Technology in Cancer Research &Treatment, Volume 18, Issue , January 2019. Objective:Tumor-treating fields are currently used to successfully treat various cancers; however, the specific pathways associated with its efficacy remain unknown in the immune responses. Here, we evaluated tumor-treating fields–mediated initiation of the macrophage-specific immune response.Materials and Methods:We subjected RAW 264.7 mouse macrophages to clinically relevant levels of tumor-treating fields (0.9 V/cm,...
Technology in Cancer Research &Treatment, Volume 18, Issue , January 2019. Oral squamous cell carcinoma is one of the most common cancers around the world. The patients with oral squamous cell carcinoma are often diagnosed at late stages, leading to unfavorable prognosis. MicroRNAs might function as oncogenes or tumor suppressor genes in the tumorigenesis of cancer. This study aimed to explore the role of miR-1254 in oral squamous cell carcinoma. We examined the expression levels of miR-1254...
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Αλέξανδρος Γ. Σφακιανάκης
Laparoscopic Hyperthermic Intraperitoneal Chemotherapy is Safe for Patients with Peritoneal Metastases...Laparoscopic Hyperthermic Intraperitoneal Chemotherapy is Safe for Patients with Peritoneal Metastases from Gastric Cancer and May Lead to Gastrectomy"Author's Response to Reflexion on Consensus Statement on Oncoplastic Surgery, by Zucca-Matthes, Gustavo, et al.Bridging the Gap: Making Sense of the Diverging Evidence for Self-Expandable Metallic Stents in Malignant Colonic ObstructionsLaparoscopic...
Frequency and risk factors of diabetic retinopathy in patients with type 2 diabetes presenting at a tertiary care hospitalAbstractObjectiveTo evaluate frequency and risk factors of diabetic retinopathy in patients with type 2 diabetes.MethodologyThis prospective observational study was conducted from January 2017 to June 2017 at the outpatient department of Baqai Institute of Diabetology and Endocrinology (BIDE) and Baqai Medical University a tertiary care diabetes hospital of Karachi, Pakistan....
Abnormal positioning of the common carotid artery clinically diagnosed as a submandibular massAbstractThe common carotid artery (CCA) usually runs along the long axis of the neck, although it is occasionally found in an abnormal position or is displaced. We report a case of an 86-year-old woman in whom the CCA was identified in the submandibular area. The patient visited our clinic and reported soft tissue swelling in the right submandibular area. It resembled a tumor mass or a swollen lymph node....
Indications for Single-Operator Cholangioscopy and Pancreatoscopy: an Expert ReviewAbstractPurpose of reviewDirect endoscopic visualization of the biliary and pancreatic ducts by single-operator cholangioscopy (SOC) and pancreatoscopy (SOP) is an expanding technique with an increasing number of indications. This review provides technical tips and tricks and a literature update on the usefulness of SOC and SOP in clinical practice.Recent findingsSOC has shown a 91.3% and 87.3% diagnostic procedural...
Cost-effectiveness of patient navigation for breast cancer screening in the National Breast and Cervical Cancer Early Detection ProgramAbstractObjectivesPatient navigation (PN) services have been shown to improve cancer screening in disparate populations. This study estimates the cost-effectiveness of implementing PN services within the National Breast and Cervical Cancer Early Detection Program (NBCCEDP).MethodsWe adapted a breast cancer simulation model to estimate a population cohort of women...
Medicine by Alexandros G. Sfakianakis,Αλέξανδρος Γ. Σφακιανάκης Angewandte Chemie International Edition Trisulfide‐Bond Acenes for Organic Batteries Electrifying... Angewandte Chemie International Edition Trisulfide‐Bond Acenes for Organic BatteriesElectrifying sulfur: Single crystals of tetrathiotetracene (TTT) and hexathiapentacene (HTP) were synthesized using a zone‐melting chemical‐vapor‐transport method. When applied as organic battery electrodes, HTP shows a superior performance, which is...
A Comparison of Job Stress Models: Associations With Employee Well-Being, Absenteeism, Presenteeism, and Resulting CostsObjective: This study investigates the associations between Effort–Reward–Imbalance (ERI), Overcommitment (OC), Job–Demand–Control (JDC), and Organizational Injustice (OIJ) with employee well-being, absenteeism, and presenteeism, as well as the costs incurred. Methods: Cross-sectional data from 1440 German pharmaceutical company employees assessing job stress, employee well-being,...
Issue HighlightsNo abstract availableAnswering the question: Is the Doctor of Philosophy or Doctor of Nursing Practice right for me?Over the past decade, leading health care organizations have recommended doubling the number of doctorally prepared nurses to meet the future demands of health care. In 2018, the National Organization of Nurse Practitioner Faculties committed to move all nurse practitioner degree programs to the Doctor of Nursing Practice degree by 2025. As more and more doctorally prepared...
Association between CIRP expression and hypoxic‑ischemic brain injury in neonatal ratsLifang Chen, Qiaohuan Tian, Weihua WangView Abstract ❯Combined dynamic spectral imaging and routine colposcopy strategy for the diagnosis of pre‑cancerous cervical lesionsDan Liu, Wanliang HuView Abstract ❯Danon disease: Two patients with atrial fibrillation in a single family and review of the literatureShaohua Guo, Linghuan Zhou, Renping Wang, Zhixin Lv, Hongzun Xu, Baoli Han, Panagiotis Korantzopoulos, Fuli Hu,...
Unusual presentation of acute pulmonary hypertension in a patient with bilateral pneumonia and hypertrophic cardiomyopathyThe incidence of acute pulmonary hypertension (APH) in hospitalized patients with pneumonia is not known with certainty, although a mild and/or moderate pulmonary hypertension is often detected by transthoracic echocardiography in these patients. We describe a rare case of pneumonia of uncertain etiology that clinically manifested with APH and S1Q3T3 pattern on ECG in a patient...
Analgesic efficacy of ultrasound-guided interscalene block vs. supraclavicular block for ambulatory arthroscopic rotator cuff repair: A randomised noninferiority studyBACKGROUND Ultrasound-guided interscalene block (ISB) is the reference technique for pain control after ambulatory upper limb surgery, but supraclavicular block (SCB) is an alternative. OBJECTIVES The aim of this study was to compare the efficacy of SCB vs. ISB in patients undergoing ambulatory arthroscopic rotator cuff repair (ARCR),...
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Abstract Purpose Hypertension is a global public issue, and sleep status was regarded as its risk factor; however, the results were inconsistent. This study aims to deeply investigate the correlation between sleep status and hypertension. Methods The electronic databases Cochrane Library, Pubmed, and Embase updated to May 31, 2019, were retrieved. Studies...
Abstract Purpose To determine the accuracy of scoring masticatory muscle activity (MMA) events in seven different polysomnography (PSG) setups. Methods Nineteen volunteers (13 females, 6 males, age 31.1 ± 12.9 years, 12 self-proclaimed bruxers) attended one-night PSG recording, supplemented with audio, video, and a separate frontal electroencephalography...
Abstract Study objectives To assess the accuracy of WatchPAT (WP—Itamar-Medical, Caesarea, Israel) enhanced with a novel systolic upstroke analysis coupled with respiratory movement analysis derived from a dedicated snoring and body position (SBP) sensor, to enable automated algorithmic differentiation between central sleep apnea (CSA) and obstructive sleep apnea (OSA) compared with simultaneous in-lab sleep studies with polysomnography...
Abstract Purpose To find out if a moderate protrusion with a mandibular advancement device (MAD) can significantly increase the upper airway volume and, further, what signs and symptoms of obstructive sleep apnea (OSA) can be improved by this maneuver. Methods There were 58 adults diagnosed with OSA who were referred for MAD therapy. The mean apnea-hypopnea...
Abstract Purpose Polysomnography (PSG) is a standard diagnostic test for obstructive sleep apnea (OSA). However, PSG requires many skin-contacted sensors to monitor vital signs of patients, which may also hamper patients’ sleep. Because impulse-radio ultra-wideband (IR-UWB) radar can detect the movements of heart and lungs without contact, it may be utilized for vital sign monitoring during sleep. Therefore, we aimed to verify the accuracy...
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Abstract Melanoma is the most aggressive form of skin cancer, with a high mortality rate and with 96,480 new cases expected in 2019 in the USS. BRAFV600E, the most common driver mutation, is found in around 50% of melanomas, contributing to tumor growth, angiogenesis, and metastatic progression. Dacarbazine (DTIC), an alkylate agent, was the first chemotherapeutic agent approved by the US Food and Drug Administration (FDA) used as a standard treatment. Since then, immunotherapies...
Abstract This review summarizes the current knowledge on the importance and role of lipids in wine yeast fermentation. Lipids play an important role in membrane structure, adaptation to stress, or as signaling molecules. They are also essential nutrients whose availability can vary depending on winemaking technology, with major effects on yeast alcoholic fermentation. Moreover, lipid supplementation can greatly stimulate the formation of yeast volatile metabolites.
Abstract Pollution affects most of the urban and forest environments at different levels causing well-known effects on human and plant health. The influence that pollutants exert on plant-associated microbiota might direct plant health and, in some cases, also the removal of pollutants by plants. With the advent of nanotechnologies, an increasing amount of engineered nanoparticles are being introduced into the environment, and consequently, their impact on plant-associated microorganisms...
Abstract Functional carbohydrates are ideal substitutes for table sugar and make up a large share of the worldwide functional food market because of their numerous physiological benefits. Growing attention has been focused on levan, a β-(2,6) fructan that possesses more favorable physicochemical properties, such as lower intrinsic viscosity and greater colloidal stability, than β-(2,1) inulin. Levan can be used not only as a functional carbohydrate but also as feedstock for the...
Abstract β-N-Acetylhexosaminidases (EC 3.2.1.52) are a unique family of glycoside hydrolases with dual substrate specificity and a particular reaction mechanism. Though hydrolytic enzymes per se, their good stability, easy recombinant production, absolute stereoselectivity, and a broad substrate specificity predestine these enzymes for challenging applications in carbohydrate synthesis. This mini-review aims to demonstrate the catalytic potential of β-N-acetylhexosaminidases in...
Abstract Chlorogenic acids (CGA), the most abundant natural polyphenol present in human diet and plants, have attracted considerable research interest because of their broad bioactivities including the antimicrobial activity. However, little is known about their influences on intestinal bacterial communities. Here, we described a response in intestinal microbiome to CGA using a porcine model. Twenty-four weaned pigs were allotted to two groups and fed with a basal diet or a basal...
Abstract The introduction of the key non-oxidative glycolytic (NOG) pathway enzyme, phosphoketolases (PKTs), into heterologous hosts can improve the yield of a variety of acetyl CoA-derived products of interest. However, the low specific activity of existing PKTs compared with that of 6-phosphofructokinase (PFK), the key EMP pathway enzyme, largely limits their potential applications. To improve PKT activity, previous attempts have focused on increasing intracellular PKT concentration...
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Obesity is a cardiovascular disease risk factor. Conventional weight loss (CWL) programmes focus on weight loss, however ‘health, not weight loss, focused’ (HNWL) programmes concentrate on improved health and ...
Psychological violence is estimated to be the most common form of intimate partner violence (IPV). Despite this, research on the independent effect of psychological violence on mental health is scarce. Moreove...
Whiplash is a common traumatic cervical injury which is most often a consequence of rear-end motor vehicle accidents. It has been estimated that up to 50% of the whiplash patients suffer from chronic symptoms,...
Non-specific low back pain (LBP) is the leading cause of disability worldwide. Acute LBP usually has a good prognosis, with rapid improvement within the first 6 weeks. However, the majority of patients develop...
One of the most challenging health problems is liver disease, which can be caused by medications, toxic substances, and excessive consumption of alcohol. Liver problems can be also caused by infections, autoim...
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Papillary lesions of the male breast (PLMB) are uncommon. To date, PLMB have been reported as individual case reports and in relatively small series. We reviewed cases of PLMB diagnosed at our medical center over a 19-year (2000-2019) period. A total of 117 cases were identified, with an age range of 7 months to 88 years. These cases included 3 of papillary ductal hyperplasia, 5 intraductal papillomas, 1 adenomyoepithelioma, 5 atypical papillomas (ie, papillomas with atypia), 51 papillary ductal...
Metastatic invasive lobular carcinoma (mILC) may masquerade as primary diffuse gastric adenocarcinoma (PDGA) by demonstrating significant clinical and pathologic overlap. Accurate distinction is of therapeutic and prognostic significance. On the basis of anecdotal cases of mILC that lacked estrogen receptor and/or GATA3 expression, we analyzed the cytoarchitectural features of 28 mILC and 44 PDGA specimens obtained from women to assess features that would help in this distinction and prompt ancillary...
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Mucinous nonneoplastic cyst of the pancreas is a rare disease defined as a cystic lesion lined with mucinous epithelium, supported by hypocellular stroma and not communicating with the pancreatic ducts. Mucino...
Hyperammonemia is a common cause of metabolic encephalopathy, mainly related to hepatic cirrhosis. Numerous nonhepatic etiologies exist but they are infrequent and not well known, thus, leading to misdiagnosis...
Cervical lymph node swelling is quite a common symptom mainly caused by infections in the face or as metastasis of a malignant tumor. In infection cases in particular, rare diseases should never be overlooked....
Acute appendicitis is known to cause intestinal obstruction. The presentation is commonly due to functional obstruction, but on very rare occasions it presents as mechanical obstruction, especially closed loop.
Solitary fibrous tumors are tumors of mesenchymal origin that occur in the extremities and occasionally in pleura, meninges, and so on, but are extremely rare in the adrenal gland. Their biological behavior is...
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Background: In an attempt to improve patient care, a perioperative complex spine surgery management protocol was developed through collaboration between spine surgeons and neuroanesthesiologists. The aim of this study was to investigate whether implementation of the protocol in 2015 decreased total hospital and intensive care unit (ICU) length of stay (LOS) and complication rates after elective complex spine surgery. Materials and Methods: A retrospective cohort study was conducted by review...
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Publication date: September 2019Source: Neoplasia, Volume 21, Issue 9Author(s): E Fiegle, D Doleschel, S Koletnik, A Rix, R Weiskirchen, E Borkham-Kamphorst, F Kiessling, W LederleAbstractImmune checkpoint inhibitors have shown clinical benefit in several cancer entities including metastatic microsatellite instable colorectal carcinomas. However, for the majority of metastatic colorectal carcinomas the potential and limitations of immune checkpoint inhibition is not fully understood. In this study,...
Publication date: September 2019Source: Neoplasia, Volume 21, Issue 9Author(s): Guangxi Sun, Xingming Zhang, Zhenhua Liu, Sha Zhu, Pengfei Shen, Haoran Zhang, Mengni Zhang, Ni Chen, Jinge Zhao, Junru Chen, Jiandong Liu, Jindong Dai, Zhipeng Wang, Xudong Zhu, Yufang Wang, Hao ZengAbstractThe survival of patients diagnosed with metastatic renal cell carcinoma (RCC) is still limited and the current targeted therapies are only partially effective. Herein, we investigated the clinical value and functions...
Publication date: September 2019Source: Neoplasia, Volume 21, Issue 9Author(s): Jingjing Wang, Ning Zhang, Minggang Peng, Xiaohui Hua, Chao Huang, Zhongxian Tian, Qipeng Xie, Junlan Zhu, Jingxia Li, Haishan Huang, Chuanshu HuangAbstractRecent studies show p85α up-regulates epidermal growth factor (EGF) receptor, thereby promoting malignant cell transformation and migration in normal mouse embryonic fibroblasts (MEFs). However, the potential role of p85α in human bladder cancer (BC) remains unknown....
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Publication date: Available online 10 August 2019Source: Journal of ProteomicsAuthor(s): Mandvi Sharma, Dres Damgaard, Ladislav Senolt, Birte Svensson, Anne-Christine Bay-Jensen, Claus Henrik Nielsen, Per HägglundAbstractCitrullination is a post-translational protein modification, which is associated with inflammation in general and is thought to play an important pathogenic role in rheumatoid arthritis (RA). Here a mass spectrometry-based proteomics approach was applied to identify citrullination...
Publication date: Available online 8 August 2019Source: Journal of ProteomicsAuthor(s): Hongyu Liang, Guixian Jiang, Tengjiao Wang, Jie Zhang, Wenwen Liu, Zheng Xu, Jing Zhang, Liang XiaoAbstractJellyfish is a common toxic zooplankton in ocean. We successfully captured a kind of jellyfish 200 m underwater in Antarctica, and identified it as a jellyfish Cyanea sp. through morphological examination and MT-CO1 phylogenetic analysis. A total of 40,468 unigenes were harvested through transcriptome sequencing....
Publication date: Available online 8 August 2019Source: Journal of ProteomicsAuthor(s): Tao Wang, Wenxu Zhu, Hongyan Zhang, Xin Wen, Shaowu Yin, Yongyi JiaAbstractOdontobutis potamophila is a valuable species for aquaculture in China, which shows asexually dimorphic growth pattern. In this study, the integrated proteomics and metabolomics were used to analyze the sex determination mechanism. A total of 2781 significantly different regulated proteins were identified by proteomics and 2693 significantly...
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Publication date: Available online 10 August 2019Source: Behavioural Brain ResearchAuthor(s): Jessica Bratzu, Rahul Bharatiya, Elias Manca, Cristina Cocco, Antonio Argiolas, Maria Rosaria Melis, Fabrizio SannaAbstractOxytocin (5, 20 and 100 ng) injected unilaterally into the bed nucleus of the stria terminalis (BNST) of male rats stereotaxically implanted with a microinjection cannula coupled to a microdialysis probe, induces penile erection and yawning that occur concomitantly with a dose-dependent...
Publication date: Available online 9 August 2019Source: Behavioural Brain ResearchAuthor(s): Ting Xu, Zhiyi Chen, Tingyong FengAbstractPeople inevitably make decisions between short-term and long-term consequences across domains like education, health and economics. In this kind of decision, the tendency to discount the value of later-larger rewards with increasing delays is defined as delay discounting (DD). A recent review has suggested that three neural systems which respectively responsible for...
Publication date: Available online 9 August 2019Source: Behavioural Brain ResearchAuthor(s): Kyle Flack, Christopher Pankey, Kelsey Ufholz, LuAnn Johnson, James N. RoemmichAbstractBackground: Exercise is a reinforcing behavior and finding exercise highly reinforcing is characteristic of habitual exercisers. Genotypes related to dopamine metabolism moderate the reinforcing value of behaviors, but genetic moderators of exercise reinforcement have not been established.Purpose: Determine whether singular...
Publication date: Available online 8 August 2019Source: Behavioural Brain ResearchAuthor(s): Mariano D’Angelo, Giuseppe di Pellegrino, Francesca FrassinettiAbstractThe brain constructs a functional representation of the space around the body, the so called peripersonal space (PPS), which is a sensorimotor interface used to ensure suitable motor acts. However, this sector of space is also involved in social interactions. Individuals indeed, maintain an interpersonal space (IPS) indicating how close...
Publication date: Available online 8 August 2019Source: Behavioural Brain ResearchAuthor(s): Hiroyuki ArakawaAbstractBehavioral studies in animal models have advanced our knowledge of brain function and the neural mechanisms of human diseases. Commonly used laboratory rodents, such as mice and rats, provide a useful tool for studying the behaviors and mechanisms associated with learning and memory processes which are cooperatively regulated by multiple underlying factors, including sensory and motor...
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Publication date: 1 January 2020Source: Talanta, Volume 206Author(s): O.D. Marbello, S. Valbuena, F.J. RacedoAbstractOrganic compounds and vegetable origin oils are subject to scratiny in the photonics and nonlinear optics area, due to their high non-linear response: a characteristic linked to the molecular nature of these compounds and their own chemical bond. In the food industry, quick and non-invasive studies are needed to evaluate the nutritional quality of edible products. The nonlinear optical...
Publication date: 1 January 2020Source: Talanta, Volume 206Author(s): Larissa M.A. de Oliveira, Vagner Bezerra dos Santos, Emelle K.N. da Silva, Alessandra Santos Lopes, Heronides A. Dantas-FilhoAbstractA new method to determine the total titratable acidity of orange, lemon and passion fruit, based on a spot test obtained from digital images and using anthocyanins as the biodegradable indicator, is presented for the first time. The colorimetric reactions were carried out by acid-base titration on...
Publication date: 1 January 2020Source: Talanta, Volume 206Author(s): Hadla S. Ferreira, Borja Moreira-Alvarez, Antonio R. Montoro Bustos, Jorge Ruiz Encinar, José M. Costa-Fernández, Alfredo Sanz-MedelAbstractThe asymmetric flow field-flow fractionation (AF4) coupled on-line with elemental (inductively coupled plasma-mass spectrometry, ICP-MS) and molecular (fluorescence and UV) detection has been investigated as a powerful tool for the characterization of bioinorganic nano-conjugates. In this study,...
Publication date: 1 January 2020Source: Talanta, Volume 206Author(s): Christian Becker, Maik A. Jochmann, Thorsten Teutenberg, Torsten C. SchmidtAbstractWithin this study, a novel liquid chromatography (LC)/flame ionization detector (FID) interface was improved. In contrast to previously published interface concepts, the main nebulizer body and the transfer capillary was made of stainless steel. Previously reported problems such as blocking of the transfer capillary were investigated. The simple...
Publication date: 1 January 2020Source: Talanta, Volume 206Author(s): Ting Xiao, Jianshe Huang, Dewen Wang, Tian Meng, Xiurong YangAbstractThis review summarizes the synthesis of gold (Au) and Au-based nanomaterials and their recent advances of application in electrochemical small-molecule sensors, DNA sensors and immunosensors. Au nanoparticles with various shape and size have been synthesized by using physical, chemical, biological, electrochemical and seeding growth methods. In order to broaden...
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Whether adaptation is limited by the beneficial mutation supply is a long-standing question of evolutionary genetics, which is more generally related to the determination of the adaptive substitution rate and its relationship with the effective population size Ne. Empirical evidence reported so far is equivocal, with some but not all studies supporting a higher adaptive substitution rate in large-Ne than in small-Ne species. We gathered coding sequence polymorphism data and estimated the adaptive...
Seasonal influenza viruses are constantly changing, and produce a different set of circulating strains each season. Small genetic changes can accumulate over time and result in antigenically different viruses; this may prevent the body's immune system from recognizing those viruses. Due to rapid mutations, in particular in the hemagglutinin gene, seasonal influenza vaccines must be updated frequently. This requires choosing strains to include in the updates to maximize the vaccines' benefits, according...
Environmental variation along the geographical space can shape populations by natural selection. In the context of global warming, accompanied by substantial changes in precipitation regimes, it is crucial to understand the role of environmental heterogeneity in tropical trees adaptation, given their disproportional contribution to water and carbon biogeochemical cycles. Here we investigated how heterogeneity in freshwater availability along tropical wetlands has influenced molecular variations of...
Variation in among-family transcriptional responses to different environmental conditions can help to identify adaptive genetic variation, even prior to a selective event. Coupling differential gene expression with formal survival analyses allows for the disentanglement of treatment effects, required for understanding how individuals plastically respond to environmental stressors, from the adaptive genetic variation responsible for among-family variation in survival and gene expression. We applied...
Human centromeres are remarkable in four ways: they are i) defined epigenetically by an elevated concentration of the histone H3 variant CENP-A, ii) inherited epigenetically by trans-generational cary-over of nucleosomes containing CENP-A, iii) formed over unusually long and complex tandem repeats (Higher Order Repeats, HORs) that extend over exceptionally long arrays of DNA (up to 8 Mb), and iv) evolve in such a rapid and punctuated manner that most HORs on orthologous chimp and human chromosomes...
Experimental evolution of microbes can be used to empirically address a wide range of questions about evolution. Because fitness assays are a central component of experimental evolution, they can limit the scope and throughput of such studies. We created an experimental evolution system in Saccharomyces cerevisiae that utilizes genetic barcoding to overcome this challenge. We confirm that barcode insertions do not alter fitness and can be used to detect fitness differences of 2%. Using this system,...
Human centromeres form over arrays of tandemly repeated DNA that are exceptionally complex (repeats of repeats) and long (spanning up to 8 Mbp). They also have an exceptionally rapid rate of evolution. The generally accepted model for the expansion/contraction, homogenization and evolution of human centromeric repeat arrays is a generic model for the evolution of satellite DNA that is based on unequal crossing over between sister chromatids. This selectively neutral model predicts that the sequences...
Under the model of micromutationism, phenotypic divergence between species is caused by accumulation of many small-effect changes. While mapping the causal changes to single nucleotide resolution could be difficult for diverged species, genetic dissection via chimeric constructs allows us to evaluate whether a large-effect gene is composed of many small-effect nucleotide changes. In a previously described non-complementation screen, we found allele difference of CUP2, a copper-binding transcription...
Modern speciation theory has greatly benefited from a variety of simple mathematical models focusing on the conditions and patterns of speciation and diversification in the presence of gene flow. Unfortunately the application of general theoretical concepts and tools to specific ecological systems remains a challenge. Here we apply modeling tools to better understand adaptive divergence of whitefish during the postglacial period in lakes of northern Fennoscandia. These lakes harbor up to three different...
The cumulative reproductive cost of multi-locus selection has been seen as a potentially limiting factor on the rate of adaptive evolution. In this paper, we show that Haldanes arguments for the accumulation of reproductive costs over multiple loci are valid only for a clonally reproducing population of asexual genotypes. We show that a sexually reproducing population avoids this accumulation of costs. Thus, sex removes a perceived reproductive constraint on the rate of adaptive evolution. The significance...
Metagenomic studies have claimed the existence of novel lineages with unprecedented properties never before observed in prokaryotes. Such lineages include Asgard archaea, which are claimed to represent archaea with eukaryotic cell complexity, and the Candidate Phyla Radiation (CPR), a novel domain level taxon erected solely on the basis of metagenomic data. However, it has escaped the attention of most biologists that these metagenomic sequences are not assembled into genomes by sequence overlap,...
Whether adaptation is limited by the beneficial mutation supply is a long-standing question of evolutionary genetics, which is more generally related to the determination of the adaptive substitution rate and its relationship with the effective population size Ne. Empirical evidence reported so far is equivocal, with some but not all studies supporting a higher adaptive substitution rate in large-Ne than in small-Ne species. We gathered coding sequence polymorphism data and estimated the adaptive...
Mycobacterium riyadhense is a novel non-tuberculous mycobacterium (NTM) that is increasingly isolated from clinical cases with tuberculosis (TB)-like symptoms in humans in various parts of the world. To elucidate the genomic hallmarks that define the relationship between M. riyadhense and other mycobacterial species, including members of the Mycobacterium tuberculosis complex (MTBC), eight clinical isolates of M. riyadhense were analysed. M. riyadhense shares a large number of conserved orthologues...
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Publication date: Available online 10 August 2019Source: CortexAuthor(s): Maura Malpetti, Giulia Carli, Arianna Sala, Chiara Cerami, Alessandra Marcone, Sandro Iannaccone, Giuseppe Magnani, Daniela PeraniAbstractBrain connectivity measures represent candidate biomarkers of neuronal dysfunction in neurodegenerative diseases. Previous findings suggest that the behavioural variant of frontotemporal dementia (bvFTD) and its variants (i.e. frontal and temporo-limbic) may be related to the vulnerability...
Publication date: Available online 10 August 2019Source: CortexAuthor(s): Celia Goffin, H.Moriah Sokolowski, Michael Slipenkyj, Daniel AnsariAbstractA key question in the field of numerical cognition is how the human brain represents numerical symbols (e.g., Arabic digits). A large body of research has implicated left parietal regions in symbolic number processing. One possible explanation for this lateralization of neural activity is the handedness of participants. Specifically, participants in...
Publication date: Available online 10 August 2019Source: CortexAuthor(s): Lisa Fleury, Claude Prablanc, Anne-Emmanuelle PriotAbstractSensorimotor plasticity allows the nervous system to set up appropriate motor and sensory compensations when individuals face changing demands in a given motor task. A much-debated question in neuroscience research is the identification of processes that encompass this capacity of plasticity. Prism adaptation is the oldest experimental paradigm that has been used to...
Publication date: Available online 10 August 2019Source: CortexAuthor(s): Ettore Ambrosini, Sandra Arbula, Chiara Rossato, Valentina Pacella, Antonino VallesiAbstractExecutive functions refer to high-level cognitive processes that, by operating on lower-level mental processes, flexibly regulate and control our thoughts and goal-directed behavior. Despite their crucial role, the study of the nature and organization of executive functions still faces inherent difficulties. Moreover, most executive...
Publication date: Available online 9 August 2019Source: CortexAuthor(s): Emily Kubicek, Lorna C. QuandtAbstractWhen a person observes someone else performing an action, the observer’s sensorimotor cortex activates as if the observer is the one performing the action, a phenomenon known as action simulation. While this process has been well-established for basic (e.g. grasping) and complex (e.g. dancing) actions, it remains unknown if the framework of action simulation is applicable to visual languages...
Publication date: Available online 9 August 2019Source: CortexAuthor(s): Franziska Storbeck, Karola Schlegelmilch, Kaspar-Josche Streitberger, Werner Sommer, Christoph J. PlonerAbstractWe investigated the impact of acute facial palsy on the recognition of emotional facial expressions. Thirty-one patients with acute facial palsy and 30 healthy controls performed a well-established test battery with tasks both for mere face recognition (FACE) and for recognition of emotional facial expressions (EMO)....
Publication date: Available online 8 August 2019Source: CortexAuthor(s): William J. Harrison
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18 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "BMJ Open"[jour] These pubmed results were generated on 2019/08/11PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
18 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "BMJ Open"[jour] These pubmed results were generated on 2019/08/11PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Related ArticlesIdentifying hearing care access barriers among older Pacific Island people in New Zealand: a qualitative study. BMJ Open. 2019 Aug 06;9(8):e029007 Authors: Reddy R, Welch D, Lima I, Thorne P, Nosa V Abstract OBJECTIVES: Hearing loss is one of the most prevalent conditions affecting older people. In addition, there is little known about the factors influencing the uptake of hearing services among underserved communities. Our objective...
Related ArticlesWhat were the impacts of the Committee on Safety of Medicines warning and publication of the NICE guidelines on trends in child and adolescent antidepressant prescribing in primary care? A population based study. BMJ Open. 2019 Aug 07;9(8):e028201 Authors: Tiffin PA, Mediavilla JL, Close H, Kasim AS, Welsh P, Paton LW, Mason JM Abstract OBJECTIVES: To assess the impact of both the Committee on Safety of Medicines (CSM) warning (December...
Related ArticlesMissing female patients: an observational analysis of sex ratio among outpatients in a referral tertiary care public hospital in India. BMJ Open. 2019 Aug 07;9(8):e026850 Authors: Kapoor M, Agrawal D, Ravi S, Roy A, Subramanian SV, Guleria R Abstract OBJECTIVE: To investigate gender discrimination in access to healthcare and its relationship with the patient's age and distance from the healthcare facility. DESIGN AND SETTING:...
Related ArticlesProcess evaluations of primary care interventions addressing chronic disease: a systematic review. BMJ Open. 2019 Aug 06;9(8):e025127 Authors: Liu H, Mohammed A, Shanthosh J, News M, Laba TL, Hackett ML, Peiris D, Jan S Abstract OBJECTIVE: Process evaluations (PEs) alongside randomised controlled trials of complex interventions are valuable because they address questions of for whom, how and why interventions had an impact. We synthesised...
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770 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: medical science These pubmed results were generated on 2019/08/11PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
770 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: medical science These pubmed results were generated on 2019/08/11PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
2221 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: medical science These pubmed results were generated on 2019/08/10PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
2376 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: medical science These pubmed results were generated on 2019/08/09PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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17 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human physiology These pubmed results were generated on 2019/08/11PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
17 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human physiology These pubmed results were generated on 2019/08/11PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
77 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human physiology These pubmed results were generated on 2019/08/10PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
123 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human physiology These pubmed results were generated on 2019/08/09PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
123 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human physiology These pubmed results were generated on 2019/08/09PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Related Articles[Olaparib and pancreatic cancer: A challenging Lesson]. Bull Cancer. 2019 Aug 06;: Authors: Louvet C, Samalin E, Michel P PMID: 31399206 [PubMed - as supplied by publisher]
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