Κυριακή 15 Σεπτεμβρίου 2019


Clinical, microbiological, immunological and imaging characteristics of tunnels and fistulas in hidradenitis suppurativa and Crohn's disease
Abstract Hidradenitis suppurativa (HS) tunnels and Crohn's disease (CD) fistulas are a challenge to treat. Although pathogenic similarities have been described between HS and CD, recent studies indicate that clinical, microbiological, immunological and imaging characteristics differ between these diseases. This review highlights the differences between HS tunnels and CD fistulas. Next generation sequencing studies demonstrate a microbiome in HS tunnels dominated by Porphyromonas spp., Prevotella...
Experimental Dermatology
Fri Sep 13, 2019 12:38
Voriconazole enhances UV‐induced DNA damage by inhibiting catalase and promoting oxidative stress
Abstract Cutaneous squamous cell carcinoma (cSCC) is the second most common form of skin cancer and is associated with cumulative UV‐exposure. Studies have shown that prolonged voriconazole usepromotescSCC formation; however, the biological mechanisms responsible for the increased incidence remain unclear. Here, we show that voriconazole directlyincreases oxidative stress in human keratinocytes and promotes UV‐induced DNA damage as determined by comet assay, 8‐oxo‐guanine immunofluorescence and...
Experimental Dermatology
Fri Sep 13, 2019 12:59
The influence of MC1R dermal morphological features of photoexposed skin in women revealed by reflectance confocal microscopy and optical coherence tomography
Abstract Background The melanocortin 1 receptor (MC1R) gene is one of the major determinants of skin pigmentation. It is a highly polymorphic gene and some of its polymorphisms, have been related to specific skin phenotypes, increased risk of skin cancers and skin photoaging. Currently, its contribution to changes in dermal features in photo‐exposed skin is unknown. Objective The main objective of this study is to evaluate the potential correlation between MC1R status and specific healthy...
Experimental Dermatology
Sat Sep 14, 2019 14:29
The adjunctive effect of rh‐BMP‐2 on the regeneration of peri‐implant bone defects after experimental peri‐implantitis
Abstract Objectives The aim was to evaluate the degree of bone regeneration and re‐osseointegration attained when combining a xenogeneic bone replacement graft plus rhBMP‐2 and a collagen membrane in ligature induced peri‐implantitis osseous defects in dogs. Material and Methods 36 implants were placed in a total of 6 Beagle dogs, 3 months after tooth extraction. Once experimental peri‐implantitis was induced, defects were randomly allocated into two treatment groups: in the test group...
Clinical Oral Implants Research
Thu Sep 12, 2019 13:38
Effect of Implant Neck Design on Primary and Secondary Implant Stability in the Posterior Maxilla: A prospective randomized controlled study
Abstract Objective To compare the early changes in implant stability of Implants with different neck design during the first 3 months of healing in the posterior maxilla. Materials and Methods Patients were randomized to receive triangular neck implant (test), or round neck implant (control). Resonance frequency analysis (ISQ) measurements were obtained at surgery and at 2, 4, 7, 14, 21, 28, 45, 60 and 90 days following implant placement. Non‐parametric statistic was used for data analysis....
Clinical Oral Implants Research
Fri Sep 13, 2019 22:29
The relationship between dental implant papilla and dental implant mucosa around single‐tooth implant in the esthetic area: a retrospective study
Abstract Objective The aim of the present study was (1) to evaluate the relationship between dental implant mucosa and dental implant papilla levels, and (2) to identify the clinical parameters associated with peri‐implant soft tissue stability over time. Materials and Methods This is a retrospective study on a cohort of patients seeking a single‐tooth implant therapy in a private practice in the Paris area. Two independent examiners analyzed photographs and radiographs taken the day of...
Clinical Oral Implants Research
Sat Sep 14, 2019 14:23
A preclinical model links osseo‐densification due to misfit and osseo‐destruction due to stress/strain
Abstract Objective Primary stability is a prerequisite for implant osseointegration. Some degree of misfit between an implant and its osteotomy is required to ensure primary stability, and this is typically achieved by undersizing an implant osteotomy. In this preclinical study, we aimed at understanding the relationship between misfit, insertion torque, implant stability, and their cumulative short‐ and longer‐term effects on peri‐implant bone. Materials and methods We placed implants...
Clinical Oral Implants Research
Sat Sep 14, 2019 14:29
Saliva microbiome in primary Sjogren's syndrome reveals distinct set of disease associated microbes
Abstract Objective This study systematically aims to evaluate the salivary microbiome in patients with primary Sjögren's syndrome(pSS) using 16S rRNA sequencing approach. Methods DNA isolation and 16S rRNA sequencing was performed on saliva of 37 pSS and 35 control (CC) samples on HiSeq 2500 platform. 16S rRNA sequence analysis was performed independently using two popular computational pipelines, QIIME and LoTuS. Results There were no significant changes in the alpha diversity between...
Oral Diseases
Thu Sep 12, 2019 14:22
Comparing the Effectiveness and Adverse Effects of Pilocarpine and Cevimeline in Patients with Hyposalivation
Abstract Objectives Pilocarpine(PILO) and cevimeline(CEV) are muscarinic acetylcholine‐receptor agonists that stimulate salivary gland function. The aim of this investigation was to retrospectively run a head‐to‐head comparison for their effectiveness and frequency of adverse effects in patients with hyposalivation. Methods A retrospective chart review was conducted for patients seen at the Oral Medicine Clinic at Tufts University School of Dental Medicine(TUSDM) and were prescribed PILO...
Oral Diseases
Sat Sep 14, 2019 15:23
Tumor depth of invasion and prognosis of early‐stage oral squamous cell carcinoma: a meta‐analysis
Abstract Objectives To assess the prognosis for early‐stage oral squamous cell carcinoma according to tumor depth of invasion (DOI). Methods PROSPERO #CRD42017059976. Search was conducted in six electronic databases up to May 2019. Fixed effect meta‐analysis was performed for the calculation of the odds ratio (OR) and respective 95% CI. Primary outcomes were lymph node metastasis, recurrence, and survival. Heterogeneity was calculated by the I2 test. Certainty of evidence was assessed by...
Oral Diseases
Sat Sep 14, 2019 18:39
Renin-Angiotensin Inhibition in Combating Malignancy: A Review
Our previous review of the literature assessed the existing knowledge (until 2000) about the possible link between angiotensin-converting enzyme inhibitors (ACEIs) and factors influencing the development of malignancies. We reviewed the literature for reports of statistical associations (or lack thereof) between ACEi treatment and incidence of specific cancers (e.g. breast, gastrointestinal, and skin). We concluded then that results from the epidemiological studies are conflicting, even taking the...
Hellenic Anticancer Institute
Sat Sep 14, 2019 03:11
Sarcopenia as Prognostic Factor in Lung Cancer Patients: A Systematic Review and Meta-analysis
Background/Aim: Sarcopenia describes the loss of skeletal muscle mass. While this condition is associated with a high mortality in cancer patients, its influence on survival is still underestimated. Patients and Methods: A systematic review for articles was performed using the PubMed database, Cochrane Library, Biomed Central, Science Direct and by manual search. We used data of overall survival in sarcopenic patients for assessing the death risk. We extracted hazard ratio estimates from univariate...
Hellenic Anticancer Institute
Sat Sep 14, 2019 03:11
Treatment Algorithm for Patients With Gastric Adenocarcinoma: An Austrian Consensus on Systemic Therapy
Despite recent advances in the treatment of gastric cancer, mortality related to this disease is still substantial. Surgery and chemotherapy represent the cornerstones of patient management. Targeted treatments that include anti-angiogenic agents and the advent of immunotherapies can contribute to improved patient prognosis. Herein, we present an Austrian consensus on the systemic treatment of patients with gastric adenocarcinoma and lower gastroesophageal junction, including those with human epidermal...
Hellenic Anticancer Institute
Sat Sep 14, 2019 03:11
Arterial Thrombosis in Cancer: Spotlight on the Neglected Vessels
Cancer patients are at risk for both venous and arterial thrombotic events. Accumulating evidence suggests a link between cancer and arterial thrombosis events. The pathophysiology of arterial thrombosis in cancer is complex and multifactorial. The risk of arterial thrombosis in cancer patients relies on individual risk factors, on cancer-related hypercoagulability, on anticancer drugs and radiotherapy often via a common underlying mechanism of endothelial dysfunction. This review describes the mechanisms...
Hellenic Anticancer Institute
Sat Sep 14, 2019 03:11
Vitamin D and Cardiovascular Disease: An Update
In the clinical setting, administration of high daily or bolus doses of vitamin D is often solely based on 25-hydroxyvitamin D [25(OH)D] testing. This review summarizes the evidence of the effect of vitamin D on cardiovascular disease (CVD). Meta-analyses of randomized controlled trials (RCTs) have demonstrated that CVD risk markers, such as lipid parameters, inflammation markers, blood pressure, and arterial stiffness, are largely unaffected by vitamin D supplementation. Similar results have been...
Hellenic Anticancer Institute
Sat Sep 14, 2019 03:11
The Role of Particle Therapy in the Risk of Radio-induced Second Tumors: A Review of the Literature
One of the most important late side-effects of radiation therapy is the development of radiation-induced secondary malignancies. In the last years, this topic has significantly influenced treatment decision-making as the number of long-term cancer survivors has significantly increased with advances in treatment modalities. All efforts are being made to prevent the incidence of tumors induced by radiation. In this review article we summarize the current knowledge about treatment-related secondary...
Hellenic Anticancer Institute
Sat Sep 14, 2019 03:11
Immune Check Point CD40-CD40L Activates Dendritic and Effector Cells Against Human Renal Carcinoma Cells
Background/Aim: Adenoviral-mediated expression of CD40 ligand (CD40L) on dendritic cells (DCs) activates immune check point CD40/CD40L, enhancing the immunostimulation of DCs and effector cells against human renal carcinoma cells (RCC) and inducing tumor cell apoptosis in vitro. Materials and Methods: DCs, isolated from buffy coats from healthy donors, were transduced with adenoviruses carrying human CD40L (Ad-hCD40L). Subsequently maturation marker and cytokine expression were analyzed by fluorescence-activated...
Hellenic Anticancer Institute
Sat Sep 14, 2019 03:11
Oral Recombinant Methioninase, Combined With Oral Caffeine and Injected Cisplatinum, Overcome Cisplatinum-Resistance and Regresses Patient-derived Orthotopic Xenograft Model of Osteosarcoma
Background/Aim: Osteosarcoma is a recalcitrant neoplasm which occurs predominantly in adolescents and young adults. Recently, using a patient-derived orthotopic xenograft (PDOX) model of malignant soft-tissue sarcoma (STS), we showed that oral recombinant methioninase (o-rMETase), in combination with caffeine, was more efficacious than o-rMETase alone in inhibiting STS tumor growth. In the present report, we determined the efficacy of o-rMETase combined with oral caffeine on a cisplatinum (CDDP)-resistant...
Hellenic Anticancer Institute
Sat Sep 14, 2019 03:11
AMMECR1 Inhibits Apoptosis and Promotes Cell-cycle Progression and Proliferation of the A549 Human Lung Cancer Cell Line
Aim: The aim of this study was to characterize the role of Alport syndrome, mental retardation, midface hypoplasia, and elliptocytosis chromosomal region gene 1 (AMMECR1) in human lung cancer cell lines. Materials and Methods: AMMECR1 gene expression was evaluated in four lung cell lines, with A549 then selected for further in-depth examination. To characterize the role of AMMECR1, silencing was achieved utilizing lentivirus-mediated RNA interference, and confirmed by quantitative real-time polymerase...
Hellenic Anticancer Institute
Sat Sep 14, 2019 03:11
Oral Recombinant Methioninase Overcomes Colorectal-cancer Liver Metastasis Resistance to the Combination of 5-Fluorouracil and Oxaliplatinum in a Patient-derived Orthotopic Xenograft Mouse Model
Background/Aim: Liver metastasis in colorectal-cancer is a recalcitrant disease. To develop precision individualized therapy of this disease, we developed a patient-derived orthotopic xenograft (PDOX) model of colorectal-cancer liver metastasis. In the present report, we evaluated the efficacy of oral recombinant methioninase (o-rMETase) in combination with 5-fluorouracil (5-FU) and oxaliplatinum (OXA) on the colorectal-cancer liver metastasis PDOX mouse model. Materials and Methods: Colorectal-cancer...
Hellenic Anticancer Institute
Sat Sep 14, 2019 03:11
High Sensitivity to Cholic Acid-induced Colonic Tumorigenesis Makes Female PIRC Rats (F344/NTac-Apcam1137) a Suitable Model for Studying CRC-promoting Agents
Background/Aim: Rats of the adenomatous polyposis coli (Apc)-mutated female polyposis in rat (PIRC) (F344/NTac-Apcam1137) model exhibit a low level of intestinal tumorigenesis and are thus potentially exploitable as a model for identifying substances increasing colorectal cancer (CRC). Materials and Methods: To test this possibility, we treated such rats with the bile acid (BA) cholic acid (CA) (0.3% w/w in the diet), known to promote CRC, and assessed tumorigenesis. Results: Precancerous colonic...
Hellenic Anticancer Institute
Sat Sep 14, 2019 03:11
Antiproliferative Effects of Short-chain Fatty Acids on Human Colorectal Cancer Cells via Gene Expression Inhibition
Background/Aim: Short-chain fatty acids (SCFAs) inhibit human colorectal cancer cell growth and tumorigenicity. We investigated the mechanism of the anti-proliferative effects of SCFAs on human colorectal cancer cells by examining their effects on gene expression. Materials and Methods: The DLD-1 cell line was cultured with different SCFAs. Gene groups whose expression levels decreased to <50% or increased >50% compared to untreated cells and the signalling pathways responsible for DLD-1 cell...
Hellenic Anticancer Institute
Sat Sep 14, 2019 03:11
Schwannoma of Foot and Ankle: Seven Case Reports and Literature Review
Background: Schwannoma is most often grown on the trunk, upper and lower extremities, and head and neck, but rarely on the foot. This study aimed to reveal clinical presentations, histopathology and treatment options for schwannoma of the foot. Materials and Methods: Seven schwannomas out of 174 soft-tissue tumors on the foot and ankle were retrieved from our Institute in a 3-year period, and 42 schwannomas on the foot and ankle in the literature in a 30-year period were reviewed. Results: The incidence...
Hellenic Anticancer Institute
Sat Sep 14, 2019 03:11
Outcome of Pediatric Acute Lymphoblastic Leukemia: Sixty Years of Progress
Background: A retrospective analysis was performed to investigate the survival outcomes in pediatric acute lymphoblastic leukemia (ALL) based on time period. We hypothesized that improvement has been obtained with the time-dependent therapeutic era and rise in the gross domestic product (GDP) and Human Development Index (HDI). Materials and Methods: Data from 710 children who were treated for ALL between 1958 and 2018 at a single pediatric center were analyzed for probability of 5-year overall survival...
Hellenic Anticancer Institute
Sat Sep 14, 2019 03:11
Pretreatment Serum Levels of Soluble Cytokeratin Fragments (Cyfra 21-1, TPS, MonoTotal) in Relation to Clinical and Pathobiological Aspects of Head and Neck Squamous Cell Carcinomas
Background/Aim: The aim of this study was to analyze the pretreatment cytokeratin serum levels in head and neck squamous cell carcinoma (HNSCC) by three assays in relation to selected clinicopathological characteristics in an effort to find diagnostic/prognostic biomarkers for HNSCC and determine the best assay. Patients and Methods: In total, 46 patients with HNSCC with different subsite (oropharyngeal-21 cases, hypopharyngeal-4 and laryngeal-21) were included in this prospective study. MonoTotal,...
Hellenic Anticancer Institute
Sat Sep 14, 2019 03:11
Genetic Variants of the IL2 Gene Related to Risk and Survival in Patients With Colorectal Cancer
Background: Interleukin 2 (IL2) is a significant factor activating T-cell-mediated immune response by stimulation of natural killer cells, T-cells and in development of regulatory T (Treg) cells. Recent studies have that IL2 participates in cancer development by modifying the local immune response. Based on the suggested role of the single nucleotide polymorphisms (SNPs) rs2069762, rs6822844 and rs11938795 of IL2 in the pathogenesis of certain diseases, the relationship of these SNPs with clinicopathological...
Hellenic Anticancer Institute
Sat Sep 14, 2019 03:11
Change in PMI During Neoadjuvant Therapy Is a Predictive Prognostic Marker in Rectal Cancer
Background/Aim: Neoadjuvant therapy is often administered to patients with locally advanced rectal cancer (LARC). The aim of this study was to investigate the correlation between the change in the psoas muscle index (PMI) during neoadjuvant therapy and the prognosis of LARC patients. Patients and Methods: Forty-seven patients who underwent potentially curative surgery for LARC with neoadjuvant therapy were enrolled in this study. We evaluated the relationship between the prognosis and clinicopathological...
Hellenic Anticancer Institute
Sat Sep 14, 2019 03:11
Peroxiredoxin 6 Serum Levels and Risk of Neutropenic Infections in Diffuse Large B-cell Lymphoma
Background/Aim: Diffuse large B-cell lymphoma (DLBCL) is an aggressive malignancy where antioxidant enzyme peroxiredoxin 6 (Prx6) has previously been associated with adverse outcomes. Its systemic effects in DLBCL are unknown. Materials and Methods: This study included 53 patients with DLBCL, five patients with primary central nervous system lymphoma (PCNSL) and 20 healthy controls. The expression of Prx6 was evaluated immunohistochemically in DLBCL tissue samples and compared to its expression in...
Hellenic Anticancer Institute
Sat Sep 14, 2019 03:11
Assessment of Outcome of Hepatic Resection for Extremely Elderly Patients With a Hepatic Malignancy
Background/Aim: We aimed to assess surgical outcome and long-term survival after elective hepatic resection for hepatocellular carcinoma (HCC) and colorectal liver metastasis (CRLM) in patients aged 80 years or older. Patients and Methods: This study included 100 patients aged 70 years or older, who underwent hepatic resection for HCC or CRLM between January 2000 and December 2012. Outcomes and clinicopathological data were compared between the elderly (aged 70-79 years; n=84) and extremely elderly...
Hellenic Anticancer Institute
Sat Sep 14, 2019 03:11
Correlation of Tumor Location to Clinical Outcomes in Colorectal Cancer: A Single-institution Retrospective Analysis
Background/Aim: Recent data highlighted that location of metastatic colorectal cancer (mCRC) may have a prognostic impact and also a predictive value of the outcomes of first-line therapy. Materials and Methods: The records of mCRC patients who underwent first-line therapy from 2011 to April 2018 at our Institute were retrospectively reviewed. Progression-free survival (PFS), overall survival (OS) and objective response rate (ORR) according to the primary tumor location were investigated. Results:...
Hellenic Anticancer Institute
Sat Sep 14, 2019 03:11
A Randomized Phase III Trial on the Role of Esophagectomy in Complete Responders to Preoperative Chemoradiotherapy for Esophageal Squamous Cell Carcinoma (ESOPRESSO)
Background/Aim: We investigated the role of esophagectomy after clinical complete response (cCR) to chemoradiotherapy for esophageal squamous cell carcinoma (ESCC). Patients and Methods: Patients with resectable cT3-T4a/anyN/M0 or anyT/N+/M0 thoracic ESCC received two cycles of induction chemotherapy and then chemoradiotherapy (50.4 Gy/28 fractions). Patients with cCR were randomized to surgery or observation. Results: Among 86 patients, 38 (44.2%) achieved cCR after chemoradiotherapy; 37 were randomized...
Hellenic Anticancer Institute
Sat Sep 14, 2019 03:11
Somatic Transformation in Metastatic Testicular Germ Cell Tumours - A Different Disease Entity
Background/Aim: The occurrence of somatic transformation in germ cell tumour (GCT) is rare, with increased incidence in teratomatous tumours. The aim of this study was to understand the clinical outcomes of patients with metastatic GCT with somatic transformation. Materials and Methods: A retrospective study was conducted in two tertiary cancer centres in London. Between 1998 and 2016, 30 cases of somatic transformation in GCT treated at the Mount Vernon Cancer Centre and St. Bartholomew's Hospital...
Hellenic Anticancer Institute
Sat Sep 14, 2019 03:11
Complete Pathological Response Following Radiochemotherapy for Locally Advanced Rectal Cancer: Short and Long-term Outcome
Background/Aim: Preoperative radiochemotherapy (RCT) followed by total mesorectum excision has become the gold standard for locally advanced carcinoma of the low and middle rectum. The aim of the study is to evaluate the short and long-term outcomes of patients in complete pathological response (PR) following this treatment sequence. Patients and Methods: One hundred and thirty patients were retrospectively included between 2005 and 2017 in an expert centre, with 3 groups formed, according to the...
Hellenic Anticancer Institute
Sat Sep 14, 2019 03:11
Solitary Cerebral Metastases vs. High-grade Gliomas: Usefulness of Two MRI Signs in the Differential Diagnosis
Background/Aim: The differentiation between cerebral metastases (CM) and high-grade gliomas (HGG) can be difficult on magnetic resonance imaging (MRI). The aim of this study was to evaluate the usefulness of searching two MRI signs (signal alteration in the adjacent cortex, SAAC, and peripheral rim sign, PRS), in order to distinguish between these entities. Patients and Methods: A total of 61 patients were retrospectively enrolled (28 HGG, 33 CM). Fluid Attenuated Inversion Recovery (FLAIR) sequences...
Hellenic Anticancer Institute
Sat Sep 14, 2019 03:11
Clinical Impact of FOLFOXIRI Aiming for Conversion Surgery in Unresectable Multiple Colorectal Liver Metastasis
Background/Aim: We evaluated the clinical impact of FOLFOXIRI regimen aiming for conversion surgery in patients with unresectable multiple colorectal liver metastasis (CRLM). Patients and Methods: A total of 42 patients with unresectable multiple CRLM who received chemotherapy with molecular agents were included in the analysis. The clinical results of FOLFOXIRI with other regimens were compared. Results: The total conversion rate of 42 unresectable CRLM was 48.1%, and conversion cases had a better...
Hellenic Anticancer Institute
Sat Sep 14, 2019 03:11
Intrauterine Progestin Therapy as a New Approach to Premalignant Endometrial Polyps: A Prospective Observational Study
Background/Aim: Endometrial hyperplastic polyps (EHP) may progress to endometrial carcinoma (EC) if left untreated. We aimed to prospectively investigate the efficacy of the low-dose levonorgestrel intrauterine system (LNG-IUS) as therapy for EHP with malignant potential. Patients and Methods: In total, 37 women with EHP underwent therapy with LNG-IUS containing 13.5 mg levonorgestrel for six months or 4-10 weeks depending on whether the EHP was characterized (by D-score analysis) as low- to medium-risk...
Hellenic Anticancer Institute
Sat Sep 14, 2019 03:11
Performance Status and Its Changes Predict Outcome for Patients With Inoperable Stage III NSCLC Undergoing Multimodal Treatment
Background/Aim: Patient performance scores are used widely in clinical practice to assess a patient's general condition. The aim of this study was to evaluate the prognostic role of Eastern Cooperative Oncology Group performance score (ECOG PS) before, after and its changes during chemoradiotherapy in patients with stage III non-small cell lung cancer (NSCLC). Patients and Methods: Records of 99 patients with stage III NSCLC were evaluated. ECOG PS before, during and after chemoradiotherapy was analyzed...
Hellenic Anticancer Institute
Sat Sep 14, 2019 03:11
The Role of Local Therapy in Multi-focal Epithelioid Haemangioendothelioma
Background/Aim: Epithelioid haemangioendothelioma (EHE) is a rare tumor with a wide spectrum of clinical behavior. There is no consensus on the role of local therapy in symptomatic, multi-focal disease. Patients and Methods: A retrospective review of patients presenting to the Royal Marsden Hospital between January 2000 and December 2017 was conducted. Results: Fifty-three patients with EHE were identified, of which 18 patients (34.0%) received local therapy, and 11 patients (20.8%) underwent active...
Hellenic Anticancer Institute
Sat Sep 14, 2019 03:11
Accelerated Middle Half Body Radiotherapy in Bone Metastases from Prostate Cancer: A Phase I Study (SHARON Project)
Background/Aim: The primary endpoint of this phase I study was the maximum tolerated dose (MTD) of middle half body (MHB) accelerated radiotherapy (RT) in multiple bone metastatic (BM) prostate cancer (PCa) patients. Patients and Methods: Three step dose escalation [13 Gy (3.25 Gy/fraction), 14 Gy (3.5 Gy/fraction), and 15 Gy (3.75 Gy/fraction)] in three consecutive patient cohorts were planned. RT was delivered in two consecutive days and two daily fractions. Six patients were enrolled in the first...
Hellenic Anticancer Institute
Sat Sep 14, 2019 03:11

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