...
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Molecules, Vol. 25, Pages 1626: A Global Model for the Estimation of Speeds of Sound in Deep Eutectic Solvents Molecules doi: 10.3390/molecules25071626 Authors: Hamed Peyrovedin Reza Haghbakhsh Ana Rita C. Duarte Sona Raeissi Deep eutectic solvents (DESs) are newly introduced green solvents that have attracted much attention regarding fundamentals and applications. Of the problems along the way of replacing a common solvent by a DES, is the lack of information on the thermophysical...
Molecules, Vol. 25, Pages 1624: Silacyclohexanes, Sila(hetero)cyclohexanes and Related Compounds: Structure and Conformational Analysis Molecules doi: 10.3390/molecules25071624 Authors: Bagrat A. Shainyan Conformational analysis of Si-mono- and Si,Si-disubstituted silacyclohexanes as well as their analogues with a heteroatom(s) in the ring is reviewed with the focus on the recent results. Experimental measurements in the gas phase (gas electron diffraction, GED) and low temperature NMR...
Molecules, Vol. 25, Pages 1623: Targeted UHPLC–HRMS (Orbitrap) Polyphenolic and Capsaicinoid Profiling for the Chemometric Characterization and Classification of Paprika with Protected Designation of Origin (PDO) Attributes Molecules doi: 10.3390/molecules25071623 Authors: Sergio Barbosa Javier Saurina Lluís Puignou Oscar Núñez Society’s interest in the quality of food products with certain attributes has increased, the attribute of a Protected Designation of Origin...
Molecules, Vol. 25, Pages 1625: Antiproliferative and Antimetastatic Effects of Praeruptorin C on Human Non–Small Cell Lung Cancer Through Inactivating ERK/CTSD Signalling Pathways Molecules doi: 10.3390/molecules25071625 Authors: Liu Shen Lin Yu Chen Liu Hsieh Praeruptorin C (PC) reportedly has beneficial effects in terms of antiinflammation, antihypertension, and antiplatelet aggregation, and it potentially has anticancer activity. However, the effect of PC...
Molecules, Vol. 25, Pages 1620: Chlorosubstituted Copper Phthalocyanines: Spectral Study and Structure of Thin Films Molecules doi: 10.3390/molecules25071620 Authors: Alexandr Sukhikh Dmitry Bonegardt Darya Klyamer Pavel Krasnov Tamara Basova In this work, the tetra-, octa- and hexadecachloro-substituted copper phthalocyanines CuPcClx (where x can equal 4, 8 or 16) were investigated by the methods of vibrational (IR and Raman) spectroscopy and X-ray diffraction. The assignment...
Molecules, Vol. 25, Pages 1621: Characteristics of Potential Protein Nutraceuticals of Plant Origin with Antioxidant Activity Molecules doi: 10.3390/molecules25071621 Authors: Iwona Szerszunowicz Jan Kłobukowski This study used selected plant proteins and the tools available in the BIOPEP-UWM database to profile proteins and release antioxidant nutraceuticals from their primary structures. The frequency of the occurrence of fragments with antioxidant activity in a protein sequence...
Molecules, Vol. 25, Pages 1619: Choline Chloride Based Natural Deep Eutectic Solvents as Extraction Media for Extracting Phenolic Compounds from Chokeberry (Aronia Melanocarpa) Molecules doi: 10.3390/molecules25071619 Authors: Maša Islamčević Razboršek Milena Ivanović Peter Krajnc Mitja Kolar For the isolation of selected phenolic compounds from dried chokeberries, natural deep eutectic solvents (NADESs) were investigated as a green alternative to conventionally used extraction...
Molecules, Vol. 25, Pages 1617: Phytostabilization of Pb-Zn Mine Tailings with Amorpha fruticosa Aided by Organic Amendments and Triple Superphosphate Molecules doi: 10.3390/molecules25071617 Authors: Ashim Sikdar Jinxin Wang Mirza Hasanuzzaman Xiaoyang Liu Shulin Feng Rana Roy Tanveer Ali Sial Altaf Hussain Lahori Parimala Gnana Soundari Arockiam Jeyasundar Xiuqing Wang A greenhouse pot trial was conducted to investigate the effect of organic amendments combined...
Molecules, Vol. 25, Pages 1622: Structure-Based Site of Metabolism (SOM) Prediction of Ligand for CYP3A4 Enzyme: Comparison of Glide XP and Induced Fit Docking (IFD) Molecules doi: 10.3390/molecules25071622 Authors: Deepak K. Lokwani Aniket P. Sarkate Kshipra S. Karnik Anna Pratima G. Nikalje Julio A. Seijas Metabolism is one of the prime reasons where most of drugs fail to accomplish their clinical trials. The enzyme CYP3A4, which belongs to the superfamily of cytochrome...
Molecules, Vol. 25, Pages 1618: Role of the Neutrophil in the Pathogenesis of Advanced Cancer and Impaired Responsiveness to Therapy Molecules doi: 10.3390/molecules25071618 Authors: Bernardo L. Rapoport Helen C. Steel Annette J. Theron Teresa Smit Ronald Anderson Notwithstanding the well-recognized involvement of chronic neutrophilic inflammation in the initiation phase of many types of epithelial cancers, a growing body of evidence has also implicated these cells in the...
Molecules, Vol. 25, Pages 1616: Computational Study of Drugs Targeting Nuclear Receptors Molecules doi: 10.3390/molecules25071616 Authors: Maša Kenda Marija Sollner Dolenc Endocrine-disrupting chemicals have been shown to interfere with the endocrine system function at the level of hormone synthesis, transport, metabolism, binding, action, and elimination. They are associated with several health problems in humans: obesity, diabetes mellitus, infertility, impaired thyroid and neuroendocrine...
Molecules, Vol. 25, Pages 1615: Role of Indole Scaffolds as Pharmacophores in the Development of Anti-Lung Cancer Agents Molecules doi: 10.3390/molecules25071615 Authors: Jyothi Dhuguru Rachid Skouta Lung cancer is the leading cause of death in men and women worldwide, affecting millions of people. Between the two types of lung cancers, non-small cell lung cancer (NSCLC) is more common than small cell lung cancer (SCLC). Besides surgery and radiotherapy, chemotherapy is the most important...
Molecules, Vol. 25, Pages 1613: Biological Evaluation of 3-Benzylidenechromanones and Their Spiropyrazolines-Based Analogues Molecules doi: 10.3390/molecules25071613 Authors: Angelika A. Adamus-Grabicka Magdalena Markowicz-Piasecka Marcin Cieślak Karolina Królewska-Golińska Paweł Hikisz Joachim Kusz Magdalena Małecka Elzbieta Budzisz A series of 3-benzylidenechrmanones 1, 3, 5, 7, 9 and their spiropyrazoline analogues 2, 4, 6, 8, 10 were synthesized. X-ray analysis...
Molecules, Vol. 25, Pages 1614: Study of the Quality Parameters and the Antioxidant Capacity for the FTIR-Chemometric Differentiation of Pistacia Vera Oils Molecules doi: 10.3390/molecules25071614 Authors: Lydia Valasi Dimitra Arvanitaki Angeliki Mitropoulou Maria Georgiadou Christos S. Pappas The aim of this work was to characterize the pistachio oil of the Greek variety, “Aegina”, evaluate its various quality indices, and investigate the potential use...
Molecules, Vol. 25, Pages 1612: Automation technique Lab-In-Syringe: A Practical Guide Molecules doi: 10.3390/molecules25071612 Authors: Burkhard Horstkotte Petr Solich About eight years ago, a new automation approach and flow technique, denoted “Lab-In-Syringe” was firstly proposed. It was derived from previous techniques, all based on handling 06 March 2020modes, and technical improvements still popping up. This article aims for assisting newcomers to this technique...
Molecules, Vol. 25, Pages 1610: Total Syntheses of Marrubiin and Related Labdane Diterpene Lactones Molecules doi: 10.3390/molecules25071610 Authors: Yukari Sakagami Naoki Kondo Yuki Sawayama Hiroyuki Yamakoshi Seiichi Nakamura Total syntheses of the labdane diterpene lactones marrubiin, marrulibacetal, desertine, marrulibacetal A, marrubasch F, cyllenine C, marrulanic acid, and marrulactone are described. The trans-decalin moiety of these molecules was constructed in a stereoselective...
Molecules, Vol. 25, Pages 1611: Chitosan-Based Agronanochemicals as a Sustainable Alternative in Crop Protection Molecules doi: 10.3390/molecules25071611 Authors: Farhatun Najat Maluin Mohd Zobir Hussein The rise in the World’s food demand in line with the increase of the global population has resulted in calls for more research on the production of sustainable food and sustainable agriculture. A natural biopolymer, chitosan, coupled with nanotechnology could offer a sustainable...
Molecules, Vol. 25, Pages 1609: Ajmalicine and Reserpine: Indole Alkaloids as Multi-Target Directed Ligands Towards Factors Implicated in Alzheimer’s Disease Molecules doi: 10.3390/molecules25071609 Authors: Priya Kashyap Vivekanandan Kalaiselvan Robin Kumar Suresh Kumar Alzheimer’s disease (AD) is a multifactorial disorder characterized by exponential loss of memory and cognitive deficit involving several disease modifying targets (amyloid beta, beta-secretase, monoaminoxidase-B,...
Molecules, Vol. 25, Pages 1608: Iron-Catalyzed Synthesis, Structure, and Photophysical Properties of Tetraarylnaphthidines Molecules doi: 10.3390/molecules25071608 Authors: Alexander Purtsas Sergej Stipurin Olga Kataeva Hans-Joachim Knölker We describe the synthesis and photophysical properties of tetraarylnaphthidines. Our synthetic approach is based on an iron-catalyzed oxidative C–C coupling reaction as the key step using a hexadecafluorinated iron–phthalocyanine...
Molecules, Vol. 25, Pages 1606: Visible Light-Induced Homolytic Cleavage of Perfluoroalkyl Iodides Mediated by Phosphines Molecules doi: 10.3390/molecules25071606 Authors: Mario Bracker Lucas Helmecke Martin Kleinschmidt Constantin Czekelius Christel M. Marian In an effort to explain the experimentally observed variation of the photocatalytic activity of t Bu 3 P, n Bu 3 P and (MeO) 3 P in the blue-light regime [Helmecke et al., Org. Lett....
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Nanomaterials, Vol. 10, Pages 657: Optimization of Mesa Etch for a Quasi-Vertical GaN Schottky Barrier Diode (SBD) by Inductively Coupled Plasma (ICP) and Device Characteristics Nanomaterials doi: 10.3390/nano10040657 Authors: Sun Kang Zheng Wei Li Wang Liu Zhang The optimization of mesa etch for a quasi-vertical gallium nitride (GaN) Schottky barrier diode (SBD) by inductively coupled plasma (ICP) etching was comprehensively investigated in this work, including...
Nanomaterials, Vol. 10, Pages 658: Modified Nanoparticles as Potential Agents in Bone Diseases: Cancer and Implant-Related Complications Nanomaterials doi: 10.3390/nano10040658 Authors: Karol P. Steckiewicz Iwona Inkielewicz-Stepniak Materials sized 1–100 nm are the nanotechnology’s field of interest. Because of the unique properties such as the ability to penetrate biological barriers and a high surface to volume ratio, nanoparticles (NPs) are a powerful tool...
Nanomaterials, Vol. 10, Pages 655: Porous Carbon Materials Obtained by the Hydrothermal Carbonization of Orange Juice Nanomaterials doi: 10.3390/nano10040655 Authors: Veltri Alessandro Scarcello Beneduci Arias Polanco Cid Perez Vacacela Gomez Tavolaro Giordano Caputi Porous carbon materials are currently subjected to strong research efforts mainly due to their excellent performances in energy storage devices. A sustainable process to obtain them is...
Nanomaterials, Vol. 10, Pages 656: Systemic Review of Biodegradable Nanomaterials in Nanomedicine Nanomaterials doi: 10.3390/nano10040656 Authors: Shi Su Peter M. Kang Background: Nanomedicine is a field of science that uses nanoscale materials for the diagnosis and treatment of human disease. It has emerged as an important aspect of the therapeutics, but at the same time, also raises concerns regarding the safety of the nanomaterials involved. Recent applications of functionalized...
Nanomaterials, Vol. 10, Pages 653: Reactive Pulsed Laser Deposition of Clustered-Type MoSx (x ~ 2, 3, and 4) Films and Their Solid Lubricant Properties at Low Temperature Nanomaterials doi: 10.3390/nano10040653 Authors: V. Fominski M. Demin V. Nevolin D. Fominski R. Romanov M. Gritskevich N. Smirnov We studied the tribological properties of amorphous molybdenum sulfide (MoSx) thin-film coatings during sliding friction in an oxidizing environment at a low temperature...
Nanomaterials, Vol. 10, Pages 654: Osteoblastic Differentiation on Graphene Oxide-Functionalized Titanium Surfaces: An In Vitro Study Nanomaterials doi: 10.3390/nano10040654 Authors: Roberta Di Carlo Antonello Di Crescenzo Serena Pilato Alessia Ventrella Adriano Piattelli Lucia Recinella Annalisa Chiavaroli Silvia Giordani Michele Baldrighi Adalberto Camisasca Barbara Zavan Mirella Falconi Amelia Cataldi Antonella Fontana Susi Zara Background:...
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ncRNA, Vol. 6, Pages 15: Dynamic Expression of Long Non-Coding RNAs Throughout Parasite Sexual and Neural Maturation in Schistosoma japonicum Non-Coding RNA doi: 10.3390/ncrna6020015 Authors: Maciel Morales-Vicente Verjovski-Almeida Schistosoma japonicum is a flatworm that causes schistosomiasis, a neglected tropical disease. S. japonicum RNA-Seq analyses has been previously reported in the literature on females and males obtained during sexual maturation from 14 to 28 days...
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Nutrients, Vol. 12, Pages 979: Purchasing Drivers of Fresh Citrus Fruits in Urban Italy: Is It All about Taste? Nutrients doi: 10.3390/nu12040979 Authors: Giuseppe Di Vita Massimiliano Borrello Riccardo Vecchio Giovanni Gulisano Mario D’Amico While the medical community supports the growth of citrus consumption as part of a healthy diet, there is limited knowledge about consumer preferences for these fruits. The current study analyzed the purchasing patterns and drivers of...
Nutrients, Vol. 12, Pages 977: Weight-Reducing Effect of Lactobacillus plantarum ZJUFT17 Isolated from Sourdough Ecosystem Nutrients doi: 10.3390/nu12040977 Authors: Liu Li Zhao Mo Feng Lactobacillus plantarum ZJUFT17 (T17) is a potential probiotic bacterium isolated from Chinese traditional sourdough. The purpose of this study was to investigate its weight-reducing effects in mice fed a high-fat diet (HFD) and further to elucidate possible mechanisms. Male C57BL/6J...
Nutrients, Vol. 12, Pages 978: Low Levels of Serum Tryptophan Underlie Skeletal Muscle Atrophy Nutrients doi: 10.3390/nu12040978 Authors: Soranobu Ninomiya Nobuhiko Nakamura Hiroshi Nakamura Taku Mizutani Yuto Kaneda Kimihiro Yamaguchi Takuro Matsumoto Junichi Kitagawa Nobuhiro Kanemura Makoto Shiraki Takeshi Hara Masahito Shimizu Hisashi Tsurumi Sarcopenia is a poor prognosis factor in some cancer patients, but little is known about the mechanisms...
Nutrients, Vol. 12, Pages 975: Erythropoiesis and Red Cell Indices Undergo Adjustments during Pregnancy in Response to Maternal Body Size but not Inflammation Nutrients doi: 10.3390/nu12040975 Authors: Vega-Sánchez Tolentino-Dolores Cerezo-Rodríguez Chehaibar-Besil Flores-Quijano During human pregnancy, iron requirements gradually increase, leading to higher amounts of erythropoietin (EPO) and reticulocytes, and changes in erythrocyte size and density. Women with pregestational...
Nutrients, Vol. 12, Pages 976: Effect of Two Meal Replacement strategies on Cardiovascular Risk Parameters in Advanced Age Patients with Obesity and Osteoarthritis Nutrients doi: 10.3390/nu12040976 Authors: Juan José López-Gómez Olatz Izaola-Jauregui David Primo-Martín Beatriz Torres-Torres Emilia Gómez-Hoyos Ana Ortolá-Buigues Miguel A. Martín-Ferrero Daniel A. De Luis-Román Background and aims: Meal replacement diets consist of replacing one or more meals with...
Nutrients, Vol. 12, Pages 973: Diminished Vitamin D Receptor Protein Levels in Crohn´s Disease Fibroblasts: Effects of Vitamin D Nutrients doi: 10.3390/nu12040973 Authors: Gisbert-Ferrándiz Cosín-Roger Hernández Macias-Ceja Ortiz-Masiá Salvador Esplugues Hinojosa Navarro Calatayud Barrachina Vitamin D (VD) deficiency has been associated to Crohn´s disease (CD) pathogenesis, and the exogenous administration of VD improves the course of...
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