Publication date: Available online 17 August 2019Source: Allergology InternationalAuthor(s): Taisuke Ito, Takahiro Suzuki, Jun-ichi Sakabe, Atsuko Funakoshi, Toshiharu Fujiyama, Yoshiki TokuraAbstractBackgroundAlopecia areata (AA) is a tissue-specific autoimmune disease, and interferon (IFN)-γ has been regarded as the key cytokine in the pathogenesis of AA. The clinical observation that AA can occur after viral infection or IFN-α administration implies that IFN-α-producing plasmacytoid dendritic...
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Publication date: Available online 17 August 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Paul J. Maglione, Huaibin M. Ko, Minami Tokuyama, Gavin Gyimesi, Camilia Soof, Mingjie Li, Eric Sanchez, Haiming Chen, Lin Radigan, James Berenson, Charlotte Cunningham-RundlesABSTRACTBackgroundPrimary antibody deficiencies (PAD) are the most prevalent primary immunodeficiencies. More severe forms of PAD, common variable immunodeficiency (CVID) and X-linked agammaglobulinemia...
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Publication date: Available online 17 August 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Alexandra Leonard, Jingya Wang, Li Yu, Hao Liu, Yeriel Estrada, Lydia Greenlees, Roderick McPhee, Alexey Ruzin, Emma Guttman-Yassky, Michael D. HowellAbstractBackgroundAtopic dermatitis (AD) is a chronic inflammatory disease with significant local and systemic inflammation and barrier disruption. AD is associated with increased risk of allergen sensitization and skin colonization...
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Publication date: Available online 17 August 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Melissa D. Gans, Carlos A. Saavedra-Matiz, Larry Bernstein
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Purpose of review Here we review the rheumatologic and autoimmune features of primary immune deficiencies with a focus on recently recognized genetic diseases, the spectrum of autoimmunity in PID, and targeted therapies. Recent findings Primary immune deficiencies (PIDs) were initially described as genetic diseases of the immune system leading to susceptibility to infection. It is now well recognized that immune dysfunction and dysregulation also cause noninfectious complications including...
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Abstract Purpose To investigate immunoglobulin E (IgE)-mediated hypersensitivity to chlorhexidine (CHX), and association between CHX exposure and serum specific IgE (SIgE) levels, among first-year dental students. Methods Participants completed a questionnaire on medical health, history of allergies/hypersensitivities and CHX exposure. A sample of venous...
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Abstract Background Asthma is a chronic disease that seriously harms the health of patients. Oxidative stress is involved in asthma. As an oxidative stress-inducible protein, sestrin2 is elevated in oxidative stress-related diseases. We aimed to explore whether sestrin2 was involved in asthma. Methods Seventy-six subjects (44 in the asthma group,...
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Abstract The Milk Allergy in Primary (MAP) Care guideline was first published in 2013 in this journal. MAP aimed to provide simple and accessible algorithms for UK clinicians in primary care, detailing all the steps between initial presentation, through diagnosis, management and tolerance development. Despite its UK focus, it soon became clear that MAP was being accessed internationally and thus an updated International Milk Allergy in Primary Care (iMAP) guideline was published...
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Title: chlorpheniramine, pseudoephedrine (Deconamine - discontinued)Category: MedicationsCreated: 12/31/1997 12:00:00 AMLast Editorial Review: 8/13/2019 12:00:00 AM (Source: MedicineNet Allergies General)
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Three medical stories from the week that we didn't cover, explained.Medscape (Source: Medscape Allergy Headlines)
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Find out how the safety profile for abatacept compared with that of other DMARDs for rheumatoid arthritis.Arthritis Research & Therapy (Source: Medscape Allergy Headlines)
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Tiny pieces of plastic have been found in ice cores drilled in the Arctic by a U.S.-led team of scientists, underscoring the threat the growing form of pollution poses to marine life in even the remotest waters on the planet.Reuters Health Information (Source: Medscape Allergy Headlines)
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The International Commission on the Clinical Use of Human Germline Genome Editing met for the first time this week and urged caution.Medscape Medical News (Source: Medscape Allergy Headlines)
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So far this year, the number of global measles cases is surging, reaching numbers that haven't been this high since 2006, according to WHO; measles vaccine uptake is also suboptimal.Medscape Medical News (Source: Medscape Allergy Headlines)
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Treatment of vitiligo can be challenging. Review current and emerging pharmacological, surgical and phototherapy management options in this article.Skin Therapy Letter (Source: Medscape Allergy Headlines)
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The experience with dupilumab, the first biologic for the treatment of atopic dermatitis, has demonstrated some marked contrasts to that seen in clinical trials.Medscape Dermatology (Source: Medscape Allergy Headlines)
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AstraZeneca Plc said on Friday a late-stage study showed its top-selling drug, Tagrisso (osimertinib), had significantly helped patients with a type of lung cancer live longer without the disease worsening.Reuters Health Information (Source: Medscape Allergy Headlines)
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Foreword. This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the author’s clinical recommendations. Stage. A 61-year-old…
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Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune, inflammatory disorder of the central nervous system that has a prevalence of 0.5 to 10 persons (predominantly women) per 100,000 population. It is characterized mainly by recurrent optic neuritis and myelitis, and such attacks are…
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