Cancers, Vol. 11, Pages 1098: Cancer Cell Lines Are Useful Model Systems for Medical Research Cancers doi: 10.3390/cancers11081098 Authors: Mirabelli Coppola Salvatore Cell lines are in vitro model systems that are widely used in different fields of medical research, especially basic cancer research and drug discovery. Their usefulness is primarily linked to their ability to provide an indefinite source of biological material for experimental purposes. Under the right conditions...
Thu Aug 01, 2019 03:00
Cancers, Vol. 11, Pages 1094: Targeting Degradation of EGFR through the Allosteric Site Leads to Cancer Cell Detachment-Promoted Death Cancers doi: 10.3390/cancers11081094 Authors: Iradyan Iradyan Hulin Hambardzumyan Gyulkhandanyan Alves de Sousa Hessani Roussakis Bollot Bauvais Sakanyan Targeting epidermal growth factor receptor (EGFR) with tyrosine kinase inhibitors (TKI) has been widely exploited to disrupt aberrant phosphorylation flux in...
Thu Aug 01, 2019 03:00
Cancers, Vol. 11, Pages 1097: Apolipoprotein A-I (ApoA-I), Immunity, Inflammation and Cancer Cancers doi: 10.3390/cancers11081097 Authors: Georgila Vyrla Drakos Apolipoprotein A-I (ApoA-I), the major protein component of high-density lipoproteins (HDL) is a multifunctional protein, involved in cholesterol traffic and inflammatory and immune response regulation. Many studies revealing alterations of ApoA-I during the development and progression of various types of cancer suggest...
Thu Aug 01, 2019 03:00
Cancers, Vol. 11, Pages 1099: Analysis of AR/ARV7 Expression in Isolated Circulating Tumor Cells of Patients with Metastatic Castration-Resistant Prostate Cancer (SAKK 08/14 IMPROVE Trial) Cancers doi: 10.3390/cancers11081099 Authors: Hench Cathomas Costa Fischer Gillessen Hench Hermanns Kremer Mingrone Mestre Püschel Rothermundt Ruiz Tolnay Burg Bubendorf Vlajnic (SAKK) Despite several treatment options and an initial...
Thu Aug 01, 2019 03:00
Cancers, Vol. 11, Pages 1095: Surgery or Locoregional Approaches for Hepatic Oligometastatic Pancreatic Cancer: Myth, Hope, or Reality? Cancers doi: 10.3390/cancers11081095 Authors: Michele Ghidini Angelica Petrillo Massimiliano Salati Shelize Khakoo Antonio Varricchio Gianluca Tomasello Francesco Grossi Fausto Petrelli Despite extensive research, pancreatic ductal adenocarcinoma (PDAC) remains a difficult-to-treat cancer associated with poor survival. Due to the...
Thu Aug 01, 2019 03:00
Cancers, Vol. 11, Pages 1093: The Benefit of Reactivating p53 under MAPK Inhibition on the Efficacy of Radiotherapy in Melanoma Cancers doi: 10.3390/cancers11081093 Authors: Mohammad Krayem Malak Sabbah Ahmad Najem An Wouters Filip Lardon Stephane Simon François Sales Fabrice Journe Ahmad Awada Ghanem E. Ghanem Dirk Van Gestel Radiotherapy (RT) in patients with melanoma historically showed suboptimal results, because the disease is often radioresistant due...
Thu Aug 01, 2019 03:00
Cancers, Vol. 11, Pages 1096: Role of the RAB7 Protein in Tumor Progression and Cisplatin Chemoresistance Cancers doi: 10.3390/cancers11081096 Authors: Guerra Bucci RAB7 is a small guanosine triphosphatase (GTPase) extensively studied as regulator of vesicular trafficking. Indeed, its role is fundamental in several steps of the late endocytic pathway, including endosome maturation, transport from early endosomes to late endosomes and lysosomes, clustering and fusion of late endosomes...
Thu Aug 01, 2019 03:00
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