Publication date: 15 September 2019Source: Hearing Research, Volume 381Author(s): Peter Heil, Adam J. PetersonAbstractHalf a century ago, Nelson Kiang and colleagues observed that some spike rate versus stimulus level functions of auditory-nerve-fiber responses to tones are nonmonotonic, exhibiting a sharp notch (“Nelson's notch”) at high stimulus levels. The notch is associated with an abrupt change in the phase of the response by ∼180°. To account for these findings, Kiang proposed a “two-factor...
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The U.S. Food and Drug Administration has approved Keytruda (Pembrolizumab) for treatment of advanced Esophageal Squamous Cell Carcinoma (ESCC). It is the first immunotherapy given approval for use in ESCC. Only patients with recurrent, locally advanced, or metastatic ESCC whose Cancer is also positive for PD-L1 qualify for this therapy. Read the FDA announcement here. How It Works Keytruda is an anti-PD-1 therapy that works by increasing the ability of the body’s immune system to help detect...
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Reddy Ravikanth, Ashwin Chandrasekhar, Anegh Pavithran, Sivakumar Kandasamy, John JoshyCHRISMED Journal of Health and Research 2019 6(3):191-193 Pneumocephalus is defined as the presence of intracranial air seen most commonly secondary to a traumatic head injury. Tension pneumocephalus is often termed in radiology as the Mount Fuji sign due to a perceived similarity with the iconic mountain peak in Japan. We present the case of a 62-year-old gentleman who presented to the emergency department following...
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Sanjay Kalra, Andrew Uloko, Jubbin Jagan JacobCHRISMED Journal of Health and Research 2019 6(3):178-180 The Book of Job, a poetic book in the Old Testament narrates the story of Job, the “richest man in the East.” Job was afflicted by a severe illness, which tested his coping abilities and his resolve. Job's illness, and the way he coped with it has many lessons for health-care providers. In this brief communication, we hypothesize that Job suffered from diabetes, with various acute and vascular...
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Sudip Bhattacharya, Amarjeet SinghCHRISMED Journal of Health and Research 2019 6(3):135-139 Many studies from India have documented that patients are not satisfied with their treatment provided in the hospitals. The common reasons of patient's dissatisfaction are overcrowding, long waiting time to meet doctors, short consultation period (2 minutes), absence of a congenial environment, and communication gap. It is well known fact that there is frustration with systemic problems of government hospitals,...
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Vidya Kadashetti, KM Shivakumar, Rajendra Baad, Nupura Vibhute, Uzma Belgaumi, B Sushma, K WasimCHRISMED Journal of Health and Research 2019 6(3):131-134 The identification of oral tissues, including bone and teeth remains, is of primary importance when the deceased person is skeletonized, decomposed, burned, or dismembered. Primary role in the identification of remains when postmortem changes, traumatic tissue injury or lack of a fingerprint record invalidate the use of visual or fingerprint methods...
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Jeslean Jose, Uttam B George, Ashish Varghese, Shubhra RathoreCHRISMED Journal of Health and Research 2019 6(3):140-145 Background: With the advent of high-resolution computed tomography (HRCT), more information can be obtained about the anatomy of the middle ear, soft tissue pathologies, and the complications of middle ear disease process as compared to the conventional diagnostic methods. Aims: This study aims to study the spectrum of HRCT temporal bone findings in inflammatory middle ear diseases...
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Paramdeep Singh, Rupinderjeet Kaur, Rashmeet KaurCHRISMED Journal of Health and Research 2019 6(3):184-186 Trigeminal neuralgia is typified by recurrent attacks of unilateral facial pain that is often severe and starts with cutaneous stimulation. These paroxysms usually last for few seconds, and the etiology comprises compression of the trigeminal nerve by vessels and space-occupying lesions of the brain and involvement by inflammatory plaques. It is rare for intracranial epidermoids to present...
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Amit Singh, Seema DayalCHRISMED Journal of Health and Research 2019 6(3):146-149 Introduction: Tuberculosis (TB) is one of the most common infectious diseases among the Indian population, especially in rural scenario. It affects young people in majority. Living at slum areas and poverty are predisposing etiological factors. The diagnosis of TB is based on microbiology, cytology, and histopathology. Materials and Methods: The present study was carried out in the Department of Microbiology in collaboration...
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V Dinesh KumarCHRISMED Journal of Health and Research 2019 6(3):196-197
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Mamta Parashar, Deeksha Ellawadi, Mitasha Singh, Ram Chander JilohaCHRISMED Journal of Health and Research 2019 6(3):150-155 Background: Modernization and increasing level of competition in day to day life has increased the expectations from teachers. Objective: To describe the level of stress and its associated factors among teachers using Teacher's stress inventory in a government school of urban area of South Delhi. Methods: A cross sectional study among teachers of a senior secondary school...
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Saurabh RamBihariLal Shrivastava, Prateek Saurabh ShrivastavaCHRISMED Journal of Health and Research 2019 6(3):176-177
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Jerry Joseph Joel, Narjeet K Osahan, Ekta Rai, Priyanka Daniel, Sunimal BhaggienCHRISMED Journal of Health and Research 2019 6(3):156-161 Aims and Objectives: This study aims to compare the effectiveness of combined spinal-epidural (CSE) analgesia and low-dose epidural analgesia in labor and study their effects on maternal and fetal well-being. Material and Methods: Sixty parturients classified as the American Society of Anesthesiologists I, in established labor and requesting epidural, were alternately...
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Reddy RavikanthCHRISMED Journal of Health and Research 2019 6(3):181-183 Oblique muscle hematomas are an uncommon cause of acute abdominal pain and are more common in elderly individuals, particularly in those under anticoagulant therapy. They are often misdiagnosed from other causes of abdominal pain. We report a case of a cough-induced internal oblique hematoma in an elderly 62-year-old male patient under antiplatelet therapy. He had no history of trauma and presented with acute worsening pain...
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Meher Rizvi, Hiba Sami, Mohd Azam, Indu Shukla, Haris M Khan, MR AjmalCHRISMED Journal of Health and Research 2019 6(3):162-166 Background: Genotypically, hepatitis B virus (HBV) is divided into 8 groups, A–H. The interaction between HBV replication and immune responses against HBV infection plays an important role in the pathogenesis of virus infection. Aims and Objectives: In an attempt to elucidate the role of immunomodulatory, pro-inflammatory, and anti-inflammatory mediators in the pathogenesis...
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Abhishek Singhai, Karan Kapur, Sagar Khadanga, Aparna ParamanandamCHRISMED Journal of Health and Research 2019 6(3):187-190 We report a case of a 54-year-old female admitted to our hospital with altered behavior. We found that severe hyponatremia (116 mEq/L) was the cause of the patient's status. In turn, hyponatremia was due to panhypopituitarism. Mild-to-moderate hyponatremia had been previously detected in this patient; however, it was overlooked. The clinical onset of panhypopituitarism is...
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Vijay Prakash Turaka, Roshini G Nair, Tunny Sebastian, Rajesh Kannangai, Joy Sarojini Michael, George M VargheseCHRISMED Journal of Health and Research 2019 6(3):167-171 Context: Tuberculosis (TB) has become the most common opportunistic infection among individuals with human immunodeficiency virus (HIV) infection worldwide and continues to be a major killer resulting in 0.4 million deaths every year. While some of the risk factors for developing TB in HIV-infected individuals are known, identifying...
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Reddy Ravikanth, Kanagasabai KamalasekarCHRISMED Journal of Health and Research 2019 6(3):194-195
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Benjamin Effiong Udoh, Anthony Chukwuka Ugwu, Alhaji Modu Ali, Hyacinth Uche Chiegwu, Joseph Chukwuma Eze, Ulu Okoro UluCHRISMED Journal of Health and Research 2019 6(3):172-175 Aim: The study was to determine the normal fetal lateral ventricular diameter using ultrasound at different gestational ages (GAs). Materials and Methods: This is a prospective cross-sectional descriptive study of the fetal cerebral lateral ventricular diameter of 685 singleton fetuses. Measurement of the fetal lateral...
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Mahmood Dhahir Al-MendalawiCHRISMED Journal of Health and Research 2019 6(3):198-198
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