Related ArticlesFGF23 at the crossroads of phosphate, iron economy and erythropoiesis. Nat Rev Nephrol. 2019 Sep 13;: Authors: Edmonston D, Wolf M Abstract Fibroblast growth factor 23 (FGF23) was initially characterized as an important regulator of phosphate and calcium homeostasis. New research advances demonstrate that FGF23 is also linked to iron economy, inflammation and erythropoiesis. These advances have been fuelled, in part, by the serendipitous...
Sun Sep 15, 2019 13:01
Related ArticlesThe redox metabolic pathways function to limit Anaplasma phagocytophilum infection and multiplication while preserving fitness in tick vector cells. Sci Rep. 2019 Sep 13;9(1):13236 Authors: Alberdi P, Cabezas-Cruz A, Prados PE, Rayo MV, Artigas-Jerónimo S, de la Fuente J Abstract Aerobic organisms evolved conserved mechanisms controlling the generation of reactive oxygen species (ROS) to maintain redox homeostasis signaling and modulate...
Sun Sep 15, 2019 13:01
Related ArticlesFrom embryogenesis to adulthood: Critical role for GATA factors in heart development and function. IUBMB Life. 2019 Sep 13;: Authors: Whitcomb J, Gharibeh L, Nemer M Abstract Cardiac development is governed by a complex network of transcription factors (TFs) that regulate cell fates in a spatiotemporal manner. Among these, the GATA family of zinc finger TFs plays prominent roles in regulating the development of the myocardium, endocardium,...
Sun Sep 15, 2019 13:01
Related ArticlesPaneth cell dysfunction mediates alcoholic steatohepatitis through promoting bacterial translocation in mice: role of zinc deficiency. Hepatology. 2019 Sep 14;: Authors: Zhong W, Wei X, Hao L, Lin TD, Yue R, Sun X, Guo W, Dong H, Li T, Ahmadi AR, Sun Z, Zhang Q, Zhao J, Zhou Z Abstract Microbial dysbiosis is associated with alcoholic hepatitis (AH) with the mechanisms yet to be elucidated. The present study aimed to determine the effects...
Sun Sep 15, 2019 19:04
Related ArticlesThe gut microbiome alterations in allergic and inflammatory skin diseases - an update. J Eur Acad Dermatol Venereol. 2019 Sep 14;: Authors: Polkowska-Pruszyńska B, Gerkowicz A, Krasowska D Abstract The human microbiome is a wide range of microorganisms residing in and on our body. The homeostasis between host immune system and the microbial environment allows mutual benefits and protection. Physiological bacterial colonization is essential...
Sun Sep 15, 2019 19:04
Related ArticlesFactors that influence the androgen receptor cistrome in benign and malignant prostate cells. Mol Oncol. 2019 Sep 14;: Authors: Copeland BT, Du J, Pal SK, Jones JO Abstract The androgen receptor (AR) plays key roles in the development of prostate tissue and the development and progression of prostate cancer (PC). AR guides cytodifferentiation and homeostasis in benign luminal epithelial cells; however, in PC, AR instead drives the uncontrolled...
Sun Sep 15, 2019 19:04
Related ArticlesTriggered ferroptotic polymer micelles for reversing multidrug resistance to chemotherapy. Biomaterials. 2019 Sep 07;223:119486 Authors: Gao M, Deng J, Liu F, Fan A, Wang Y, Wu H, Ding D, Kong D, Wang Z, Peer D, Zhao Y Abstract Drug-tolerant persister cancer cells (PCCs) play an important role in the development of multidrug resistance (MDR) to anti-cancer drugs. This is due to the strong link between PCCs formation and epithelial-mesenchymal...
Sun Sep 15, 2019 19:04
Related ArticlesGlucocorticoid and mineralocorticoid receptors and corticosteroid homeostasis are potential targets for endocrine-disrupting chemicals. Environ Int. 2019 Sep 11;133(Pt A):105133 Authors: Zhang J, Yang Y, Liu W, Schlenk D, Liu J Abstract Endocrine-disrupting chemicals (EDCs) have received significant concern, since they ubiquitously exist in the environment and are able to induce adverse health effects on human and wildlife. Increasing...
Sun Sep 15, 2019 19:04
Related ArticlesCervical Myelopathy Presenting without Symptoms in the Upper Extremities: Incidence and Presenting Characteristics. World Neurosurg. 2019 Sep 09;: Authors: Houten JK, Pasternack J, Norton RP Abstract BACKGROUND: A preponderance of common signs and symptoms of cervical myelopathy (CM) manifest in the upper extremities and include hand numbness, hand clumsiness, and distal upper extremity weakness. Cervical myelopathy presenting without...
Fri Sep 13, 2019 14:30
Related ArticlesThe Use of BrainPath™ Tubular Retractors in the Management of Deep Brain Lesions: A Review of Current Studies. World Neurosurg. 2019 Sep 09;: Authors: Mansour S, Echeverry N, Shapiro S, Snelling B PMID: 31513954 [PubMed - as supplied by publisher]
Fri Sep 13, 2019 14:30
Related ArticlesFourth ventricle enlargement in Chiari malformation type I. World Neurosurg. 2019 Sep 09;: Authors: Seaman SC, Dawson JD, Magnotta V, Menezes AH, Dlouhy BJ Abstract OBJECT: How Chiari malformation type I (CM-I) affects posterior fossa brain structures and produces various symptoms remains unclear. The 4th ventricle is surrounded by critical structures required for normal function. The foramen of Magendie can be obstructed in CM-I; therefore,...
Fri Sep 13, 2019 14:30
Related ArticlesCompensatory mechanisms for kyphotic change in the cervical spine according to alignment analysis of the cases after anterior cervical corpectomy and fusion. World Neurosurg. 2019 Sep 10;: Authors: Ikeda N, Odate S, Shikata J Abstract BACKGROUND: Compensatory mechanisms for cervical kyphosis are unclear. Few alignment analyses targeted on ongoing cervical kyphosis and detailed each effect of compensatory alignment change. METHODS:...
Sat Sep 14, 2019 15:46
Related ArticlesDirect suturing of sciatic nerve defects in high-degree knee flexion: an experimental study. World Neurosurg. 2019 Sep 10;: Authors: Pfister G, Ghabi A, de Carbonnières A, Oberlin C, Belkheyar Z, Mathieu L Abstract OBJECTIVES: This work sought to elucidate the conditions of direct suturing of sciatic nerve defects in high-degree knee flexion. We aimed to establish a correlation between the defect length, the defect location, the degree...
Sat Sep 14, 2019 15:46
Related ArticlesBasal cistern effacement and pseudo-subarachnoid hemorrhage on CT images of chronic subdural hematoma. World Neurosurg. 2019 Sep 10;: Authors: Atsumi H, Sorimachi T, Nonaka Y, Matsumae M Abstract OBJECTIVE: Computed tomography (CT) images of patients with chronic subdural hematoma (CSDH) sometimes show obliteration of the basal cistern with high density in an obliterated Sylvian cistern termed "pseudo-subarachnoid hemorrhage (SAH)". However,...
Sat Sep 14, 2019 15:46
Related ArticlesENDONASAL ENDOSCOPIC AND TRANSORAL APPROACHES TO THE CRANIOVERTEBRAL JUNCTION AND THE CLIVAL REGION: A COMPARATIVE ANATOMICAL STUDY. World Neurosurg. 2019 Sep 10;: Authors: Spina A, Gagliardi F, Abarca-Olivas J, Bailo M, Boari N, Gonzalez-Lopez P, Gragnaniello C, Caputy AJ, Mortini P Abstract OBJECTIVE: Anterior craniovertebral junction (CVJ) surgery is still one of the most debated neurosurgical topics. Transoral approach (TOA) has been...
Sat Sep 14, 2019 15:46
Related ArticlesImpact of spot sign etiology in supratentorial intracerebral hemorrhage on outcomes of endoscopic surgery. World Neurosurg. 2019 Sep 10;: Authors: Miki K, Abe H, Nonaka M, Morishita T, Iwaasa M, Arima H, Inoue T Abstract BACKGROUND: The spot sign (SS) in spontaneous intracerebral hemorrhage (sICH) has been reported to be a predictive factor of poor outcome, however, how SS is related with the clinical outcome remain unclear. We aimed...
Sat Sep 14, 2019 15:46
Related ArticlesTreatment risk for elderly patients with unruptured cerebral aneurysm from a nationwide database in Japan. World Neurosurg. 2019 Sep 10;: Authors: Ikawa F, Michihata N, Akiyama Y, Iihara K, Matano F, Morita A, Kato Y, Iida K, Kurisu K, Fushimi K, Yasunaga H Abstract BACKGROUND: This study aimed to clarify the risk factors of treatment for unruptured cerebral aneurysms (UCAs) in elderly patients by comparing the morbidity at discharge...
Sat Sep 14, 2019 15:46
Related ArticlesEllagic Acid enhances the Antitumor Efficacy of Bevacizumab in an In Vitro Glioblastoma Model. World Neurosurg. 2019 Sep 10;: Authors: Çetin A, Biltekin B, Degirmencioglu S Abstract OBJECTIVE: The anticarcinogenic effect of ellagic acid (EA), one of natural phenols of fruits and vegetables, has been investigated in several types of tumors, while the combining effect with Bevacizumab (BEV), a common drug used in the treatment of recurrent...
Sat Sep 14, 2019 15:46
Related ArticlesAttenuation of white matter damage following Deferoxamine treatment in rats after spinal cord injury. World Neurosurg. 2019 Sep 10;: Authors: Shi J, Tang R, Zhou Y, Xian J, Zuo C, Wang L, Wang J, Feng H, Hu S Abstract BACKGROUND: and purpose -With little information available on axonal and myelin damage surrounding the contusion, the study of spinal cord injury (SCI) so far has focused on neuronal death. In this study, we investigated...
Sat Sep 14, 2019 15:46
Related ArticlesBrain lobotomy: a historical and moral dilemma with no alternative? World Neurosurg. 2019 Sep 10;: Authors: Terrier LM, Lévêque M, Amelot A Abstract BACKGROUND: Pioneered in 1936 by Portuguese neurologist and politician Egas Moniz, lobotomy was a definitive lesional surgery on the brain, which consisted in splitting white fibers in the frontal lobes. Sixteen years later, the first anti-psychotic medication appeared at Sainte-Anne mental...
Sat Sep 14, 2019 15:46
Related ArticlesLaser Interstitial Thermal Therapy to the Posterior Fossa: Challenges and Nuances. World Neurosurg. 2019 Sep 10;: Authors: Traylor JI, Patel R, Habib A, Muir M, de Almeida Bastos DC, Rao G, Prabhu SS Abstract OBJECTIVE: Posterior fossa tumors are rare in adults and pose a challenge to treat due to the bony contour of the posterior fossa, complex anatomical structures including deep venous sinuses, and the proximity of the fourth ventricle...
Sat Sep 14, 2019 15:46
Related ArticlesTransnasal and Transoral Approaches to Atlantoaxial Synovial Cysts: Report of 3 Cases and Review of the Literature. World Neurosurg. 2019 Sep 10;: Authors: Delavari N, Geh N, Hervey-Jumper SL, McKean EL, Sullivan SE Abstract BACKGROUND: Synovial cysts are cystic masses lined with pseudostratified columnar cells and contain clear or xanthochromic fluid. Though commonly encountered in the lumbar spine, synovial cysts infrequently occur...
Sat Sep 14, 2019 15:46
Related ArticlesOutcome of Microsurgery for Arteriovenous Malformations in a Resource Restricted Environment: A Single-Surgeon Series from Vietnam. World Neurosurg. 2019 Sep 10;: Authors: Jean WC, Huynh T, Tai AX, Felbaum DR, Syed HR, Ngo HM Abstract BACKGROUND: The health care expenditure in Vietnam is equivalent to 1% of that in the United States. For most patients with brain arteriovenous malformations (AVM), surgery is the only available treatment...
Sat Sep 14, 2019 15:46
Related ArticlesIntraoperative repair of CSF rhinorrhea in skull base tumor resection: A retrospective study of acellular dermal matrix vs. turbinate flap. World Neurosurg. 2019 Sep 10;: Authors: Zhong B, Song NY, Deng D, Li LK, Du JT, Liu F, Liu YF, Liu SX Abstract BACKGROUND: Acellular dermal matrix(ADM) and turbinate flap(TF) are widely used in reconstruction of skull base defects. However, due to the lack of literature, the therapeutic effects have...
Sat Sep 14, 2019 15:46
Related ArticlesEndoscopic Versus Microscopic Transcallosal Excision of Colloid Cysts: a Systematic Review in the Era of Complete Endoscopic Excision. World Neurosurg. 2019 Sep 10;: Authors: Sethi A, Cavalcante D, Ormond DR Abstract Background; Transcallosal microscopic and endoscopic excisions are both well established; approaches to colloid cyst resection; however, there has been no clear consensus; regarding the favored approach. OBJECTIVE:...
Sat Sep 14, 2019 15:46
Related ArticlesAn alternative route to the posterior half of the third ventricle: the trans-occipital horn approach. Technical note. World Neurosurg. 2019 Sep 10;: Authors: Muscas G, Battista F, Lastrucci G, Della Puppa A Abstract BACKGROUND: Lesions arising or abutting in the posterior half of the III ventricle are approached through established routes to avoid damage of essential brain structures. Occasionally, the features of the lesion require rethinking...
Sat Sep 14, 2019 15:46
Related ArticlesGrade II/III glioma microenvironment mining and its prognostic merit. World Neurosurg. 2019 Sep 10;: Authors: Chen J, Hou C, Wang P, Yang Y, Zhou D Abstract OBJECTIVE: The tumor microenvironment greatly influences tumor formation, invasion, and progression. The ESTIMATE algorithm quantifies stromal and immune components in a tumor, reflecting the tumor microenvironment. This study aimed to explore key prognostic genes in grade II/III...
Sat Sep 14, 2019 15:46
Related ArticlesThe neuroprotective effects of simvastatin on high cholesterol following traumatic brain injury in rats. World Neurosurg. 2019 Sep 10;: Authors: Jack Chong A, Lim SW, Lee YL, Chio CC, Chang CH, Kuo JR Abstract BACKGROUND: High cholesterol has been correlated with a higher risk of cerebrovascular diseases. Whether pre-existing high cholesterol exacerbates traumatic brain injury (TBI), and whether treatment with the cholesterol lowering...
Sat Sep 14, 2019 15:46
Related ArticlesPatient safety analysis in radiation burden of head computed tomography imaging in 1,185 neurosurgical inpatients. World Neurosurg. 2019 Sep 11;: Authors: Sheppard JP, Duong C, Romiyo P, Azzam D, Alkhalid Y, Nguyen T, Babayan D, Lagman C, Sun MZ, Prashant GN, Beckett JS, Yang I Abstract OBJECTIVE: We performed a retrospective analysis in a cohort of 1,185 patients at our institution who were identified as undergoing one or more head CT...
Sun Sep 15, 2019 14:27
Related ArticlesCDX2 STAINING DEFINES INTRACRANIAL MATURE TERATOMA WITH DIFFERENTIATION TO COLONIC ADENOCARCINOMA. World Neurosurg. 2019 Sep 11;: Authors: Riedy LN, Kim M, Yun JJ, Borys E, Prabhu VC Abstract BACKGROUND: Malignant transformation of a mature intracranial teratoma into an adenocarcinoma is an extremely rare event and portends a poor prognosis. The clinical progression, radiographic changes, histopathology, and immunohistochemistry of these...
Sun Sep 15, 2019 14:27
Related ArticlesThe safety and efficacy of hydrogen peroxide in controlling blood loss and surgical site infection after multi-segmental lumbar spine surgery: a retrospective, case-controlled study. World Neurosurg. 2019 Sep 11;: Authors: Chen H, Yang JS, Zou P, Zhao YT, Liu TJ, Tian Y, Ding KY, Liu P, Zhang JN, Hao DJ Abstract OBJECTIVE: To first explore the safety and efficacy of H2O2 in controlling blood loss and SSI after multi-segmental lumbar spine...
Sun Sep 15, 2019 14:27
Related ArticlesTwo-Operator Endoscopic Resection of Left Cerebellopontine Angle Epidermoid. World Neurosurg. 2019 Sep 11;: Authors: Cecchini G, Sorenson TJ, Graffeo CS, Vitale G, Di Biase F Abstract Intracranial epidermoid cysts are developmental central nervous system abnormalities that arise from erroneous ectodermal inclusion during neural tube closure. Epidermoids are relatively common representing 1% of all intracranial masses and are particularly...
Sun Sep 15, 2019 14:27
Related ArticlesAn Anatomical Feasibility Study for Revascularization of the Ophthalmic Artery. Part II: Intraorbital Segment. World Neurosurg. 2019 Sep 11;: Authors: Rubio RR, Vigo V, Gandhi S, Tabani H, Meybodi AT, Winkler EA, Abla AA, Lawton MT, Benet A Abstract INTRODUCTION: Distal ophthalmic artery (OpA) aneurysms are a rare subset of vascular lesions with lack of optimal treatment. The management of these aneurysms may require complete occlusion...
Sun Sep 15, 2019 14:27
Related ArticlesSpinal textiloma after diskectomy, a case report and review of literature. World Neurosurg. 2019 Sep 11;: Authors: Lotfinia I, Mahdkhah A Abstract Spinal masses can be diagnosed by clinical and radiographic examinations. Infrequently, pseudotumors may be due to retained masses after surgical interventions. In fact, these spinal or paraspinal expansions are caused by iatrogenic foreign bodies. Pseudotumors are mentioned as textilomas....
Sun Sep 15, 2019 14:27
Related ArticlesThe morphological characteristics of pericallosal artery aneurysms and their high propensity for rupture. World Neurosurg. 2019 Sep 11;: Authors: Zhai XD, Yu JX, Li CJ, Ren J, Ji Z, He C, Ye M, Hu P, Zhang HQ Abstract BACKGROUND: Compared with intracranial aneurysms (IAs) at other locations, pericallosal artery aneurysms (PAAs) demonstrate an extremely high risk of rupture. However, due to their rarity, our understanding of their morphological...
Sun Sep 15, 2019 14:27
Related ArticlesAnterolateral Approach for Retrostyloid Superior Parapharyngeal Space Schwannomas Involving the Jugular Foramen Area: A 20-Years Experience. World Neurosurg. 2019 Sep 11;: Authors: Luzzi S, Lucifero AG, Del Maestro M, Marfia G, Navone SE, Baldoncini M, Nuñez M, Campero A, Elbabaa SK, Galzio R Abstract BACKGROUND: Schwannomas encompassing the superior parapharyngeal space are challenging lesions because of the anatomical complexity of...
Sun Sep 15, 2019 14:27
Related ArticlesUse of 3D printing technology in complex spine surgeries. World Neurosurg. 2019 Sep 11;: Authors: Lador R, Regev G, Salame K, Khashan M, Lidar Z PMID: 31520760 [PubMed - as supplied by publisher]
Sun Sep 15, 2019 14:27
Related ArticlesThalamus Cavernous Malformation Resection via Contralateral Anterior Interhemispheric Transcallosal Approach: Two-Dimensional Operative Video. World Neurosurg. 2019 Sep 11;: Authors: Song J, Liu P, Pan Z, Quan K, Zhao X, Zhu W Abstract Thalamic cavernous malformations (CM) are highly surgically challenging. In this illustrative video, we present a case of a 36-year-old male with a CM located at the left medial thalamus, which was successfully...
Sun Sep 15, 2019 14:27
Related ArticlesFull-Endoscopic Lumbar Foraminoplasty for Symptomatic Cement Leakage With Exiting Nerve Root Impingement. World Neurosurg. 2019 Sep 11;: Authors: Wu C, Lee CY, Huang TJ, Wu MH PMID: 31520762 [PubMed - as supplied by publisher]
Sun Sep 15, 2019 14:27
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